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Original Article

The Possible Role of Phospholipase a in the Pathogenesis of Acute Pancreatitis

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Pages 39-48 | Received 04 Jul 1968, Accepted 22 Sep 1968, Published online: 25 Feb 2010

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Read on this site (17)

Erich Kaiser. (1999) Phospholipase A2: Its Usefulness in Laboratory Diagnostics. Critical Reviews in Clinical Laboratory Sciences 36:2, pages 65-163.
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A. Mäkelä, T. Kuusi & T. Schröder. (1997) Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scandinavian Journal of Clinical and Laboratory Investigation 57:5, pages 401-407.
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R. Bialek, S. Willemer, R. Arnold & G. Adler. (1991) Evidence of Intracellular Activation of Serine Proteases in Acute Cerulein-Induced Pancreatitis in Rats. Scandinavian Journal of Gastroenterology 26:2, pages 190-196.
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A. Mäkelä, B. Sternby, T. Kuusi, P. Puolakkainen & T. Schröder. (1990) Phospholipase A2 Activity and Concentration in Several Body Fluids in Patients with Acute Pancreatitis. Scandinavian Journal of Gastroenterology 25:9, pages 944-950.
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Timo J. Nevalainen. (1988) Phospholipase A2 in Acute Pancreatitis. Scandinavian Journal of Gastroenterology 23:8, pages 897-904.
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Anu Mäkelä, Timo Kuusi, Pentti Somerharju & Tom Schröder. (1987) A simple isotopic assay method for human serum phospholipase A2 activity. Scandinavian Journal of Clinical and Laboratory Investigation 47:6, pages 529-534.
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J. Hermon-Taylor & G. C. Heywood. (1985) A Rational Approach to the Specific Chemotherapy of Pancreatitis. Scandinavian Journal of Gastroenterology 20:sup117, pages 39-46.
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H. T. Tykkau, E. J. Vaittinen, K. L. Mahlberg, J. E. Railo, P. J. Pantzar, S. Sarna & T. Tallberg. (1985) A Randomized Double-Blind Study Using CaNa2EDTA, a Phospholipase A2 Inhibitor, in the Management of Human Acute Pancreatitis. Scandinavian Journal of Gastroenterology 20:1, pages 5-12.
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Timo J. Nevalainen. (1980) The Role of Phospholipase A in Acute Pancreatitis. Scandinavian Journal of Gastroenterology 15:6, pages 641-650.
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T. Schröder, E. Kivilaakso, P. K. J. Kinnunen & M. Lempinen. (1980) Serum Phospholipase A2 in Human Acute Pancreatitis. Scandinavian Journal of Gastroenterology 15:5, pages 633-636.
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H. Tykkä, K. Mahlberg, P. Pantzar & T. Tallberg. (1980) Phospholipase A2 Inhibitors and Their Possible Clinical Use in the Treatment of Acute Pancreatitis. Scandinavian Journal of Gastroenterology 15:5, pages 519-528.
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T. Schröder, P. K. J. Kinnunen & M. Lempinen. (1978) Xylocaine Treatment in Experimental Pancreatitis in Pigs. Scandinavian Journal of Gastroenterology 13:7, pages 863-865.
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P. Jalovaara & M. Apaja. (1978) Alcohol and Acute Pancreatitis. Scandinavian Journal of Gastroenterology 13:6, pages 703-709.
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Timo J. Nevalainen & Anders Seppä. (1975) Acute Pancreatitis Caused by Closed Duodenal Loop in the Rat. Scandinavian Journal of Gastroenterology 10:5, pages 521-527.
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Per-Anders Mårdh & Bo Ursing. (1974) The Occurrence of Acute Pancreatitis in Mycoplasma Pneumoniae Infection. Scandinavian Journal of Infectious Diseases 6:2, pages 167-171.
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Articles from other publishers (78)

C. Thangam, Rozario Cyril, Ramya Sekar, R. Jayasree, Veerakumar Ramachandran, Kulanthaivel Langeswaran, A. Billy Asir & Gowtham Kumar Subbaraj. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 315 335 .
Julia Mayerle, Frank Ulrich Weiss, Walter Halangk & Markus M. Lerch. 2018. The Pancreas. The Pancreas 178 192 .
Soraia K. P. Costa, Enilton A. Camargo & Edson Antunes. 2017. Toxins and Drug Discovery. Toxins and Drug Discovery 35 52 .
Soraia K.P. Costa, Enilton A. Camargo & Edson Antunes. 2015. Toxins and Drug Discovery. Toxins and Drug Discovery 1 18 .
John D. Brunzell & Helmut G. Schrott. (2012) The interaction of familial and secondary causes of hypertriglyceridemia: Role in pancreatitis. Journal of Clinical Lipidology 6:5, pages 409-412.
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Timo J. Nevalainen. (2007) Phospholipase A2 in acute pancreatitis: review. The American Journal of Surgery 194:4, pages S28-S32.
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P-A Clavien, S Burgan & A R Moossa. (1989) Serum enzymes and other laboratory tests in acute pancreatitis. British Journal of Surgery 76:12, pages 1234-1243.
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R Earlam. (1983) Bile reflux and the Roux en Y anastomosis. British Journal of Surgery 70:7, pages 393-397.
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Geoffrey Glazer. (1975) Haemorrhagic and necrotizing pancreatitis. British Journal of Surgery 62:3, pages 169-176.
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Catherine M. Pastor, Michael A. Matthay & Jean-Louis Frossard. (2003) Pancreatitis-Associated Acute Lung Injury. Chest 124:6, pages 2341-2351.
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Inken Hilgendorf, Maren Van de Perck, Jörg Emmrich, Heinz-Jürgen Krammer & Charli Kruse. (2003) Vigilin and enzyme expression in isolated pancreatic acini after mellitin and gamma-interferon treatment. Pancreatology 3:4, pages 336-341.
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Johannes Aufenanger, Michael Samman, Michael Quintel, Klaus Fassbender, Wilma Zimmer & Thomas Bertsch. (2002) Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk. Clinical Chemistry and Laboratory Medicine 40:3.
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Krystyna Sztefko & Józefa Panek. (2001) Serum Free Fatty Acid Concentration in Patients with Acute Pancreatitis. Pancreatology 1:3, pages 230-236.
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Atsushi Masamune, Yoshitaka Sakai, Akihiko Satoh, Motokazu Fujita, Masayoshi Yoshida & Tooru Shimosegawa. (2001) Lysophosphatidylcholine Induces Apoptosis in AR42J Cells. Pancreas 22:1, pages 75-83.
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Alan H. Cruickshank & Emyr W. BenbowAlan H. Cruickshank & Emyr W. Benbow. 1995. Pathology of the Pancreas. Pathology of the Pancreas 235 280 .
Timo J. Nevalainen & Juha M. Grönroos. 1994. Esterases, Lipases, and Phospholipases. Esterases, Lipases, and Phospholipases 253 261 .
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Kazuko Yamamoto, Yasuhisa Shinomura, Hiromasa Tojo, Mitsuhiro Okamoto & Sciichiro Tarui. (1993) Serum pancreatic phospholipase A2 and prophospholipase A2 in acute pancreatitis and after endoscopic retrograde pancreatography. Gastroenterologia Japonica 28:5, pages 679-686.
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Timo J. Nevalainen & Timo J. Haapanen. (1993) Distribution of pancreatic (group I) and synovial-type (group II) phospholipases A2 in human tissues. Inflammation 17:4, pages 453-464.
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Michael Larvin, David J. Alexander, Stanislaus F. Switala & Michael J. McMahon. (1993) Impaired mononuclear phagocyte function in patients with severe acute pancreatitis: Evidence from studies of plasma clearance of trypsin and monocyte phagocytosis. Digestive Diseases and Sciences 38:1, pages 18-27.
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Wataru Kimura, Frank Meyer, Dagmar Hess, Thomas Kirchner, Wolfgang Fischbach & Joachim Mössner. (1992) Comparison of different treatment modalities in experimental pancreatitis in rats. Gastroenterology 103:6, pages 1916-1924.
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Joachim Mössner, Hans Bödeker, Wataru Kimura, Frank Meyer, Stephan Böhm & Wolfgang Fischhach. (1992) Isolated rat pancreatic acini as a model to study the potential role of lipase in the pathogenesis of acinar cell destruction. International journal of pancreatology 12:3, pages 285-296.
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Akiko Kanda, Mikio Tamaki, Etsuo Nakamura, Hiroshi Teraoka & Nobuo Yoshida. (1992) Characterization of recombinant human and rat pancreatic phospholipases A2 secreted from Saccharomyces cerevisiae: Difference in proteolytic processing. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1171:1, pages 1-10.
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H. Shinohara, H. Ishida, E. J. Fernandezf, Y. Amabe, T. Nagata & Y. Wakano. (2006) Phospholipase A 2 in rat gingival tissue . Journal of Periodontal Research 27:5, pages 528-533.
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Tetsuya Hirano, Tadao Manabe & Takayoshi Tobe. (1992) Cytoprotective Effects of Prostaglandins and a New Potent Protease Inhibitor in Acute Pancreatitis. The American Journal of the Medical Sciences 304:3, pages 154-163.
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Tetsuya Hirano, Tadao Manabe & Takayoshi Tobe. (1992) Impaired hepatic energy metabolism in rat acute pancreatitis: Protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307. Journal of Surgical Research 53:3, pages 238-244.
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Antti J. Hietaranta, Zoltán G. Lászik, Heikki J. A ho, Pirjo T. Kortesuo & Timo J. Nevalainen. (1991) The role of phospholipase a2 in pancreatic acinar cell injury. International journal of pancreatology 8:2, pages 187-201.
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Motoji Kitagawa, Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Yuzo Sakai, Hiroshi Sobajima, Hiroshi Ishiguro & Yasuyuki Nakae. (1991) The diagnostic value of serum pancreatic phospholipase A2 (PLA2) in pancreatic diseases. Gastroenterologia Japonica 26:1, pages 62-68.
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