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Original Article

A Secretory Epithelium of the Small Intestine with Increased Sensitivity to Bile Acids in Irritable Bowel Syndrome Associated with Diarrhoea

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Pages 409-416 | Received 28 Nov 1977, Accepted 10 Jan 1978, Published online: 23 Feb 2010

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Read on this site (8)

Hans Törnblom, Magnus Simrén & Hasse Abrahamsson. (2015) Gastrointestinal motility and neurogastroenterology. Scandinavian Journal of Gastroenterology 50:6, pages 685-697.
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Michael Camilleri. (2013) Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome. Expert Opinion on Pharmacotherapy 14:9, pages 1151-1160.
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Rickard Ekesbo, Peter M. Nilsson & Kristina Sjölund. (2008) Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS). Scandinavian Journal of Primary Health Care 26:2, pages 106-110.
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George Triadafilopoulos, Mary Ann Finlayson & Catherine Grellet. (1998) Bowel Dysfunction in Postmenopausal Women. Women & Health 27:4, pages 55-66.
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E. Krag & E. H. Thaysen. (1996) Bile Acids in Health and Disease. Scandinavian Journal of Gastroenterology 31:sup216, pages 73-81.
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S. M. Collins. (1992) Is the Irritable Gut an Inflamed Gut?. Scandinavian Journal of Gastroenterology 27:sup192, pages 102-105.
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Einar Krag. (1985) Irritable Bowel Syndrome: Current Concepts and Future Trends. Scandinavian Journal of Gastroenterology 20:sup109, pages 107-115.
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B. Hempel Sparsø, H.-J. Bøge Frederiksen, A. Malchow-Møller, J. H. Henriksen & E. Krag. (1983) Mucosal Function of the Perfused Ileum in Patients with and without Diarrhoea and Dumping after Vagotomy and Pyloroplasty. Scandinavian Journal of Gastroenterology 18:5, pages 669-674.
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Articles from other publishers (43)

Bruno Kotska Rodiño-Janeiro, Cristina Pardo-Camacho, Javier Santos & Cristina Martínez. (2019) Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa. American Journal of Physiology-Gastrointestinal and Liver Physiology 316:6, pages G701-G719.
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Michael CamilleriPaula CarlsonVictor ChedidPriya VijayvargiyaDuane BurtonIrene Busciglio. (2019) Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea. Clinical and Translational Gastroenterology 10:4, pages e00019.
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Zhenyang Ge, Zhijun Duan, Hang Yang, Shengai Zhang, Shuang Zhang, Lixia Wang, Dong Yang, Xiaoyu Sun, Zhifeng Zhang, Liping Su, Hong Zhu, Dongdong Zhou, Bojia Liu, Honggang Shi, Jun Yu, Hui Yang, Qingyong Chang, Nina Zhang, Dongsheng Wu & Jiande D. Z. Chen. (2018) Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-12.
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M. Dior, H. Delagrèverie, H. Duboc, P. Jouet, B. Coffin, L. Brot, L. Humbert, G. Trugnan, P. Seksik, H. Sokol, D. Rainteau & J.-M. Sabate. (2016) Interplay between bile acid metabolism and microbiota in irritable bowel syndrome. Neurogastroenterology & Motility 28:9, pages 1330-1340.
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Shan Li, Guijun Fei, Xiucai Fang, Xilin Yang, Xiaohong Sun, Jiaming Qian, Jackie D Wood & Meiyun Ke. (2016) Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea. Journal of Neurogastroenterology and Motility 22:2, pages 310-320.
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Michael Camilleri & Alexander C. Ford. 2017. Gastrointestinal Pharmacology. Gastrointestinal Pharmacology 75 113 .
Michael Camilleri, Paula Carlson, Andres Acosta & Irene Busciglio. (2015) Colonic mucosal gene expression and genotype in irritable bowel syndrome patients with normal or elevated fecal bile acid excretion. American Journal of Physiology-Gastrointestinal and Liver Physiology 309:1, pages G10-G20.
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Michael Camilleri. (2015) Intestinal Secretory Mechanisms in Irritable Bowel Syndrome–Diarrhea. Clinical Gastroenterology and Hepatology 13:6, pages 1051-1057.
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Antal Bajor, Hans Törnblom, Mats Rudling, Kjell-Arne Ung & Magnus Simrén. (2015) Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS. Gut 64:1, pages 84-92.
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Michael Camilleri, Paula Carlson, Andres Acosta, Irene Busciglio, Asha A. Nair, Simon J. Gibbons, Gianrico Farrugia & Eric W. Klee. (2014) RNA sequencing shows transcriptomic changes in rectosigmoid mucosa in patients with irritable bowel syndrome-diarrhea: a pilot case-control study. American Journal of Physiology-Gastrointestinal and Liver Physiology 306:12, pages G1089-G1098.
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Michael Camilleri. (2012) Peripheral Mechanisms in Irritable Bowel Syndrome. New England Journal of Medicine 367:17, pages 1626-1635.
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N. Mazurak, N. Seredyuk, H. Sauer, M. Teufel & P. Enck. (2012) Heart rate variability in the irritable bowel syndrome: a review of the literature. Neurogastroenterology & Motility 24:3, pages 206-216.
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Michael Camilleri. (2012) Editorial: Fecal Granins in IBS: Cause or Indicator of Intestinal or Colonic Irritation?. American Journal of Gastroenterology 107:3, pages 448-450.
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J. Gunnarsson & M. Simrén. (2009) Peripheral factors in the pathophysiology of irritable bowel syndrome. Digestive and Liver Disease 41:11, pages 788-793.
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m. camilleri, a. nadeau, w. j. tremaine, j. lamsam, d. burton, s. odunsi, s. sweetser & r. singh. (2009) Measurement of serum 7α-hydroxy-4-cholesten-3-one (or 7αC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterology & Motility 21:7, pages 734-e43.
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m. a. storr, b. yce, c. n. andrews & k. a. sharkey. (2008) The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome. Neurogastroenterology & Motility 20:8, pages 857-868.
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m. h. larsson*,‡m. simrén, e. a. thomas, j. c. bornstein, e. lindström & h. sjövall. (2007) Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome. Neurogastroenterology & Motility 19:10, pages 812-820.
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Jeroen Aerssens, Kirk Hillsley, Pieter J. Peeters, Ronald de Hoogt, Andrzej Stanisz, Jia–Hui Lin, Ilse Van den Wyngaert, Hinrich W. Göhlmann, David Grundy, Ronald H. Stead & Bernard Coulie. (2007) Alterations in the Brain–Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis-Infected Mice. Gastroenterology 132:4, pages 1375-1387.
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Iris Posserud. (2006) Functional findings in irritable bowel syndrome. World Journal of Gastroenterology 12:18, pages 2830.
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A Yazar, K Büyükafpar, G Polat, C Pata, A Kanýk, EN Tiftik & Ö Baðdatoðlu. (2016) The Urinary 5-Hydroxyindole Acetic Acid and Plasma Nitric Oxide Levels in Irritable Bowel Syndrome: A Preliminary Study. Scottish Medical Journal 50:1, pages 27-29.
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M. Z. D. Castle, D. B. A. Silk & G. W. Libby. (2004) The rationale for antidepressant therapy in functional gastrointestinal disorders. Alimentary Pharmacology & Therapeutics 19:9, pages 969-979.
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Michael Camilleri, Doe-Young Kim, Sanna Mckinzie, H.Jae Kim, George M. Thomforde, Duane D. Burton, Phillip A. Low & Alan R. Zinsmeister. (2003) A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome. Clinical Gastroenterology and Hepatology 1:2, pages 111-121.
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M. Camilleri, R. C. Heading & W. G. Thompson. (2002) Consensus report: clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 16:8, pages 1407-1430.
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Derek Moriarty, Norma Selve, Alan W. Baird & Jon Goldhill. (2001) Potent NK 1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation . American Journal of Physiology-Cell Physiology 280:4, pages C852-C858.
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Michael Camilleri. (2001) Management of the irritable bowel syndrome. Gastroenterology 120:3, pages 652-668.
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XIAN‐YONG GUI. (2008) Mast cells: A possible link between psychological stress, enteric infection, food allergy and gut hypersensitivity in the Irritable Bowel syndrome. Journal of Gastroenterology and Hepatology 13:10, pages 980-989.
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