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Scandinavian Journal of Gastroenterology Volume 50, 2015 - Issue 11
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Original Article

Gastric neuroendocrine neoplasms and proton pump inhibitors: fact or coincidence?

Federica CavalcoliFondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit, Milan, Italy;Università degli Studi di Milano, Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Milan, ItalyCorrespondence[email protected]
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Alessandra ZilliFondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit, Milan, Italy;Università degli Studi di Milano, Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Milan, Italy
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Dario ConteFondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit, Milan, Italy;Università degli Studi di Milano, Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Milan, Italy
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Clorinda CiafardiniFondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit, Milan, Italy
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Sara MassironiFondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit, Milan, Italy
Pages 1397-1403 | Received 02 May 2015, Accepted 20 May 2015, Published online: 10 Jun 2015

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Roberta Modica, Alessia Liccardi, Roberto Minotta, Giuseppe Cannavale, Elio Benevento & Annamaria Colao. (2023) Current understanding of pathogenetic mechanisms in neuroendocrine neoplasms. Expert Review of Endocrinology & Metabolism 0:0, pages 1-13.
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Helge L. Waldum. (2020) Clinical consequences of controversies in gastric physiology. Scandinavian Journal of Gastroenterology 55:6, pages 752-758.
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Helge L. Waldum & Jens F. Rehfeld. (2019) Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia. Scandinavian Journal of Gastroenterology 54:9, pages 1118-1123.
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Helge L. Waldum, Øyvind Hauso, Eiliv Brenna, Gunnar Qvigstad & Reidar Fossmark. (2016) Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?. Scandinavian Journal of Gastroenterology 51:7, pages 767-773.
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Selma Şengiz Erhan, Aytül Buğra, Sevinç Hallaç Keser & Ali Alemdar. (2022) Metastatic multiple gastric neuroendocrine tumors with a long history of proton pump inhibitor use: A case report. Journal of Surgery and Medicine 6:10, pages 882-886.
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Conrad J. Fernandes, Galen Leung, Jennifer R. Eads & Bryson W. Katona. (2022) Gastroenteropancreatic Neuroendocrine Tumors. Gastroenterology Clinics of North America 51:3, pages 625-647.
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Kaneez Fatima, Talal Almas, Shan Lakhani, Arshia Jahangir, Abdullah Ahmed, Ayra Siddiqui, Aiman Rahim, Saleha Ahmed Qureshi, Zukhruf Arshad, Shilpa Golani & Adeena Musheer. (2022) The Use of Proton Pump Inhibitors and COVID-19: A Systematic Review and Meta-Analysis. Tropical Medicine and Infectious Disease 7:3, pages 37.
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Helge Waldum & Reidar Fossmark. (2021) Gastritis, Gastric Polyps and Gastric Cancer. International Journal of Molecular Sciences 22:12, pages 6548.
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Marcel Yibirin, Diana De Oliveira, Roberto Valera, Andrea E Plitt & Sophia Lutgen. (2021) Adverse Effects Associated with Proton Pump Inhibitor Use. Cureus.
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Takeshi Okamoto, Takaaki Yoshimoto, Nobuyuki Ohike, Aoi Fujikawa, Takayoshi Kanie & Katsuyuki Fukuda. (2021) Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum: A case report and review of literature. World Journal of Gastroenterology 27:1, pages 129-142.
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Davide Ravizza & Giancarla Fiori. 2021. Neuroendocrine Neoplasia Management. Neuroendocrine Neoplasia Management 179 190 .
Vincent Q‐H Trinh, Chanjuan Shi & Changqing Ma. (2020) Gastric neuroendocrine tumours from long‐term proton pump inhibitor users are indolent tumours with good prognosis. Histopathology 77:6, pages 865-876.
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Helge Waldum & Patricia Mjønes. (2020) Towards Understanding of Gastric Cancer Based upon Physiological Role of Gastrin and ECL Cells. Cancers 12:11, pages 3477.
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Monjur Ahmed. (2020) Gastrointestinal neuroendocrine tumors in 2020. World Journal of Gastrointestinal Oncology 12:8, pages 791-807.
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Denis M. McCarthy. (2020) Proton Pump Inhibitor Use, Hypergastrinemia, and Gastric Carcinoids—What Is the Relationship?. International Journal of Molecular Sciences 21:2, pages 662.
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Helge L. Waldum & Reidar Fossmark. 2020. Encyclopedia of Gastroenterology. Encyclopedia of Gastroenterology 265 272 .
Helgadottir & Bjornsson. (2019) Problems Associated with Deprescribing of Proton Pump Inhibitors. International Journal of Molecular Sciences 20:21, pages 5469.
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Reidar Fossmark, Tom C. Martinsen & Helge L. Waldum. (2019) Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility. International Journal of Molecular Sciences 20:20, pages 5203.
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Lingaku Lee, Irene Ramos-Alvarez, Tetsuhide Ito & Robert T. Jensen. (2019) Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome. International Journal of Molecular Sciences 20:20, pages 5128.
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Fatma Özge KAYHAN KOÇAK, Sercan SAHUTOĞLU, Bahattin GOKDEMİR, Zeliha Fulden SARAÇ, Sevnaz ŞAHİN & Selahattin Fehmi AKÇİÇEK. (2018) Uzun süreli proton pompa inhibitörü kullanımına sekonder gastrik nöroendokrin hiperplaziNeuroendocrine hyperplasia caused by long term use of proton pump inhibitors. Ege Tıp Dergisi 57:4, pages 244-246.
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Federica Cavalcoli, Aoife Garrahy, Marco Castellaneta & Gianluca Tamagno. 2018. Neuroendocrine Tumors in Real Life. Neuroendocrine Tumors in Real Life 3 27 .
Sinju Sundaresan, Anthony J. Kang & Juanita L. Merchant. (2017) Pathophysiology of Gastric NETs: Role of Gastrin and Menin. Current Gastroenterology Reports 19:7.
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QU Baoge. (2017) Influence of Long-Term Use of Proton Pump Inhibitors on Esophageal and Gastrointestinal Precancerous Lesions or Carcinoma. Archives of Clinical Gastroenterology, pages 029-032.
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C. R?cken. (2017) Tumoren und Tumorvorstufen des MagensGastric tumors and tumor precursors. Der Pathologe 38:2, pages 75-86.
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Helge L. Waldum, Liv Sagatun & Patricia Mjønes. (2017) Gastrin and Gastric Cancer. Frontiers in Endocrinology 8.
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Vincenzo Savarino, Pietro Dulbecco & Edoardo Savarino. (2016) Are proton pump inhibitors really so dangerous?. Digestive and Liver Disease 48:8, pages 851-859.
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Reidar Fossmark, Oriol Calvete, Patricia Mjønes, Javier Benitez & Helge L. Waldum. (2016) ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H + K + ATPase alpha subunit . APMIS 124:7, pages 561-566.
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Nina Nandy, Joshua A. Hanson, Robert G. Strickland & Denis M. McCarthy. (2015) Solitary Gastric Carcinoid Tumor Associated with Long-Term Use of Omeprazole: A Case Report and Review of the Literature. Digestive Diseases and Sciences 61:3, pages 708-712.
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G. Delle Fave, D. O''Toole, A. Sundin, B. Taal, P. Ferolla, J.K. Ramage, D. Ferone, T. Ito, W. Weber, Z. Zheng-Pei, W.W. De Herder, A. Pascher & P. Ruszniewski. (2016) ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms. Neuroendocrinology 103:2, pages 119-124.
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H. L. Waldum, Ø. Hauso & R. Fossmark. (2015) Letter: proton pump inhibitors, hypergastrinaemia and the risk of gastric neoplasia. Alimentary Pharmacology & Therapeutics 42:3, pages 389-389.
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