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Scandinavian Journal of Gastroenterology Volume 51, 2016 - Issue 6
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Original Article

Reduced numbers of mucosal DRint macrophages and increased numbers of CD103+ dendritic cells during anti-TNF-α treatment in patients with Crohn’s disease

Anders DigeGastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Correspondence[email protected]
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Maria K. MagnussonDepartment of Microbiology and Immunology, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; ;Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Lena ÖhmanDepartment of Microbiology and Immunology, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; ;Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Christian Lodberg HvasGastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;
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Jens KelsenGastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;
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Mary Jo WickDepartment of Microbiology and Immunology, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
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Jørgen AgnholtGastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;
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Pages 692-699 | Received 02 Oct 2015, Accepted 15 Dec 2015, Published online: 19 Jan 2016

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Christian L. Hvas, Mia Bendix, Anders Dige, Jens F. Dahlerup & Jørgen Agnholt. (2018) Current, experimental, and future treatments in inflammatory bowel disease: a clinical review. Immunopharmacology and Immunotoxicology 40:6, pages 446-460.
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Articles from other publishers (22)

Yue Li & Helen Ka Wai Law. (2022) Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease. Frontiers in Pharmacology 13.
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Marcello Delfini, Nathalie Stakenborg, Maria Francesca Viola & Guy Boeckxstaens. (2022) Macrophages in the gut: Masters in multitasking. Immunity 55:9, pages 1530-1548.
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David Meriwether, Anthony E. Jones, Julianne W. Ashby, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Shoreh Noori, Victor Grijalva, Andréa B. Ball, Margarita Semis, Ajit S. Divakaruni, Julia J. Mack, Harvey R. Herschman, Martin G. Martin, Alan M. Fogelman & Srinivasa T. Reddy. (2022) Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial Repair. Cellular and Molecular Gastroenterology and Hepatology 13:4, pages 1095-1120.
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Katja A Selin, Charlotte R H Hedin & Eduardo J Villablanca. (2021) Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases. Journal of Crohn's and Colitis 15:11, pages 1959-1973.
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Theresa V. Rohm, Regula Fuchs, Rahel L. Müller, Lena Keller, Zora Baumann, Angela J. T. Bosch, Romano Schneider, Danny Labes, Igor Langer, Julia B. Pilz, Jan H. Niess, Tarik Delko, Petr Hruz & Claudia Cavelti-Weder. (2021) Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation. Frontiers in Immunology 12.
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Lorena Ortega Moreno, Samuel Fernández-Tomé, María Chaparro, Alicia C Marin, Irene Mora-Gutiérrez, Cecilio Santander, Montserrat Baldan-Martin, Javier P Gisbert & David Bernardo. (2021) Profiling of Human Circulating Dendritic Cells and Monocyte Subsets Discriminates Between Type and Mucosal Status in Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 27:2, pages 268-274.
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Greta Caprara, Paola Allavena & Marco Erreni. (2020) Intestinal Macrophages at the Crossroad between Diet, Inflammation, and Cancer. International Journal of Molecular Sciences 21:14, pages 4825.
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Yuning Jia, Shoaib Anwaar, Linyun Li, Zhihua Yin, Zhizhon Ye & Zhong Huang. (2020) A new target for the treatment of inflammatory bowel disease: Interleukin-37. International Immunopharmacology 83, pages 106391.
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Laurence Chapuy & Marika Sarfati. (2020) Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn’s Disease Patients. Cells 9:4, pages 813.
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Charles Caër & Mary Jo Wick. (2020) Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease. Frontiers in Immunology 11.
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Iris Dotan, Matthieu Allez, Silvio Danese, Mary Keir, Swati Tole & Jacqueline McBride. (2019) The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies. Medicinal Research Reviews 40:1, pages 245-262.
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Yi Rang Na, Michelle Stakenborg, Seung Hyeok Seok & Gianluca Matteoli. (2019) Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD. Nature Reviews Gastroenterology & Hepatology 16:9, pages 531-543.
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Takeshi Yamamoto, Emi Matsunami, Koji Komori, Shusaku Hayashi & Makoto Kadowaki. (2019) The isoflavone puerarin induces Foxp3+ regulatory T cells by augmenting retinoic acid production, thereby inducing mucosal immune tolerance in a murine food allergy model. Biochemical and Biophysical Research Communications 516:3, pages 626-631.
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Natasa Smrekar, David Drobne, Lojze M. Smid, Ivan Ferkolj, Borut Stabuc, Alojz Ihan & Andreja Natasa Kopitar. (2018) Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease. Radiology and Oncology 52:4, pages 443-452.
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Nina Friis Bak, M. Bendix, S. Hald, L. Reinert, M. K. Magnusson & J. Agnholt. (2017) High-dose vitamin D3 supplementation decreases the number of colonic CD103+ dendritic cells in healthy subjects. European Journal of Nutrition 57:7, pages 2607-2619.
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D. Bernardo, A.C. Marin, S. Fernández-Tomé, A. Montalban-Arques, A. Carrasco, E. Tristán, L. Ortega-Moreno, I. Mora-Gutiérrez, A. Díaz-Guerra, R. Caminero-Fernández, P. Miranda, F. Casals, M. Caldas, M. Jiménez, S. Casabona, F. De la Morena, M. Esteve, C. Santander, M. Chaparro & J.P. Gisbert. (2018) Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease. Mucosal Immunology 11:4, pages 1114-1126.
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Jamie L. Tweedle & George S. DeepeJr.Jr.. (2018) Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection. Infection and Immunity 86:6.
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Nobuo Fuke, Tomohisa Takagi, Yasuki Higashimura, Toshifumi Tsuji, Ryohei Umeda, Katsura Mizushima, Makoto Tanaka, Hiroyuki Suganuma, Koichi Aizawa, Nobuhiro Yajima & Yuji Naito. (2018) Lactobacillus brevis KB290 With Vitamin A Ameliorates Murine Intestinal Inflammation Associated With the Increase of CD11c+ Macrophage/CD103− Dendritic Cell Ratio. Inflammatory Bowel Diseases 24:2, pages 317-331.
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Anders Dige, Maria K. Magnusson, Claus Uhrenholt, Tue Kruse Rasmussen, Tue Kragstrup, Lena Öhman, Jens Dahlerup & Jørgen Agnholt. (2018) Effects of Anti-TNF α Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn’s Disease . Mediators of Inflammation 2018, pages 1-7.
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Hiroshi Matsuno, Hisako Kayama, Junichi Nishimura, Yuki Sekido, Hideki Osawa, Soumik Barman, Takayuki Ogino, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Motoi Uchino, Hiroki Ikeuchi, Yuichiro Doki, Masaki Mori, Kiyoshi Takeda & Tsunekazu Mizushima. (2017) CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis. Inflammatory Bowel Diseases 23:9, pages 1524-1534.
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David Aebisher, Dorota Bartusik & Jacek Tabarkiewicz. (2017) Laser flow cytometry as a tool for the advancement of clinical medicine. Biomedicine & Pharmacotherapy 85, pages 434-443.
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Carolijn Smids, Carmen S. Horjus Talabur Horje, Femke van Wijk & Ellen G. van Lochem. (2016) The Complexity of alpha E beta 7 Blockade in Inflammatory Bowel Diseases. Journal of Crohn's and Colitis, pages jjw163.
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