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Scandinavian Journal of Clinical and Laboratory Investigation Volume 46, 1986 - Issue 7
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Original Article

A HPLC method for the simultaneous determination of disopyramide, lidocaine and their monodealkylated metabolites

Helle R. Angelo Departments of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark
,
Jan Bonde Anaesthesiology R, Bispebjerg Hospital, Copenhagen, Denmark
,
Jens P. Kampmann Internal Medicine P, Bispebjerg Hospital, Copenhagen, Denmark
&
Jens Kastrup Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark
Pages 623-627 | Received 23 Dec 1985, Accepted 20 May 1986, Published online: 08 Jul 2009

Citations (15)

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Read on this site (1)

Y. Chen & J.M. Potter. (1994) High Performance Liquid Chromatography (HPLC): An Important Technique in the Studies of Lignocaine and its Metabolism. Journal of Liquid Chromatography 17:10, pages 2273-2289.
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Articles from other publishers (14)

Quynh Khoa Pham, Hyewon Seo & Sung-Hoon Ahn. (2018) A rapid and sensitive liquid chromatography/tandem mass spectrometry assay for simultaneous quantitation of disopyramide and its major metabolite, mono-isopropyl-disopyramide, in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B 1096, pages 154-159.
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Steven Karch. 2007. Postmortem Toxicology of Abused Drugs. Postmortem Toxicology of Abused Drugs 141 179 .
Lili Chen, Linchuan Liao, Zhong Zuo, Youyi Yan, Lin Yang, Qiang Fu, Yu Chen & Junhong Hou. (2007) Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 43:5, pages 1757-1762.
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. 2006. Drug Abuse Handbook, Second Edition. Drug Abuse Handbook, Second Edition 1175 1224 .
Roland ValdesJr.Jr., Saeed A Jortani & Mihai Gheorghiade. (1998) Standards of laboratory practice: cardiac drug monitoring. Clinical Chemistry 44:5, pages 1096-1109.
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N. Milman, M. Laub, E.P. Munch & H.R. Angelo. (1998) Serum concentrations of lignocaine and its metabolite monoethylglycinexylidide during fibre-optic bronchoscopy in local anaesthesia. Respiratory Medicine 92:1, pages 40-43.
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Y. Chen, Julia M. Potter & P.J. Ravenscroft. (1992) High-performance liquid chromatographic method for the simultaneous determination of monoethylglycinexylidide and lignocaine. Journal of Chromatography B: Biomedical Sciences and Applications 574:2, pages 361-364.
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Frank Mayer, Bernhard K. Krämer, Klaudia M. Ress, Volker Kühlkamp, Hartmut M. Liebich, Teut Risler & Ludger Seipel. (1991) Simplified, rapid and inexpensive extraction procedure for a high-performance liquid chromatographic method for determination of disopyramide and its main metabolite mono-N-dealkylated disopyramide in serum. Journal of Chromatography B: Biomedical Sciences and Applications 572:1-2, pages 339-345.
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M. KjaerN. H. SecherF. W. BachH. GalboD. R. ReevesJrJrJ. H. Mitchell. (1991) Hormonal, metabolic, and cardiovascular responses to static exercise in humans: influence of epidural anesthesia. American Journal of Physiology-Endocrinology and Metabolism 261:2, pages E214-E220.
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Jens Kastrup, Palle Petersen & Anders Dejgård MD. (2013) Intravenous Lidocaine and Cerebral Blood Flow: Impaired Microvascular Reactivity in Diabetic Patients. The Journal of Clinical Pharmacology 30:4, pages 318-323.
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Jan Bonde, Niels Melchior Jensen, Lars E. Pedersen, Helle R. Angelo, Seren N. Rasmussen, Jens Trap-Jensen & Jens P. Kampmann. (1989) Disposition Kinetics of Disopyramide in Human Healthy Volunteers Described by an Open Three Compartment Model. Pharmacology & Toxicology 64:5, pages 412-416.
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Amnon Sintov, Rivka Siden & Robert J. Levy. (1989) Sensitive high-performance liquid chromatographic assay using 9-fluorenylmethylchloroformate for monitoring controlled-release lidocaine in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 496, pages 335-344.
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Jan Bonde, Niels Melchior Jensen, Lars E. Pedersen, Niels A. Graudal, Helle R. Angelo & Jens P. Kampmann. (2009) Elimination Kinetics and Urinary Excretion of Disopyramide in Human Healthy Volunteers. Pharmacology & Toxicology 62:5, pages 298-301.
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Jan Bonde, Niels Melchior Jensen, Peder Burgaard, Helle R. Angelo, Niels Graudal, Jens P. Kampmann & Lars E. Pedersen. (1987) Displacement of Lidocaine from Human Plasma Proteins by Disopyramide. Pharmacology & Toxicology 60:2, pages 151-155.
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