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Scandinavian Journal of Clinical and Laboratory Investigation Volume 6, 1954 - Issue 4
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Original Article

The Titration of Heparin with Protamine

I. Refn NOVO Terapeutisk Laboratorium A/S, Copenhagen, Denmark
&
L. Vestergaard NOVO Terapeutisk Laboratorium A/S, Copenhagen, Denmark
Pages 284-287 | Received 26 May 1954, Published online: 08 Jul 2009

Citations (31)

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H. C. Godal. (1961) The Assay of Heparin in Thrombin Systems. Scandinavian Journal of Clinical and Laboratory Investigation 13:1, pages 153-166.
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Articles from other publishers (30)

John Hogwood, Barbara Mulloy, Rebeca Lever, Elaine Gray & Clive P. Page. (2023) Pharmacology of Heparin and Related Drugs: An Update. Pharmacological Reviews 75:2, pages 328-379.
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Barbara Mulloy, John Hogwood, Elaine Gray, Rebecca Lever & Clive P. Page. (2015) Pharmacology of Heparin and Related Drugs. Pharmacological Reviews 68:1, pages 76-141.
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Marilyn Johnston. 2013. Quality in Laboratory Hemostasis and Thrombosis. Quality in Laboratory Hemostasis and Thrombosis 244 252 .
Fiona Newall. 2013. Haemostasis. Haemostasis 279 287 .
Gastón A. Crespo, Majid Ghahraman Afshar & Eric Bakker. (2012) Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes. Angewandte Chemie International Edition 51:50, pages 12575-12578.
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Gastón A. Crespo, Majid Ghahraman Afshar & Eric Bakker. (2012) Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes. Angewandte Chemie 124:50, pages 12743-12746.
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Fiona Newall, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick, Paul Monagle & Vera Ignjatovic. (2010) Novel interactions between UFH and TFPI in children. British Journal of Haematology 151:4, pages 376-380.
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Fiona Newall, Vera Ignjatovic, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick & Paul Monagle. (2010) research paper: Clinical use of unfractionated heparin therapy in children: time for change?. British Journal of Haematology 150:6, pages 674-678.
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F. NEWALL, L. JOHNSTON, V. IGNJATOVIC, R. SUMMERHAYES & P. MONAGLE. (2009) Refinement and feasibility testing of a manual micro-method for protamine titration. International Journal of Laboratory Hematology 31:4, pages 457-461.
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Maureen Andrew, Alan D. Michelson, Ted Bovill, Michael Leaker, Patti Massicotte, Velma Marzinotto & Lu Ann Brooker. (1997) The Prevention and Treatment of Thromboembolic Disease in Children: A Need for Thrombophilia Programs. Journal of Pediatric Hematology/Oncology 19:1, pages 7-22.
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Maureen Andrew & Lu Ann Brooker. (1996) Hemostatic complications in renal disorders of the young. Pediatric Nephrology 10:1, pages 88-99.
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Dennis Mungall, Gary Raskob, Robert Coleman, David Rosenbloom, Thomas Ludden & Russel Hull. (1989) Pharmacokinetics and Dynamics of Heparin in Patients with Proximal Vein Thrombosis. The Journal of Clinical Pharmacology 29:10, pages 896-900.
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Alexander G.G. Turpie, John G. Robinson, Daniel J. Doyle, Amin S. Mulji, Gregory J. Mishkel, Brian J. Sealey, John A. Cairns, Leslie Skingley, Jack Hirsh & Michael Gent. (1989) Comparison of High-Dose with Low-Dose Subcutaneous Heparin to Prevent Left Ventricular Mural Thrombosis in Patients with Acute Transmural Anterior Myocardial Infarction. New England Journal of Medicine 320:6, pages 352-357.
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J. Missliwetz, C. Korninger & W. Denk. (1989) Todesfall infolge Heparin�berdosierungDeath due to heparin overdosage. Zeitschrift f�r Rechtsmedizin 103:2, pages 147-153.
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Russell D. Hull, Gary E. Raskob, Jack Hirsh, Richard M. Jay, Jacques R. Leclerc, William H. Geerts, David Rosenbloom, David L. Sackett, Christine Anderson, Linda Harrison & Michael Gent. (1986) Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein Thrombosis. New England Journal of Medicine 315:18, pages 1109-1114.
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J.R. Leclerc, W. Geerts, A. Panju, P. Nguyen & J. Hirsh. (1986) Management of anti-thrombin III deficiency during pregnancy without administration of anti-thrombin III. Thrombosis Research 41:4, pages 567-573.
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Patricia V. Nash & Thorir D. Bjornsson. (1984) Determination of plasma heparin by polybrene neutralization. Analytical Biochemistry 138:2, pages 319-323.
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Horst F. Schran, Douglas W. Bitz, Frank J. Diserio & Jack Hirsh. (1983) The pharmacokinetics and bioavailability of subcutaneously administered dihydroergotamine, heparin and the dihydroergotamine-heparin combination. Thrombosis Research 31:1, pages 51-67.
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Friedrich Nachtmann, Günter Atzl & Wolf Dieter Roth. 1983. 215 276 .
C.J. Carter, J.G. Kelton, J. Hirsh & M. Gent. (1981) Relationship between the antithrombotic and anticoagulant effects of low molecular weight heparin. Thrombosis Research 21:1-2, pages 169-174.
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K T Goodall, C C Chooi & A S Gallus. (1980) Heparin stability: effects of diluent, heparin activity, container, and pH.. Journal of Clinical Pathology 33:12, pages 1206-1211.
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F.W Peuscher, W.G van Aken, Odilia Th.N Flier, Elly A Stoepman-van Dalen, Thea M Cremer-Goote & J.A van Mourik. (1980) Effect of anticoagulant treatment measured by fibrinopeptide a (fpA) in patients with venous thrombo-embolism. Thrombosis Research 18:1-2, pages 33-43.
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J. Hirsh, W.G. van Aken & H. Chiu. 1979. Heparin: Structure, Cellular Functions, and Clinical Applications. Heparin: Structure, Cellular Functions, and Clinical Applications 323 331 .
C.J. Carter, J.G. Kelton & J. Hirsh. (1979) Comparison of the haemorrhagic effects of porcine and bovine heparin in rabbits. Thrombosis Research 15:3-4, pages 581-586.
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M.W.C. Hatton & E. Regoeczi. (1977) The inactivation of thrombin and plasmin by antithrombin III in the presence of Sepharose-heparin. Thrombosis Research 10:5, pages 645-660.
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J Hirsh, W G van Aken, A S Gallus, C T Dollery, J F Cade & W L Yung. (1976) Heparin kinetics in venous thrombosis and pulmonary embolism.. Circulation 53:4, pages 691-695.
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EBERHARD F. MAMMEN. 1971. Thrombosis and Bleeding Disorders. Thrombosis and Bleeding Disorders 268 291 .
F. Holzknecht & F. Spöttl. (1965) Heparintoleranz bei Hyperlipämikern. Klinische Wochenschrift 43:17, pages 938-940.
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F. K. Beller & D. Steichele. (1957) Der Protamintoleranztest als Abwandlung des Heparintoleranztestes und der Protamintitration. Zeitschrift für Die Gesamte Experimentelle Medizin 128:5, pages 458-470.
Crossref
G. Fekete. (1956) Turbidimetric estimation of heparin with protamine. Die Naturwissenschaften 43:12, pages 279-280.
Crossref

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