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Scandinavian Journal of Clinical and Laboratory Investigation Volume 26, 1970 - Issue 1
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Original Article

Human Forearm Muscle Metabolism during Exercise: V. Quantitative Aspects of Glucose Uptake and Lactate Production during Prolonged Exercise

L. Jorfeldt Dept. of Clinical Physiology, Karolinska Institutet at Serafimerlasarettet, Stockholm, Sweden
&
J. Wahren Dept. of Clinical Physiology, Karolinska Institutet at Serafimerlasarettet, Stockholm, Sweden
Pages 73-81 | Received 16 Feb 1970, Accepted 05 May 1970, Published online: 08 Jul 2009

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Lennart Kaijser, Brita Eklund, Gabriele Riccardi & Lars A. Carlson. (1979) Insulin and substrate exchange in the forearm during prolonged forearm work. Scandinavian Journal of Clinical and Laboratory Investigation 39:4, pages 321-328.
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L. Kaijser, E. R. Nye, B. Eklund, A. G. Olsson & L. A. Carlson. (1978) The relation between carbohydrate extraction by the forearm and arterial free fatty acid concentration in man: I. Forearm work with nicotinic acid infusion. Scandinavian Journal of Clinical and Laboratory Investigation 38:1, pages 41-47.
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Gunvor Ahlborg & J. Wahren. (1972) Brain Substrate Utilization during Prolonged Exercise. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 397-402.
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L. Hagenfeldt & J. Wahren. (1971) Human Forearm Muscle Metabolism during Exercise VI. Substrate Utilization in Prolonged Fasting. Scandinavian Journal of Clinical and Laboratory Investigation 27:4, pages 299-306.
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Articles from other publishers (47)

Lykke Sylow, Victoria L. Tokarz, Erik A. Richter & Amira Klip. (2021) The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. Cell Metabolism 33:4, pages 758-780.
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Alexandria Béland-Millar & Claude Messier. (2018) Fluctuations of extracellular glucose and lactate in the mouse primary visual cortex during visual stimulation. Behavioural Brain Research 344, pages 91-102.
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Ragadeepthi Tunduguru & Debbie C. Thurmond. (2017) Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out. Frontiers in Endocrinology 8.
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Xijun Liang, Lin Liu, Tingting Fu, Qian Zhou, Danxia Zhou, Liwei Xiao, Jing Liu, Yan Kong, Hui Xie, Fanchao Yi, Ling Lai, Rick B. Vega, Daniel P. Kelly, Steven R. Smith & Zhenji Gan. (2016) Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. Journal of Biological Chemistry 291:49, pages 25306-25318.
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Abram Katz. (2016) Role of reactive oxygen species in regulation of glucose transport in skeletal muscle during exercise. The Journal of Physiology 594:11, pages 2787-2794.
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M. Hargreaves. (2015) Exercise, muscle, and CHO metabolism. Scandinavian Journal of Medicine & Science in Sports 25, pages 29-33.
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Mette Cathrine ØrngreenTina Dysgaard JeppesenTanja TaivassaloSimon HauerslevNicolai PreislerKatja HeinickeRonald G. Haller, John VissingGerrit van Hall. (2015) Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease). The Journal of Clinical Endocrinology & Metabolism 100:8, pages E1096-E1104.
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Erik A. Richter & Mark Hargreaves. (2013) Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews 93:3, pages 993-1017.
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Serge Summermatter, Gesa Santos, Joaquín Pérez-Schindler & Christoph Handschin. (2013) Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences 110:21, pages 8738-8743.
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M. Hilbert, V. Shushakov & N. Maassen. (2012) The influence of respiratory acid-base changes on muscle performance and excitability of the sarcolemma during strenuous intermittent hand grip exercise. Journal of Applied Physiology 112:4, pages 571-579.
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Gerrit van Hall. (2010) Lactate kinetics in human tissues at rest and during exercise. Acta Physiologica 199:4, pages 499-508.
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R. Chudalla, S. Baerwalde, G. Schneider & N. Maassen. (2006) Local and systemic effects on blood lactate concentration during exercise with small and large muscle groups. Pflügers Archiv - European Journal of Physiology 452:6, pages 690-697.
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S. Volianitis, C. C. Yoshiga, P. Nissen & N. H. Secher. (2004) Effect of fitness on arm vascular and metabolic responses to upper body exercise. American Journal of Physiology-Heart and Circulatory Physiology 286:5, pages H1736-H1741.
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S. Volianitis, P. Krustrup, E. Dawson & N. H. Secher. (2003) Arm Blood Flow and Oxygenation on the Transition from Arm to Combined Arm and Leg Exercise in Humans. The Journal of Physiology 547:2, pages 641-648.
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G. van Hall, M. Jensen-Urstad, H. Rosdahl, H.-C. Holmberg, B. Saltin & J. A. L. Calbet. (2003) Leg and arm lactate and substrate kinetics during exercise. American Journal of Physiology-Endocrinology and Metabolism 284:1, pages E193-E205.
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G. van Hall, J. A. L. Calbet, H. Søndergaard & B. Saltin. (2002) Similar carbohydrate but enhanced lactate utilization during exercise after 9 wk of acclimatization to 5,620 m. American Journal of Physiology-Endocrinology and Metabolism 283:6, pages E1203-E1213.
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S. Volianitis & N. H. Secher. (2002) Arm blood flow and metabolism during arm and combined arm and leg exercise in humans. The Journal of Physiology 544:3, pages 977-984.
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Gregory J. Crowther, William F. Kemper, Michael F. CareyKevin E. Conley. (2002) Control of glycolysis in contracting skeletal muscle. II. Turning it off. American Journal of Physiology-Endocrinology and Metabolism 282:1, pages E74-E79.
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Gregory J. Crowther, Michael F. CareyWilliam F. Kemper & Kevin E. Conley. (2002) Control of glycolysis in contracting skeletal muscle. I. Turning it on. American Journal of Physiology-Endocrinology and Metabolism 282:1, pages E67-E73.
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G. Van Hall. (2002) Lactate as a fuel for mitochondrial respiration. Acta Physiologica Scandinavica 168:4, pages 643-656.
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Erik A. Richter, Søren Kristiansen, Jørgen Wojtaszewski, Jens R. Daugaard, Sven Asp, Peter Hespel & Bente Kiens. 1998. Skeletal Muscle Metabolism in Exercise and Diabetes. Skeletal Muscle Metabolism in Exercise and Diabetes 107 116 .
Erik A. Richter. 2011. Comprehensive Physiology. Comprehensive Physiology 912 951 .
Iva K. Martin & John Wahren. 1993. New Concepts in the Pathogenesis of NIDDM. New Concepts in the Pathogenesis of NIDDM 221 233 .
Harriet Wallberg-Henriksson & John Wahren. (1989) Effect of nutrition and diabetes mellitus on the regulation of metabolic fuels during exercise. The American Journal of Clinical Nutrition 49:5, pages 938-943.
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A. Knüttel, E. Rommel, M. Clausen & R. Kimmich. (1988) Integrated volume-selective/spectral editing1H NMR and postdetection signal processing for the sensitive determination of lactate. Magnetic Resonance in Medicine 8:1, pages 70-79.
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T. Joreteg, S. Efendic & T. Jogestrand. (2008) Glucose uptake and binding of digoxin to skeletal muscle. Clinical Physiology 6:2, pages 191-196.
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Veikko A. Koivisto, Hanele Yki‐Järvinen & Ralph A. DeFronzo. (2009) Physical training and insulin sensitivity. Diabetes/Metabolism Reviews 1:4, pages 445-481.
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Ola Bjorkman. (2009) Fuel metabolism during exercise in normal and diabetic man. Diabetes/Metabolism Reviews 1:4, pages 319-357.
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D. E. James, E. W. Kraegen & D. J. Chisholm. (1985) Muscle glucose metabolism in exercising rats: comparison with insulin stimulation. American Journal of Physiology-Endocrinology and Metabolism 248:5, pages E575-E580.
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Georg Löffler, Petro E. Petrides, Ludwig Weiss & Harold A. HarperP. E. Petrides & G. Löffler. 1985. Physiologische Chemie. Physiologische Chemie 779 794 .
B. Jakober, R. M. Schmülling, P. H. Müller & M. Eggstein. (2014) Hormonal and metabolic changes in starving obese patients during exhaustive physical exercise. Journal of Endocrinological Investigation 6:6, pages 445-453.
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Michael G. Clark, Glen S. Patten, Owen H. Filsell & Stephen Rattigan. (2001) Co‐ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via α‐receptors. FEBS Letters 158:1, pages 1-6.
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PAUL A. MOLÉ. 1983. Exercise Medicine. Exercise Medicine 43 88 .
Ralph A. Defronzo, Eleuterio Ferrannini & Veikko Koivisto. (1983) New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. The American Journal of Medicine 74:1, pages 52-81.
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Hans Stjernström, Lennart Jorfeldt & Lars Wiklund. (2016) The Influence of Abdominal Surgical Trauma Upon the Turnover of Some Blood-Borne Energy Metabolites in the Human Leg. Journal of Parenteral and Enteral Nutrition 5:3, pages 207-214.
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E. Ravussin, P. Pahud, A. Dörner, M. J. Arnaud & E. Jéquier. (1979) Substrate utilization during prolonged exercise preceded by ingestion of13C-glucose in glycogen depleted and control subjects. Pflügers Archiv - European Journal of Physiology 382:3, pages 197-202.
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Georg Löffler, Petro E. Petrides, Ludwig Weiss & Harold A. HarperP. E. Petrides & G. Löffler. 1979. Physiologische Chemie. Physiologische Chemie 779 794 .
M. Wicklmayr, G. Dietze & H. Mehnert. (1978) Effect of phenformin on substrate metabolism of working muscle in maturity onset diabetics. Diabetologia 15:2, pages 99-104.
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MATTHIAS WICKLMAYR & GÜNTHER DIETZE. (2008) On the mechanism of glucose release from the muscle of juvenile diabetics in acute insulin deficiency. European Journal of Clinical Investigation 8:2, pages 81-86.
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J. Wahren, P. Felig & L. Hagenfeldt. (1978) Physical exercise and fuel homeostasis in diabetes mellitus. Diabetologia 14:4, pages 213-222.
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John Wahren. (1977) GLUCOSE TURNOVER DURING EXERCISE IN MAN. Annals of the New York Academy of Sciences 301:1 The Marathon, pages 45-55.
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S. W. J. Shaw & R. H. Johnson. (1975) THE EFFECT OF NAFTIDROFURYL ON THE METABOLIC RESPONSE TO EXERCISE IN MAN. Acta Neurologica Scandinavica 52:3, pages 231-237.
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Harold A. Harper, Georg Löffler, Petro E. Petrides & Ludwig WeissP. E. Petrides & G. Löffler. 1975. Physiologische Chemie. Physiologische Chemie 791 809 .
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Philip Felig. (1973) The glucose-alanine cycle. Metabolism 22:2, pages 179-207.
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Philip Felig & John Wahren. 1971. Muscle Metabolism During Exercise. Muscle Metabolism During Exercise 205 214 .
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