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Scandinavian Journal of Clinical and Laboratory Investigation Volume 23, 1969 - Issue 3
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Original Article

Plasma Clearance of 57Cobalt-Labelled Vitamin B12 Bound in Vitro and in Vivo to Transcobalamin I and II

B. L. Hom Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark
&
H. A. Olesen Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark
Pages 201-211 | Received 27 Jan 1969, Accepted 20 Feb 1969, Published online: 08 Jul 2009

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Agata Sobczyńska-Malefora, Edgard Delvin, Andrew McCaddon, Kourosh R. Ahmadi & Dominic J. Harrington. (2021) Vitamin B12 status in health and disease: a critical review. Diagnosis of deficiency and insufficiency – clinical and laboratory pitfalls . Critical Reviews in Clinical Laboratory Sciences 58:6, pages 399-429.
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P. Gimsing & Ebba Nexö. (1976) The Metabolism in Man of Intravenously Injected Iodine-Labelled Transcobalamin I Not Saturated with Cobalamin. Scandinavian Journal of Clinical and Laboratory Investigation 36:7, pages 669-672.
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Ragnhild Gullberg. (1975) Classification of Human Vitamin-B12-binding Proteins. Scandinavian Journal of Gastroenterology 10:6, pages 561-564.
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K. Jensen. (1970) Metabolism of Bence Jones Proteins in Non-Myeloma Patients with Normal Renal Function. Scandinavian Journal of Clinical and Laboratory Investigation 25:3, pages 281-289.
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Articles from other publishers (32)

Dominic J. Harrington. 2019. Laboratory Assessment of Vitamin Status. Laboratory Assessment of Vitamin Status 265 299 .
Luciana Hannibal, Keerthana Bolisetty, Armend Axhemi, Patricia M. DiBello, Edward V. Quadros, Sergey Fedosov & Donald W. Jacobsen. (2018) Transcellular transport of cobalamin in aortic endothelial cells. The FASEB Journal 32:10, pages 5506-5519.
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Dominic J. Harrington. 2017. Dacie and Lewis Practical Haematology. Dacie and Lewis Practical Haematology 187 213 .
. (2015) Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12). EFSA Journal 13:7.
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Simona Ferraro, Roberta Mozzi & Mauro Panteghini. (2014) Tracing a roadmap for vitamin B12 testing using the health technology assessment approach. Clinical Chemistry and Laboratory Medicine (CCLM) 52:6.
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Sadanand Naik, Vijayshri Bhide, Ashish Babhulkar, Namita Mahalle, Sonali Parab, Ravi Thakre & Mohan Kulkarni. (2013) Daily milk intake improves vitamin B-12 status in young vegetarian Indians: an intervention trial. Nutrition Journal 12:1.
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Sergey N. Fedosov. 2012. Water Soluble Vitamins. Water Soluble Vitamins 347 367 .
Ebba Nexo & Elke Hoffmann-Lücke. (2011) Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility. The American Journal of Clinical Nutrition 94:1, pages S1-S7.
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Dattatray S. Bhat, Nileema V. Thuse, Himangi G. Lubree, Charudatta V. Joglekar, Sadanand S. Naik, Lalita V. Ramdas, Carole Johnston, Helga Refsum, Caroline H. Fall & Chittaranjan S. Yajnik. (2009) Increases in Plasma Holotranscobalamin Can Be Used to Assess Vitamin B-12 Absorption in Individuals with Low Plasma Vitamin B-12. The Journal of Nutrition 139:11, pages 2119-2123.
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Gry Hay, Carole Johnston, Andrew Whitelaw, Kerstin Trygg & Helga Refsum. (2008) Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants. The American Journal of Clinical Nutrition 88:1, pages 105-114.
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Kristina M von Castel-Roberts, Anne Louise Morkbak, Ebba Nexo, Claire A Edgemon, David R Maneval, Jonathan J Shuster, John F Valentine, Gail PA Kauwell & Lynn B Bailey. (2007) Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. The American Journal of Clinical Nutrition 85:4, pages 1057-1061.
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Xinke Chen, Angel F Remacha, M Pilar Sardà & Ralph Carmel. (2005) Influence of cobalamin deficiency compared with that of cobalamin absorption on serum holo-transcobalamin II. The American Journal of Clinical Nutrition 81:1, pages 110-114.
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Mustafa Vakur Bor, Ebba Nexø & Anne-Mette Hvas. (2004) Holo-Transcobalamin Concentration and Transcobalamin Saturation Reflect Recent Vitamin B12 Absorption Better than Does Serum Vitamin B12. Clinical Chemistry 50:6, pages 1043-1049.
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Karin Nilsson, Anders Isaksson, Lars Gustafson & Björn Hultberg. (2004) Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms. Clinical Chemistry and Laboratory Medicine (CCLM) 42:6.
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Saila Loikas, Minna Löppönen, Pauli Suominen, Jan Møller, Kerttu Irjala, Raimo Isoaho, Sirkka-Liisa Kivelä, Pertti Koskinen & Tarja-Terttu Pelliniemi. (2003) RIA for Serum Holo-Transcobalamin: Method Evaluation in the Clinical Laboratory and Reference Interval. Clinical Chemistry 49:3, pages 455-462.
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Marius Ulleland, Ingar Eilertsen, Edward V Quadros, Sheldon P Rothenberg, Sergey N Fedosov, Erling Sundrehagen & Lars Örning. (2002) Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Serum. Clinical Chemistry 48:3, pages 526-532.
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Ralph Carmel, Shabneet Brar & Zohreh Frouhar. (2001) Plasma Total Transcobalamin I. American Journal of Clinical Pathology 116:4, pages 576-580.
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Lindgren, Kilander, Bagge & Nexø. (1999) Holotranscobalamin - a sensitive marker of cobalamin malabsorption. European Journal of Clinical Investigation 29:4, pages 321-329.
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S N Wickramasinghe & I D Ratnayaka. (1996) Limited value of serum holo-transcobalamin II measurements in the differential diagnosis of macrocytosis.. Journal of Clinical Pathology 49:9, pages 755-758.
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Karin Sparring Björkstén, Lars-Håkan Thorell & Ebba Nexø. (1995) Circadian variation of plasma cobalamin, transcobalamin-bound cobalamin and unsaturated binding capacity of transcobalamin and haptocorrin in healthy elderly. Journal of Affective Disorders 36:1-2, pages 37-42.
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Zenon Schneider & Andrzej StroinskiZ. Schneider. 1987. Comprehensive B 12 . Comprehensive B 12 267 334 .
J. Lindemans, M. Schoester & J. van Kapel. (1983) Application of a simple immunoadsorption assay for the measurement of saturated and unsaturated transcobalamin II and R-binders. Clinica Chimica Acta 132:1, pages 53-61.
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J. Lindemans, E.J.M. de Jongh, F.C.M. Brand, M. Schoester, J. Van Kapel & J. Abels. (1982) The uptake of R-type cobalamin-binding protein by isolated rat liver cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 720:2, pages 203-210.
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Peder Kern Hansen, Hans Jørgen Fenger, Peter Gimsing, Eivind Gudmand-Høyer & Erik Hippe. (2009) The Concentration of Vitamin B12, Transcobalamins and Folate in Blood in a Greenland Eskimo Population Sample.. Scandinavian Journal of Haematology 25:2, pages 175-180.
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Ebba Nexø. (2009) Transcobalamin I and other Human R‐Binders: Purification, Structural, Spectral and Physiological Studies. Scandinavian Journal of Haematology 20:3, pages 221-236.
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Ulf-Håkan Stenman. (1976) Intrinsic Factor and the Vitamin B12 Binding Proteins. Clinics in Haematology 5:3, pages 473-495.
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Robert H. Allen. (2008) THE PLASMA TRANSPORT OF VITAMIN B 12 . British Journal of Haematology 33:2, pages 161-171.
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RL Burger, RJ Schneider, CS Mehlman & RH Allen. (1975) Human plasma R-type vitamin B12-binding proteins. II. The role of transcobalamin I, transcobalamin III, and the normal granulocyte vitamin B12-binding protein in the plasma transport of vitamin B12.. Journal of Biological Chemistry 250:19, pages 7707-7713.
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Ralph Gräsbeck. (1975) Absorption and Transport of Vitamin B 12 . British Journal of Haematology 31:s1, pages 103-110.
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Ulf‐Håkan Stenman. (2009) Vitamin B 12 ‐Binding Proteins of R‐Type, Cobalophilin . Scandinavian Journal of Haematology 14:2, pages 91-107.
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David W. Sonneborn, Ann B. Baskerville & William Regelson. (2009) Levels of Transcobalamin II in Normal Human Serum: Measured with Zirconyl Phosphate Gel. Scandinavian Journal of Haematology 11:1, pages 8-12.
Crossref
Robert H. Allen & Philip W. Majerus. (1972) Isolation of Vitamin B12-binding Proteins Using Affinity Chromatography. Journal of Biological Chemistry 247:23, pages 7709-7717.
Crossref

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