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Scandinavian Journal of Clinical and Laboratory Investigation Volume 23, 1969 - Issue 2
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Original Article

Low Binding of 2,3-Diphosphoglycerate to Haemoglobin F: A Contribution to the Knowledge of the Binding Site and an Explanation for the High Oxygen Affinity of Foetal Blood

C. H. de Verdier Departments of Clinical Chemistry and Clinical Physiology, University Hospital, Uppsala, Sweden
&
L. Garby Departments of Clinical Chemistry and Clinical Physiology, University Hospital, Uppsala, Sweden
Pages 149-152 | Received 21 Jan 1969, Accepted 04 Feb 1969, Published online: 08 Jul 2009

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Richard Juel & John O. Milam. (1979) 2,3-Diphosphoglycerate: Its Role in Health and Disease. CRC Critical Reviews in Clinical Laboratory Sciences 10:2, pages 113-146.
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Paul R. Sohmer, R. Ben Dawson & Charles Huggins. (1979) The Significance of 2, 3–DPG in Red Blood Cell Transfusions. CRC Critical Reviews in Clinical Laboratory Sciences 11:2, pages 107-174.
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O. Siggaard-Andersen & L. Garby. (1973) The Bohr Effect and the Haldane Effect. Scandinavian Journal of Clinical and Laboratory Investigation 31:1, pages 1-8.
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L. Garby & C.-H. De Verdier. (1971) Affinity of Human Hemoglobin a to 2,3—Diphosphoglycerate. Effect of Hemoglobin Concentration and of pH. Scandinavian Journal of Clinical and Laboratory Investigation 27:4, pages 345-350.
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. (1970) Section II. Binding of Organic Phosphates to Hemoglobin. CRC Critical Reviews in Clinical Laboratory Sciences 1:3, pages 490-501.
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Carl-Henric de Verdier, Lars Garby, Magnus Hjelm, Poul Astrup & Mikael Rörth. (1970) The Erythrocyte as a Vehicle for Oxygen with Self-regulating Adjustment of Unloading. Scandinavian Journal of Clinical and Laboratory Investigation 26:3, pages 193-198.
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G. Duc & K. Engel. (1969) Effect of 2,3-DPG Concentration on Hemoglobin-Oxygen Affinity of Whole Blood. Scandinavian Journal of Clinical and Laboratory Investigation 24:4, pages 405-412.
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Articles from other publishers (64)

Lawrence D. LongoLawrence D. Longo. 2018. The Rise of Fetal and Neonatal Physiology. The Rise of Fetal and Neonatal Physiology 581 629 .
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Keiko Nibu & Kazuhiko Adachi. (1985) Effect of FS (α2γβs) hybrid hemoglobin on Hb S nucleation and aggregation. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 829:1, pages 97-102.
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Richard J. Labotka. (2002) Measurement of intracellular pH and deoxyhemoglobin concentration in deoxygenated erythrocytes by phosphorus-31 nuclear magnetic resonance. Biochemistry 23:23, pages 5549-5555.
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L. A. Ivanov & N. D. Chebotarev. (1984) Effect of hyperoxia on the oxyhemoglobin dissociation curve at different ages. Bulletin of Experimental Biology and Medicine 98:2, pages 1033-1036.
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Marianne Hartvig & Roy E. Weber. 1984. Respiration and metabolism of embryonic vertebrates. Respiration and metabolism of embryonic vertebrates 17 30 .
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S. Tomita. (1981) Modulation of the oxygen equilibria of human fetal and adult hemoglobins by 2,3-diphosphoglyceric acid.. Journal of Biological Chemistry 256:18, pages 9495-9500.
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G. Gros, H.S. Rollema & R.E. Forster. (1981) The carbamate equilibrium of alpha- and epsilon-amino groups of human hemoglobin at 37 degrees C.. Journal of Biological Chemistry 256:11, pages 5471-5480.
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John G. Gilman. (1981) Red cells of newborn rats have low bisphosphoglyceromutase and high pyruvate kinase activities in association with low 2,3-bisphosphoglycerate. Biochemical and Biophysical Research Communications 98:4, pages 1057-1062.
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Manfred GAHR. (1980) Different Biochemical Properties of Foetal and Adult Red Cell Hexokinase Isoenzymes. Hoppe-Seyler´s Zeitschrift für physiologische Chemie 361:1, pages 829-838.
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C.R. BEDDELL, P.J. GOODFORD, D.K. STAMMERS & R. WOOTTON. (2012) SPECIES DIFFERENCES IN THE BINDING OF COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN ADULT HUMAN HAEMOGLOBIN. British Journal of Pharmacology 65:3, pages 535-543.
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R.E. Isaacks, D.R. Harkness & P.R. Witham. (1978) Relationship between the major phosphorylated metabolic intermediates and oxygen affinity of whole blood in the loggerhead (Caretta caretta) and the green sea turtle (Chelonia mydas) during development. Developmental Biology 62:2, pages 344-353.
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Klaus P. Riegel & Hans T. Versmold. 1978. Perinatal Physiology. Perinatal Physiology 241 255 .
Enno Kleihauer. 1978. Perinatal Physiology. Perinatal Physiology 215 239 .
Marshall A. Lichtman, Marion Murphy & Meredith Pogal. (2008) The Use of a Single Venous Blood Sample to Assess Oxygen Binding to Haemoglobin. British Journal of Haematology 32:1, pages 89-98.
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S. Haidas, L. Zannos‐Mariolea & N. Matsaniotis. (2008) Red Cell 2,3‐Diphosphoglycerate Levels in Children with Hereditary Haemolytic Anaemias. British Journal of Haematology 31:4, pages 521-530.
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ENRIQUE M. OSTREAJR.JR. & GERARD B. ODELL. (2008) PHOTOSENSITIZED SHIFT IN THE O 2 DISSOCIATION CURVE OF FETAL BLOOD . Acta Paediatrica 63:3, pages 341-346.
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E. Bursaux, A. Freminet & C. Poyart. (1974) Effects of CO2, and diphosphoglycerate on foetal blood affinity for oxygen. Respiration Physiology 20:2, pages 181-189.
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Christian Bauer. 1974. Reviews of Physiology, Biochemistry and Pharmacology, Volume 70. Reviews of Physiology, Biochemistry and Pharmacology, Volume 70 1 31 .
A. J. Bellingham & A. J. Grimes. (2008) RED CELL 2,3‐DIPHOSPHOGLYCERATE. British Journal of Haematology 25:5, pages 555-562.
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Hans Versmold, Günter Seifert & Klaus P. Riegel. (1973) Blood oxygen affinity in infancy: the interaction of fetal and adult hemoglobin, oxygen capacity, and red cell hydrogen ion and 2,3-diphosphoglycerate concentration. Respiration Physiology 18:1, pages 14-25.
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Simon H. de Bruin & Lambert H.M. Janssen. (1973) The Interaction of 2,3-Diphosphoglycerate with Human Hemoglobin. Journal of Biological Chemistry 248:8, pages 2774-2777.
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K. Riegel, H. Versmold, H. Windthorst & K. Horn. (1973) Thyroxine and red cell 2,3-diphosphoglycerate in the newborn periodThyroxin und 2,3-Diphosphoglycerat im Erythrocyten in der Neugeborenenperiode. Klinische Wochenschrift 51:3, pages 138-139.
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Lambert H. M. Janssen & Simon H. DE Bruin. (2009) ALLOSTERIC MODELS FOR THE INTERACTION OF 2,3‐DIPHOSPHOGLYCERIC ACID WITH HEMOGLOBIN. International Journal of Peptide and Protein Research 5:1, pages 27-31.
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Ulrich Willenbockel. 1973. Current Aspects of Perinatology and Physiology of Children. Current Aspects of Perinatology and Physiology of Children 40 70 .
Enno Kleihauer. 1973. Current Aspects of Perinatology and Physiology of Children. Current Aspects of Perinatology and Physiology of Children 21 39 .
M. M. Orzalesi & W. W. Hay. (1972) The relative effect of 2,3-diphosphoglycerate on the oxygen affinity of fetal and adult hemoglobin in whole blood. Experientia 28:12, pages 1480-1481.
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Frank A. Oski. (1972) Fetal Hemoglobin, The Neonatal Red Cell, and 2,3-Diphosphoglycerate. Pediatric Clinics of North America 19:4, pages 907-917.
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Berthold Schmidt. (2003) Genetic Aspects of Hemoglobin Synthesis. Angewandte Chemie International Edition in English 11:7, pages 576-583.
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Berthold Schmidt. (2006) Genetische Aspekte zur Hämoglobinsynthese. Angewandte Chemie 84:14, pages 649-656.
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A.G. Mauk & F. Taketa. (1972) Effects of organic phosphates on oxygen equilibria and kinetics of SH reaction in feline hemoglobins. Archives of Biochemistry and Biophysics 150:2, pages 376-381.
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STIG BERGLUND. (2009) The Oxygen Dissociation Curve of Whole Blood Containing Haemoglobin Malmö. Scandinavian Journal of Haematology 9:1-6, pages 377-386.
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C.-H. de Verdier & L. Garby. (1972) 2,3-Diphosphoglycerate and respiratory function of hemoglobin. Biochimie 54:5-6, pages 613-617.
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Fumito Taketa, Mark H. Attermeier & A. Grant Mauk. (1972) Acetylated Hemoglobins in Feline Blood. Journal of Biological Chemistry 247:1, pages 33-35.
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Hans Versmold, Johannes Wenner & Klaus Riegel. (1972) Changes of blood oxygen affinity and capacity and red cell 2,3-diphosphoglycerate evoked by exchange transfusions with ACD preserved blood in newborn infants: Their interrelationship and influences on oxygen supply of tissues and erythropoiesis. Zeitschrift f�r Kinderheilkunde 113:1, pages 1-18.
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Christian Bauer. 1972. Hemoglobin and Red Cell Structure and Function. Hemoglobin and Red Cell Structure and Function 225 236 .
J.M. Salhany, H. Mizukami & R.S. Eliot. (1971) The deoxygenation kinetic properties of human fetal hemoglobin: Effect of 2,3-diphosphoglycerate. Biochemical and Biophysical Research Communications 45:5, pages 1350-1356.
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S.H. De Bruin, L.H.M. Janssen & G.A.J. Van Os. (1971) Effect of 2,3-diphosphoglycerate on the Bohr effect of human adult hemoglobin. Biochemical and Biophysical Research Communications 45:2, pages 544-550.
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Thomas H. Kirschbaum. (1971) Red cell pH in human maternal and fetal blood as determined by 5, 5-dimethyl-2, 4-oxazolidine dione. American Journal of Obstetrics and Gynecology 111:4, pages 515-523.
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F. Taketa, A.G. Mauk & J.L. Lessard. (1971) β Chain Amino Termini of the Cat Hemoglobins and the Response to 2,3-Diphosphoglycerate and Adenosine Triphosphate. Journal of Biological Chemistry 246:14, pages 4471-4476.
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E. Kleihauer, H. D. Waller, H. Chr Ben�hr, E. Kohne & P. Gelinsky. (1971) Hb T�bingen. Eine neue?-Kettenvariante (? Tp 10?12) mit erh�hter SpontanoxydationHb T�bingen. A new?-chain variant (? Tp 10?12) showing increased spontaneous oxidation. Klinische Wochenschrift 49:11, pages 651-658.
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J.M. Salhany. (1971) The effects of 2,3-diphosphoglycerate on native and chemically modified horse hemoglobin. FEBS Letters 14:1, pages 11-13.
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Susumu Tomita & Austen Riggs. (1971) Studies of the Interaction of 2,3-Diphosphoglycerate and Carbon Dioxide with Hemoglobins from Mouse, Man, and Elephant. Journal of Biological Chemistry 246:3, pages 547-554.
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Bennett F. Horton & Amoz I. Chernoff. (1971) Phosphocellulose chromatography of human hemoglobins. Journal of Chromatography A 63, pages 414-419.
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R. Baumann, Ch. Bauer & H. Bartels. (1971) Influence of chronic and acute hypoxia on oxygen affinity and red cell 2,3 diphosphoglycerate of rats and guinea pigs. Respiration Physiology 11:2, pages 135-144.
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Gerd-Rudiger Janig, Gerhard Gerber, Klaus Ruckpaul, Samuel Rapoport & Friedrich Jung. (1970) Interaction of Haemoglobin with Ions. Thermodynamic Data on Binding of Adenosine Triphosphate to Methaemoglobin. European Journal of Biochemistry 17:3, pages 441-444.
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N. P. Mathers, G. B. James & J. Walker. (2005) THE OXYGEN AFFINITY OF THE BLOOD OF INFANTS TREATED BY INTRAUTERINE TRANSFUSION. BJOG: An International Journal of Obstetrics & Gynaecology 77:7, pages 648-653.
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Ch. Bauer, M. Ludwig, I. Ludwig & H. Bartels. (1969) Factors governing the oxygen affinity of human adult and foetal blood. Respiration Physiology 7:3, pages 271-277.
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Ch. Bauer. (1969) Antagonistic influence of CO2 and 2,3 diphosphoglycerate on the Bohr effect of human haemoglobin. Life Sciences 8:20, pages 1041-1046.
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