36
Views
80
CrossRef citations to date
0
Altmetric
Original Article

Screening for Metabolic Disorders Using Gas-Liquid Chromatography, Mass Spectrometry, and Computer Technique

, &
Pages 273-285 | Received 29 Jan 1971, Accepted 03 Mar 1971, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Oddvar Stokke, Sverre Marstein, Egil Jellum & Sverre O. Lie. (1982) Accumulation of pyroglutamic acid (5-oxoproline) in homocystinuria. Scandinavian Journal of Clinical and Laboratory Investigation 42:4, pages 361-369.
Read now
S. Skrede & O. Slaattelid. (1979) Fatty acid metabolism during hypothermic perfusion of the isolated dog kidney. Scandinavian Journal of Clinical and Laboratory Investigation 39:8, pages 765-771.
Read now
Benjamin J. Gurizinoiwicz, Michael J. Gudzinowicz & Horace F. Martin. (1977) Integrated GC-MS Analytical Systems. Part I Recent Technological Advances Affecting Integrated GC-MS System Utilization. Instrumentation Science & Technology 8:4, pages 225-293.
Read now
O. Slaattelid, A. Flatmark & S. Skrede. (1976) The Importance of Perfusate Content of Free Fatty Acids for Dog Kidney Preservation. Scandinavian Journal of Clinical and Laboratory Investigation 36:3, pages 239-245.
Read now
K. Rootwelt. (1975) The Influence of Fatty Acids on Serum Thyroxine Determination by Competitive Protein-Binding Radioassay. Scandinavian Journal of Clinical and Laboratory Investigation 35:7, pages 649-653.
Read now
S. Landaas & J. E. Pettersen. (1975) Clinical Conditions Associated with Urinary Excretion of 2-Hydroxybutyric Acid. Scandinavian Journal of Clinical and Laboratory Investigation 35:3, pages 259-266.
Read now

Articles from other publishers (74)

Haleem J. Issaq, Stephen D. Fox, King C. Chan & Timothy D. Veenstra. (2011) Global proteomics and metabolomics in cancer biomarker discovery. Journal of Separation Science 34:24, pages 3484-3492.
Crossref
Michael D. Reily, Petia Shipkova & Serhiy Hnatyshyn. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 685 722 .
D. G. Robertson, P. B. Watkins & M. D. Reily. (2010) Metabolomics in Toxicology: Preclinical and Clinical Applications. Toxicological Sciences 120:Supplement 1, pages S146-S170.
Crossref
Haleem J. Issaq, Que N. Van, Timothy J. Waybright, Gary M. Muschik & Timothy D. Veenstra. (2009) Analytical and statistical approaches to metabolomics research. Journal of Separation Science 32:13, pages 2183-2199.
Crossref
Haleem J. Issaq, Eric Abbott & Timothy D. Veenstra. (2008) Utility of separation science in metabolomic studies. Journal of Separation Science 31:11, pages 1936-1947.
Crossref
Que N. Van, Haleem J. Issaq, Qiujie Jiang, Qiaoli Li, Gary M. Muschik, Timothy J. Waybright, Hong Lou, Michael Dean, Jouni Uitto & Timothy D. Veenstra. (2007) Comparison of 1D and 2D NMR Spectroscopy for Metabolic Profiling. Journal of Proteome Research 7:2, pages 630-639.
Crossref
Paolo Iadarola, Giuseppe Cetta, Maurizio Luisetti, Laura Annovazzi, Begona Casado, James Baraniuk, Chiara Zanone & Simona Viglio. (2005) Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: A critical review of the state‐of‐the‐art. ELECTROPHORESIS 26:4-5, pages 752-766.
Crossref
Katja B. Presto Elgstoen, Jane Y. Zhao, Joseph F. Anacleto & Egil Jellum. (2001) Potential of capillary electrophoresis, tandem mass spectrometry and coupled capillary electrophoresis–tandem mass spectrometry as diagnostic tools. Journal of Chromatography A 914:1-2, pages 265-275.
Crossref
. (1995) Introduction. Clinica Chimica Acta 241-242, pages 3-12.
Crossref
James D. Shoemaker & William H. Elliott. (1991) Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. Journal of Chromatography B: Biomedical Sciences and Applications 562:1-2, pages 125-138.
Crossref
E. Jellum, O. Thoresen, L. Horn, R. Seip, E. Nilsen, E.A. Kvittingen & O. Stokke. (1989) Advances in the use of computerized gas chromatography—mass spectrometry and high-performance liquid chromatography with rapid scanning detection for clinical diagnosis. Journal of Chromatography A 468, pages 43-53.
Crossref
. 1989. Analytical Artifacts: GC, MS, HPLC, TLC and PC. Analytical Artifacts: GC, MS, HPLC, TLC and PC 753 801 .
Egil Jellum, Eli Anne Kvittingen & Oddvar Stokke. (1988) Mass spectrometry in diagnosis of metabolic disorders. Biological Mass Spectrometry 16:1-12, pages 57-62.
Crossref
D.P. Brenton & S. Krywawych. (1986) Alkaptonuria. Clinics in Rheumatic Diseases 12:3, pages 755-769.
Crossref
E.A. Kvittingen, G. Guldal, S. Børsting, I.O. Skalpe, O. Stokke & E. Jellum. (1986) N-Acetylaspartic aciduria in a child with a progressive cerebral atrophy. Clinica Chimica Acta 158:3, pages 217-227.
Crossref
Henry Weiner, Frederic G. Coker & James J. Vrbanac. (1984) Application of metabolic profiling to study the effects of ethanol on metabolism in rats. Alcohol 1:2, pages 105-109.
Crossref
Milos Novotny & Donald Wiesler. 1984. Separation Methods. Separation Methods 41 147 .
Heinz Thoma & Gerhard Spiteller. (2006) Meerwein‐Verseifung von 3‐Oxoalkansäure‐alkylestern im Gaschromatographen. Liebigs Annalen der Chemie 1983:7, pages 1237-1248.
Crossref
Carl-Gustaf V. Hammar. (1983) A novel gel electrophoretic extraction and fractionation technique in comparative analysis of functional differences and alterations in cellular metabolism. Analytical Biochemistry 130:1, pages 226-236.
Crossref
J. Freudenthal, J.H. Canton, G.J.Ten Hove & R.C.C. Wegman. (1982) Pyrolysis—high-resolution mass spectrometry of biological materials. Journal of Analytical and Applied Pyrolysis 3:3, pages 243-252.
Crossref
R. A. Chalmers & A. M. LawsonR. A. Chalmers & A. M. Lawson. 1982. Organic Acids in Man. Organic Acids in Man 1 8 .
I. Matsumoto, T. Kuhara, T. Shinka, T. Mizuno, H. Teshima & N. Abe. 1981. Data for Science and Technology. Data for Science and Technology 55 58 .
Howard S. Ramsdell & Kay Tanaka. (1980) Gas chromatographic retention indices of twenty metabolically important acylglycines as trimethylsilyl derivatives. Journal of Chromatography B: Biomedical Sciences and Applications 181:1, pages 90-94.
Crossref
Norman Milleron. 1980. 199 324 .
Michael Spiteller & Gerhard Spiteller. (1979) Trennung und charakterisierung saurer harnbestandteile. Journal of Chromatography B: Biomedical Sciences and Applications 164:3, pages 253-317.
Crossref
O. Sjaastad, L. Gjessing, S. Ritland, P. Blichfeldt & K. Sandnes. (1979) Chronic relapsing pancreatitis, encephalopathy with disturbance of consciousness, and CSF amino acid aberration. Journal of Neurology 220:2, pages 83-94.
Crossref
M. Mantel, Z. B. Alfassi & S. Amiel. (2002) Magnetic fields to eliminate beta-ray interference in measurement of x-rays following neutron activation. Analytical Chemistry 50:3, pages 441-444.
Crossref
S. C. Gates, M. J. Smisko, C. L. Ashendel, N. D. Young, J. F. Holland & C. C. Sweeley. (2002) Automated simultaneous qualitative and quantitative analysis of complex organic mixtures with a gas chromatography-mass spectrometry-computer system. Analytical Chemistry 50:3, pages 433-441.
Crossref
Garry K. Brown, Oddvar Stokke & Egil Jellum. (1978) Chromatographic profile of high boiling point organic acids in human urine. Journal of Chromatography B: Biomedical Sciences and Applications 145:2, pages 177-184.
Crossref
J. Alm, L. Hagenfeldt & A. Larsson. (2016) Concentrations of Organic Acids in the Urine of Healthy Newborn Children. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 15:1-6, pages 245-249.
Crossref
Robert M. Cohn, Stephen Updegrove, John R. Yandrasitz, Ronald Rothman & Kenneth Tomer. (1978) Evaluation of continuous solvent extraction of organic acids from biological fluids. Clinical Biochemistry 11:3, pages 126-130.
Crossref
M. Duran, D. Gompertz, L. Bruinvis, D. Ketting & S.K. Wadman. (1978) The variability of metabolite excretion in propionicacidaemia. Clinica Chimica Acta 82:1-2, pages 93-99.
Crossref
Kenneth B. Tomer, Ronald Rothman, Marc Yudkoff & Stanton Segal. (1977) Unusual pattern of metabolites in the urine of a child with tyrosinemia: Glyceraldehyde. Clinica Chimica Acta 81:2, pages 109-117.
Crossref
Egil Jellum. (1977) Profiling of human body fluids in healthy and diseased states using gas chromatography and mass spectrometry, with special reference to organic acids. Journal of Chromatography B: Biomedical Sciences and Applications 143:5, pages 427-462.
Crossref
Imre Molnár & Csaba Horváth. (1977) Rapid separation of urinary acids by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 143:4, pages 391-400.
Crossref
William L. Nyhan. (1977) An approach to the diagnosis of overwhelming metabolic disease in early infancy. Current Problems in Pediatrics 7:6, pages 3-20.
Crossref
Motoo Nakajima, Yoshinori Ozawa, Takenori Tanimura & Zenzo Tamura. (1976) A highly efficient carboxylic acid analyzer and its application. Journal of Chromatography A 123:1, pages 129-138.
Crossref
M.D.A. Finnie, R.S. Ersser, J.W.T. Seakins & W. Snedden. (1976) The occurrence and identification of o-hydroxyhippuric acid (salicyluric acid) in the urine of sick children. Clinica Chimica Acta 70:1, pages 171-178.
Crossref
O. Sjaastad, J. Berstad, P. Gjesdahl & L. Gjessino. (1976) HOMOCARNOSINOSIS. 2. A FAMILIAL METABOLIC DISORDER ASSOCIATED WITH SPASTIC PARAPLEGIA, PROGRESSIVE MENTAL DEFICIENCY, and RETINAL PIGMENTATION. Acta Neurologica Scandinavica 53:4, pages 275-290.
Crossref
Petr Hušek & Karel Macek. (1975) Gas chromatography of amino acids. Journal of Chromatography A 113:2, pages 139-230.
Crossref
R.W.E Watts, R.A Chalmers & A.M Lawson. (1975) ABNORMAL ORGANIC ACIDURIAS IN MENTALLY RETARDED PATIENTS. The Lancet 305:7903, pages 368-372.
Crossref
Martin F. Schulman & Fred P. Abramson. (1975) Plasma amino acid analysis by isotope ratio gas chromatography mass spectrometry computer techniques. Biological Mass Spectrometry 2:1, pages 9-14.
Crossref
A. M. Lawson. (2016) Prospects for Mass Spectrometry in Clinical Chemistry. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 12:1-6, pages 51-57.
Crossref
A.M. Lawson & G.H. Draffan. 1975. 1 103 .
John Roboz. 1975. Advances in Clinical Chemistry Volume 17. Advances in Clinical Chemistry Volume 17 109 191 .
C. J. Epstein. 1975. Early Diagnosis and Prevention of Genetic Diseases. Early Diagnosis and Prevention of Genetic Diseases 110 131 .
Kay Tanaka. 1975. Biology of Brain Dysfunction. Biology of Brain Dysfunction 145 214 .
A. M. Lawson, R. A. Chalmers & R. W. E. Watts. (1974) Studies ofO-substituted oxime-trimethylsilyl ester derivatives of some metabolically-important oxocarboxylic acids. Biological Mass Spectrometry 1:3, pages 199-205.
Crossref
Lorentz Eldjarn, Egil Jellum & Oddvar Stokke. (1974) Application of gas chromatography-mass spectrometry in routine and research in clinical chemistry. Journal of Chromatography A 91, pages 353-366.
Crossref
Ronald A. Chalmers, Sheila Bickle & R.W.E. Watts. (1974) A method for the determination of volatile organic acids in aqueous solutions and urine, and the results obtained in propionic acidaemia, β-methylcrotonylglycinuria and methylmalonic aciduria. Clinica Chimica Acta 52:1, pages 31-41.
Crossref
E.C. HORNING, M.G. HORNING & R.N. STILLWELL. 1974. Advances in Biomedical Engineering. Advances in Biomedical Engineering 1 74 .
Hans J. Sternowsky, John Roboz, Ferenc Hutterer & Gerald Gaull. (1973) Determination of α-keto acids as silylated oximes in urine and serum by combined gas chromatography-mass spectrometry. Clinica Chimica Acta 47:3, pages 371-379.
Crossref
Egil Jellum, Hans Chr. Børresen & Lorentz Eldjarn. (1973) The presence of furan derivatives in patients receiving fructose-containing solutions intravenously. Clinica Chimica Acta 47:2, pages 191-201.
Crossref
A. J. Blotcky, L. J. Arsenault & E. P. Rack. (2002) Study of metabolic pathways in vivo using stable isotopes. Analytical Chemistry 45:7, pages 1107-1110.
Crossref
U. Langenbeck & J.E. Seegmiller. (1973) Gas chromatography—mass spectrometry studies of hipuric acid derivatives. Journal of Chromatography A 80:1, pages 81-88.
Crossref
B. S. Middleditch & D. M. Desiderio. (2002) Comparison of selective ion monitoring and repetitive scanning during gas chromatography-mass spectrometry. Analytical Chemistry 45:4, pages 806-808.
Crossref
H. B. Valman, A. D. Patrick, J. W. T. Seakins, J. W. Platt & D. Gompertz. (1973) Family with intermittent maple syrup urine disease. Archives of Disease in Childhood 48:3, pages 225-228.
Crossref
C.R. Scriver, C.L. Clow & P. Lamm. (1973) On the screening, diagnosis and investigation of hereditary aminoacidopathies. Clinical Biochemistry 6, pages 142-188.
Crossref
P. Stavem, E. Saltvedt, K. Elgjo & K. Rootwelt. (2009) Congenital Hypochromic Microcytic Anaemia with Iron Overload of the Liver and Hyperferraemia. Scandinavian Journal of Haematology 10:2, pages 153-160.
Crossref
A. Zlatkis, H. A. Lichtenstein & A. Tishbee. (1973) Concentration and analysis of trace volatile organics in gases and biological fluids with a new solid adsorbent. Chromatographia 6:2, pages 67-70.
Crossref
Kent E. Matsumoto, David H. Partridge, Arthur B. Robinson, Linus Pauling, Robert A. Flath, T.Richard Mon & Roy Teranishi. (1973) The identification of volatile compounds in human urine. Journal of Chromatography A 85:1, pages 31-34.
Crossref
John Roboz. 1973. Applications of the Newer Techniques of Analysis. Applications of the Newer Techniques of Analysis 273 301 .
J. V. Neel, T. O. Tiffany & N. G. Anderson. 1973. Chemical Mutagens. Chemical Mutagens 105 150 .
L.R. Treiber, B. Örtengren, R. Lindsten & T. Örtegren. (1972) Zurstandardisierung der direkten spektrophotometrischen auswertung von chromatogrammen. Journal of Chromatography A 73:1, pages 151-159.
Crossref
Lars Hagenfeldt & Kerstin Hagenfeldt. (1972) Gas chromatographic—mass spectrometric analysis of organic acids in amniotic fluid. Clinica Chimica Acta 42:1, pages 219-220.
Crossref
Lena Borg, Sven Lindstedt, Göran Steen & Ola Hjalmarson. (1972) Aliphatic C6−C14 dicarboxylic acids in urine from an infant with fatal congenital lactic acidosis. Clinica Chimica Acta 41, pages 363-366.
Crossref
Jon E. Pettersen & Egil Jellum. (1972) The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine. Clinica Chimica Acta 41, pages 199-207.
Crossref
L. Eldjarn, E. Jellum & O. Stokke. (1972) Pyroglutamic aciduria: Studies on the enzymic block and on the metabolic origin of pyroglutamic acid. Clinica Chimica Acta 40:2, pages 461-476.
Crossref
D. Gompertz & G.H. Draffan. (1972) The gas-chromatographic diagnosis of intermittent maple syrup urine disease (branch-chain ketoaciduria). Clinica Chimica Acta 40:1, pages 5-11.
Crossref
A L. Burlingame & G A. Johanson. (2003) Mass Spectrometry.. Analytical Chemistry 44:5, pages 337-378.
Crossref
Jon E. Pettersen, Egil Jeelum & Lorentz Eedjarn. (1972) The occurrence of adipic and suberic acid in urine from ketotic patients. Clinica Chimica Acta 38:1, pages 17-24.
Crossref
Harold M. Nitowsky. 1972. Heredity and Society. Heredity and Society 225 261 .
E.C. HORNING & M.G. HORNING. 1972. Advances in Biomedical Engineering. Advances in Biomedical Engineering 287 341 .
Rolf Nyberg-Hansen. (1972) Metachromatic leucodystrophy. Zeitschrift f�r Neurologie 203:2, pages 145-154.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.