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Original Article

Determination of Non-Albumin-Bound Bilirubin in Human Serum

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Pages 237-241 | Received 28 Apr 1970, Accepted 31 Aug 1970, Published online: 08 Jul 2009

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Read on this site (10)

Roland Stocker & Ernst Peterhans. (1989) Antioxidant Properties of Conjugated Bilirubin and Biliverdin: Biologically Relevant Scavenging of Hypochlorous Acid. Free Radical Research Communications 6:1, pages 57-66.
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S. Øie, D. T. Lotenthal & G. Levy. (1980) Protein Binding of Bilirubin in Plasma of Anephric Patients. Journal of Dialysis 4:2-3, pages 91-100.
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R. Brodersen, W. J. Cashore, R. P. Wennberg, C. E. Ahlfors, L. F. Rasmussen & D. Shusterman. (1979) Kinetics of bilirubin oxidation with peroxidase, as applied to studies of bilirubin—albumin binding. Scandinavian Journal of Clinical and Laboratory Investigation 39:2, pages 143-150.
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H. Hertz. (1975) A Direct Spectrometric Method for Determination of the Concentration of Available Bilirubin Binding Sites in Serum Using Bromphenol Blue. Scandinavian Journal of Clinical and Laboratory Investigation 35:6, pages 545-559.
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D. Bratlid. (1972) The Effect of Free Fatty Acids, Bile Acids, and Hematin on Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 30:1, pages 107-112.
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D. Bratlid. (1972) Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 29:1, pages 91-97.
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R. Brodersen. (1972) Supersaturation with Bilirubin followed by Colloid Formation and Disposition, with a Hypothesis on the Etiology of Kernicterus. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 447-452.
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R. Brodersen, L. Funding, A. O. Pedersen & H. Röigaard-Petersen. (1972) Binding of Bilirubin to Low-Affinity Sites of Human Serum Albumin in Vitro Followed by Co-Crystallization. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 433-446.
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J. Jacobsen. (1970) Dimerisation of Bilirubin Diglucuronide and Formation of a Complex of Bilirubin and the Diglucuronide. Scandinavian Journal of Clinical and Laboratory Investigation 26:4, pages 395-398.
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R. Brodersen & J. Theilgaard. (1969) Bilirubin Colloid Formation in Neutral Aqueous Solution. Scandinavian Journal of Clinical and Laboratory Investigation 24:4, pages 395-398.
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Articles from other publishers (41)

Lei Ouyang, Ling Yao, Rongmei Tang, Xiangliang Yang & Lihua Zhu. (2021) Biomimetic point-of-care testing of trace free bilirubin in serum by using glucose selective capture and surface-enhanced Raman spectroscopy. Sensors and Actuators B: Chemical 340, pages 129941.
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Walid Albanna, Jan Niklas Lüke, Gerrit Alexander Schubert, Maxine Dibué-Adjei, Konstantin Kotliar, Jürgen Hescheler, Hans Clusmann, Hans-Jakob Steiger, Daniel Hänggi, Marcel A. Kamp, Toni Schneider & Felix Neumaier. (2019) Modulation of Cav2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity. Molecular and Cellular Neuroscience 96, pages 35-46.
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Christine Mölzer, Hedwig Huber, Andrea Steyrer, Gesa V. Ziesel, Marlies Wallner, Iryna Goncharova, Sergey Orlov, Marie Urbanová, Charles E. Ahlfors, Libor Vítek, Andrew C. Bulmer & Karl-Heinz Wagner. (2013) Interaction between TNFone and tetrapyrroles may account for their anti-genotoxic effects — a novel mechanism for DNA-protection. Journal of Porphyrins and Phthalocyanines 17:12, pages 1157-1166.
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Francesco De Matteis, David P. Ballou, Minor J. Coon, Ronald W. Estabrook & Donovan C. Haines. (2012) Peroxidase-like activity of uncoupled cytochrome P450. Biochemical Pharmacology 84:3, pages 374-382.
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Leon Aarons, Patricia Clifton, George Fleming & Malcolm Rowland. (1980) Aspirin binding and the effect of albumin on spontaneous and enzyme-catalysed hydrolysis. Journal of Pharmacy and Pharmacology 32:1, pages 537-543.
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M J Daood, A F McDonagh & J F Watchko. (2009) Calculated free bilirubin levels and neurotoxicity. Journal of Perinatology 29:S1, pages S14-S19.
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Antony F. McDonagh, Hendrik J. Vreman, Ronald J. Wong & David K. Stevenson. (2009) Photoisomers: Obfuscating Factors in Clinical Peroxidase Measurements of Unbound Bilirubin?. Pediatrics 123:1, pages 67-76.
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Roland Stocker. (2004) Antioxidant Activities of Bile Pigments. Antioxidants & Redox Signaling 6:5, pages 841-849.
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Jinhua Yuan, Dai Chang Yang, Jill Birkmeier & James Stolzenbach. (1995) Determination of protein binding byin vitro charcoal adsorption. Journal of Pharmacokinetics and Biopharmaceutics 23:1, pages 41-55.
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I MuraokaT HasegawaM NadaiL WangS HaghgooO TagayaT Nabeshima. (1995) Biliary and renal excretions of cefpiramide in Eisai hyperbilirubinemic rats. Antimicrobial Agents and Chemotherapy 39:1, pages 70-74.
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J D Ostrow, P Mukerjee & C Tiribelli. (1994) Structure and binding of unconjugated bilirubin: relevance for physiological and pathophysiological function. Journal of Lipid Research 35:10, pages 1715-1737.
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Roland Stocker, Antony F. McDonagh, Alexander N. Glazer & Bruce N. Ames. 1990. Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants. Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants 301 309 .
Gregory A. Reed, Jerome M. Lasker, Thomas E. Eling & Kandiah Sivarajah. (1985) Peroxidative oxidation of bilirubin during prostaglandin biosynthesis. Prostaglandins 30:1, pages 153-165.
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L. Okolicsanyi. 1983. Clinical Hepatology. Clinical Hepatology 70 77 .
C.E. Ahlfors, M.L. Shwer & R.P. Wennberg. (1982) Absence of bilirubin binding competitors during phototherapy for neonatal jaundice. Early Human Development 6:2, pages 125-130.
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Charles E. Ahlfors. (1981) Competitive interaction of biliverdin and bilirubin only at the primary bilirubin binding site on human albumin. Analytical Biochemistry 110:2, pages 295-307.
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Ulf W. Wiegand, David M. Soda & Gerhard Levy. (1980) Effect of heparin on bilirubin clearance in rats: Pharmacokinetic consequences of extensive hepatic extraction of plasma protein binding inhibitors. Journal of Pharmaceutical Sciences 69:10, pages 1228-1230.
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Ulf W. Wiegand & Gerhard Levy. (1980) Hepatic Extraction of Endogenous Inhibitors of Plasma Protein Binding. Journal of Pharmaceutical Sciences 69:4, pages 480-481.
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R. BRODERSEN, L. LAKATOS & L. KARMAZSIN. (1980) D-PENICILLAMINE, A NON-BILIRUBIN-DISPLACING DRUG IN NEONATAL JAUNDICE. Acta Paediatrica 69:1, pages 31-35.
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AUDREY K. BROWN & ANTONY F. MCDONAGH. (1980) Phototherapy for Neonatal Hyperbilirubinemia: Efficacy, Mechanism and Toxicity*. Advances in Pediatrics 27:1, pages 341-389.
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Ulf W. Wiegand & Gerhard Levy. (1979) Effect of Heparin Injection on Plasma Protein Binding of Bilirubin and Salicylate in Rats. Journal of Pharmaceutical Sciences 68:12, pages 1483-1486.
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Ulf W. Wiegand, John T. Slattery, Kenneth L. Hintze & Gerhard Levy. (1979) Differences in the protein binding of several drugs and bilirubin in serum and heparinized plasma of rats. Life Sciences 25:5, pages 471-477.
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ANTONY F. McDONAGH. 1979. The Porphyrins. The Porphyrins 293 491 .
Svein Øie & Gerhard Levy. (1979) Effect of Sulfisoxazole on Pharmacokinetics of Free and Plasma Protein-Bound Bilirubin in Experimental Unconjugated Hyperbilirubinemia. Journal of Pharmaceutical Sciences 68:1, pages 6-9.
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Svein Øie & Gerhard Levy. (1979) Effect of Salicylic Acid on Pharmacokinetics of Free and Plasma Protein-Bound Bilirubin in Experimental Unconjugated Hyperbilirubinemia. Journal of Pharmaceutical Sciences 68:1, pages 1-6.
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Svein Øie & Gerhard Levy. (1978) Frequency Distribution of Bilirubin Intrinsic Clearance in Adult Male Sprague–Dawley Rats. Journal of Pharmaceutical Sciences 67:1, pages 45-47.
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Kwang-sun Lee, Lawrence M. Gartner, Arthur I. Eidelman & Sudhakar Ezhuthachan. (1977) Unconjugated Hyperbilirubinemia in Very Low Birth Weight Infants. Clinics in Perinatology 4:2, pages 305-320.
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Avraham Yacobi, Svein Øie & Gerhard Levy. (1977) Relationship between Protein Binding of Bilirubin, Salicylic Acid, and Sulfisoxazole in Serum of Unmedicated and Phenobarbital-Treated Rats. Journal of Pharmaceutical Sciences 66:7, pages 1025-1027.
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Seetha Shankaran & Ronald L. Poland. (1977) The displacement of bilirubin from albumin byfurosemide. The Journal of Pediatrics 90:4, pages 642-646.
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Yoshio SAWASAKI, Noriko YAMADA & Hiroshi NAKAJIMA. (1976) Studies on Kernicterus. IV. Proceedings of the Japan Academy 52:2, pages 45-48.
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U. Mittelst�dt, J. Biester & K. Sandhage. (1976) Der Einflu� von Bilirubin auf das Mechanogramm des isolierten, spontan schlagenden FroschherzensThe influence of bilirubin on the mechanogram of isolated, spontaneously beating frog heart. European Journal of Pediatrics 122:3, pages 187-193.
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R. Brodersen. 1976. Liver Diseases in Infancy and Childhood. Liver Diseases in Infancy and Childhood 18 24 .
Svein Øie Gerhard & Gerhard Levy. (1975) Effect of Plasma Protein Binding on Elimination of Bilirubin. Journal of Pharmaceutical Sciences 64:8, pages 1433.
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Thyge Faerch & Jørgen Jacobsen. (1975) Determination of association and dissociation rate constants for bilirubin-bovine serum albumin. Archives of Biochemistry and Biophysics 168:2, pages 351-357.
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J. Kapitulnik, Ruth Horner-Mibashan, S.H. Blondheim, N.A. Kaufmann & Alex Russell. (1975) Increase in bilirubin-binding affinity of serum with age of infant. The Journal of Pediatrics 86:3, pages 442-445.
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M. Pays & M. Beljean. (1975) Microdetermination of unbound bilirubin in sera. Application to the prevention of kernicterus by estimating the bilirubin-binding capacity of serum albumin. Clinica Chimica Acta 59:2, pages 121-128.
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W. WALKER. (1975) Haemolytic Anaemia in the Newborn Infant. Clinics in Haematology 4:1, pages 145-166.
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J. Kapitulnik, T. Valaes, N. A. Kaufmann & S. H. Blondheim. (1974) Clinical evaluation of Sephadex gel filtration in estimation of bilirubin binding in serum in neonatal jaundice. Archives of Disease in Childhood 49:11, pages 886-894.
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K. P. M. Heirwegh, J. Fevery, J. A. T. P. Meuwissen, J. De Groote, F. Compernolle, V. Desmet & F. P. Van Roy. 1974. Methods of Biochemical Analysis. Methods of Biochemical Analysis 205 250 .
H. THIESSEN, J. JACOBSEN & R. BRODERSEN. (2008) DISPLACEMENT OF ALBUMIN‐BOUND BILIRUBIN BY FATTY ACIDS. Acta Paediatrica 61:3, pages 285-288.
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J. FOG & A. F. BAKKEN. (1972) Definitions of Human Bilirubin and Bilirubin Compounds. Clinical Chemistry and Laboratory Medicine 10:12, pages 562-565.
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