Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 14, 1979 - Issue 2
Submit an article Journal homepage
6
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Carcinogenic Effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in Male Wistar Rats: Promotion of Pancreatic Cancer by a Raw Soya Flour Diet

D. A. Levison Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
,
R. G. H. Morgan Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
,
J. S. Brimacombe Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
,
D. Hopwood Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
,
G. Coghill Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
&
K. G. Wormsley Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland
Pages 217-224 | Received 29 Sep 1978, Accepted 17 Oct 1978, Published online: 23 Feb 2010

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

IrvinE. Liener. (1994) Implications of antinutritional components in soybean foods. Critical Reviews in Food Science and Nutrition 34:1, pages 31-67.
Read now
Aharon Hasdai & IrvinE. Liener. (1986) The failure of long‐term feeding of raw soy flour, in the presence or absence of Azaserine, to induce carcinogenic changes in the mouse pancreas. Nutrition and Cancer 8:2, pages 85-91.
Read now
Taisan Chiu & Parviz M. Pour. (1985) Hypertrophic Foci of Pancreatic Acinar Cells in Rats. CRC Critical Reviews in Toxicology 14:2, pages 133-157.
Read now
Å. Andrén-Sandberg, S. Dawiskiba & I. Ihse. (1984) Studies of the Effect of Cerulein Administration on Experimental Pancreatic Carcinogenesis. Scandinavian Journal of Gastroenterology 19:1, pages 122-128.
Read now
E. E. McGuinness, D. Hopwood & K. G. Wormsley. (1983) Potentiation of Pancreatic Carcinogenesis in the Rat by DL-Ethionine-Induced Pancreatitis. Scandinavian Journal of Gastroenterology 18:2, pages 189-192.
Read now
E. E. Mcguinness, D. Hopwood & K. G. Wormsley. (1982) Further Studies of the Effects of Raw Soya Flour on the Rat Pancreas. Scandinavian Journal of Gastroenterology 17:2, pages 273-277.
Read now
E. E. Mcguinness, R. G. H. Morgan, D. A. Levison, D. L. Frape, D. Hopwood & K. G. Wormsley. (1980) The Effects of Long-Term Feeding of Soya Flour on the Rat Pancreas. Scandinavian Journal of Gastroenterology 15:4, pages 497-502.
Read now

Articles from other publishers (42)

Peter Greaves. 2012. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 433 535 .
Peter Greaves. 2007. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 457 569 .
L.H. Garthoff, G.R. Henderson, A.O. Sager, T.J. Sobotka, R. O'Dell, C.W. Thorpe, W.J. Trotter, V.R. Bruce, H.L. Dallas, P.L. Poelma, H.M. Solomon, J.W. Bier, M.W. O'DonnellJrJr, R.K. Chi, S.J. Chirtel, C.N. Barton, L.H. Brown, V.P. Frattali & M.A. Khan. (2002) The Autosow raised miniature swine as a model for assessing the effects of dietary soy trypsin inhibitor. Food and Chemical Toxicology 40:4, pages 487-500.
Crossref
Peter Greaves. 2000. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 432 544 .
Daniel S. Longnecker. 1998. Pancreatic Cancer. Pancreatic Cancer 53 70 .
KIN‐CHOR KWOK & KESHAVAN NIRANJAN. (2007) Review: Effect of thermal processing on soymilk. International Journal of Food Science & Technology 30:3, pages 263-295.
Crossref
GRAHAM S. BALDWIN. (2008) The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. Journal of Gastroenterology and Hepatology 10:2, pages 215-232.
Crossref
Sultan Mahmood & Ron Smithard. (2007) A comparison of effects of body weight and feed intake on digestion in broiler cockerels with effects of tannins. British Journal of Nutrition 70:3, pages 701-709.
Crossref
Y. C. Ge & R. G. H. Morgan. (2007) The effect of trypsin inhibitor on the pancreas and small intestine of mice. British Journal of Nutrition 70:1, pages 333-345.
Crossref
Mark L. Silen & Jerry D. Gardner. (1993) Gastrointestinal peptides and cancer. Trends in Endocrinology & Metabolism 4:4, pages 131-135.
Crossref
B. D. Roebuck & Daniel S. Longnecker. 1993. Protease Inhibitors as Cancer Chemopreventive Agents. Protease Inhibitors as Cancer Chemopreventive Agents 295 303 .
Leonardo Magnani, Daniele Bani, Giancarlo Biliotti & Tatiana Bani Sacchi. (1992) Structural changes of the exocrine pancreas in a patient with cholecystolithiasis. International journal of pancreatology 12:1, pages 53-59.
Crossref
R.W. Peace, G. Sarwar, S.P. Touchburn & H.G. Botting. (1991) Effects of soybean trypsin inhibitors and dl-ethionine on growth and serum parameters in young rats. Nutrition Research 11:10, pages 1197-1208.
Crossref
A. E. Ahmed, R. Smithard & M. Ellis. (2007) Activities of enzymes of the pancreas, and the lumen and mucosa of the small intestine in growing broiler cockerels fed on tannin-containing diets. British Journal of Nutrition 65:2, pages 189-197.
Crossref
B.A. Myers, J. Hathcock, N. Shiekh & B.D. Roebuck. (1991) Effects of dietary soya bean trypsin inhibitor concentrate on initiation and growth of putative preneoplastic lesions in the pancreas of the rat. Food and Chemical Toxicology 29:7, pages 437-443.
Crossref
Y. C. Ge & R. G. H. Morgan. (1990) Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice. American Journal of Anatomy 189:3, pages 207-212.
Crossref
Courtney M. TownsendJrJr, Pomila Singh & James C. Thompson. (1989) Effects of Gastrointestinal Peptides on Gastrointestinal Cancer Growth. Gastroenterology Clinics of North America 18:4, pages 777-791.
Crossref
P R Taylor, R H Dowling, T J Palmer, D C Hanley, G M Murphy, R C Mason & I McColl. (1989) Induction of pancreatic tumours by longterm duodenogastric reflux.. Gut 30:11, pages 1596-1600.
Crossref
Michael R. Gumbmann, Glenda M. Dugan, William L. Spangler, Eugene C. Baker & Joseph J. Rackis. (1989) Pancreatic Response in Rats and Mice to Trypsin Inhibitors from Soy and Potato After Short- and Long-Term Dietary Exposure. The Journal of Nutrition 119:11, pages 1598-1609.
Crossref
CORNELIS B.H.W. LAMERS & JAN B.M.J. JANSEN. (1988) Hormonal manipulation of gastrointestinal cancer by gut peptides. Journal of Gastroenterology and Hepatology 3:4, pages 379-386.
Crossref
Cornelis B.H.W. Lamers & Jan B.M.J. Jansen. (1988) Role of gastrin and cholecystokinin in tumours of the gastrointestinal tract. European Journal of Cancer and Clinical Oncology 24:2, pages 267-273.
Crossref
R.J. Tudor & A.D. Dayan. (1987) Comparative subacute effects of dietary raw soya flour on the pancreas of three species, the marmoset, mouse and rat. Food and Chemical Toxicology 25:10, pages 739-745.
Crossref
John Calam, Joanna C. Bojarski & Caroline J. Springer. (2007) Raw soya-bean flour increases cholecystokinin release in man. British Journal of Nutrition 58:2, pages 175-179.
Crossref
N H Stace, T J Palmer, S Vaja & R H Dowling. (1987) Longterm pancreaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation.. Gut 28:Suppl, pages 265-268.
Crossref
B. D. Roebuck. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 91 107 .
R. G. H. Morgan, R. A. Crass & P. S. Oates. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 81 89 .
Michael R. Gumbmann, William L. Spangler, Glenda M. Dugan & Joseph J. Rackis. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 33 79 .
J. J. Rackis, W. J. Wolf & E. C. Baker. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 299 347 .
J. P. Harwood, L. M. Ausman, N. W. King, P. K. Sehgal, R. J. Nicolosi, I. E. Liener, D. Donatucci & J. Tarcza. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 223 237 .
Irvin E. Liener & Aharon Hasdai. 1986. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods 189 197 .
Lynne M. Ausman, James P. Harwood, Norval W. King, Prabhat K. Sehgal, Robert J. Nicolosi, D. Mark Hegsted, Irvin E. Liener, Dana Donatucci & James Tarcza. (1985) The Effects of Long-Term Soy Protein and Milk Protein Feeding on the Pancreas of Cebus albifrons Monkeys. The Journal of Nutrition 115:12, pages 1691-1701.
Crossref
B. D. Roebuck, Paul V. Kaplita & Denise L. Macmillan. (1985) Interaction of Dietary Fat and Soybean Isolate (SBI) on Azaserine-induced Pancreatic Carcinogenesis. Qualitas Plantarum Plant Foods for Human Nutrition 35:3, pages 323-329.
Crossref
J. J. Rackis, M. R. Gumbmann & I. E. Liener. (1985) The USDA trypsin inhibitor study. I. Background, objectives, and procedural details. Qualitas Plantarum Plant Foods for Human Nutrition 35:3, pages 213-242.
Crossref
Paris Constantinides & Martha Harkey. (1985) Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Archiv A Pathological Anatomy and Histopathology 405:3, pages 285-297.
Crossref
E E McGuinness, R G Morgan & K G Wormsley. (1984) Effects of soybean flour on the pancreas of rats.. Environmental Health Perspectives 56, pages 205-212.
Crossref
Daniel S. Longnecker. 1983. Application of Biological Markers to Carcinogen Testing. Application of Biological Markers to Carcinogen Testing 43 60 .
Rosa A. Crass & R. G. H. Morgan. (2007) The effect of long-term feeding of soya-bean flour diets on pancreatic growth in the rat. British Journal of Nutrition 47:1, pages 119-129.
Crossref
Tim Spector. (1981) COFFEE, SOYA, AND PANCREATIC CANCER. The Lancet 318:8244, pages 474.
Crossref
Parviz M. Pour, Richard G. Runge, Diane Birt, Ralph Gingell, Terence Lawson, Donald Nagel, Lawrence Wallcave & Shahrokh Z. Salmasi. (1981) Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease. Cancer 47:S6, pages 1573-1587.
Crossref
Alberta D. Berton & K. Bernice OdomAlberta D. Berton & K. Bernice Odom. 1980. Smoking and Health. Smoking and Health 1 530 .
David A. Levison. (2005) Carcinoma of the pancreas. The Journal of Pathology 129:4, pages 203-223.
Crossref
D. A. Levison, D. Hopwood, R. G. H. Morgan, G. Coghill, G. A. Milne & K. G. Wormsley. (2005) Oesophageal neoplasia in male wistar rats due to parenteral di(2‐hydroxypropyl)nitrosamine (DHPN): A combined histopathological, histochemical and electron microscopic study. The Journal of Pathology 129:1, pages 31-36.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.