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Original Article

Characteristics of doxorubicin transport in human red blood cells

Pages 633-639 | Received 21 Jul 1980, Accepted 15 Mar 1981, Published online: 08 Jul 2009

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Read on this site (2)

David J. Kerr, Thomas E. Wheldon, Sharyn Hydns & Stanley B. Kaye. (1988) Cytotoxic drug penetration studies in multicellular tumour spheroids. Xenobiotica 18:6, pages 641-648.
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Mads Dalmark & Else K. Hoffmann. (1983) Doxorubicin (Adriamycin) transport in Ehrlich ascites tumour cells: Comparison with transport in human red blood cells. Scandinavian Journal of Clinical and Laboratory Investigation 43:3, pages 241-248.
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Articles from other publishers (37)

Emelie Ahnfelt, Oliver Degerstedt, Elsa Lilienberg, Erik Sjögren, Per Hansson & Hans Lennernäs. (2019) Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality. Journal of Drug Delivery Science and Technology 53, pages 101143.
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Chen‐Guang Liu, Ranjith Kumar Kankala, Hong‐Yue Liao, Ai‐Zheng Chen & Shi‐Bin Wang. (2019) Engineered pH‐responsive hydrazone‐carboxylate complexes‐encapsulated 2D matrices for cathepsin‐mediated apoptosis in cancer. Journal of Biomedical Materials Research Part A 107:6, pages 1184-1194.
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Karolina Matyjaszczyk, Marta Kolonko, Anna Gonciarz-Dytman, Irena Oszczapowicz, Małgorzata Łukawska, Wojciech Jawień, Stefan Chlopicki & Maria Walczak. (2017) Effects of structural modification of the daunosamine moiety of anthracycline antibiotics on pKa values determined by capillary zone electrophoresis. Journal of Chromatography B 1060, pages 44-52.
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Juan Wang, Zhuping Yin, Xiang Xue, Subhas Kundu, Xiumei Mo & Shenzhou Lu. (2016) Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release. International Journal of Molecular Sciences 17:12, pages 2012.
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Emelie Ahnfelt, Erik Sjögren, Per Hansson & Hans Lennernäs. (2016) In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System. Journal of Pharmaceutical Sciences 105:11, pages 3387-3398.
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Eva Csuhai, Sogol Kangarlou, Tian-Xiang Xiang, Andrei Ponta, Paul Bummer, Duhyung Choi & Bradley D. Anderson. (2015) Determination of Key Parameters for a Mechanism-Based Model to Predict Doxorubicin Release from Actively Loaded Liposomes. Journal of Pharmaceutical Sciences 104:3, pages 1087-1098.
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Suvi K. Soininen, Pauliina Lehtolainen-Dalkilic, Tanja Karppinen, Tiina Puustinen, Galina Dragneva, Minna U. Kaikkonen, Marjo Jauhiainen, Brigitte Allart, David L. Selwood, Thomas Wirth, Hanna P. Lesch, Ann-Marie Määttä, Jukka Mönkkönen, Seppo Ylä-Herttuala & Marika Ruponen. (2012) Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes. European Journal of Pharmaceutical Sciences 47:5, pages 848-856.
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Emily J. Danoff, Xiang Wang, Shih-Huang Tung, Nikolai A. Sinkov, Alice M. Kemme, Srinivasa R. Raghavan & Douglas S. English. (2007) Surfactant Vesicles for High-Efficiency Capture and Separation of Charged Organic Solutes. Langmuir 23:17, pages 8965-8971.
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Katsuhito Nagai, Kazuki Nagasawa, Atsushi Ishimoto & Sadaki Fujimoto. (2003) Pirarubicin is taken up by a uridine-transportable sodium-dependent concentrative nucleoside transporter in Ehrlich ascites carcinoma cells. Cancer Chemotherapy and Pharmacology 51:6, pages 512-518.
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Eugene A. Konorev, Hao Zhang, Joy Joseph, M. Claire Kennedy & B. Kalyanaraman. (2000) Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes. American Journal of Physiology-Heart and Circulatory Physiology 279:5, pages H2424-H2430.
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Frédéric Frézard & Arlette Garnier-Suillerot. (1998) Permeability of lipid bilayer to anthracycline derivatives. Role of the bilayer composition and of the temperature. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1389:1, pages 13-22.
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Per Ole Iversen, Borge Thing-Mortensen, Gunnar Nicolaysen & Haakon Breien Benestad. (1993) Decreased blood flow to rat bone marrow, bone, spleen, and liver in acute leukemia. Leukemia Research 17:8, pages 663-668.
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Jolanta Tarasiuk, Jean Foucrier & Arlette Garnier-Suillerot. (1993) Cell cycle dependent uptake and release of anthracycline by drug-resistant and drug-sensitive human leukaemic K562 cells. Biochemical Pharmacology 45:9, pages 1801-1808.
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Ellen C. SPOELSTRA, Hans V. WESTERHOFF, Henk DEKKER & Jan LANKELMA. (2005) Kinetics of daunorubicin transport by P‐glycoprotein of intact cancer cells. European Journal of Biochemistry 207:2, pages 567-579.
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C.A. Slapak, J.M. Lecerf, J.C. Daniel & S.B. Levy. (1992) Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.. Journal of Biological Chemistry 267:15, pages 10638-10644.
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Abbas Pezeshk, Vida Pezeshk, Jerzy Wojas, Witold K. Subczynski & Witold K. Subczynski. (1992) Partitional and motional properties of a spin-labeled daunomycin in lipid bilayers. An ESR study. Journal of Inorganic Biochemistry 46:2, pages 67-76.
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Christopher F. Higgins & Michael M. Gottesman. (1992) Is the multidrug transporter a flippase?. Trends in Biochemical Sciences 17:1, pages 18-21.
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Frédéric FREZARD & Arlette GARNIER‐SUILLEROT. (2005) Comparison of the membrane transport of anthracycline derivatives in drug‐resistant and drug‐sensitive K562 cells. European Journal of Biochemistry 196:2, pages 483-491.
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Ellen C. Spoelstra, Henk Dekker, Gerrit Jan Schuurhuis, Henricus J. Broxterman & Jan Lankelma. (1991) P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Biochemical Pharmacology 41:3, pages 349-359.
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Jolanta Tarasiuk, Frédéric Frézard, Arlette Garnier-Suillerot & Liliane Gattegno. (1989) Anthracycline incorporation in human lymphocytes. Kinetics of uptake and nuclear concentration. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1013:2, pages 109-117.
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Edward J. Osborne & William J. MacKillop. (1987) The effect of exposure to elevated temperatures on membrane permeability to Adriamycin in Chinese hamster ovary cells in vitro. Cancer Letters 37:2, pages 213-224.
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Romano Danesi, Mario del Tacca, Carla Bernardini & Sergio Penco. (1987) Exogenous doxorubicinol induces cardiotoxic effects in rats. European Journal of Cancer and Clinical Oncology 23:7, pages 907-913.
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D.J. KERR, T.E. WHELDON, A.M. KERR & S.B. KAYE. (1987) In Vitro Chemosensitivity Testing Using the Multicellular Tumor Spheroid Model . Cancer Drug Delivery 4:2, pages 63-73.
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David J. Kerr, Anne M. Kerr, R.Ian Freshney & Stanley B. Kaye. (1986) Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by nonsmall cell lung tumor cells in culture and its relationship to cell survival. Biochemical Pharmacology 35:16, pages 2817-2823.
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Karen G. Louie, Thomas C. Hamilton, Margaret A. Winker, Brent C. Behrens, Takashi Tsuruo, Raymond W. KleckerJr.Jr., McKoy, Karen R. Grotzinger, Charles E. Myers, Robert C. Young & Robert F. Ozols. (1986) Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines. Biochemical Pharmacology 35:3, pages 467-472.
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Diana A. Bates, Henry Fung & William J. Mackillop. (1985) Adriamycin uptake, intracellular binding and cytotoxicity in Chinese hamster ovary cells. Cancer Letters 28:2, pages 213-221.
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Thomas G. Burke & Thomas R. Tritton. (2002) Structural basis of anthracycline selectivity for unilamellar phosphatidylcholine vesicles: an equilibrium binding study. Biochemistry 24:7, pages 1768-1776.
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Jill M. Siegfried, Thomas G. Burke & Thomas R. Tritton. (1985) Cellular transport of anthracyclines by passive diffusion. Biochemical Pharmacology 34:5, pages 593-598.
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