Advanced search
Publication Cover
Scandinavian Journal of Clinical and Laboratory Investigation Volume 29, 1972 - Issue 3
Submit an article Journal homepage
7
Views
44
CrossRef citations to date
0
Altmetric
Original Article

Micromethod for the Determination of Diphenylhydantoin in Plasma and Cerebrospinal Fluid—A Comparison Between a Gas Chromatographic and a Spectrophotometric Method

Anita Berlin Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden; Dept. of Pharmacology, Division for Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Dept. of Neurology, Karolinska Hospital, Stockholm, Sweden
,
S. Agurell Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden; Dept. of Pharmacology, Division for Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Dept. of Neurology, Karolinska Hospital, Stockholm, Sweden
,
O. Borgå Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden; Dept. of Pharmacology, Division for Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Dept. of Neurology, Karolinska Hospital, Stockholm, Sweden
,
L. Lund Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden; Dept. of Pharmacology, Division for Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Dept. of Neurology, Karolinska Hospital, Stockholm, Sweden
&
F. Sjöqvist Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden; Dept. of Pharmacology, Division for Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Dept. of Neurology, Karolinska Hospital, Stockholm, Sweden
Pages 281-287 | Received 28 Sep 1971, Accepted 09 Jan 1972, Published online: 08 Jul 2009

Citations (44)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

K. Liewendahl & H. Majuri. (1976) Thyroxine, Triiodothyronine, and Thyrotropin in Serum during Long-Term Diphenylhydantoin Therapy. Scandinavian Journal of Clinical and Laboratory Investigation 36:2, pages 141-144.
Read now

Articles from other publishers (43)

P. S�derman & I. Matheson. (1988) Clonazepam in breast milk. European Journal of Pediatrics 147:2, pages 212-213.
Crossref
M Kaste, A Muuronen, E A Nikkilä & P J Neuvonen. (1983) Increase of low serum concentrations of high-density lipoprotein (HDL) cholesterol in TIA-patients treated with phenytoin.. Stroke 14:4, pages 525-530.
Crossref
G. M. Frigo, S. Lecchini, M. Caravaggi, G. Gatti, M. Tonini, L. D'Angelo, E. Perucca & A. Crema. (1983) Reduction in phenytoin clearance caused by cimetidine. European Journal of Clinical Pharmacology 25:1, pages 135-137.
Crossref
S. Lindahl & D. Westerling. (2008) DETOXIFICATION WITH PERITONEAL DIALYSIS AND BLOOD EXCHANGE AFTER DIPHENYLHYDANTOIN INTOXICATION. Acta Paediatrica 71:4, pages 665-666.
Crossref
T. MODEER, G. TOMSON, O. FALK & A. RANE. (2008) PHENYTOIN AND IgA CONCENTRATIONS IN PLASMA AND SALIVA IN EPILEPTIC CHILDREN. Acta Paediatrica 70:3, pages 373-378.
Crossref
P. J. Neuvonen, R. A. Tokola & M. Kaste. (1981) Cimetidine-phenytoin interaction: Effect on serum phenytoin concentration and antipyrine test. European Journal of Clinical Pharmacology 21:3, pages 215-220.
Crossref
U. Bergman & B. -E. Wiholm. (1981) Patient medication on admission to a medical clinic. European Journal of Clinical Pharmacology 20:3, pages 185-191.
Crossref
W. Fr�scher, M. Eichelbaum, R. Gugler, G. Hildenbrand & H. Penin. (1981) A prospective randomised trial on the effect of monitoring plasma anticonvulsant levels in epilepsy. Journal of Neurology 224:3, pages 193-201.
Crossref
P. J. Neuvonen & E. Elonen. (1980) Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man. European Journal of Clinical Pharmacology 17:1, pages 51-57.
Crossref
GM Frigo, S Lecchini, G Gatti, E Perucca & A Crema. (2012) Modification of phenytoin clearance by valproic acid in normal subjects.. British Journal of Clinical Pharmacology 8:6, pages 553-556.
Crossref
I. C. Dijkhuis, H. J. De Jong, A. Richens, C. E. Pippenger, E. E. A. Leskinen & A. P. W. Nyberg. (1979) Joint international quality control programme on the determination of antiepileptic drugs. Pharmaceutisch weekblad 1:1, pages 1171-1204.
Crossref
Ö. Johansson, T. Lindberg & A. Melander. (2009) In Vivo Absorption of Phenytoin from Rat Small Intestine and its Inhibition by Phlorizin . Acta Pharmacologica et Toxicologica 45:4, pages 265-271.
Crossref
C. T. Bäckström & R. Södergård. (2014) Testosterone-estradiol-binding globulin, unbound and total estradiol and testosterone, and total progesterone during the menstrual cycle in women with epilepsy taking antiepileptic drugs. Journal of Endocrinological Investigation 2:4, pages 359-366.
Crossref
TORBJÖRN BÄCKSTRÖM & PER JORPES. (2009) Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy. Acta Neurologica Scandinavica 59:2, pages 63-71.
Crossref
Q. T. Smith, M. J. Hamilton, M. H. Biros & B. L. Pihlstrom. (2007) Salivary and Plasma IgA of Seizure Subjects Receiving Phenytoin. Epilepsia 20:1, pages 17-23.
Crossref
A. Melander, G. Brante, �. Johansson, T. Lindberg & E. W�hlin-Boll. (1979) Influence of food on the absorption of phenytoin in man. European Journal of Clinical Pharmacology 15:4, pages 269-274.
Crossref
P. J. Neuvonen, R. Lehtovaara, A. Bardy & E. Elomaa. (1979) Antipyretic analgesics in patients on antiepileptic drug therapy. European Journal of Clinical Pharmacology 15:4, pages 263-268.
Crossref
Esko A. Nikkilä, Markku Kaste, Christian Ehnholm & Jorma Viikari. (2009) Elevation of High-Density Lipoprotein in Epileptic Patients Treated with Phenytoin. Acta Medica Scandinavica 204:1-6, pages 517-520.
Crossref
P. J. Neuvonen, S. M. Elfving & E. Elonen. (1978) Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man. European Journal of Clinical Pharmacology 13:3, pages 213-218.
Crossref
Johan Elfström. (1977) PLASMA PROTEIN BINDING OF PHENYTOIN AFTER CHOLECYSTECTOMY AND NEUROSURGICAL OPERATIONS. Acta Neurologica Scandinavica 55:6, pages 455-464.
Crossref
J. Gordos, J. Schäublin & P. Spring. (1977) Micro-determination of plasma diphenylhydantoin by gas—liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 143:2, pages 171-181.
Crossref
J. D. Baty & P. R. Robinson. (1977) Single and multiple ion recording techniques for the analysis of diphenylhydantoin and its major metabolite in plasma. Biological Mass Spectrometry 4:1, pages 36-41.
Crossref
E. Karlsson, A. Kinman & C. Sonnhag. (1977) Comparative evaluation of intravenous phenytoin, procainamide and practolol in the acute treatment of ventricular arrhythmias. European Journal of Clinical Pharmacology 11:1, pages 1-6.
Crossref
R. Gugler, W. Fr�scher, M. Eichelbaum & G. Hildenbrand. (1977) The bioavailability of phenytoin. Journal of Neurology 216:3, pages 155-162.
Crossref
Torbjörn Bäckström. (1976) EPILEPTIC SEIZURES IN WOMEN RELATED to PLASMA ESTROGEN and PROGESTERONE DURING the MENSTRUAL CYCLE. Acta Neurologica Scandinavica 54:4, pages 321-347.
Crossref
Felicity Reynolds, P.N Ziroyanis, N.F Jones & S.E Smith. (1976) SALIVARY PHENYTOIN CONCENTRATIONS IN EPILEPSY AND IN CHRONIC RENAL FAILURE. The Lancet 308:7982, pages 384-386.
Crossref
J. T. WILSON, C. J. VAN BOXTEL, G. ALVAN & F. SJOQVIST. (1976) Failure of Vitamin C to Affect the Pharmacokinetic Profile of Antipyrine in Man. The Journal of Clinical Pharmacology 16:5-6, pages 265-270.
Crossref
Marcela Gutová, Olof Borgå & Anders Rane. (2009) Kinetics of Phenytoin in Pregnant and Non‐pregnant Rats. Acta Pharmacologica et Toxicologica 38:3, pages 254-259.
Crossref
STEPHEN E. SMITH & MICHAEL D. RAWLINS. 1976. Variability in Human Drug Response. Variability in Human Drug Response 132 148 .
E Karlsson. (1975) Procainamide and phenytoin. Comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels.. Heart 37:7, pages 731-740.
Crossref
A. S. Troupin & P. Friel. (2007) Anticonvulsant Level in Saliva, Serum, and Cerebrospinal Fluid. Epilepsia 16:2, pages 223-227.
Crossref
P. J. Pentik�inen, P. J. Neuvonen & S. M. Elfving. (1975) Bioavailability of four brands of phenytoin tablets. European Journal of Clinical Pharmacology 9:2-3, pages 213-218.
Crossref
B. Karl�n, M. Garle, A. Rane, Marcela Gutova & B. Lindborg. (1975) Assay of the major (4-hydroxylated) metabolites of diphenylhydantoin in human urine. European Journal of Clinical Pharmacology 8:5, pages 359-363.
Crossref
Anders Rane. (1974) Urinary excretion of diphenylhydantoin metabolites in newborn infants. The Journal of Pediatrics 85:4, pages 543-545.
Crossref
Robert J. Perchalski & B.J. Wilder. (1974) GLC Microdetermination of Plasma Anticonvulsant Levels. Journal of Pharmaceutical Sciences 63:5, pages 806-807.
Crossref
I. Odar-Cederl�f & O. Borg�. (1974) Kinetics of diphenylhydantoin in uraemic patients: Consequences of decreased plasma protein binding. European Journal of Clinical Pharmacology 7:1, pages 31-37.
Crossref
Dieter Janz & Dieter Schmidt. (1974) Comparison of spectrophotometric and gas-liquid chromatographic measurements of serum diphenylhydantoin concentrations in epileptic out-patients. Journal of Neurology 207:2, pages 109-116.
Crossref
L. Lund. (1974) Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin. European Journal of Clinical Pharmacology 7:2, pages 119-124.
Crossref
L. Lund, G. Alvan, A. Berlin & B. Alexanderson. (1974) Pharmacokinetics of single and multiple doses of phenytoin in man. European Journal of Clinical Pharmacology 7:2, pages 81-86.
Crossref
E. Karlsson, P. Collste & M. D. Rawlins. (1974) Plasma levels of lidocaine during combined treatment with phenytoin and procainamide. European Journal of Clinical Pharmacology 7:6, pages 455-459.
Crossref
P. Reizenstein & L. Lund. (2009) Effect of Anticonvulsive Drugs on Folate Absorption and the Cerebrospinal Folate Pump. Scandinavian Journal of Haematology 11:2, pages 158-165.
Crossref
GISELA GAUCHEL, F. D. GAUCHEL & L. BIRKOFER. (1973) Eine Mikromethode zur Bestimmung von Diphenylhydantoin (Phenhydan) im Blut durch Flüssigkeits-Chromatographie mit hohen Eingangsdrucken. Clinical Chemistry and Laboratory Medicine 11:1.
Crossref
Vincent Marks, W.Edward Lindup & E.Mary Baylis. 1973. Advances in Clinical Chemistry Volume 16. Advances in Clinical Chemistry Volume 16 47 109 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.