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Original Article

Everolimus treatment for patients with autoimmune hepatitis and poor response to standard therapy and drug alternatives in use

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Pages 1025-1031 | Received 07 Oct 2014, Accepted 07 Dec 2014, Published online: 10 Apr 2015

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Yooyun Chung, Mussarat N Rahim, Jonathon J Graham, Yoh Zen & Michael A Heneghan. (2021) An update on the pharmacological management of autoimmune hepatitis. Expert Opinion on Pharmacotherapy 22:11, pages 1475-1488.
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Articles from other publishers (39)

. (2023) KASL clinical practice guidelines for management of autoimmune hepatitis 2022. Clinical and Molecular Hepatology 29:3, pages 542-592.
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Ja Kyung Kim. (2023) Treatment of Autoimmune Hepatitis. The Korean Journal of Gastroenterology 81:2, pages 72-85.
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玉兰 朱. (2023) Diagnosis and Treatment of Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome. Advances in Clinical Medicine 13:03, pages 4678-4685.
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Linda Skibsted Kornerup, Lisbet Grønbæk, Mikkel Breinholt Kjær & Henning Grønbæk. 2023. Comprehensive Guide to Hepatitis Advances. Comprehensive Guide to Hepatitis Advances 429 441 .
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Ignasi Olivas, Sergio Rodríguez-Tajes & Maria Carlota Londoño. (2022) Hepatitis autoinmune: retos y novedades. Medicina Clínica 159:6, pages 289-298.
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Ignasi Olivas, Sergio Rodriguez-Tajes & Maria Carlota Londoño. (2022) Autoimmune hepatitis: Challenges and novelties. Medicina Clínica (English Edition) 159:6, pages 289-298.
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Y. Y. Chung & Michael A. Heneghan. (2022) Autoimmune hepatitis in pregnancy: Pearls and pitfalls. Hepatology 76:2, pages 502-517.
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Kehui Zhang, Jiacheng Li, Zhe Shi, Yingying Zhu, Jing Yang, Xiaolin Liu, Renye Que, Liubing Lin, Yirong Chen & Yong Li. (2022) Ginsenosides Regulates Innate Immunity to Affect Immune Microenvironment of AIH Through Hippo-YAP/TAZ Signaling Pathway. Frontiers in Immunology 13.
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Giulia Jannone, Isabelle Scheers, Françoise Smets, Xavier Stephenne & Etienne M Sokal. (2022) Everolimus is Safe as a Second-/Third-Line Therapy in Pediatric Autoimmune Hepatitis. JPGN Reports 3:3, pages e227.
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Nedim Hadžić & Marianne Samyn. 2022. Liver Disease in Adolescence. Liver Disease in Adolescence 129 141 .
Diego Vergani, Benedetta Terziroli Beretta-Piccoli & Giorgina Mieli-Vergani. (2021) A reasoned approach to the treatment of autoimmune hepatitis. Digestive and Liver Disease 53:11, pages 1381-1393.
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Rodrigo Liberal, Ynto S de Boer & Michael A Heneghan. (2021) Established and novel therapeutic options for autoimmune hepatitis. The Lancet Gastroenterology & Hepatology 6:4, pages 315-326.
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Ansgar W. Lohse, Marcial Sebode, Marianne H. Jørgensen, Henriette Ytting, Tom H. Karlsen, Deirdre Kelly, Michael P. Manns & Mette Vesterhus. (2020) Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology 73:6, pages 1496-1506.
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Stephan Klöß, Susann Dehmel, Armin Braun, Michael J. Parnham, Ulrike Köhl & Susanne Schiffmann. (2020) From Cancer to Immune-Mediated Diseases and Tolerance Induction: Lessons Learned From Immune Oncology and Classical Anti-cancer Treatment. Frontiers in Immunology 11.
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Diego Vergani, Ian R. Mackay & Giorgina Mieli-Vergani. 2020. The Autoimmune Diseases. The Autoimmune Diseases 1117 1147 .
Paul A. Schmeltzer. 2020. Diagnosis and Management of Autoimmune Hepatitis. Diagnosis and Management of Autoimmune Hepatitis 93 108 .
Marco Sciveres, Silvia Nastasio & Giuseppe Maggiore. (2019) Novel Diagnostic and Therapeutic Strategies in Juvenile Autoimmune Hepatitis. Frontiers in Pediatrics 7.
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Marilena Durazzo, Giulia Lupi, Michela Scandella, Arianna Ferro & Gabriella Gruden. (2019) Autoimmune hepatitis treatment in the elderly: A systematic review. World Journal of Gastroenterology 25:22, pages 2809-2818.
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Iliana Doycheva, Kymberly D. Watt & Aliya F. Gulamhusein. (2019) Autoimmune hepatitis: Current and future therapeutic options. Liver International 39:6, pages 1002-1013.
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Carolin F. Manthey, Marcial Sebode, Helen Hayward-Koennecke, Andreas Lutterotti & Samuel Huber. 2019. Nijkamp and Parnham's Principles of Immunopharmacology. Nijkamp and Parnham's Principles of Immunopharmacology 751 775 .
Richard Taubert, Katharina Luise Hupa-Breier, Elmar Jaeckel & Michael P. Manns. (2018) Novel therapeutic targets in autoimmune hepatitis. Journal of Autoimmunity 95, pages 34-46.
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M. V. Matsievich, A. O. Bueverov & M. Yu. Petrachenkova. (2018) Alternative treatment regimens in autoimmune hepatitis: how justified is their choice?. Almanac of Clinical Medicine 46:5, pages 504-513.
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Keaton R. Jones & Craig S. Lammert. (2018) Management of Autoimmune Hepatitis Patients Refractory to or Intolerant of Standard Therapies. Current Hepatology Reports 17:3, pages 166-174.
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Cumali Efe, Haider Al Taii, Henriette Ytting, Niklas Aehling, Rahima A. Bhanji, Hannes Hagström, Tugrul Purnak, Luigi Muratori, Mårten Werner, Paolo Muratori, Daniel Klintman, Thomas D. Schiano, Aldo J. Montano-Loza, Thomas Berg, Fin Stolze Larsen, Naim Alkhouri, Ersan Ozaslan, Michael A. Heneghan, Eric M. Yoshida & Staffan Wahlin. (2018) Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis. Digestive Diseases and Sciences 63:5, pages 1348-1354.
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Feng‑Bin Lu, En‑De Hu Hu, Lan‑Man Xu, Yi‑Bing Hu, Lu Chen, Jin‑Lu Wu, Hui Li, Da‑Zhi Chen & Yong‑Ping Chen. (2018) Comparative efficacy and tolerability of treatments for adult autoimmune hepatitis: A systematic review and network meta‑analysis. Experimental and Therapeutic Medicine.
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Timur Liwinski & Christoph Schramm. (2017) Autoimmune hepatitis — update on clinical management in 2017. Clinics and Research in Hepatology and Gastroenterology 41:6, pages 617-625.
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Cumali Efe, Hannes Hagström, Henriette Ytting, Rahima A. Bhanji, Niklas F. Müller, Qixia Wang, Tugrul Purnak, Luigi Muratori, Mårten Werner, Hanns-Ulrich Marschall, Paolo Muratori, Fulya Gunşar, Daniel Klintman, Albert Parés, Alexandra Heurgué–Berlot, Thomas D. Schiano, Mustafa Cengiz, Michele May-Sien Tana, Xiong Ma, Aldo J. Montano-Loza, Thomas Berg, Sumita Verma, Fin Stolze Larsen, Ersan Ozaslan, Michael A. Heneghan, Eric M. Yoshida & Staffan Wahlin. (2017) Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis. Clinical Gastroenterology and Hepatology 15:12, pages 1950-1956.e1.
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Benedetta Terziroli Beretta-Piccoli, Giorgina Mieli-Vergani & Diego Vergani. (2017) Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments. World Journal of Gastroenterology 23:33, pages 6030-6048.
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Xin Zhao, MingJiang Liu, JinGui Li, ShaoJie Yin, YangYang Wu & AnYuan Wang. (2017) Antimalarial agent artesunate protects Concanavalin A-induced autoimmune hepatitis in mice by inhibiting inflammatory responses. Chemico-Biological Interactions 274, pages 116-123.
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Angela Cropley & Martin Weltman. (2017) The use of immunosuppression in autoimmune hepatitis: A current literature review. Clinical and Molecular Hepatology 23:1, pages 22-26.
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D. Vergani & G. Mieli-Vergani. 2017. The Digestive Involvement in Systemic Autoimmune Diseases. The Digestive Involvement in Systemic Autoimmune Diseases 103 117 .
Rodrigo Liberal, Edward L. Krawitt, John M. Vierling, Michael P. Manns, Giorgina Mieli-Vergani & Diego Vergani. (2016) Cutting edge issues in autoimmune hepatitis. Journal of Autoimmunity 75, pages 6-19.
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Paolo Muratori, Claudine Lalanne, Giampaolo Bianchi, Marco Lenzi & Luigi Muratori. (2016) Predictive factors of poor response to therapy in Autoimmune Hepatitis. Digestive and Liver Disease 48:9, pages 1078-1081.
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Ranran Han, Juan Gao, Hui Zhai, Jinting Xiao, Ya'nan Ding & Junwei Hao. (2016) RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages. Experimental Neurology 280, pages 106-114.
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Craig Lammert, Veronica M. Loy, Kiyoko Oshima & Samer Gawrieh. (2016) Management of Difficult Cases of Autoimmune Hepatitis. Current Gastroenterology Reports 18:2.
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Nwe Ni Than, Hannah C. Jeffery & Ye H. Oo. (2016) Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy. Canadian Journal of Gastroenterology and Hepatology 2016, pages 1-12.
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. (2015) Everolimus. Reactions Weekly 1582:1, pages 198-198.
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John M. Vierling. (2015) Autoimmune Hepatitis and Overlap Syndromes: Diagnosis and Management. Clinical Gastroenterology and Hepatology 13:12, pages 2088-2108.
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