Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 50, 2015 - Issue 1
Submit an article Journal homepage
10,069
Views
61
CrossRef citations to date
0
Altmetric
Review

The genetics of Crohn’s disease and ulcerative colitis – status quo and beyond

David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
,
Jörn BethuneInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
,
Britt-Sabina PetersenInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
&
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, GermanyCorrespondence[email protected]
Pages 13-23 | Received 02 Nov 2014, Accepted 18 Nov 2014, Published online: 19 Dec 2014

Citations (61)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Kevimy Agossa, Lidia Roman, Marjolaine Gosset, Clara Yzet & Mathurin Fumery. (2021) Periodontal and dental health in inflammatory bowel diseases: a systematic review. Expert Review of Gastroenterology & Hepatology 0:0, pages 1-15.
Read now
Robert Pieper, Niels van Best, Kira van Vorst, Friederike Ebner, Monika Reissmann, Mathias W. Hornef & Marcus Fulde. (2020) Toward a porcine in vivo model to analyze the pathogenesis of TLR5-dependent enteropathies. Gut Microbes 12:1.
Read now
Jonas F. Ludvigsson, Marie Andersson, Jonas Bengtsson, Michael Eberhardson, Ulrika L. Fagerberg, Olof Grip, Jonas Halfvarson, Henrik Hjortswang, Susanna Jäghult, Pontus Karling, Caroline Nordenvall, Ola Olén, Malin Olsson, Martin Rejler, Hans Strid & Pär Myrelid. (2019) Swedish Inflammatory Bowel Disease Register (SWIBREG) – a nationwide quality register. Scandinavian Journal of Gastroenterology 54:9, pages 1089-1101.
Read now
Abdulkadir Salih, Lovisa Widbom, Johan Hultdin & Pontus Karling. (2018) Smoking is associated with risk for developing inflammatory bowel disease including late onset ulcerative colitis: a prospective study. Scandinavian Journal of Gastroenterology 53:2, pages 173-178.
Read now

Articles from other publishers (57)

Hans Eiberg, Josephine B. Olsson, Mads Bak, Claus Heiner Bang-Berthelsen, Jesper T. Troelsen & Lars Hansen. (2023) A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene. European Journal of Human Genetics 31:12, pages 1440-1446.
Crossref
Sepide Talebi, Sheida Zeraattalab-Motlagh, Mehran Rahimlou, Fatemeh Naeini, Mahsa Ranjbar, Ali Talebi & Hamed Mohammadi. (2023) The Association between Total Protein, Animal Protein, and Animal Protein Sources with Risk of Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Cohort Studies. Advances in Nutrition 14:4, pages 752-761.
Crossref
Seref Kul, Zuhal Caliskan, Tolga Sinan Guvenc, Fatma Betul Celik, Abdurrahman Sarmis, Adem Atici, Oguz Konal, Mesut Akıl, Ahmet Selin Cumen, Nermin Mutlu Bilgic, Yusuf Yilmaz & Mustafa Caliskan. (2023) Gut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel disease. Microvascular Research 146, pages 104458.
Crossref
Johanna Holman, Molly Hurd, Peter L. Moses, Gary M. Mawe, Tao Zhang, Suzanne L. Ishaq & Yanyan Li. (2023) Interplay of broccoli/broccoli sprout bioactives with gut microbiota in reducing inflammation in inflammatory bowel diseases. The Journal of Nutritional Biochemistry 113, pages 109238.
Crossref
Debora Garza-Hernandez, Maricruz Sepulveda-Villegas, Jose Garcia-Pelaez, Raul Aguirre-Gamboa, Peter L. Lakatos, Karol Estrada, Manuel Martinez-Vazquez & Victor Trevino. (2022) A systematic review and functional bioinformatics analysis of genes associated with Crohn’s disease identify more than 120 related genes. BMC Genomics 23:1.
Crossref
Dennis Freuer, Jakob Linseisen & Christa Meisinger. (2022) Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis. JAMA Dermatology 158:11, pages 1262.
Crossref
Pengfei Xu, Tengteng Lv, Shenghui Dong, Zhihao Cui, Xinyuan Luo, Baolei Jia, Che Ok Jeon & Jie Zhang. (2022) Association between intestinal microbiome and inflammatory bowel disease: Insights from bibliometric analysis. Computational and Structural Biotechnology Journal 20, pages 1716-1725.
Crossref
Ondrej Pös, Jan Radvanszky, Gergely Buglyó, Zuzana Pös, Diana Rusnakova, Bálint Nagy & Tomas Szemes. (2021) DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects. Biomedical Journal 44:5, pages 548-559.
Crossref
Imteyaz Ahmad Khan, Baibaswata Nayak, Manasvini Markandey, Aditya Bajaj, Mahak Verma, Sambudhha Kumar, Mukesh Kumar Singh, Saurabh Kedia & Vineet Ahuja. (2021) Differential prevalence of pathobionts and host gene polymorphisms in chronic inflammatory intestinal diseases: Crohn’s disease and intestinal tuberculosis. PLOS ONE 16:8, pages e0256098.
Crossref
Takahiro Tsuzuno, Naoki Takahashi, Miki Yamada‐Hara, Mai Yokoji‐Takeuchi, Benso Sulijaya, Yukari Aoki‐Nonaka, Aoi Matsugishi, Kyoko Katakura, Koichi Tabeta & Kazuhisa Yamazaki. (2021) Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice . Journal of Periodontal Research 56:2, pages 275-288.
Crossref
Luiz C. Di Stasi. (2021) Coumarin Derivatives in Inflammatory Bowel Disease. Molecules 26:2, pages 422.
Crossref
Peter R. Sternes, Tammy M. Martin, Michael Paley, Sarah Diamond, Mark J. Asquith, Matthew A. Brown & James T. Rosenbaum. (2020) HLA-A alleles including HLA-A29 affect the composition of the gut microbiome: a potential clue to the pathogenesis of birdshot retinochoroidopathy. Scientific Reports 10:1.
Crossref
Meng Chen, Hua Zhu, Yu-juan Mao, Nan Cao, Ya-li Yu, Lian-yun Li, Qiu Zhao, Min Wu & Mei Ye. (2020) Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing. Current Medical Science 40:5, pages 900-909.
Crossref
Yanzhi Wang, Rongrong Ren, Gang Sun, Lihua Peng, Yaping Tian & Yunsheng Yang. (2020) Pilot study of cytokine changes evaluation after fecal microbiota transplantation in patients with ulcerative colitis. International Immunopharmacology 85, pages 106661.
Crossref
Elisa Rosati, Mikhail V Pogorelyy, C Marie Dowds, Frederik T Moller, Signe B Sorensen, Yuri B Lebedev, Norbert Frey, Stefan Schreiber, Martina E Spehlmann, Vibeke Andersen, Ilgar Z Mamedov & Andre Franke. (2020) Identification of Disease-associated Traits and Clonotypes in the T Cell Receptor Repertoire of Monozygotic Twins Affected by Inflammatory Bowel Diseases. Journal of Crohn's and Colitis 14:6, pages 778-790.
Crossref
Andriy E. Dorofeyev, Anna A. Dorofeyeva, Elena A. Kiriyan, Olga A. Rassokhina & Yulia Z. Dynia. (2020) GENETIC POLYMORPHISM IN PATIENTS WITH EARLY AND LATE ONSET OF ULCERATIVE COLITIS. Wiadomości Lekarskie 73:1, pages 87-90.
Crossref
Xitao Zhang & Jianping He. (2020) Meta-analysis of protein intake on the effect of Crohn�s disease and ulcerative colitis. Revista Española de Enfermedades Digestivas.
Crossref
Leokadia Bąk-Romaniszyn, Anna S. Świerzko, Anna Sokołowska, Łukasz Durko, Grażyna Mierzwa, Agnieszka Szala-Poździej, Ewa Małecka-Panas & Maciej Cedzyński. (2020) Mannose-binding lectin (MBL) in adult patients with inflammatory bowel disease. Immunobiology 225:1, pages 151859.
Crossref
Wei-Ti Chen & Ching-Chi Chi. (2019) Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease. JAMA Dermatology 155:9, pages 1022.
Crossref
Pablo Olivera, Silvio Danese, Nicolas Jay, Gioacchino Natoli & Laurent Peyrin-Biroulet. (2019) Big data in IBD: a look into the future. Nature Reviews Gastroenterology & Hepatology 16:5, pages 312-321.
Crossref
Stelios Pavlidis, Calixte Monast, Matthew J. Loza, Patrick Branigan, Kiang F. Chung, Ian M. Adcock, Yike Guo, Anthony Rowe & Frédéric Baribaud. (2019) I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment. PLOS Computational Biology 15:4, pages e1006951.
Crossref
Kiyonori Kobayashi, Yasuo Suzuki, Kenji Watanabe, Kazunori Oda, Miyuki Mukae, Akihiro Yamada, Hirokazu Yamagami, Akira Nishimura & Hiroyuki Okamoto. (2019) A Phase 1, Multiple-Dose Study of Vedolizumab in Japanese Patients With Ulcerative Colitis. The Journal of Clinical Pharmacology 59:2, pages 271-279.
Crossref
Henrik Hjortswang. 2019. The Kock Pouch. The Kock Pouch 143 165 .
Yun Fu, Cheng-Han Lee & Ching-Chi Chi. (2018) Association of Psoriasis With Inflammatory Bowel Disease. JAMA Dermatology 154:12, pages 1417.
Crossref
Alexis Bretin, Cécily Lucas, Anaïs Larabi, Guillaume Dalmasso, Elisabeth Billard, Nicolas Barnich, Richard Bonnet & Hang Thi Thu Nguyen. (2018) AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation. Scientific Reports 8:1.
Crossref
Anthony P. Corfield. (2018) The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human. Microorganisms 6:3, pages 78.
Crossref
Miriam Goebel-Stengel, Gerald Holtmann & Paul Enck. (2018) Opportunities of twin research in gastroenterology. Nature Reviews Gastroenterology & Hepatology 15:6, pages 325-326.
Crossref
Marco Colonna. (2018) Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity. Immunity 48:6, pages 1104-1117.
Crossref
J. Schmidt, M. Weigert, C. Leuschner, H. Hartmann, D. Raddatz, R. Haak, R.F. Mausberg, T. Kottmann, G. Schmalz & D. Ziebolz. (2018) Active matrix metalloproteinase-8 and periodontal bacteria-interlink between periodontitis and inflammatory bowel disease?. Journal of Periodontology 89:6, pages 699-707.
Crossref
V. J. A. A. Nuij, M. P. Peppelenbosch, C. J. van der Woude & G. M. Fuhler. (2017) Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease. Journal of Translational Medicine 15:1.
Crossref
Britt-Sabina Petersen, Broder Fredrich, Marc P. Hoeppner, David Ellinghaus & Andre Franke. (2017) Opportunities and challenges of whole-genome and -exome sequencing. BMC Genetics 18:1.
Crossref
Tanzhou Chen, Haibo Xue, Ruoyang Lin & Zhiming Huang. (2017) MiR-126 impairs the intestinal barrier function via inhibiting S1PR2 mediated activation of PI3K/AKT signaling pathway. Biochemical and Biophysical Research Communications 494:3-4, pages 427-432.
Crossref
Garland Castaneda, Benny Liu, Sharon Torres, Taft Bhuket & Robert J. Wong. (2017) Race/Ethnicity-Specific Disparities in the Severity of Disease at Presentation in Adults with Ulcerative Colitis: A Cross-Sectional Study. Digestive Diseases and Sciences 62:10, pages 2876-2881.
Crossref
Gerhard Rogler. (2017) Resolution of inflammation in inflammatory bowel disease. The Lancet Gastroenterology & Hepatology 2:7, pages 521-530.
Crossref
Spyridon N. Papageorgiou, Martin Hagner, Andressa Vilas Boas Nogueira, Andre Franke, Andreas Jäger & James Deschner. (2017) Inflammatory bowel disease and oral health: systematic review and a meta-analysis. Journal of Clinical Periodontology 44:4, pages 382-393.
Crossref
Bérenger Largeau, Anne-Claire Dupont, Denis Guilloteau, Maria-João Santiago-Ribeiro & Nicolas Arlicot. (2017) TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?. Contrast Media & Molecular Imaging 2017, pages 1-17.
Crossref
O. Fogel, C. Richard-Miceli & J. Tost. 2017. Chromatin Remodelling and Immunity. Chromatin Remodelling and Immunity 139 189 .
Philipp Zimmer, Alexander Schenk & Wilhelm Bloch. 2017. Körperliche Aktivität und Gesundheit. Körperliche Aktivität und Gesundheit 359 367 .
Jerzy Ostrowski, Agnieszka Paziewska, Izabella Lazowska, Filip Ambrozkiewicz, Krzysztof Goryca, Maria Kulecka, Tomasz Rawa, Jakub Karczmarski, Michalina Dabrowska, Natalia Zeber-Lubecka, Roman Tomecki, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Katarzyna Paczkowska, Jaroslaw Kierkus, Piotr Socha, Michal Lodyga, Grazyna Rydzewska, Maria Klopocka, Grazyna Mierzwa, Barbara Iwanczak, Elzbieta Krzesiek, Katarzyna Bak-Drabik, Jaroslaw Walkowiak, Beata Klincewicz, Piotr Radwan, Urszula Grzybowska-Chlebowczyk, Piotr Landowski, Agnieszka Jankowska, Bartosz Korczowski, Teresa Starzynska, Piotr Albrecht & Michal Mikula. (2016) Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population. Scientific Reports 6:1.
Crossref
Jennifer S. Ko, Georgina Uberti, Karl Napekoski, Deepa T. Patil & Steven D. Billings. (2016) Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non-neoplastic biopsies over 13 years. Journal of Cutaneous Pathology 43:11, pages 946-955.
Crossref
Zhihui Tian, Jie Liu, Mengyu Liao, Wenjuan Li, Jiaqi Zou, Xinxin Han, Mingjie Kuang, Wanqiu Shen & Haidong Li. (2016) Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice. Digestive Diseases and Sciences 61:8, pages 2262-2271.
Crossref
Ishfaq Ahmed, Badal Roy, Salman Khan, Seth Septer & Shahid Umar. (2016) Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms 4:2, pages 20.
Crossref
Warren M. Miner-Williams & Paul J. Moughan. (2016) Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel. Nutrition Research Reviews 29:1, pages 40-59.
Crossref
Nicholas JD Gould, Katharine LM Davidson, Chuka U Nwokolo & Ramesh P Arasaradnam. (2016) A systematic review of the role of DNA methylation on inflammatory genes in ulcerative colitis. Epigenomics 8:5, pages 667-684.
Crossref
William Adams, Lisa Mitchell, Roberto Candelaria-Santiago, Jody Hefner & Joseph Gramling. (2016) Concurrent Ulcerative Colitis and Neurofibromatosis Type 1: The Question of a Common Pathway. Pediatrics 137:2.
Crossref
Amit Kumar Dutta. (2016) Influence of environmental factors on the onset and course of inflammatory bowel disease. World Journal of Gastroenterology 22:3, pages 1088.
Crossref
Katarina Zupančič, Kristijan Skok, Katja Repnik, Rinse K Weersma, Uroš Potočnik & Pavel Skok. (2016) Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population. World Journal of Gastroenterology 22:14, pages 3777.
Crossref
Nobuhiko Kamada & Gerhard Rogler. (2016) The Innate Immune System: A Trigger for Many Chronic Inflammatory Intestinal Diseases. Inflammatory Intestinal Diseases 1:2, pages 70-77.
Crossref
Michael A. Mcilhatton, Gregory P. Boivin & Joanna Groden. (2016) Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer. BioMed Research International 2016, pages 1-18.
Crossref
Maureen J. Ostaff, Eduard F. Stange & Jan Wehkamp. 2016. Antimicrobial Peptides. Antimicrobial Peptides 67 88 .
Daniela Elena Serban. (2015) Microbiota in Inflammatory Bowel Disease Pathogenesis and Therapy. Nutrition in Clinical Practice 30:6, pages 760-779.
Crossref
Shubha Priyamvada, Rochelle Gomes, Ravinder K. Gill, Seema Saksena, Waddah A. Alrefai & Pradeep K. Dudeja. (2015) Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease–Associated Diarrhea. Inflammatory Bowel Diseases 21:12, pages 2926-2935.
Crossref
Heba N. Iskandar, Tanvi Dhere & Francis A. Farraye. (2015) Ulcerative Colitis: Update on Medical Management. Current Gastroenterology Reports 17:11.
Crossref
Nathan R. West, Sarah McCuaig, Fanny Franchini & Fiona Powrie. (2015) Emerging cytokine networks in colorectal cancer. Nature Reviews Immunology 15:10, pages 615-629.
Crossref
Lea-Maxie Haag & Britta Siegmund. (2015) Intestinal Microbiota and the Innate Immune System – A Crosstalk in Crohn’s Disease Pathogenesis. Frontiers in Immunology 6.
Crossref
Christoph Becker, Markus F. Neurath & Stefan Wirtz. (2015) The Intestinal Microbiota in Inflammatory Bowel Disease. ILAR Journal 56:2, pages 192-204.
Crossref
Pooja Mehta & Glenn T. Furuta. (2015) Eosinophils in Gastrointestinal Disorders. Immunology and Allergy Clinics of North America 35:3, pages 413-437.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.