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Scandinavian Journal of Gastroenterology Volume 3, 1968 - Issue 5
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Original Article

Gastrointestinal Distribution of Glucuronide Synthesis and the Relevant Enzymes in the Rat

O. Hänninen Department of Physiology, University of Turku, Turku, Finland
,
A. Aitio Department of Physiology, University of Turku, Turku, Finland
&
K. Hartiala Department of Physiology, University of Turku, Turku, Finland
Pages 461-464 | Received 13 Apr 1968, Accepted 01 May 1968, Published online: 25 Feb 2010

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M. VARGAS & M. R. FRANKLIN*. (1997) Intestinal UDP-glucuronosyltransferase activities in rat and rabbit. Xenobiotica 27:5, pages 413-421.
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Robert W. Chadwick, S. Elizabeth George & Larry D. Claxton. (1992) Role of the Gastrointestinal Mucosa and Microflora in the Bioactivation of Dietary and Environmental Mutagens or Carcinogens. Drug Metabolism Reviews 24:4, pages 425-492.
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Jerome C. Pekas & H. W. Dorough. (1980) Gastrointestinal Metabolism and Transport of Pesticidal Carbamates. CRC Critical Reviews in Toxicology 7:1, pages 37-101.
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Jerome Lasker & Douglas E. Rickert. (1978) Absorption and Glucuronylation of Diethylstilbestrol by the Rat Small Intestine. Xenobiotica 8:11, pages 665-672.
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Articles from other publishers (34)

Karla Johanning, Gregg Hancock, Beate Escher, Adebayo Adekola, Mary Jo Bernhard, Christina Cowan‐Ellsberry, Jeanne Domoradzki, Scott Dyer, Curtis Eickhoff, Michelle EmbrySusan Erhardt, Patrick Fitzsimmons, Marlies Halder, James Hill, Dustin Holden, Rebecca Johnson, Sibylle Rutishauser, Helmut Segner, Irvin Schultz & John Nichols. (2012) Assessment of Metabolic Stability Using the Rainbow Trout ( Oncorhynchus mykiss ) Liver S9 Fraction . Current Protocols in Toxicology 53:1.
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David C Taylor & Rosalind Grundy. (1980) Propranolol absorption in different regions of the rat gastrointestinal tract in situ: implications for sustained release formulations. Journal of Pharmacy and Pharmacology 32:1, pages 499-500.
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Jerjang Chang, R.W. Chadwick, Joycelyn C. Allison, Yumiko O. Hayes, Detra L. Talley & Cari E. Autry. (2008) Microbial succession and intestinal enzyme activities in the developing rat. Journal of Applied Bacteriology 77:6, pages 709-718.
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Daniel Goon & Curtis D. Klaassen. (1992) Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver. Toxicology and Applied Pharmacology 115:2, pages 253-260.
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Michael Schwenk, Christa Linz & Gerhard Rechkemmer. (1992) First pass effect of 1-naphthol in the gastric mucosa. Biochemical Pharmacology 43:4, pages 771-774.
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G. LARRIEU, M. KADDOURI & P. GALTIER. (2008) Comparison of mucosal drug conjugative rates along the gastrointestinal tract of female sheep. Journal of Veterinary Pharmacology and Therapeutics 14:3, pages 263-268.
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Michael Schwenk, Christa Linz & A.-B Kobusch. (1991) Conjugation of 1-naphthol in the gastric mucosa of guinea pigs. Biochemical Pharmacology 42:3, pages 469-473.
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Michael Schwenk. (2016) Mucosal Biotransformation. Toxicologic Pathology 16:2, pages 138-146.
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D. J. BACK & S. M. ROGERS. (2007) Review: first‐pass metabolism by the gastrointestinal mucosa. Alimentary Pharmacology & Therapeutics 1:5, pages 339-357.
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Andrees Sj. Koster, Ank C. Frankhuijzen-Sierevogel & Jan Noordhoek. (1985) Distribution of glucuronidation capacity (1-naphthol and morphine) along the rat intestine. Biochemical Pharmacology 34:19, pages 3527-3532.
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O. Hänninen. 1986. Receptors and Other Targets for Toxic Substances. Receptors and Other Targets for Toxic Substances 83 86 .
M J Farthing, G P Vinson, C R Edwards & A M Dawson. (1982) Testosterone metabolism by the rat gastrointestinal tract, in vitro and in vivo.. Gut 23:3, pages 226-234.
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Ulla Koivusaari, Pirjo Lindström-Seppä & Osmo Hänninen. 1981. Gastrointestinal Defence Mechanisms. Gastrointestinal Defence Mechanisms 433 440 .
O. Hänninen, P. Mackenzie & L. Toivonen. 1981. Gastrointestinal Defence Mechanisms. Gastrointestinal Defence Mechanisms 353 372 .
J.R. Dawson & J.W. Bridges. (1979) Conjugation and excretion of metabolites of 7-hydroxycoumarin in the small intestine of rats and guinea-pigs. Biochemical Pharmacology 28:22, pages 3291-3297.
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Thomas C. Marshall & H.Wyman Dorough. (1979) Biliary excretion of carbamate insecticides in the rat. Pesticide Biochemistry and Physiology 11:1-3, pages 56-63.
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Carl J. Pfeiffer & Osmo Hänninen. 2011. Comprehensive Physiology. Comprehensive Physiology 513 535 .
Kaarlo Hartiala. 2011. Comprehensive Physiology. Comprehensive Physiology 375 388 .
Terje O. RØd & Tore Midtvedt. (2009) ORIGIN OF INTESTINAL β‐GLUCURONIDASE IN GERMFREE, MONOCONTAMINATED AND CONVENTIONAL RATS. Acta Pathologica Microbiologica Scandinavica Section B Microbiology 85B:4, pages 271-276.
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Eino Hietanen & Harri Vainio. (1976) Effect of administration route of ddt on acute toxicity and on drug biotransformation in various rodents. Archives of Environmental Contamination and Toxicology 4:1, pages 201-216.
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Hans Erik Rugstad & E. Dybing. (2011) Glucuronidation in Cultures of Human Skin Epithelial Cells. European Journal of Clinical Investigation 5:2, pages 133-137.
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Karl W. Bock & Dietrich Winne. (1975) Glucuronidation of 1-naphthol in the rat intestinal loop. Biochemical Pharmacology 24:8, pages 859-862.
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H. E. Rugstad & E. Dybing. (2008) Glucuronidation in Cultures of Human Skin Epithelial Cells. European Journal of Clinical Investigation 5:1, pages 133-137.
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Eino Hietanen. (1975) Mucosal and hepatic metabolism during the spontaneous disappearance of salicylate-induced gastric erosions. The American Journal of Digestive Diseases 20:1, pages 31-41.
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Berton E. Ballard. (1974) Pharmacokinetics and Temperature. Journal of Pharmaceutical Sciences 63:9, pages 1345-1358.
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Antero Aitio. (1974) UDF glucuronyltransferase activity in various rat tissues. International Journal of Biochemistry 5:3, pages 325-330.
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E. Hietanen & H. Vainio. (2009) Interspecies Variations in Small Intestinal and Hepatic Drug Hydroxylation and Glucuronidation. Acta Pharmacologica et Toxicologica 33:1, pages 57-64.
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Eino Hietanen & Osmo Hänninen. (1972) Effect of chyme on mucosal enzyme levels in small intestine of the rat. Metabolism 21:11, pages 991-1000.
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J.C. Pekas. (1972) Intestinal hydrolysis, metabolism and transport of a pesticidal carbamate in pH 6.5 medium. Toxicology and Applied Pharmacology 23:1, pages 62-70.
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E. Hietanen, A. Aitio & O. Hänninen. (1972) Studies on the Control of Glucuronide Synthesis in the Rat Small Intestine. Acta Pharmacologica et Toxicologica 31:3, pages 186-192.
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Nathan R. Strahl & William H. Barr. (1971) Intestinal Drug Absorption and Metabolism III: Glycine Conjugation and Accumulation of Benzoic Acid in Rat Intestinal Tissue. Journal of Pharmaceutical Sciences 60:2, pages 278-281.
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. (1970) Abstracts from Meeting of the Scandinavian Physiological Society in Helsinki 24-25 April 1970. DEMONSTRATIONS.. Acta Physiologica Scandinavica 79, pages 1A-10A.
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Ruth R. Levine. (1970) Factors affecting gastrointestinal absorption of drugs. The American Journal of Digestive Diseases 15:2, pages 171-188.
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TATU A. MIETTINEN & ERKKI LESKINEN. 1970. Metabolic Conjugation and Metabolic Hydrolysis. Metabolic Conjugation and Metabolic Hydrolysis 157 237 .

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