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Original Article

Bilirubin Binding by Human Erythrocytes

Pages 91-97 | Received 09 Jul 1971, Accepted 06 Oct 1971, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

D. Brites, R. Silva & A. Brito. (1997) Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age. Scandinavian Journal of Clinical and Laboratory Investigation 57:4, pages 337-349.
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Rolf Brodersen & Leo Stern. (1980) Binding of Bilirubin to Albumin. CRC Critical Reviews in Clinical Laboratory Sciences 11:4, pages 307-399.
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D. Bratlid. (1972) The Effect of Antimicrobial Agents on Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 30:3, pages 331-337.
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D. Bratlid. (1972) The Effect of Free Fatty Acids, Bile Acids, and Hematin on Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 30:1, pages 107-112.
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D. Bratlid & H. E. Rugstad. (1972) Effect of Albumin Binding on Bilirubin Conjugation and Toxicity in Cell Culture of a Clonal Strain of Rat Hepatoma Cells. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 461-465.
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D. Bratlid. (1972) The Effect of pH on Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 453-459.
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Articles from other publishers (52)

Thor W. R. Hansen, Ronald J. Wong & David K. Stevenson. (2020) Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn. Physiological Reviews 100:3, pages 1291-1346.
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Amaj A. Laskar, Masood A. Khan, Arshad H. Rahmani, Sana Fatima & Hina Younus. (2016) Thymoquinone, an active constituent of Nigella sativa seeds, binds with bilirubin and protects mice from hyperbilirubinemia and cyclophosphamide-induced hepatotoxicity. Biochimie 127, pages 205-213.
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Boh Boon Kim & Saad Tayyab. (2008) Resistance towards calcium induced bilirubin dependent hemolysis in porcine erythrocytes. Indian Journal of Clinical Biochemistry 23:1, pages 17-23.
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Richard P. Wennberg, Charles E. Ahlfors, Vinod K. Bhutani, Lois H. Johnson & Steven M. Shapiro. (2006) Toward Understanding Kernicterus: A Challenge to Improve the Management of Jaundiced Newborns. Pediatrics 117:2, pages 474-485.
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Ellen Bruzell Roll, Terje Christensen & Odrun A Gederaas. (2007) Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes. Acta Paediatrica 94:10, pages 1443-1447.
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Lars Kaestner, Asta Juzeniene & Johan Moan. (2004) Erythrocytes—the ‘house elves’ of photodynamic therapy. Photochemical & Photobiological Sciences 3:11-12, pages 981-989.
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Michael Mark, Roland Walter, John Contesse & Walter H Reinhart. (2003) Impairment of blood rheology by cholestatic jaundice in human beings. Journal of Laboratory and Clinical Medicine 142:6, pages 391-398.
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Lawrence M. Gartner & Marguerite Herschel. (2001) JAUNDICE AND BREASTFEEDING. Pediatric Clinics of North America 48:2, pages 389-400.
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Brito, Silva, Tiribelli & Brites. (2000) Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management. European Journal of Clinical Investigation 30:3, pages 239-247.
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Saad Tayyab & Mohammad Kutub Ali. (1999) A comparative study on the extraction of membrane-bound bilirubin from erythrocyte membranes using various methods. Journal of Biochemical and Biophysical Methods 39:1-2, pages 39-45.
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Mohammad K. Ali & Saad Tayyab. (1999) Differential resistance to calcium-induced bilirubin-dependent hemolysis in mammalian erythrocytes. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 122:1, pages 109-113.
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Saad Tayyab & Mohammad K. Ali. (1997) Binding of Bilirubin to Mammalian Erythrocytes. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 118:1, pages 97-103.
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Mohammad Kutub Ali & Saad Tayyab. (1997) Calcium-induced bilirubin-dependent hemolysis of human erythrocytes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1326:1, pages 124-130.
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Maria A. Brito, Rui M. Silva, Deolinda C. Matos, António T. da Silva & Dora T. Brites. (1996) Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia. Clinica Chimica Acta 249:1-2, pages 149-165.
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S. Tayyab & M.K. Ali. (1995) Binding of bilirubin to erythrocytes from different mammalian species. Comparative Biochemistry and Physiology Part A: Physiology 111:3, pages 507-509.
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J D Ostrow, P Mukerjee & C Tiribelli. (1994) Structure and binding of unconjugated bilirubin: relevance for physiological and pathophysiological function. Journal of Lipid Research 35:10, pages 1715-1737.
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JS Hahm, JD Ostrow, P Mukerjee & L Celic. (1992) Ionization and self-association of unconjugated bilirubin, determined by rapid solvent partition from chloroform, with further studies of bilirubin solubility.. Journal of Lipid Research 33:8, pages 1123-1137.
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William J. Cashore. (1990) The Neurotoxicity of Bilirubin. Clinics in Perinatology 17:2, pages 437-447.
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Henri Saxerholt. 1989. The Regulatory and Protective Role of the Normal Microflora. The Regulatory and Protective Role of the Normal Microflora 169 199 .
Simon Pett & Alex P. Mowat. (1987) Crigler-Najjar syndrome Types I and II. Clinical experience — King's College Hospital 1972–1978. Phenobarbitone, phototherapy and liver transplantation. Molecular Aspects of Medicine 9:5, pages 473-482.
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G. K. MALIK, G. K. GOEL, P. N. VISHWANATHAN, P. K. MISRA & B. SHARMA. (1986) Free and Erythrocyte-Bound Bilirubin in Neonatal Jaundice. Acta Paediatrica 75:4, pages 545-549.
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T. W. R. HANSEN & D. BRATLID. (1986) Bilirubin and Brain Toxicity. Acta Paediatrica 75:4, pages 513-522.
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ENRIQUE M. OSTREAJR.JR., EUGENE E. CEPEDA, CHERYL A. FLEURY & JAMES E. BALUN. (2008) Red Cell Membrane Lipid Peroxidation and Hemolysis Secondary to Phototherapy. Acta Paediatrica 74:3, pages 378-381.
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C La Rosa, DJ Morgan & LE Mather. (2012) Pethidine binding in whole blood: methodology and clinical significance.. British Journal of Clinical Pharmacology 17:4, pages 405-409.
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V. Glushko, M. Thaler & M. Ros. (1982) The fluorescence of bilirubin upon interaction with human erythrocyte ghosts. Biochimica et Biophysica Acta (BBA) - General Subjects 719:1, pages 65-73.
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Richard B. Krakaur & John W. Scanlon. (1981) Detection of Free Bilirubin and Estimation of Reserve Albumin Binding Capacity. Clinics in Laboratory Medicine 1:2, pages 329-343.
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A Bouillerot, C Fessard & F Sauger. (1981) La bilirubine erythrocytairE: Ses variations — interet pratique de son dosage. Clinica Chimica Acta 109:1, pages 39-44.
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George Chan, Roma Ilkiw & David Schiff. (1980) Clinical relevance of the plasma reserve albumin binding capacity for bilirubin (RABC) and “free” bilirubin concentration. Clinical Biochemistry 13:6, pages 292-294.
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M.R. Deziel & A.W. Girotti. (1980) Photodynamic action of bilirubin on liposomes and erythrocyte membranes.. Journal of Biological Chemistry 255:17, pages 8192-8198.
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Mark R. Deziel & Albert W. Girotti. (2008) BILIRUBIN‐PHOTOSENSITIZED LYSIS OF RESEALED ERYTHROCYTE MEMBRANES*. Photochemistry and Photobiology 31:6, pages 593-596.
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AUDREY K. BROWN & ANTONY F. MCDONAGH. (1980) Phototherapy for Neonatal Hyperbilirubinemia: Efficacy, Mechanism and Toxicity*. Advances in Pediatrics 27:1, pages 341-389.
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Richard P. Wennberg, Charles E. Ahlfors & L.Fraser Rasmussen. (1979) The pathochemistry of kernicterus. Early Human Development 3:4, pages 353-372.
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Angelo A. Lamola, Josef Eisinger, William E. Blumberg, Samantha C. Patel & Jorge Flores. (1979) Fluorometric study of the partition of bilirubin among blood components: Basis for rapid microassays of bilirubin and bilirubin binding capacity in whole blood. Analytical Biochemistry 100:1, pages 25-42.
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Toshio Yamamoto, Yukihiko Adachi & Ichiro Kuwahara. (1979) Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albuminin vivo andin vitro. Gastroenterologia Japonica 14:5, pages 483-491.
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Juan Lelio Corchs, Raquel E. Serrani & Mauricio Palchick. (1979) Effects of bilirubin on potassium (86Rb+) influx and ionic content in Ehrlich ascites cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 555:3, pages 512-518.
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A W Wolkoff, C A Goresky, J Sellin, Z Gatmaitan & I M Arias. (1979) Role of ligandin in transfer of bilirubin from plasma into liver.. American Journal of Physiology-Endocrinology and Metabolism 236:6, pages E638.
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ANTONY F. McDONAGH. 1979. The Porphyrins. The Porphyrins 293 491 .
LAWRENCE H. PIETTE & J. CARLETON HSIA. 1979. Spin Labeling. Spin Labeling 247 290 .
L. FRASER RASMUSSEN, CHARLES E. AHLFORS & RICHARD P. WENNBERG. (1978) Displacement of Bilirubin from Albumin by Indomethacin. The Journal of Clinical Pharmacology 18:10, pages 477-481.
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Kwang-sun Lee, Lawrence M. Gartner, Arthur I. Eidelman & Sudhakar Ezhuthachan. (1977) Unconjugated Hyperbilirubinemia in Very Low Birth Weight Infants. Clinics in Perinatology 4:2, pages 305-320.
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D.J. Wood & J.C. Hsia. (1977) Spin assay as a general method for studying plasma protein binding. Bilirubin — Albumin binding. Biochemical and Biophysical Research Communications 76:3, pages 863-868.
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Richard P. Wennberg, L. Fraser Rasmussen & Charles E. Ahlfors. (1977) Displacement of bilirubin from human albumin bythree diuretics. The Journal of Pediatrics 90:4, pages 647-650.
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Seetha Shankaran & Ronald L. Poland. (1977) The displacement of bilirubin from albumin byfurosemide. The Journal of Pediatrics 90:4, pages 642-646.
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L. Fraser Rasmussen, Charles E. Ahlfors & Richard P. Wennberg. (1976) The effect of paraben preservatives on albumin binding of bilirubin. The Journal of Pediatrics 89:3, pages 475-478.
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George Chan & David Schiff. (1976) Variance in albumin loading in exchange transfusions. The Journal of Pediatrics 88:4, pages 609-613.
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Gail Andrew, George Chan & David Schiff. (1976) Lipid metabolism in the neonate. The Journal of Pediatrics 88:2, pages 279-284.
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Charles A. Cruze & Marvin C. Meyer. (1976) Binding of Salicylate and Sulfathiazole by Whole Blood Constituents. Journal of Pharmaceutical Sciences 65:1, pages 33-37.
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Paul S. Lietman, Richard P. Wennberg & L. Fraser Rasmussen. (1975) Effects of gentamicin on albumin binding of bilirubin. The Journal of Pediatrics 86:4, pages 611-613.
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M. Pays & M. Beljean. (1975) Microdetermination of unbound bilirubin in sera. Application to the prevention of kernicterus by estimating the bilirubin-binding capacity of serum albumin. Clinica Chimica Acta 59:2, pages 121-128.
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Chr. Petrich, U. Göbel & U. Delvos. (1975) Effect of Bilirubin on Stored Red Blood Cells. Clinical Chemistry and Laboratory Medicine 13:10.
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J. Kapitulnik, T. Valaes, N. A. Kaufmann & S. H. Blondheim. (1974) Clinical evaluation of Sephadex gel filtration in estimation of bilirubin binding in serum in neonatal jaundice. Archives of Disease in Childhood 49:11, pages 886-894.
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DAG BRATLID & ASBJØSRN LANGSLET. (2008) DISPLACEMENT OF ALBUMIN‐BOUND BILIRUBIN BY INJECTABLE DIAZEPAM PREPARATIONS IN VITRO. Acta Paediatrica 62:5, pages 510-512.
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