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Scandinavian Journal of Gastroenterology Volume 50, 2015 - Issue 1
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Review

The genetics of Crohn’s disease and ulcerative colitis – status quo and beyond

David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
,
Jörn BethuneInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
,
Britt-Sabina PetersenInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
&
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, GermanyCorrespondence[email protected]
Pages 13-23 | Received 02 Nov 2014, Accepted 18 Nov 2014, Published online: 19 Dec 2014

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Wei-Ti Chen & Ching-Chi Chi. (2019) Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease. JAMA Dermatology 155:9, pages 1022.
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Pablo Olivera, Silvio Danese, Nicolas Jay, Gioacchino Natoli & Laurent Peyrin-Biroulet. (2019) Big data in IBD: a look into the future. Nature Reviews Gastroenterology & Hepatology 16:5, pages 312-321.
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Henrik Hjortswang. 2019. The Kock Pouch. The Kock Pouch 143 165 .
Yun Fu, Cheng-Han Lee & Ching-Chi Chi. (2018) Association of Psoriasis With Inflammatory Bowel Disease. JAMA Dermatology 154:12, pages 1417.
Crossref
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Anthony P. Corfield. (2018) The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human. Microorganisms 6:3, pages 78.
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Miriam Goebel-Stengel, Gerald Holtmann & Paul Enck. (2018) Opportunities of twin research in gastroenterology. Nature Reviews Gastroenterology & Hepatology 15:6, pages 325-326.
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Marco Colonna. (2018) Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity. Immunity 48:6, pages 1104-1117.
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V. J. A. A. Nuij, M. P. Peppelenbosch, C. J. van der Woude & G. M. Fuhler. (2017) Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease. Journal of Translational Medicine 15:1.
Crossref
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Garland Castaneda, Benny Liu, Sharon Torres, Taft Bhuket & Robert J. Wong. (2017) Race/Ethnicity-Specific Disparities in the Severity of Disease at Presentation in Adults with Ulcerative Colitis: A Cross-Sectional Study. Digestive Diseases and Sciences 62:10, pages 2876-2881.
Crossref
Gerhard Rogler. (2017) Resolution of inflammation in inflammatory bowel disease. The Lancet Gastroenterology & Hepatology 2:7, pages 521-530.
Crossref
Spyridon N. Papageorgiou, Martin Hagner, Andressa Vilas Boas Nogueira, Andre Franke, Andreas Jäger & James Deschner. (2017) Inflammatory bowel disease and oral health: systematic review and a meta-analysis. Journal of Clinical Periodontology 44:4, pages 382-393.
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Bérenger Largeau, Anne-Claire Dupont, Denis Guilloteau, Maria-João Santiago-Ribeiro & Nicolas Arlicot. (2017) TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?. Contrast Media & Molecular Imaging 2017, pages 1-17.
Crossref
O. Fogel, C. Richard-Miceli & J. Tost. 2017. Chromatin Remodelling and Immunity. Chromatin Remodelling and Immunity 139 189 .
Philipp Zimmer, Alexander Schenk & Wilhelm Bloch. 2017. Körperliche Aktivität und Gesundheit. Körperliche Aktivität und Gesundheit 359 367 .
Jerzy Ostrowski, Agnieszka Paziewska, Izabella Lazowska, Filip Ambrozkiewicz, Krzysztof Goryca, Maria Kulecka, Tomasz Rawa, Jakub Karczmarski, Michalina Dabrowska, Natalia Zeber-Lubecka, Roman Tomecki, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Katarzyna Paczkowska, Jaroslaw Kierkus, Piotr Socha, Michal Lodyga, Grazyna Rydzewska, Maria Klopocka, Grazyna Mierzwa, Barbara Iwanczak, Elzbieta Krzesiek, Katarzyna Bak-Drabik, Jaroslaw Walkowiak, Beata Klincewicz, Piotr Radwan, Urszula Grzybowska-Chlebowczyk, Piotr Landowski, Agnieszka Jankowska, Bartosz Korczowski, Teresa Starzynska, Piotr Albrecht & Michal Mikula. (2016) Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population. Scientific Reports 6:1.
Crossref
Jennifer S. Ko, Georgina Uberti, Karl Napekoski, Deepa T. Patil & Steven D. Billings. (2016) Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non-neoplastic biopsies over 13 years. Journal of Cutaneous Pathology 43:11, pages 946-955.
Crossref
Zhihui Tian, Jie Liu, Mengyu Liao, Wenjuan Li, Jiaqi Zou, Xinxin Han, Mingjie Kuang, Wanqiu Shen & Haidong Li. (2016) Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice. Digestive Diseases and Sciences 61:8, pages 2262-2271.
Crossref
Ishfaq Ahmed, Badal Roy, Salman Khan, Seth Septer & Shahid Umar. (2016) Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms 4:2, pages 20.
Crossref
Warren M. Miner-Williams & Paul J. Moughan. (2016) Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel. Nutrition Research Reviews 29:1, pages 40-59.
Crossref
Nicholas JD Gould, Katharine LM Davidson, Chuka U Nwokolo & Ramesh P Arasaradnam. (2016) A systematic review of the role of DNA methylation on inflammatory genes in ulcerative colitis. Epigenomics 8:5, pages 667-684.
Crossref
William Adams, Lisa Mitchell, Roberto Candelaria-Santiago, Jody Hefner & Joseph Gramling. (2016) Concurrent Ulcerative Colitis and Neurofibromatosis Type 1: The Question of a Common Pathway. Pediatrics 137:2.
Crossref
Amit Kumar Dutta. (2016) Influence of environmental factors on the onset and course of inflammatory bowel disease. World Journal of Gastroenterology 22:3, pages 1088.
Crossref
Katarina Zupančič, Kristijan Skok, Katja Repnik, Rinse K Weersma, Uroš Potočnik & Pavel Skok. (2016) Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population. World Journal of Gastroenterology 22:14, pages 3777.
Crossref
Nobuhiko Kamada & Gerhard Rogler. (2016) The Innate Immune System: A Trigger for Many Chronic Inflammatory Intestinal Diseases. Inflammatory Intestinal Diseases 1:2, pages 70-77.
Crossref
Michael A. Mcilhatton, Gregory P. Boivin & Joanna Groden. (2016) Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer. BioMed Research International 2016, pages 1-18.
Crossref
Maureen J. Ostaff, Eduard F. Stange & Jan Wehkamp. 2016. Antimicrobial Peptides. Antimicrobial Peptides 67 88 .
Daniela Elena Serban. (2015) Microbiota in Inflammatory Bowel Disease Pathogenesis and Therapy. Nutrition in Clinical Practice 30:6, pages 760-779.
Crossref
Shubha Priyamvada, Rochelle Gomes, Ravinder K. Gill, Seema Saksena, Waddah A. Alrefai & Pradeep K. Dudeja. (2015) Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease–Associated Diarrhea. Inflammatory Bowel Diseases 21:12, pages 2926-2935.
Crossref
Heba N. Iskandar, Tanvi Dhere & Francis A. Farraye. (2015) Ulcerative Colitis: Update on Medical Management. Current Gastroenterology Reports 17:11.
Crossref
Nathan R. West, Sarah McCuaig, Fanny Franchini & Fiona Powrie. (2015) Emerging cytokine networks in colorectal cancer. Nature Reviews Immunology 15:10, pages 615-629.
Crossref
Lea-Maxie Haag & Britta Siegmund. (2015) Intestinal Microbiota and the Innate Immune System – A Crosstalk in Crohn’s Disease Pathogenesis. Frontiers in Immunology 6.
Crossref
Christoph Becker, Markus F. Neurath & Stefan Wirtz. (2015) The Intestinal Microbiota in Inflammatory Bowel Disease. ILAR Journal 56:2, pages 192-204.
Crossref
Pooja Mehta & Glenn T. Furuta. (2015) Eosinophils in Gastrointestinal Disorders. Immunology and Allergy Clinics of North America 35:3, pages 413-437.
Crossref

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