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TechnicalNote Article

Enzymatic Assay for Methotrexate in Erythrocytes

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Pages 657-659 | Received 08 Feb 1985, Accepted 28 Feb 1985, Published online: 08 Jul 2009

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Read on this site (3)

S de Lathouder, AH Gerards, ER de Groot, MG Valkhof, BAC Dijkmans & LA Aarden. (2004) Bioassay for detection of methotrexate in serum. Scandinavian Journal of Rheumatology 33:3, pages 167-173.
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Charlotte Rask, Freidoun Albertioni, Soeren M. Bentzen, Henrik Schroeder & Curt Peterson. (1998) Clinical and Pharmacokinetic Risk Factors for High-dose Methotrexate-induced Toxicity in Children with Acute Lymphoblastic Leukemia: A Logistic Regression Analysis. Acta Oncologica 37:3, pages 277-284.
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Henrik Schrøder, Niels Clausen, Erik Øtergård & Tania Pressler. (1986) Folic Acid Supplements in Vitamin Tablets: A Determinant of Hematological Drug Tolerance in Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia. Pediatric Hematology and Oncology 3:3, pages 241-247.
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Articles from other publishers (14)

Mara L. Becker. (2015) Using Methotrexate Metabolites to Make Clinical Decisions in JIA. Current Treatment Options in Rheumatology 1:4, pages 381-395.
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Xiaolan Mo, Yuguan Wen, Bin Ren, Jie Chen, Chenshu Xu, Xueding Wang, Min Huang & Xiao Chen. (2012) Determination of erythrocyte methotrexate polyglutamates by liquid chromatography/tandem mass spectrometry after low-dose methotrexate therapy in Chinese patients with rheumatoid arthritis. Journal of Chromatography B 907, pages 41-48.
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JANA TUKOVÁ, JAROSLAV CHLÁDEK, MILOS HROCH, DANA NĚMCOVÁ, JOZEF HOZA & PAVLA DOLEŽALOVÁ. (2010) 677TT Genotype Is Associated with Elevated Risk of Methotrexate (MTX) Toxicity in Juvenile Idiopathic Arthritis: Treatment Outcome, Erythrocyte Concentrations of MTX and Folates, and MTHFR Polymorphisms. The Journal of Rheumatology 37:10, pages 2180-2186.
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Leon van Haandel, Mara L. Becker, J. Steven Leeder, Todd D. Williams & John F. Stobaugh. (2009) A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells. Rapid Communications in Mass Spectrometry 23:23, pages 3693-3702.
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Sachie INOUE, Masayuki HASHIGUCHI, Shinichi KAWAI & Mayumi MOCHIZUKI. (2009) Erythrocyte Methotrexate-polyglutamate Assay Using Fluorescence Polarization Immunoassay Technique: Application to the Monitoring of Patients with Rheumatoid Arthritis. YAKUGAKU ZASSHI 129:8, pages 1001-1005.
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H. Hayashi, C. Fujimaki, T. Daimon, S. Tsuboi, T. Matsuyama & K. Itoh. (2009) Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis. Journal of Clinical Pharmacy and Therapeutics 34:3, pages 355-361.
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Miloš Hroch, Jana Tuková, Pavla Doležalová & Jaroslav Chládek. (2009) An improved high-performance liquid chromatography method for quantification of methotrexate polyglutamates in red blood cells of children with juvenile idiopathic arthritis. Biopharmaceutics & Drug Disposition 30:3, pages 138-148.
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Hideki Hayashi, Chihiro Fujimaki, Seiji Tsuboi, Taiji Matsuyama, Takashi Daimon & Kunihiko Itoh. (2008) Application of Fluorescence Polarization Immunoassay for Determination of Methotrexate-Polyglutamates in Rheumatoid Arthritis Patients. The Tohoku Journal of Experimental Medicine 215:1, pages 95-101.
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Jaroslav Chladek, Jiri Grim, Jirina Martinkova, Marie Simkova & Jaroslava Vaneckova. (2005) Low-Dose Methotrexate Pharmacokinetics and Pharmacodynamics in the Therapy of Severe Psoriasis. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:3, pages 247-248.
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Thierry Dervieux, Diana Orentas Lein, John Marcelletti, Ken Pischel, Katie Smith, Michael Walsh & Russell Richerson. (2003) HPLC Determination of Erythrocyte Methotrexate Polyglutamates after Low-Dose Methotrexate Therapy in Patients with Rheumatoid Arthritis. Clinical Chemistry 49:10, pages 1632-1641.
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Sylvie Leung, Glenn M. Marshall, Mohammed Al Mahr, Vivienne Tobias, Doris B.G. Lee & Darcy O'Gorman Hughes. (1997) Prognostic significance of chemotherapy dosage characteristics in children with osteogenic sarcoma. Medical and Pediatric Oncology 28:3, pages 179-182.
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Frederik G. Larsen, Folmer Nielsen‐Kudsk, Preben Jakobsen, Henrik Schrøder & Knud Kragballe. (2013) Interaction of Etretinate with Methotrexate Pharmacokinetics in Psoriatic Patients. The Journal of Clinical Pharmacology 30:9, pages 802-807.
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Kjeld Schmiegelow, Henrick Schr�der, Malgorzata K. Pulczynska & Mogens Hejl. (1989) Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes. Cancer Chemotherapy and Pharmacology 25:1, pages 65-69.
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H. Schr�der & E. K. Foged. (1986) Methotrexate in erythrocytes of patients with psoriasis. European Journal of Clinical Pharmacology 30:4, pages 453-456.
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