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Original Article

The Interaction of Protamine with Human Fibrinogen and the Significance of this Interaction for the Coagulation of Fibrinogen

Pages 433-445 | Received 27 Apr 1960, Published online: 13 May 2010

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J. S. Rø, T. H. Kluge, S. Taksdal & S. Skrede. (1974) Haemostatic Parameters and Erythrocyte Sedimentation Rate in Dextran-Warfarin Treated Vascular Surgical Patients. Scandinavian Journal of Thoracic and Cardiovascular Surgery 8:3, pages 206-215.
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J. Krôll. (1965) Studies on The Effect of low Molecular Weight Dextran Upon the Clotting Process in Vitro. Scandinavian Journal of Clinical and Laboratory Investigation 17:1, pages 51-56.
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H. C. Godal & I. Helle. (1963) In Vitro Studies on Fibrinogenolysis Induced by Streptokinase. Scandinavian Journal of Clinical and Laboratory Investigation 15:3, pages 303-310.
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H. C. Godal. (1962) A Study on the Beta Naphtol Reaction of Plasma (»Fibrinogen B«-test). Scandinavian Journal of Clinical and Laboratory Investigation 14:2, pages 203-206.
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P. Ollendorff. (1962) The Nature of the Anticoagulant Effect of Heparin, Protamine, Polybrene and Toluidine Blue. Scandinavian Journal of Clinical and Laboratory Investigation 14:3, pages 267-276.
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H. C. Godal. (1962) The Antiheparin Effect of Platelets. Scandinavian Journal of Clinical and Laboratory Investigation 14:3, pages 223-229.
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H. C. Godal. (1961) The Assay of Heparin in Thrombin Systems. Scandinavian Journal of Clinical and Laboratory Investigation 13:1, pages 153-166.
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H. C. Godal. (1961) Heparin Tolerance and the Plasma Proteins. Scandinavian Journal of Clinical and Laboratory Investigation 13:2, pages 314-325.
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H. C. Godal. (1961) The Influence of Heparin on the Fibrin Clot. Scandinavian Journal of Clinical and Laboratory Investigation 13:2, pages 306-313.
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Articles from other publishers (31)

Marc E. Stone & Michael W. Vespe. (2023) Heparin Rebound: An In-Depth Review. Journal of Cardiothoracic and Vascular Anesthesia 37:4, pages 601-612.
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Patrick Hecht, Martin Besser & Florian Falter. (2020) Are We Able to Dose Protamine Accurately Yet? A Review of the Protamine Conundrum. The Journal of ExtraCorporeal Technology 52:1, pages 63-70.
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Jiwon Kwak & Soo Suk Lee. (2019) Sensitivity and reproducibility improvements in a human plasma immunoassay with removal of clotting factors. Analytical Biochemistry 585, pages 113410.
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C.E. Dempfle & D.L. Heene. (1987) Purification of human plasma fibrinogen by chromatography on protamine-agarose. Thrombosis Research 46:1, pages 19-27.
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Steven L. Gonias, John J. Pasqua, Charles Greenberg & Salvatore V. Pizzo. (1985) Precipitation of fibrinogen, fibrinogen degradation products and fibrin monomer by histone H3. Thrombosis Research 39:1, pages 97-116.
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Marta S. Killner & Robert S. Lees. (1981) High molecular weight fibrinogen derivatives in hyperlipidemia. Thrombosis Research 22:3, pages 329-344.
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T. Ohtomo, K. Yoshida & A. Hasegawa. (1980) Comparison of the reactions of the compact-colony forming active substance (CCFAS) to the clumping-factor reaction in a strain ofStaphylococcus aureus with animal plasma. Medical Microbiology and Immunology 168:4, pages 261-265.
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D. A. Lane, M. F. Scully, D. P. Thomas, V. V. Kakkar, I. L. Woolf & Roger Williams. (2008) Acquired Dysfibrinogenaemia in Acute and Chronic Liver Disease. British Journal of Haematology 35:2, pages 301-308.
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M. Kopeć, Z. Węgrzynowicz, M. Zajdel, J. Sawecka & I. Szumiel. (1974) Effects of histones and dextran on some properties of fibrin, particularly on its susceptibility to plasmin. Thrombosis Research 5:3, pages 359-374.
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U. Abildgaard, O.R. Ødegård, P. Kierulf & D.S. Pepper. (1974) Influence of platelet factor 4 on inhibited thrombin substrate reactions. Thrombosis Research 5:2, pages 185-196.
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Clarence Merskey. (2006) PATHOGENESIS AND TREATMENT OF ALTERED BLOOD COAGULABILITY IN PATIENTS WITH MALIGNANT TUMORS*. Annals of the New York Academy of Sciences 230:1, pages 289-293.
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Marie-Claude Guillin & Doris Menache. (1973) Fetal fibrinogen and fibrinogen Paris I: Comparative fibrin monomers aggregation studies. Thrombosis Research 3:2, pages 117-135.
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Bruce Lages & S. S. Stivala. (2004) Copper ion binding and heparin interactions of human fibrinogen. Biopolymers 12:5, pages 961-974.
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Carl Ditlef Jacobsen & John C. Hoak. (1973) Fibrinogen Iowa City : An abnormal fibrinogen with no clinical symptoms. Thrombosis Research 2:3, pages 261-270.
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K. MiehlkeH. Holzhüter, S. M. Pusztai-Markos, E. Wenzel, H.-G. Ochs, B. Angelkort & K.-H. Stürner. 1973. Neunundsiebzigster Kongress. Neunundsiebzigster Kongress 1325 1327 .
Madeleine Klings, Ann L. Adams & Leo Vroman. (1972) Effects of protamine sulfate, polybrene and heparin on the behavior of plasma, plasma proteins, platelets and factor XII activity at interfaces. Thrombosis Research 1:5, pages 507-525.
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C. EIKA. (2009) On the Mechanism of Platelet Aggregation Induced by Heparin, Protamine and Polybrene. Scandinavian Journal of Haematology 9:1-6, pages 248-257.
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C. Eika & H. C. Godal. (2009) Thrombocytopenia in Rabbits Induced by Heparin, Protamine, and Polybrene. Scandinavian Journal of Haematology 8:6, pages 481-486.
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H. C. Godal & G. Gjengedal. (2009) Activation of Coagulation by Heparin‐Protamine Complexes as Demonstrated by Thrombotest. Scandinavian Journal of Haematology 8:3, pages 194-199.
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Gwendolyn J. Stewart. (2009) 21. AN ELECTRON MICROSCOPE STUDY OF THE POLYMERIZATION OF FIBRINOGEN AND ITS DERIVATIVES. Scandinavian Journal of Haematology 8:S13, pages 165-178.
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Z.S. Latallo, Z. Wegrzynowicz, A.Z. Budzyński & M. Kopeć. (2009) 19. EFFECT OF PROTAMINE SULPHATE ON THE SOLUBILITY OF FIBRINOGEN, ITS DERIVATIVES AND OTHER PLASMA PROTEINS. Scandinavian Journal of Haematology 8:S13, pages 151-162.
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Stefan Niewiarowski, Gwendolyn J. Stewart & Victor J. Marder. (1970) Formation of highly ordered polymers from fibrinogen and fibrin degradation products. Biochimica et Biophysica Acta (BBA) - Protein Structure 221:2, pages 326-341.
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H. C. Godal. (2009) An Inhibitor to Fibrin Stabilizing Factor (FSF, Factor XIII). Scandinavian Journal of Haematology 7:1, pages 43-48.
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U. Abildgaard. (2009) Inhibition of the Thrombin‐Fibrinogen Reaction by Heparin and Purified Cofactor. Scandinavian Journal of Haematology 5:6, pages 440-453.
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U. Abildgaard. (2009) Inhibition of the Thrombin‐Fibrinogen Reaction by Heparin in the Absence of Cofactor. Scandinavian Journal of Haematology 5:6, pages 432-439.
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H. Gans, V. Subramanian, S. John, A. R. Castaneda & C. W. Lillehei. (2006) THEORETICAL AND PRACTICAL (CLINICAL) CONSIDERATIONS CONCERNING PROTEOLYTIC ENZYMES AND THEIR INHIBITORS WITH PARTICULAR REFERENCE TO CHANGES IN THE PLASMINOGEN‐PLASMIN SYSTEM OBSERVED DURING ASSISTED CIRCULATION IN MAN * . Annals of the New York Academy of Sciences 146:2, pages 721-736.
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Louis Rosenfeld. (1965) Clot opacity and the thrombin-plasma reaction. Archives of Biochemistry and Biophysics 111:3, pages 660-670.
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Margaret M. Niall & J.A. Owen. (1962) Heparin as a source of error in the determination of plasma albumin on a basis of selective dye-binding. Clinica Chimica Acta 7:2, pages 155-158.
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Rudolf Holemans & Dionysius Adamis. (1962) HYPOTENSIVE ACTION OF PROTAMINE AND HEXADIMETHRINE. The Lancet 279:7226, pages 434-435.
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R.J. Wieme & M.J. Lauryssens. (1962) LACTATE DEHYDROGENASE MULTIPLICITY IN NORMAL AND DISEASED HUMAN MUSCLE. The Lancet 279:7226, pages 433-434.
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H. C. GODAL. (2009) Quantitative and Qualitative Changes in Fibrinogen Following Major Surgical Operations. Acta Medica Scandinavica 171:6, pages 687-694.
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