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Original Article

Effects of oral contraceptive combinations containing levonorgestrel or desogestrel on serum proteins and androgen binding

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Pages 663-668 | Received 30 Oct 1980, Accepted 16 Mar 1981, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Mylène Aubertin-Leheudre, Esa Hämäläinen & Herman Adlercreutz. (2011) Diets and Hormonal Levels in Postmenopausal Women With or Without Breast Cancer. Nutrition and Cancer 63:4, pages 514-524.
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A. van den Ende, T. B. P. Geurts & H. J. Kloosterboer. (1997) A randomized cross-over study comparing pharmacodynamic and metabolic variables of a new combiphasic and a well-established triphasic oral contraceptive. The European Journal of Contraception & Reproductive Health Care 2:3, pages 173-180.
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Göran Cullberg. (1985) Pharmacodynamic Studies on Desogestrel Administered Alone and in Combination with Ethinylestradiol. Acta Obstetricia et Gynecologica Scandinavica 64:sup133, pages 1-30.
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GÖRan Cullberg, Lars Hamberger, Lars-Åke Mattsson, HÅKan Mobacken & GÖRan Samsioe. (1985) Effects of a low-dose desogestrel-ethinylestradiol combination on hirsutism, androgens and sex hormone binding globulin in women with a polycystic ovary syndrome. Acta Obstetricia et Gynecologica Scandinavica 64:3, pages 195-202.
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Kalevi Käär, Kurt Rhen & Tuukka Tarkkila. (1984) Short-term effects of desogestrel and ethinyloestradiol on serum proteins in women. Scandinavian Journal of Clinical and Laboratory Investigation 44:7, pages 623-627.
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K. Fotherby. (1983) A metabolic assessment of different oral contraceptives. Journal of Obstetrics and Gynaecology 3:sup2, pages S77-S82.
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Carl Gustaf Nilsson & Nils-Erik Backas. (1983) XXII Scandinavian Congress of Obstetrics and Gynecology. Acta Obstetricia et Gynecologica Scandinavica 62:sup116, pages 8-112.
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Articles from other publishers (52)

Y. Zimmerman, M. J. C. Eijkemans, H. J. T. Coelingh Bennink, M. A. Blankenstein & B. C. J. M. Fauser. (2013) The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis. Human Reproduction Update 20:1, pages 76-105.
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Antony D. Karelis, Annie Fex, Marie-Eve Filion, Herman Adlercreutz & Mylène Aubertin-Leheudre. (2010) Comparison of sex hormonal and metabolic profiles between omnivores and vegetarians in pre- and post-menopausal women. British Journal of Nutrition 104:2, pages 222-226.
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Mylène Aubertin-Leheudre, Sherwood Gorbach, Margo Woods, Johanna T. Dwyer, Barry Goldin & Herman Adlercreutz. (2008) Fat/fiber intakes and sex hormones in healthy premenopausal women in USA. The Journal of Steroid Biochemistry and Molecular Biology 112:1-3, pages 32-39.
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Jeanet M. KemmerenAle AlgraJoost C. M. MeijersGuido TansBonno N. BoumaJoyce CurversJan RosingDiederick E. Grobbee. (2004) Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Blood 103:3, pages 927-933.
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M.van Rooijen, A Silveira, A Hamsten & K Bremme. (2004) Sex hormone–binding globulin—A surrogate marker for the prothrombotic effects of combined oral contraceptives. American Journal of Obstetrics and Gynecology 190:2, pages 332-337.
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Daniel M. Breitkopf, Mitchell P. Rosen, Steven L. Young & Manubai Nagamani. (2003) Efficacy of second versus third generation oral contraceptives in the treatment of hirsutism. Contraception 67:5, pages 349-353.
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Viveca Odlind, Ian Milsom, Ingemar Persson & Arne Victor. (2002) Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?. Acta Obstetricia et Gynecologica Scandinavica 81:6, pages 482-490.
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D. Cibula, M. Hill, M. Fanta, G. Sindelka & J. Zivny. (2001) Does obesity diminish the positive effect of oral contraceptive treatment on hyperandrogenism in women with polycystic ovarian syndrome?. Human Reproduction 16:5, pages 940-944.
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Thomas H. Schwend & Joel S. Lippman. 1996. Estrogens, Progestins, and Their Antagonists. Estrogens, Progestins, and Their Antagonists 273 296 .
Thomas H. Schwend & Joel S. Lippman. 1997. Estrogens, Progestins, and Their Antagonists. Estrogens, Progestins, and Their Antagonists 273 296 .
Aarno Hautanen, Matti Mänttäri, Markku Kupari, Seppo Sarna, Vesa Manninen, M. Heikki Frick & Herman Adlercreutz. (1993) Cigarette smoking is associated with elevated adrenal androgen response to adrenocorticotropin. The Journal of Steroid Biochemistry and Molecular Biology 46:2, pages 245-251.
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Aarno Hautanen, Seppo Sarna, Risto Pelkonen & Herman Adlercreutz. (1993) Serum sex hormone-binding globulin, cardiovascular risk factors, and adrenal cortisol responses to dexamethasone and corticotropin. Metabolism 42:7, pages 870-874.
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A. Saure, E. Hirvonen, M.J. Tikkanen, L. Viinikka & O. Ylikorkala. (1993) A novel oestradiol-desogestrel preparation for hormone replacement therapy: Effects on hormones, lipids, bone, climacteric symptoms and endometrium. Maturitas 16:1, pages 1-12.
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Michael Juchem & Kunhard Pollow. (1990) Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor. American Journal of Obstetrics and Gynecology 163:6, pages 2171-2183.
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N. van der Vange, M.A. Blankenstein, H.J. Kloosterboer, A.A. Haspels & J.H.H. Thijssen. (1990) Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone. Contraception 41:4, pages 345-352.
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Béatrice Couzinet, Guy Thomas, Jean Christophe Thalabard, Sylvie Brailly & Gilbert Schaison. (1989) Effects of a pure antiandrogen on gonadotropin secretion in normal women and in polycystic ovarian disease. Fertility and Sterility 52:1, pages 42-50.
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J. A. Yabur, M. Alvarado & V. Brito. (1989) Clinical evaluation of a new combined oral contraceptive desogrestrel-ethinylestradiol. Advances in Contraception 5:2, pages 57-70.
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H Adlercreutz, E Hämäläinen, S L Gorbach, B R Goldin, M N Woods & J T Dwyer. (1989) Diet and plasma androgens in postmenopausal vegetarian and omnivorous women and postmenopausal women with breast cancer. The American Journal of Clinical Nutrition 49:3, pages 433-442.
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Roberto Frairia, Laura Berta, Paola Gennari, Maria Roberta Crua & Gianpiero Gaidano. (1988) Estro-progestogen combinations: Effect on sex Steroid Binding Protein (SBP) synthesis. Steroids 52:4, pages 403-404.
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K. FOTHERBY. (1988) Interactions of Contraceptive Steroids with Binding Proteins and the Clinical Implications. Annals of the New York Academy of Sciences 538:1 Steroid-Prote, pages 313-320.
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J. H. H. THIJSSEN. (1988) Hormonal and Nonhormonal Factors Affecting Sex Hormone-Binding Globulin Levels in Blood. Annals of the New York Academy of Sciences 538:1 Steroid-Prote, pages 280-286.
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L M J W Swinkels, P M M Meulenberg, H A Ross & Th J Benraad. (2016) Salivary and Plasma Free Testosterone and Androstenedione Levels in Women Using Oral Contraceptives Containing Desogestrel or Levonorgestrel. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 25:4, pages 354-359.
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C. Harvengt, J.P. Desager, U. Gaspard & M. Lepot. (1988) Changes in lipoprgtein composition in women receiving two low-dose oral contraceptives containing ethinylestradiol and gonane prcgestins. Contraception 37:6, pages 565-575.
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R. Haapiainen, S. Rannikko, O. Alfthan & H. Adlercreutz. (1988) Pretreatment plasma levels of testosterone and sex hormone binding globulin binding capacity in relation to clinical staging and survival in prostatic cancer patients. The Prostate 12:4, pages 325-332.
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L. Falsetti, M.R. Schivardi & B.D. Prandini. (1987) A new low-dose estrogen oral contraceptive combination: Effect on endocrine parameters and lipid status. Contraception 36:5, pages 489-497.
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E. Ha¨ma¨la¨inen, H. Tikkanen, M. Ha¨rko¨nen, H. Na¨veri & H. Adlercreutz. (1987) Serum lipoproteins, sex hormones and sex hormone binding globulin in middle-aged men of different physical fitness and risk of coronary heart disease. Atherosclerosis 67:2-3, pages 155-162.
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E Hamalainen, J T Korpela & H Adlercreutz. (1987) Effect of oxytetracycline administration on intestinal metabolism of oestrogens and on plasma sex hormones in healthy men.. Gut 28:4, pages 439-445.
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Matti J Tikkanen & Esko A Nikkilä. (1987) Regulation of hepatic lipase and serum lipoproteins by sex steroids. American Heart Journal 113:2, pages 562-567.
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K. Ruutiainen. (1986) The effect of an oral contraceptive containing ethinylestradiol and desogestrel on hair growth and hormonal parameters of hirsute women. International Journal of Gynecology & Obstetrics 24:5, pages 361-368.
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H.J. Kloosterboer, R.G.A. van Wayjen & A. van den Ende. (1986) Comparative effects of monophasic desogestrel plus ethinyloestradiol and triphasic levonorgestrel plus ethinyloestradiol on lipid metabolism. Contraception 34:2, pages 135-144.
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E. Hämäläinen, H. Adlercreutz, C. Ehnholm & P. Puska. (1986) Relationships of serum lipoproteins and apoproteins to sex hormones and to the binding capacity of sex hormone binding globulin in healthy finnish men. Metabolism 35:6, pages 535-541.
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M.J. Tikkanen, T. Kuusi, E.A. Nikkilä & S. Sipinen. (1986) Post-menopausal hormone replacement therapy: effects of progestogens on serum lipids and lipoproteins. A review. Maturitas 8:1, pages 7-17.
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R. Haapiainen, S. Rannikko, H. Adlercreutz & O. Alfthan. (2006) Correlation of pretreatment plasma levels of estradiol and sex‐hormone‐binding globulin‐binding capacity with clinical stage and survival of patients with prostatic cancer. The Prostate 8:2, pages 127-137.
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A. Ruokonen & K. Käär. (1985) Effects of desogestrel, levonorgestrel and lynestrenol on serum sex hormone binding globulin, cortisol binding globulin, ceruloplasmin and HDL-cholesterol. European Journal of Obstetrics & Gynecology and Reproductive Biology 20:1, pages 13-18.
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N. Crona, G. Silfverstolpe & G. Samsioe. (1985) The effects of two gonane progestins alone and in combination with ethinyl estradiol on serum lipoproteins. European Journal of Obstetrics & Gynecology and Reproductive Biology 19:6, pages 365-374.
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K. Fotherby. (1984) A New Look at Progestogens. Clinics in Obstetrics and Gynaecology 11:3, pages 701-722.
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Lars-Åke Mattsson, Göran Cullberg, Lars Hamberger, Göran Samsioe & Gunnar Silfverstolpe. (1984) Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease. Fertility and Sterility 42:4, pages 579-584.
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N. Crona, L. Enk, G. Samsioe & G. Silfverstolpe. (1984) Changes in relative fatty acid composition of serum lecithin and cholesterol ester after treatment with two gonane progestins administered alone and in combination with ethinyl estradiol. Archives of Gynecology 236:1, pages 35-40.
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Geoffrey L. Hammond, Mark S. Langley, Philip A. Robinson, Simo Nummi & Leif Lund. (1984) Serum steroid binding protein concentrations, distribution of progestogens, and bioavailability of testosterone during treatment with contraceptives containing desogestrel or levonorgestrel. Fertility and Sterility 42:1, pages 44-51.
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E. Hämäläinen, H. Adlercreutz, P. Puska & P. Pietinen. (1984) Diet and serum sex hormones in healthy men. Journal of Steroid Biochemistry 20:1, pages 459-464.
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J. R. Newton. 1984. Trends in Oral Contraception. Trends in Oral Contraception 57 65 .
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E.W. Bergink, F. van Meel, E.W. Turpijn & J. van der Vies. (1983) Binding of progestagens to receptor proteins in MCF-7 cells. Journal of Steroid Biochemistry 19:5, pages 1563-1570.
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U.J. Gaspard, M.A. Romus, D. Gillain, J. Duvivier, E. Demey-Ponsart & P. Franchimont. (1983) Plasma hormone levels in women receiving new oral contraceptives containing ethinyl estradiol plus levonorgestrel or desogestrel. Contraception 27:6, pages 577-590.
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E.K. Hämäläinen, H. Adlercreutz, P. Puska & P. Pietinen. (1983) Decrease of serum total and free testosterone during a low-fat high-fibre diet. Journal of Steroid Biochemistry 18:3, pages 369-370.
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Sakari Rannikko & Herman Adlercreutz. (2006) Plasma estradiol, free testosterone, sex hormone binding globulin binding capacity, and prolactin in benign prostatic hyperplasia and prostatic cancer. The Prostate 4:3, pages 223-229.
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Göran Cullberg, Göran Samsioe, Randi Finstad Andersen, Preben Bredesgaard, Nicolai Boe Andersen, Hans Ernerot, Erik Fanøe, Petter Fylling, Paul-Erik Haack-Sørensen, Paul Klottrup, Jørgen H Pedersen & Torben Sandager. (1982) Two oral contraceptives, efficacy, serum proteins, and lipid metabolism. Contraception 26:3, pages 229-243.
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E.W Bergink, N. Crona, E. Dahlgren & G. Samsioe. (1981) Effect of oestriol, oestradiol valerate and ethinyloestradiol on serum proteins in oestrogen-deficient women. Maturitas 3:3-4, pages 241-247.
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S. L. S. DROP, G. J. BRUINING, H. K. A. VISSER & W. G. SIPPELL. (2008) PROLONGED GALACTORRHOEA IN A 6‐YEAR‐OLD GIRL WITH ISOSEXUAL PRECOCIOUS PUBERTY DUE TO A FEMINIZING ADRENAL TUMOUR. Clinical Endocrinology 15:1, pages 37-43.
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