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Original Article

Elimination of theobromine metabolites in healthy adults

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Pages 373-383 | Received 20 Oct 1995, Accepted 25 Mar 1996, Published online: 08 Jul 2009

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João Monteiro, Marco G. Alves, Pedro F. Oliveira & Branca M. Silva. (2019) Pharmacological potential of methylxanthines: Retrospective analysis and future expectations. Critical Reviews in Food Science and Nutrition 59:16, pages 2597-2625.
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N. Rodopoulos & A. Norman. (1997) Elimination of theophylline metabolites in healthy adults. Scandinavian Journal of Clinical and Laboratory Investigation 57:3, pages 233-240.
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Articles from other publishers (25)

Antonia Costa-Bauzá, Paula Calvó, Yumaira Hernández & Fèlix Grases. (2023) Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis. International Journal of Molecular Sciences 24:13, pages 10879.
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Francesca Julià, Antonia Costa-Bauza, Francisco Berga & Felix Grases. (2022) Effect of theobromine on dissolution of uric acid kidney stones. World Journal of Urology 40:8, pages 2105-2111.
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Yumaira Hernandez, Antonia Costa-Bauza, Paula Calvó, Joan Benejam, Pilar Sanchis & Felix Grases. (2020) Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine. Nutrients 12:7, pages 2012.
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Lotte Smolders, Ronald P. Mensink, Mark V. Boekschoten, Rogier J.J. de Ridder & Jogchum Plat. (2018) Theobromine does not affect postprandial lipid metabolism and duodenal gene expression, but has unfavorable effects on postprandial glucose and insulin responses in humans. Clinical Nutrition 37:2, pages 719-727.
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Lotte Smolders, Ronald P. Mensink, Mark V. Boekschoten, Rogier J. J. de Ridder & Jogchum Plat. (2018) The acute effects on duodenal gene expression in healthy men following consumption of a low-fat meal enriched with theobromine or fat. Scientific Reports 8:1.
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María Raquel Mateos Briz*Beatriz Sarriá Ruiz & Laura Bravo‐Clemente. 2017. Fruit and Vegetable Phytochemicals. Fruit and Vegetable Phytochemicals 183 198 .
Lotte Smolders, Ronald P. Mensink & Jogchum Plat. (2017) An acute intake of theobromine does not change postprandial lipid metabolism, whereas a high-fat meal lowers chylomicron particle number. Nutrition Research 40, pages 85-94.
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Jing Tao, Yuan Kang, Zhiyu Xue, Yongting Wang, Yan Zhang, Qiu Chen, Zeqin Chen & Ying Xue. (2015) Theoretical study on the N-demethylation mechanism of theobromine catalyzed by P450 isoenzyme 1A2. Journal of Molecular Graphics and Modelling 61, pages 123-132.
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Ivan Senta, Emma Gracia-Lor, Andrea Borsotti, Ettore Zuccato & Sara Castiglioni. (2015) Wastewater analysis to monitor use of caffeine and nicotine and evaluation of their metabolites as biomarkers for population size assessment. Water Research 74, pages 23-33.
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Mar Garcia-Aloy, Rafael Llorach, Mireia Urpi-Sarda, Olga Jáuregui, Dolores Corella, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Montserrat Fitó, Emilio Ros, Ramon Estruch & Cristina Andres-Lacueva. (2015) A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study. Molecular Nutrition & Food Research 59:2, pages 212-220.
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Felix Grases, Adrian Rodriguez & Antonia Costa-Bauza. (2014) Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis. PLoS ONE 9:10, pages e111184.
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Sara Martínez-López, Beatriz Sarriá, Miren Gómez-Juaristi, Luis Goya, Raquel Mateos & Laura Bravo-Clemente. (2014) Theobromine, caffeine, and theophylline metabolites in human plasma and urine after consumption of soluble cocoa products with different methylxanthine contents. Food Research International 63, pages 446-455.
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Maj-Britt S. Andersen, Åsmund Rinnan, Claudine Manach, Sanne K. Poulsen, Estelle Pujos-Guillot, Thomas M. Larsen, Arne Astrup & Lars O. Dragsted. (2014) Untargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern. Journal of Proteome Research 13:3, pages 1405-1418.
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Maj-Britt Schmidt Andersen, Mette Kristensen, Claudine Manach, Estelle Pujos-Guillot, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Arne Astrup & Lars Dragsted. (2014) Discovery and validation of urinary exposure markers for different plant foods by untargeted metabolomics. Analytical and Bioanalytical Chemistry 406:7, pages 1829-1844.
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Samantha EllamGary Williamson. (2013) Cocoa and Human Health. Annual Review of Nutrition 33:1, pages 105-128.
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Rafael Llorach, Mireia Urpi-Sarda, Sara Tulipani, Mar Garcia-Aloy, Maria Monagas & Cristina Andres-Lacueva. (2013) Metabolomic fingerprint in patients at high risk of cardiovascular disease by cocoa intervention. Molecular Nutrition & Food Research 57:6, pages 962-973.
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Nasiruddin Khan & Nathalie M. Nicod. 2012. Chocolate and Health. Chocolate and Health 33 40 .
Bertil B. FredholmMaurice J. Arnaud. 2011. Methylxanthines. Methylxanthines 33 91 .
R. Llorach-Asunción, O. Jauregui, M. Urpi-Sarda & C. Andres-Lacueva. (2010) Methodological aspects for metabolome visualization and characterization. Journal of Pharmaceutical and Biomedical Analysis 51:2, pages 373-381.
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Rafael Llorach, Mireia Urpi-Sarda, Olga Jauregui, Maria Monagas & Cristina Andres-Lacueva. (2009) An LC-MS-Based Metabolomics Approach for Exploring Urinary Metabolome Modifications after Cocoa Consumption. Journal of Proteome Research 8:11, pages 5060-5068.
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Elizabeth W. Triche, Laura M. Grosso, Kathleen Belanger, Amy S. Darefsky, Neal L. Benowitz & Michael B. Bracken. (2008) Chocolate Consumption in Pregnancy and Reduced Likelihood of Preeclampsia. Epidemiology 19:3, pages 459-464.
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Krzysztof Safranow & Zygmunt Machoy. (2005) Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection. Journal of Chromatography B 819:2, pages 229-235.
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K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food and Chemical Toxicology 39:7, pages 667-680.
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J.L.C.M Dorne, K Walton & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment. Food and Chemical Toxicology 39:7, pages 681-696.
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Alyse M Baron, Richard L Donnerstein, Ricardo A Samson, Jonathan A Baron, Jodi N Padnick & Stanley J Goldberg. (1999) Hemodynamic and electrophysiologic effects of acute chocolate ingestion in young adults. The American Journal of Cardiology 84:3, pages 370-373.
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