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Original Article

The Effect of Sustained Hyperammonemia upon the Metabolic State of the Brain

Pages 245-255 | Received 17 Apr 1972, Accepted 08 Sep 1972, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

T. Holmin. (1976) The Effect of Hepatectomy on the Energy State and on Acid-Base Variables of the Rat Brain. Scandinavian Journal of Clinical and Laboratory Investigation 36:5, pages 423-429.
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A. Scheen, F. Pirnay, J. Juchmès & A. Cession-Fossion. (1974) Influence du blocage des récepteurs β-adrénergiques sur l'hyperlactacidémie d'exercice en hypoxie. Archives Internationales de Physiologie et de Biochimie 82:4, pages 737-761.
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B. Hindfelt. (1973) The Effect of Acute Hypocapnia upon the Energy State of the Brain in Sustained Hyperammonemia. Scandinavian Journal of Clinical and Laboratory Investigation 31:4, pages 399-408.
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B. Hindfelt. (1973) The Effect of Acute Ammonia Intoxication upon the Brain Energy State in Rats Pretreated with L-Methionine D-L-Sulphoximine. Scandinavian Journal of Clinical and Laboratory Investigation 31:3, pages 289-299.
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Articles from other publishers (34)

Leif Hertz, Dan Song, Liang Peng & Ye Chen. (2016) Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity. Neurochemical Research 42:3, pages 721-736.
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Peter Good. (2013) Does infectious fever relieve autistic behavior by releasing glutamine from skeletal muscles as provisional fuel?. Medical Hypotheses 80:1, pages 1-12.
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Kakulavarapu V. Rama Rao & Michael D. Norenberg. (2012) Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy. Neurochemistry International 60:7, pages 697-706.
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Chinta R.K. Murthy & Michael D. Norenberg. (2002) Suppression of ammonia-induced swelling by aspartate but not by ornithine in primary cultures of rat astrocytes. Neurochemistry International 41:2-3, pages 171-176.
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D. Astore & C. A. Boicelli. (2000) Hyperammonemia and chronic hepatic encephalopathy: an in vivo PMRS study of the rat brain. Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine 10:3, pages 160-166.
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N. Haghighat, D. W. McCandless & P. Geraminegad. (2000) The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cellsin vitro. Metabolic Brain Disease 15:2, pages 151-162.
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N. Haghighat & D. W. McCandless. (1997) Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cellsin vitro. Metabolic Brain Disease 12:4, pages 287-298.
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Hideyoshi Sugimoto, Raymond C. Koehler, David A. Wilson, Saul W. Brusilow & Richard J. Traystman. (2016) Methionine Sulfoximine, a Glutamine Synthetase Inhibitor, Attenuates Increased Extracellular Potassium Activity during Acute Hyperammonemia. Journal of Cerebral Blood Flow & Metabolism 17:1, pages 44-49.
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John P. Seery & Simon D. Taylor-Robinson. (1996) The application of magnetic resonance spectroscopy to the study of hepatic encephalopathy. Journal of Hepatology 25:6, pages 988-998.
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Michael Markefski & Gerald Wolf. (1991) Influence of ammonia, octanoate, quinolinate and hypoxic conditions on NAD(P)H fluorescence of hippocampal slices. Neurochemistry International 18:3, pages 323-329.
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Alli T. A. Manninen & H. Savolainen. (1989) Effect of Short-Term Ammonia Inhalation on Selected Amino Acids in Rat Brain. Pharmacology & Toxicology 64:3, pages 244-246.
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Thomas E. Fick, Solko W. Schalm & Marinus de Vlieger. (1989) Continuous intravenous ammonia infusion as a model for the study of hepatic encephalopathy in rabbits. Journal of Surgical Research 46:3, pages 221-225.
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R. Friolet, J.P. Colombo, F. Lazeyras, W.P. Aue, R. Kretschmer, A. Zimmermann & C. Bachmann. (1989) In vivo 31P NMR spectroscopy of energy rich phosphates in the brain of the hyperammonemic rat. Biochemical and Biophysical Research Communications 159:2, pages 815-820.
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E. Holm, H. Leweling, U. Staedt, J.-P. Striebel, A. Tschepe & W. Uhl. 1988. Wahl der Nahrungsproteine—Grundlagen und Diätetik. Wahl der Nahrungsproteine—Grundlagen und Diätetik 46 98 .
B. Debski, B. Siwecka & T. Motyl. (1987) Portal Blood Flow Changes in Hyperammonaemic Rabbits. Journal of Veterinary Medicine Series A 34:1-10, pages 1-6.
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Leif Hertz, Ch. R. K. Murthy, James C. K. Lai, Susan M. Fitzpatrick & Arthur J. L. Cooper. (1987) Some metabolic effects of ammonia on astrocytes and neurons in primary cultures. Neurochemical Pathology 6:1-2, pages 97-129.
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E. Holm, H. Leweling, U. Staedt, J.-P. Striebel, A. Tschepe & W. Uhl. 1986. Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 685 737 .
T. HOLMIN, C.‐D. AGARDH, G. ALINDER, P. HERLIN & B. HULTBERG. (2008) The influence of total hepatectomy on cerebral energy state, ammonia‐related amino acids of the brain and plasma amino acids in the rat. European Journal of Clinical Investigation 13:3, pages 215-220.
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Kodama Hiroko, Nose Osamu, Okada Shintaro, Maki Ichiro, Tajiri Hitoshi, Sano Tetsuya & Yabuuchi Hyakuji. (1982) Organic acid metabolism in a patient with ornithine transcarbamylase deficiency. Clinica Chimica Acta 123:1-2, pages 83-91.
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Hiroko Kodama, Osamu Nose, Shintaro Okada & Hyakuji Yabuuchi. 1982. Urea Cycle Diseases. Urea Cycle Diseases 341 350 .
A. M. Mans, S. J. Saunders, R. E. Kirsch & J. F. Biebuyck. (2006) CORRELATION OF PLASMA AND BRAIN AMINO ACID AND PUTATIVE NEUROTRANSMITTER ALTERATIONS DURING ACUTE HEPATIC COMA IN THE RAT. Journal of Neurochemistry 32:2, pages 285-292.
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Jay P. Marshall, Telfair H. Parker, Roderick K. Roberts & Steven Schenker. 1979. Biochemistry and Pharmacology of Ethanol. Biochemistry and Pharmacology of Ethanol 479 502 .
GE ShambaughIIIIII. (1978) Urea biosynthesis II. Normal and abnormal regulation. The American Journal of Clinical Nutrition 31:1, pages 126-133.
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Arne Brun, Sigmund Dawiskiba, Bengt Hindfelt & Jan-Edvin Olson. (1977) BRAIN PROTEINS IN HEPATIC ENCEPHALOPATHY. Acta Neurologica Scandinavica 55:3, pages 213-225.
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J. Papenberg, G. Lanzinger, B. Kommerell & S. Hoyer. (1975) Comparative studies of the electroencephalogram and the cerebral oxidative metabolism in patients with liver cirrhosisVergleichende Untersuchungen von Elektroenzephalogramm und zerebralem oxydativem Stoffwechsel bei Patienten mit Leberzirrhose. Klinische Wochenschrift 53:23, pages 1107-1113.
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Bengt Hindfelt. (1975) l-Methionine dl-sulphoximine (MSO) and ammonia distribution between extra- and intracellular compartments of the rat brain. Journal of the Neurological Sciences 25:4, pages 499-506.
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George E. Merino, Thomas Jetzer, William M.D. Doizaki & John S. Najarian. (1975) Methionine-induced hepatic coma in dogs. The American Journal of Surgery 130:1, pages 41-46.
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Neil R.M. Buist, Nancy G. Kennaway, Cecilia A. Hepburn, J. Jeffrey Strandholm & Donald A. Ramberg. (1974) Citrullinemia: Investigation and treatment over afour-year period. The Journal of Pediatrics 85:2, pages 208-214.
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Y. Edward Hsia. (1974) Inherited Hyperammonemic Syndromes. Gastroenterology 67:2, pages 347-374.
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B. Hindfelt. (2006) ACUTE HYPERCAPNIA AND BRAIN ENERGY STATE IN SUSTAINED HYPERAMMONAEMIA. Journal of Neurochemistry 23:1, pages 17-21.
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T. Holmin & B. K. Siesjö. (1974) INFLUENCE OF HYPOXIA ON CEREBRAL ENERGY STATE IN RATS WITH PORTA-CAVAL ANASTOMOSIS. Journal of Neurochemistry 22:3, pages 413-417.
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T. Holmin & B. K. Siesjö. (1974) THE EFFECT OF PORTA-CAVAL ANASTOMOSIS UPON THE ENERGY STATE AND UPON ACID-BASE PARAMETERS OF THE RAT BRAIN. Journal of Neurochemistry 22:3, pages 403-412.
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Torsten Holmin, Halldór Jóhannsson & Bo K. Siesjö. (2008) Effects on Cerebral Energy State of Arterial Hypotension in Rats with Porta‐Caval Anastomosis. Acta Physiologica Scandinavica 90:2, pages 345-357.
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Bo Eklöf, Torsten Holmin, Halldór Jóhannsson & Bo K. Siesjö. (2008) Cerebral Blood Flow and Cerebral Metabolic Rate for Oxygen in Rats with Porta‐Caval Anastomosis. Acta Physiologica Scandinavica 90:2, pages 337-344.
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