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Research Article

Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero

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Pages 570-575 | Received 10 May 2012, Accepted 10 Jul 2012, Published online: 30 Aug 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Claudia Raperport, Elpiniki Chronopoulou & Roy Homburg. (2021) Effects of metformin treatment on pregnancy outcomes in patients with polycystic ovary syndrome. Expert Review of Endocrinology & Metabolism 16:2, pages 37-47.
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Daniella R. B. S. Novi, Camila B. Vidigal, Bruno V. D. Marques, Simone Forcato, Hiviny A. Raquel, Dimas A. M. Zaia, Cássia T. B. V. Zaia, Marli C. Martins-Pinge, Daniela C. C. Gerardin & Graziela S. Ceravolo. (2020) Can maternal treatment with metformin during gestation and lactation cause metabolic and cardiovascular disorders in rat offspring?. Archives of Physiology and Biochemistry 126:3, pages 276-281.
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Maka S. Hedrington & Stephen N. Davis. (2017) The care of pregestational and gestational diabetes and drug metabolism considerations. Expert Opinion on Drug Metabolism & Toxicology 13:10, pages 1029-1038.
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Articles from other publishers (54)

Christine Newman, Louise Rabbitt, Adesuwa Ero & Fidelma P. Dunne. (2023) Focus on Metformin: Its Role and Safety in Pregnancy and Beyond. Drugs 83:11, pages 985-999.
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Michaela Rickert, Aaron B. Caughey & Amy M. Valent. (2023) Medications for Managing Preexisting and Gestational Diabetes in Pregnancy. Obstetrics and Gynecology Clinics of North America 50:1, pages 121-136.
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Denice S Feig, J Johanna Sanchez, Kellie E Murphy, Elizabeth Asztalos, Bernard Zinman, David Simmons, Andrea M Haqq, I George Fantus, Lorraine Lipscombe, Anthony Armson, Jon Barrett, Lois Donovan, Paul Karanicolas, Siobhan Tobin, Kathryn Mangoff, Gail Klein, Yidi Jiang, George Tomlinson, Jill Hamilton, DS Feig, A Galper, B Cleave, M Strom, K Poolman, D Fong, E Viguiliouk, L Legault, L Boutin, J Ho, H Virtanen, A Zahedi, K Szwiega, J Coolen, R Dias, E Sellers, B Fletcher, L Bourrier, A Haqq, H Rylance, S Hadjiyannakis, J Courtney, R McManus, I Halperin, D Miller, K Coles, D Simmons, J Nema, SJ Weisnagel, MC Dubé, JP Chanoine, J Kwan, HD McIntyre, J Laurie, F Maguire, J Soper, T Bridger, R Houlden, A Breen, M McLean, A Duke, S Hendon & A Sigmund. (2023) Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial. The Lancet Diabetes & Endocrinology 11:3, pages 191-202.
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Nicole D. White. (2022) Drug-Induced Microbiome Changes: Considerations in Pregnancy. American Journal of Lifestyle Medicine 17:1, pages 50-53.
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Noha M. Shawky. (2022) Cardiovascular disease risk in offspring of polycystic ovary syndrome. Frontiers in Endocrinology 13.
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Denice S. Feig. (2022) Epidemiology and Therapeutic Strategies for Women With Preexisting Diabetes in Pregnancy: How Far Have We Come? The 2021 Norbert Freinkel Award Lecture. Diabetes Care 45:11, pages 2484-2491.
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Liu Yang, Lauren Lacey, Sonia Whyte, Siobhan Quenby, Fiona C. Denison, Neeraj Dhaun, Jane E. Norman, Amanda J. Drake & Rebecca M. Reynolds. (2021) Metformin in obese pregnancy has no adverse effects on cardiovascular risk in early childhood. Journal of Developmental Origins of Health and Disease 13:3, pages 390-394.
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Christine Newman & Fidelma P Dunne. (2021) Metformin for pregnancy and beyond: the pros and cons. Diabetic Medicine 39:3.
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Romina Fornes, Johanna Simin, Minh Hanh Nguyen, Gonzalo Cruz, Nicolás Crisosto, Maartje van der Schaaf, Lars Engstrand & Nele Brusselaers. (2022) Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. Reproductive Biology and Endocrinology 20:1.
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Kerstin M G Brand, Laura Saarelainen, Jaak Sonajalg, Emmanuelle Boutmy, Caroline Foch, Marja Vääräsmäki, Laure Morin-Papunen, Judith Schlachter, Katja M Hakkarainen & Pasi Korhonen. (2022) Metformin in pregnancy and risk of adverse long-term outcomes: a register-based cohort study. BMJ Open Diabetes Research & Care 10:1, pages e002363.
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Ayan Roy & Jayaprakash Sahoo. (2021) Long-term effects of metformin use in gestational diabetes mellitus on offspring health. World Journal of Diabetes 12:11, pages 1812-1817.
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Mélanie C. Faure, Rita Khoueiry, Jusal Quanico, Hervé Acloque, Marie-Justine Guerquin, Michael J. Bertoldo, Claire Chevaleyre, Christelle Ramé, Isabelle Fournier, Michel Salzet, Joëlle Dupont & Pascal Froment. (2021) In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood. Frontiers in Endocrinology 12.
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Huma Quadir. (2021) Current Therapeutic Use of Metformin During Pregnancy: Maternal Changes, Postnatal Effects and Safety. Cureus.
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Linh Nguyen, Lillian Yuxian Lim, Shirley Suet Lee Ding, Nur Shabrina Amirruddin, Shawn Hoon, Shiao-Yng Chan & Adrian Kee Keong Teo. (2021) Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells. Diabetes 70:8, pages 1689-1702.
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Josca M. Schoonejans, Heather L. Blackmore, Thomas J. Ashmore, Catherine E. Aiken, Denise S. Fernandez-Twinn & Susan E. Ozanne. (2021) Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. International Journal of Molecular Sciences 22:15, pages 8104.
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Amy M. Valent & Linda A. Barbour. (2021) Management of Women with Polycystic Ovary Syndrome During Pregnancy. Endocrinology and Metabolism Clinics of North America 50:1, pages 57-69.
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Samantha Bedell, Janine Hutson, Barbra de Vrijer & Genevieve Eastabrook. (2020) Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions. Current Vascular Pharmacology 19:2, pages 176-192.
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Gonzalo Jorquera, Bárbara Echiburú, Nicolás Crisosto, Ramón Sotomayor-Zárate, Manuel Maliqueo & Gonzalo Cruz. (2020) Metformin during Pregnancy: Effects on Offspring Development and Metabolic Function. Frontiers in Pharmacology 11.
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Megan Jones & Allison Akers. 2020. Obesity and Diabetes. Obesity and Diabetes 493 508 .
Riki Bergel, Eran Hadar, Yoel Toledano & Moshe Hod. 2020. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 653 685 .
Eszter Vanky, Liv Guro Engen Hanem & David H. Abbott. (2019) Children born to women with polycystic ovary syndrome—short- and long-term impacts on health and development. Fertility and Sterility 111:6, pages 1065-1075.
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Qing Xu & Qinglian Xie. (2019) Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics 299:5, pages 1295-1303.
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Linda A. Barbour & Denice S. Feig. (2019) Metformin for Gestational Diabetes Mellitus: Progeny, Perspective, and a Personalized Approach. Diabetes Care 42:3, pages 396-399.
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Dana R. Fasanella, Sarah L. Benner, Frederick R. Tejada & Patrice Jackson-Ayotunde. 2019. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 505 517 .
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Maki Kawasaki, Naoko Arata & Yoshihiro Ogawa. (2018) Obesity and abnormal glucose tolerance in the offspring of mothers with diabetes. Current Opinion in Obstetrics & Gynecology 30:6, pages 361-368.
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Linda A. Barbour, Christina Scifres, Amy M. Valent, Jacob E. Friedman, Thomas A. Buchanan, Donald Coustan, Kjersti Aagaard, Kent L. Thornburg, Patrick M. Catalano, Henry L. Galan, William W. HayJrJr, Antonio E. Frias, Kartik Shankar, Rebecca A. Simmons, Robert G. Moses, David A. Sacks & Mary R. Loeken. (2018) A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. American Journal of Obstetrics and Gynecology 219:4, pages 367.e1-367.e7.
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Wenneke van Weelden, Vincent Wekker, Leon de Wit, Jacqueline Limpens, Hilkka Ijäs, Aleid G. van Wassenaer-Leemhuis, Tessa J. Roseboom, Bas B. van Rijn, J. Hans DeVries & Rebecca C. Painter. (2018) Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs. Diabetes Therapy 9:5, pages 1811-1829.
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Linh Nguyen, Shiao-Yng Chan & Adrian Kee Keong Teo. (2018) Metformin from mother to unborn child – Are there unwarranted effects?. EBioMedicine 35, pages 394-404.
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Steve Hyer, Jyoti Balani & Hassan Shehata. (2018) Metformin in Pregnancy: Mechanisms and Clinical Applications. International Journal of Molecular Sciences 19:7, pages 1954.
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Liv Guro Engen Hanem, Solhild Stridsklev, Pétur B Júlíusson, Øyvind Salvesen, Mathieu Roelants, Sven M Carlsen, Rønnaug Ødegård & Eszter Vanky. (2018) Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs. The Journal of Clinical Endocrinology & Metabolism 103:4, pages 1612-1621.
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Janet A Rowan, Elaine C Rush, Lindsay D Plank, Jun Lu, Victor Obolonkin, Suzette Coat & William M Hague. (2018) Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7–9 years of age. BMJ Open Diabetes Research & Care 6:1, pages e000456.
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Riki Bergel, Eran Hadar, Yoel Toledano & Moshe Hod. 2018. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 655 687 .
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Sarah H. Koning, Klaas Hoogenberg, Helen L. Lutgers, Paul P. van den Berg & Bruce H.R. Wolffenbuttel. (2016) Gestational Diabetes Mellitus:current knowledge and unmet needs. Journal of Diabetes 8:6, pages 770-781.
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Kristiina Tertti, Eeva Eskola, Tapani Rönnemaa & Leena Haataja. (2015) Neurodevelopment of Two-Year-Old Children Exposed to Metformin and Insulin in Gestational Diabetes Mellitus. Journal of Developmental & Behavioral Pediatrics 36:9, pages 752-757.
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