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Scandinavian Journal of Clinical and Laboratory Investigation Volume 18, 1966 - Issue 1
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Original Article

pH and Molecular CO2 Components of the Bohr Effect in Human Blood

N. Næraa From the Departments of Physiology, Clinical Chemistry, Medical-Epidemics and Cardiology, University of Aarhus, Denmark
,
E. Strange Petersen From the Departments of Physiology, Clinical Chemistry, Medical-Epidemics and Cardiology, University of Aarhus, Denmark
,
E. Boye The Cardiovascular Research Institute and Department of Anesthesia, University of California, San Francisco, USA
&
J. W. Severinghaus The Cardiovascular Research Institute and Department of Anesthesia, University of California, San Francisco, USA
Pages 96-102 | Received 30 Aug 1965, Published online: 08 Jul 2009

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Richard Juel & John O. Milam. (1979) 2,3-Diphosphoglycerate: Its Role in Health and Disease. CRC Critical Reviews in Clinical Laboratory Sciences 10:2, pages 113-146.
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M. Rörth, S. F. Nygaard, H. H. Parving, V. Hansen & T. Kalsig. (1973) Human Red Cell Metabolism and in Vivo Oxygen Affinity of Red Cells during 24 Hours' Exposure to Simulated High Altitude (4500 m). Scandinavian Journal of Clinical and Laboratory Investigation 31:4, pages 447-452.
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O. Siggaard-Andersen & L. Garby. (1973) The Bohr Effect and the Haldane Effect. Scandinavian Journal of Clinical and Laboratory Investigation 31:1, pages 1-8.
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O. Siggaard-Andersen, M. Rörth, B. Nörgaard-Pedersen, O. Sparre Andersen & E. Johansen. (1972) Oxygen-Linked Hydrogen Ion Binding of Human Hemoglobin. Effects of Carbon Dioxide and 2,3-Diphosphoglycerate: IV. Thermodynamical Relationship between the Variables. Scandinavian Journal of Clinical and Laboratory Investigation 29:3, pages 303-320.
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O. Siggaard-Andersen. (1971) Oxygen-Linked Hydrogen Ion Binding of Human Hemoglobin. Effects of Carbon Dioxide and 2,3-Diphosphoglycerate I. Studies on Erythrolysate. Scandinavian Journal of Clinical and Laboratory Investigation 27:4, pages 351-360.
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Mathias Baumann Melberg, Arnljot Flaa, Geir Øystein Andersen, Kjetil Sunde, Rinaldo Bellomo, Glenn Eastwood, Theresa Mariero Olasveengen & Eirik Qvigstad. (2023) Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial. Resuscitation 193, pages 109970.
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Jan Stepanek, Ryan A. Dunn, Gaurav N. Pradhan & Michael J. Cevette. (2020) Supplemental CO 2 improves oxygen saturation, oxygen tension , and cerebral oxygenation in acutely hypoxic healthy subjects . Physiological Reports 8:14.
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Sandeep Bansal & Geetha Ganesan. (2019) Advanced Evaluation Methodology for Water Quality Assessment Using Artificial Neural Network Approach. Water Resources Management 33:9, pages 3127-3141.
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A. A. Guslisty, N. P. Malomuzh & A. I. Fisenko. (2018) Optimal Temperature for Human Life Activity. Ukrainian Journal of Physics 63:9, pages 809.
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Gerard F. Curley, Brian P. Kavanagh & John G. Laffey. 2016. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 1527 1546.e8 .
Julie-Ann Collins, Aram Rudenski, John Gibson, Luke Howard & Ronan O’Driscoll. (2015) Relating oxygen partial pressure, saturation and content: the haemoglobin–oxygen dissociation curve. Breathe 11:3, pages 194-201.
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Maria Delivoria-Papadopoulos & Jane E. McGowan. 2011. Fetal and Neonatal Physiology. Fetal and Neonatal Physiology 970 979 .
Maria Delivoria-Papadopoulos & Jane E. McGowan. 2004. Fetal and Neonatal Physiology. Fetal and Neonatal Physiology 880 889 .
T.J. Morgan. (1999) The Oxyhaemoglobin Dissociation Curve in Critical Illness. Critical Care and Resuscitation 1:1, pages 93-100.
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T. J. Morgan. 1999. Yearbook of Intensive Care and Emergency Medicine 1999. Yearbook of Intensive Care and Emergency Medicine 1999 433 447 .
Carl-Friedrich Cartheuser. (1993) Standard and pH-affected hemoglobin-O2 binding curves of Sprague-Dawley rats under normal and shifted P50 conditions. Comparative Biochemistry and Physiology Part A: Physiology 106:4, pages 775-782.
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B. Agroyannis, H. Tzanatos, I. Konstadinidou, D. Tsoutsos, G. Tserkezis, E. Logothetis & D. Koutsikos. (2018) Changes of Arterio-venous Differences in pH and pCO 2 by Hemodialysis . The International Journal of Artificial Organs 16:10, pages 716-719.
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Eugene E. Nattie. 2011. Comprehensive Physiology. Comprehensive Physiology 421 438 .
Robert M. Winslow, Carlos Monge C.Nancy J. Winslow, Carter G. Gibson & Jose Whittembury. (1985) Normal whole blood Bohr effect in Peruvian natives of high altitude. Respiration Physiology 61:2, pages 197-208.
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Leigh A. Maginniss. (1985) Red cell organic phosphates and Bohr effects in house sparrow blood. Respiration Physiology 59:1, pages 93-103.
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Kazuhiko Imaizumi, Kiyohiro Imai & Itiro Tyuma. (1982) Linkage between carbon dioxide binding and four-step oxygen binding to hemoglobin. Journal of Molecular Biology 159:4, pages 703-719.
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Ronald A. Gabel. (1980) Algorithms for calculating and correcting blood-gas and acid-base variables. Respiration Physiology 42:3, pages 211-232.
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David S. Sheps, Bruce F. Cameron, Stephen M. Mallon, Leonard S. Sommer, William C. Lo, Donald R. Harkness & Robert J. Myerburg. (1980) Depression of intramyocardial oxyhemoglobin dissociation by angiographic contrast media. American Heart Journal 99:2, pages 193-197.
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Gordon C. Grigg & Margie Gruca. (2005) Possible adaptive significance of low red cell organic phosphates in crocodiles. Journal of Experimental Zoology 209:1, pages 161-167.
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E. Humpeler, K. Inama & P. Deetjen. (1979) Improvement of tissue oxygenation during a 20 days-stay at moderate altitude in connection with mild exerciseVerbesserung der O2 Versorgung des Gewebes bei einem 20t�gigen Aufenthalt verbunden mit k�rperlicher Aktivit�t in mittlerer H�henlage. Klinische Wochenschrift 57:6, pages 267-272.
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H. Bachofen. 1979. Bronchitis · Asthma Emphysem. Bronchitis · Asthma Emphysem 27 98 .
L. Palenciano, M.C. Rodríguez, F. Payo, A. de Vega, M. Corrales & G. Ocio. (1978) Afinidad de la hemoglobina para el oxigeno en la hipoxemia de los obstructivos. Archivos de Bronconeumología 14:4, pages 149-153.
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QUENTIN H. GIBSON. 1978. The Porphyrins. The Porphyrins 153 203 .
Frank A. Oski & Julia A. McMillan. 1977. The Year in Hematology. The Year in Hematology 103 130 .
Jochen Duhm. (1976) Dual effect of 2,3-diphosphoglycerate on the Bohr effects of human blood. Pfl�gers Archiv European Journal of Physiology 363:1, pages 55-60.
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Rita McConn. (1975) The Oxyhemoglobin Dissociation Curve in Acute Disease. Surgical Clinics of North America 55:3, pages 627-658.
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STEPHEN D. SHAPPELL & CLAUDE J.M. LENFANT. 1975. The Red Blood Cell. The Red Blood Cell 841 871 .
F. Lecompte, H. Aberkane, E. Azoulay, M. Muffat-Joly & J. J. Pocidalo. (1975) Blood affinity for oxygen in experimental hemorrhagic shock with metabolic acidosis. Pfl�gers Archiv European Journal of Physiology 359:1-2, pages 147-155.
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Henry M. ThomasIIIIII, Stephen S. Lefrak, Richard S. Irwin, Harry W. FrittsJr.Jr. & Peter R.B. Caldwell. (1974) The oxyhemoglobin dissociation curve in health and disease. The American Journal of Medicine 57:3, pages 331-348.
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E. Bursaux, A. Freminet & C. Poyart. (1974) Effects of CO2, and diphosphoglycerate on foetal blood affinity for oxygen. Respiration Physiology 20:2, pages 181-189.
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Ulrich Meier, Dieter B�ning & Howard J. Rubenstein. (1974) Oxygenation dependent variations of the Bohr coefficient related to whole blood and erythrocyte pH. Pfl�gers Archiv European Journal of Physiology 349:3, pages 203-213.
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L. Garby, M. Robert & B. Zaar. (2008) Proton‐ and Carbamino‐linked Oxygen Affinity of Normal Human Blood. Acta Physiologica Scandinavica 84:4, pages 482-492.
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B. Wranne, R. Woodson & J. Detter. 1972. Hemoglobin and Red Cell Structure and Function. Hemoglobin and Red Cell Structure and Function 449 455 .
J. Grote. 1971. Nomogramme zum Säure-Basen-Status des Blutes und zum Atemgastransport. Nomogramme zum Säure-Basen-Status des Blutes und zum Atemgastransport 47 83 .
Leopold Dintenfass. 1970. Blood Oxygenation. Blood Oxygenation 262 275 .
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O. J. Malm. (1968) Treatment of Acidosis and Electrolyte Disturbances in Asphyxia and Cardiac Arrest. Acta Anaesthesiologica Scandinavica 12, pages 165-182.
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T.H. Kirschbaum & J.C. DeHaven. 1968. The Fetus and Neonate. The Fetus and Neonate 143 187 .

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