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Original Article

Discontinuation of anti-tumor necrosis factor therapy in inflammatory bowel disease patients: a prospective observation

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Pages 196-202 | Received 05 Jun 2015, Accepted 31 Jul 2015, Published online: 02 Sep 2015

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Read on this site (4)

Mohammed Razvi & Mark Lazarev. (2018) Optimization of biologic therapy in Crohn’s disease. Expert Opinion on Biological Therapy 18:3, pages 263-272.
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Andrew S. Day, Steven T. Leach & Daniel A. Lemberg. (2017) An update on diagnostic and prognostic biomarkers in inflammatory bowel disease. Expert Review of Molecular Diagnostics 17:9, pages 835-843.
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Pauliina Molander, Martti Färkkilä, Helena Kemppainen, Timo Blomster, Airi Jussila, Harri Mustonen & Taina Sipponen. (2017) Long-term outcome of inflammatory bowel disease patients with deep remission after discontinuation of TNFα-blocking agents. Scandinavian Journal of Gastroenterology 52:3, pages 284-290.
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Guillaume Pineton de Chambrun, Pierre Blanc & Laurent Peyrin-Biroulet. (2016) Current evidence supporting mucosal healing and deep remission as important treatment goals for inflammatory bowel disease. Expert Review of Gastroenterology & Hepatology 10:8, pages 915-927.
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Remi Mahmoud, Edo H.J. Savelkoul, Bindia Jharap & Bas Oldenburg. (2023) Reply. Clinical Gastroenterology and Hepatology 21:7, pages 1967-1968.
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Cong Dai, Min Jiang & Yu-Hong Huang. (2023) Anti-TNF Withdrawal in Inflammatory Bowel Disease With Endoscopic Healing and the Risk of Relapse. Clinical Gastroenterology and Hepatology 21:7, pages 1967.
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Reezwana Chowdhury & Sunanda V Kane. (2022) Pregnancy and Crohn’s disease: concerns and assurance of medical therapy. Gastroenterology Report 10.
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Taku Kobayashi. (2022) Stopping Anti-TNF in CD Remitters: Cons. Inflammatory Intestinal Diseases 7:1, pages 59-63.
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Joerg Mahlich, Melanie May, Chiara Feig, Vincent Straub & Renate Schmelz. (2021) Persistence With Biologic Therapy and Associated Costs of Patients With Inflammatory Bowel Disease: A German Retrospective Claims Data Analysis. Crohn's & Colitis 360 3:2.
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E. Yu. Chashkova, N. S. Korotayeva, E. E. Kunetsova, V. G. Gorokhova & E. V. Soboleva. (2019) Assessment of the State of Cell Membranes against the Background of Prolonged Use of Anticytokine Therapy in Patients with Ulcerative Colitis. Acta Biomedica Scientifica (East Siberian Biomedical Journal) 4:5, pages 84-90.
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Emilio J. Laserna-Mendieta & Alfredo J. Lucendo. (2019) Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations. Clinical Chemistry and Laboratory Medicine (CCLM) 57:9, pages 1295-1307.
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Crossref
Fabiana Castiglione, Nicola Imperatore, Anna Testa, Giovanni Domenico De Palma, Olga Maria Nardone, Lucienne Pellegrini, Nicola Caporaso & Antonio Rispo. (2019) One‐year clinical outcomes with biologics in Crohn's disease: transmural healing compared with mucosal or no healing. Alimentary Pharmacology & Therapeutics 49:8, pages 1026-1039.
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Rocío Sedano Muñoz, Rodrigo Quera Pino, Jaime Lubascher Correa, Gonzalo Pizarro Jofré & Daniela Simian Marín. (2019) Evaluación del retiro progresivo y/o la suspensión de la terapia anti-TNF-α en la enfermedad inflamatoria intestinal. Gastroenterología y Hepatología 42:2, pages 133-140.
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Rocío Sedano Muñoz, Rodrigo Quera Pino, Jaime Lubascher Correa, Gonzalo Pizarro Jofré & Daniela Simian Marín. (2019) Evaluation of de-escalation of anti-TNF-α therapy in inflammatory bowel disease. Gastroenterología y Hepatología (English Edition) 42:2, pages 133-140.
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Camille Lucidarme, Antoine Petitcollin, Charlène Brochard, Laurent Siproudhis, Marie Dewitte, Amandine Landemaine, Eric Bellissant & Guillaume Bouguen. (2018) Predictors of relapse following infliximab de‐escalation in patients with inflammatory bowel disease: the value of a strategy based on therapeutic drug monitoring. Alimentary Pharmacology & Therapeutics 49:2, pages 147-154.
Crossref
Catarina Frias Gomes, Jean-Frédéric Colombel & Joana Torres. (2018) De-escalation of Therapy in Inflammatory Bowel Disease. Current Gastroenterology Reports 20:8.
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Clémence Legué, Charlène Brochard, Grégoire Bessi, Timothée Wallenhorst, Marie Dewitte, Laurent Siproudhis & Guillaume Bouguen. (2018) Outcomes of Perianal Fistulising Crohn’s Disease Following Anti-TNFα Treatment Discontinuation. Inflammatory Bowel Diseases 24:6, pages 1107-1113.
Crossref
Ray K Boyapati, Joana Torres, Carolina Palmela, Claire E Parker, Orli M Silverberg, Sonam D Upadhyaya, Tran M Nguyen & Jean-Frédéric Colombel. (2018) Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease. Cochrane Database of Systematic Reviews 2018:5.
Crossref
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Crossref
Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, Jarosław Kierkuś, Loris Lopetuso, Edyta Szymanska & Edouard Louis. (2018) European Crohn’s and Colitis Organisation Topical Review on Treatment Withdrawal [‘Exit Strategies’] in Inflammatory Bowel Disease. Journal of Crohn's and Colitis 12:1, pages 17-31.
Crossref
Hang Hock Shim & Cynthia H. Seow. 2018. Treatment of Inflammatory Bowel Disease with Biologics. Treatment of Inflammatory Bowel Disease with Biologics 141 162 .
Jean-Frederic Colombel, Neeraj Narula & Laurent Peyrin-Biroulet. (2017) Management Strategies to Improve Outcomes of Patients With Inflammatory Bowel Diseases. Gastroenterology 152:2, pages 351-361.e5.
Crossref
N. A. Kennedy, B. Warner, E. L. Johnston, L. Flanders, P. Hendy, N. S. Ding, R. Harris, A. S. Fadra, C. Basquill, C. A. Lamb, F. L. Cameron, C. D. Murray, M. Parkes, I. Gooding, T. Ahmad, D. R. Gaya, S. Mann, J. O. Lindsay, J. Gordon, J. Satsangi, A. Hart, S. McCartney, P. Irving & C. W. Lees. (2016) Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis. Alimentary Pharmacology & Therapeutics 43:8, pages 910-923.
Crossref

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