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Original Article

Effects of a Biguanide (Metformin) on Vitamin B12 and Folic Acid Absorption and Intestinal Enzyme Activities

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Pages 751-754 | Received 26 Jun 1971, Accepted 22 Jul 1971, Published online: 23 Feb 2010

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Michael Wakeman & David T Archer. (2020) Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?. Diabetes, Metabolic Syndrome and Obesity 13, pages 2093-2108.
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S. M. Carlsen, I. Følling, V. Grill, K. S. Bjerve, J. Schneede & H. Refsum. (1997) Metformin increases total serum homocysteine levels in non-diabetic male patients with coronary heart disease. Scandinavian Journal of Clinical and Laboratory Investigation 57:6, pages 521-527.
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G. Samsioe, P. Johnson & A. Gustafson. (1975) Treatment of Pruritus in Cholestasis of Pregnancy with a New Anion Exchange Resin (Secholexr`). Acta Obstetricia et Gynecologica Scandinavica 54:4, pages 333-340.
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Bincy P. Abraham & Joseph H. Sellin. 2019. Evidence-based Gastroenterology and Hepatology 4e. Evidence-based Gastroenterology and Hepatology 4e 208 224 .
礼琴 贺. (2019) Research Progress on Anti-Tumor Effect of Metformin in Gastric Cancer. Advances in Clinical Medicine 09:07, pages 831-836.
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Alen Bišćanin. 2018. Gastrointestinal Complications of Diabetes. Gastrointestinal Complications of Diabetes 177 189 .
Kunal Maniar, Amal Moideen, Ankur Mittal, Amol Patil, Amitava Chakrabarti & Dibyajyoti Banerjee. (2017) A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?. Pharmacological Research 117, pages 103-128.
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Vanita R. Aroda, Sharon L. Edelstein, Ronald B. Goldberg, William C. Knowler, Santica M. Marcovina, Trevor J. Orchard, George A. Bray, David S. Schade, Marinella G. Temprosa, Neil H. White & Jill P. Crandall. (2016) Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. The Journal of Clinical Endocrinology & Metabolism 101:4, pages 1754-1761.
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Zhouwen Tang & Joseph Sellin. 2015. Nutritional Care of the Patient with Gastrointestinal Disease. Nutritional Care of the Patient with Gastrointestinal Disease 29 61 .
Matteo Monami & Edoardo Mannucci. (2015) Dipeptidyl Peptidase-4 Inhibitors and Heart Failure: Friends or Foes?. Current Cardiovascular Risk Reports 9:8.
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Mitra Niafar, Faizi Hai, Jahan Porhomayon & Nader Djalal Nader. (2014) The role of metformin on vitamin B12 deficiency: a meta-analysis review. Internal and Emergency Medicine 10:1, pages 93-102.
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Bincy P. Abraham & Joseph H. Sellin. (2012) Drug-induced, factitious, & idiopathic diarrhoea. Best Practice & Research Clinical Gastroenterology 26:5, pages 633-648.
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Parakkal Deepak & Eli D. Ehrenpreis. (2011) Diarrhea. Disease-a-Month 57:9, pages 490-510.
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Bincy P Abraham & Joseph H Sellin. 2010. Evidence‐Based Gastroenterology and Hepatology. Evidence‐Based Gastroenterology and Hepatology 267 279 .
Bincy P. Abraham & Joseph H. Sellin. 2011. Diarrhea. Diarrhea 393 423 .
Milena Gould & Joseph H. Sellin. (2009) Diabetic diarrhea. Current Gastroenterology Reports 11:5, pages 354-359.
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Bincy Abraham & Joseph H. Sellin. (2007) Drug-induced diarrhea. Current Gastroenterology Reports 9:5, pages 365-372.
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Tessa G Lebinger. (2007) Metformin and polycystic ovary syndrome. Current Opinion in Endocrinology, Diabetes & Obesity 14:2, pages 132-140.
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André Scheen. 2006. Nutrient-Drug Interactions. Nutrient-Drug Interactions 1 30 .
L. S. Hermann. 1996. Oral Antidiabetics. Oral Antidiabetics 373 407 .
J H Scarpello & G E Sladen. (1978) Diabetes and the gut.. Gut 19:12, pages 1153-1162.
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CHARLES H. HALSTED. 1978. Nutrition and Drug Interrelations. Nutrition and Drug Interrelations 83 112 .
Charles S. Lieber. 1978. The Year in Metabolism 1977. The Year in Metabolism 1977 411 434 .
W. F. Caspary, I. Zavada, W. Reimold, U. Deuticke, D. Emrich & B. Willms. (1977) Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Diabetologia 13:3, pages 187-193.
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William Perlow, Enrique Baraona & Charles S. Lieber. (1977) Symptomatic Intestinal Disaccharidase Deficiency in Alcoholics. Gastroenterology 72:4, pages 680-684.
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K. Oberdisse. 1977. Diabetes mellitus • B. Diabetes mellitus • B 999 1066 .
W. F. Caspary & W. Creutzfeldt. (1975) Inhibition of bile salt absorption by blood-sugar lowering biguanides. Diabetologia 11:2, pages 113-117.
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R.A. Giannella, W.R. Rout & P.P. Toskes. (1974) Jejunal Brush Border Injury and Impaired Sugar and Amino Acid Uptake in the Blind Loop Syndrome. Gastroenterology 67:5, pages 965-974.
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A. J. Jounela, H. Pirttiaho & I. P. Palva. (2009) DRUG-INDUCED MALABSORPTION OF VITAMIN B12. Acta Medica Scandinavica 196:1-6, pages 267-269.
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