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Scandinavian Journal of Gastroenterology Volume 6, 1971 - Issue 3
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Original Article

Absorption of Cyanocobalamin, Coenzyme B12, Methylcobalamin, and Hydroxocobalamin at Different Dose Levels

J. F. Adams Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland
,
Sheila K. Ross Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland
,
L. Mervyn Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland
,
K. Boddy Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland
&
Priscilla King Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland
Pages 249-252 | Received 18 Jul 1970, Accepted 16 Nov 1970, Published online: 25 Feb 2010

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Christian Koeder & Federico J. A. Perez-Cueto. (2022) Vegan nutrition: a preliminary guide for health professionals. Critical Reviews in Food Science and Nutrition 0:0, pages 1-38.
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Agata Sobczyńska-Malefora, Edgard Delvin, Andrew McCaddon, Kourosh R. Ahmadi & Dominic J. Harrington. (2021) Vitamin B12 status in health and disease: a critical review. Diagnosis of deficiency and insufficiency – clinical and laboratory pitfalls . Critical Reviews in Clinical Laboratory Sciences 58:6, pages 399-429.
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E. Kittang, E. Aadland, H. Schjønsby & K. Røhss. (1987) The Effect of Omeprazole on Gastric Acidity and the Absorption of Liver Cobalamins. Scandinavian Journal of Gastroenterology 22:2, pages 156-160.
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Hong Yang, Jie Song, Aole Li, Linshuoshuo Lv, Xiaohui Sun, Yingying Mao & Ding Ye. (2023) Genetically predicted levels of folate, vitamin B12, and risk of autoimmune diseases: A Mendelian randomization study. Frontiers in Immunology 14.
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Amanda J. Benham, Danielle Gallegos, Katherine L. Hanna & Mary T. Hannan-Jones. (2022) Vitamin B12 Supplementation Adequacy in Australian Vegan Study Participants. Nutrients 14:22, pages 4781.
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Damian K Francis, Eunice B Awuah, Martha S Field, Crystal D Karakochuk, Ruchita Dixit & Patricia A Cassano. (2022) Vitamin B supplementation for sickle cell disease. Cochrane Database of Systematic Reviews 2022:10.
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Sarita Devi, Roshni M Pasanna, Zeeshan Shamshuddin, Kishor Bhat, Ambily Sivadas, Amit K Mandal & Anura V Kurpad. (2020) Measuring vitamin B-12 bioavailability with [13C]-cyanocobalamin in humans. The American Journal of Clinical Nutrition 112:6, pages 1504-1515.
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Eva Greibe, Namita Mahalle, Vijayshri Bhide, Sergey Fedosov, Christian W. Heegaard, Sadanand Naik & Ebba Nexo. (2017) Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. European Journal of Nutrition 58:1, pages 261-270.
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Eva Greibe, Namita Mahalle, Vijayshri Bhide, Christian W. Heegaard, Sadanand Naik & Ebba Nexo. (2017) Increase in circulating holotranscobalamin after oral administration of cyanocobalamin or hydroxocobalamin in healthy adults with low and normal cobalamin status. European Journal of Nutrition 57:8, pages 2847-2855.
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Eva Greibe, Ole Nymark, Sergey Fedosov, Christian Heegaard & Ebba Nexo. (2018) Differences in Tissue Distribution of Cyano–B12 and Hydroxo–B12 One Week after Oral Intake: An Experimental Study in Male Wistar Rats. Nutrients 10:10, pages 1487.
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David H Alpers. (2018) Another indication for the use of oral vitamin B-12 supplementation. The American Journal of Clinical Nutrition 108:1, pages 1-3.
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Linda S. Kornerup, Sergey N. Fedosov, Christian B. Juul, Eva Greibe, Christian W. Heegaard & Ebba Nexo. (2017) Tissue distribution of oral vitamin B12 is influenced by B12 status and B12 form: an experimental study in rats. European Journal of Nutrition 57:4, pages 1459-1469.
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Ann Reed Mangels. 2018. Handbook of Nutrition and Pregnancy. Handbook of Nutrition and Pregnancy 89 108 .
Jörn Schneede. 2017. Vitamin B12. Vitamin B12 1 29 .
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. (2015) Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12). EFSA Journal 13:7.
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Rima Obeid, Sergey N. Fedosov & Ebba Nexo. (2015) Cobalamin coenzyme forms are not likely to be superior to cyano‐ and hydroxyl‐cobalamin in prevention or treatment of cobalamin deficiency. Molecular Nutrition & Food Research 59:7, pages 1364-1372.
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Amanda J. MacFarlane, Yipu Shi & Linda S. Greene-Finestone. (2014) High-Dose Compared with Low-Dose Vitamin B-12 Supplement Use Is Not Associated with Higher Vitamin B-12 Status in Children, Adolescents, and Older Adults. The Journal of Nutrition 144:6, pages 915-920.
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A. Doscherholmen, J. McMahon & D. Ripley. (2008) Inhibitory Effect of Eggs on Vitamin B 12 Absorption: Description of a Simple Ovalbumin 57 Co‐Vitamin B 12 Absorption Test . British Journal of Haematology 33:2, pages 261-272.
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A. M. Mackinnon. (1973) Small bowel adaptation after intestinal resection in guinea pig with functional adaptation of vitamin B12 absorption. The American Journal of Digestive Diseases 18:7, pages 576-582.
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