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Original Article

Ifn-β1B Treatment of Relapsingmultiple Sclerosis Has no Effect on Cd3-Induced Inflammatory or Counterregulatory Anti-Inflammatory Cytokine Secretion Ex Vivo After Nine Months

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Pages 135-144 | Received 01 Nov 1996, Published online: 07 Jul 2009

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Eilhard Mix, Katja Stefan, Jaqueline Höppner, Thomas Klauer, Uwe K. Zettl, Ulf Strauss, Hans-J. Meyer-Rienecker & Arndt Rolfs. (2003) Lymphocyte Subpopulations, Oxidative Burst and Apoptosis in Peripheral Blood Cells of Patients with Multiple Sclerosis–Effect of Interferon-β. Autoimmunity 36:5, pages 291-305.
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Nicolas Boivin, Joanie Baillargeon, Prenitha Mercy Ignatius Arokia Doss, Andrée-Pascale Roy & Manu Rangachari. (2015) Interferon-β Suppresses Murine Th1 Cell Function in the Absence of Antigen-Presenting Cells. PLOS ONE 10:4, pages e0124802.
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Chris J. Hedegaard, Martin Krakauer, Klaus Bendtzen, Per Soelberg Sørensen, Finn Sellebjerg & Claus H. Nielsen. (2008) The effect of β-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis. Clinical Immunology 129:1, pages 80-89.
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Anne L. Astier, Gregory Meiffren, Samuel Freeman & David A. Hafler. (2006) Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. Journal of Clinical Investigation 116:12, pages 3252-3257.
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Volkan Özenci, Mathilde Kouwenhoven, Natalia Teleshova, Mikhail Pashenkov, Sten Fredrikson & Hans Link. (2000) Multiple sclerosis:. Journal of Neuroimmunology 108:1-2, pages 236-243.
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Ferdinando Nicoletti, Roberto Di Marco, Francesco Patti, Paola Zaccone, Maria Rita L'Episcopo, Ester Reggio, Ming Xiang, Alessandra Nicoletti & Arturo Reggio. (2000) SHORT-TERM TREATMENT OF RELAPSING REMITTING MULTIPLE SCLEROSIS PATIENTS WITH INTERFERON (IFN)-β1B TRANSIENTLY INCREASES THE BLOOD LEVELS OF INTERLEUKIN (IL)-6, IL-10 AND IFN-γ WITHOUT SIGNIFICANTLY MODIFYING THOSE OF IL-1β, IL-2, IL-4 AND TUMOUR NECROSIS FACTOR-α. Cytokine 12:6, pages 682-687.
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M.E Duddy, M.A Armstrong, A.D Crockard & S.A Hawkins. (1999) Changes in plasma cytokines induced by interferon-β1a treatment in patients with multiple sclerosis. Journal of Neuroimmunology 101:1, pages 98-109.
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Giovanni Ristori, Chiara Montesperelli, Claudio Gasperini, Luca Battistini, Giovanna Borsellino, Carla Buttinelli, Stefania Cannoni, Alessia Perna, Carlo Pozzilli & Marco Salvetti. (1999) T cell response to myelin basic protein before and after treatment with interferon beta in multiple sclerosis. Journal of Neuroimmunology 99:1, pages 91-96.
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Laura E Rothuizen, Thierry Buclin, François Spertini, Isabelle Trinchard, Alain Munafo, Pierre-Alexandre Buchwalder, Arnaud Ythier & Jérôme Biollaz. (1999) Influence of interferon β-1a dose frequency on PBMC cytokine secretion and biological effect markers. Journal of Neuroimmunology 99:1, pages 131-141.
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Elora J. Weringer & Ronald P. Gladue. 1999. In Vivo Models of Inflammation. In Vivo Models of Inflammation 237 263 .

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