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Scandinavian Journal of Gastroenterology Volume 15, 1980 - Issue 1
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Original Article

Cimetidine for Severe Gastroduodenal Haemorrhage: A Randomized Controlled Trial

H. E. Carstensen Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
S. Bülow Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
O. Hart Hansen Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
B. Hamilton Jakobsen Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
T. Krarup Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
T. Pedersen Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
D. Raahave Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
,
L. B. Svendsen Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
&
O. Backer Dept. of Surgery F, Bispebjerg Hospital, Copenhagen, Denmark
 show all
Pages 103-105 | Received 03 Aug 1979, Accepted 28 Aug 1979, Published online: 23 Feb 2010

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K. Lauritsen & E. Christensen. (1996) The Randomized Controlled Clinical Trial in Gastroenterology: The Danish Contributions from 1970 to 1994. Scandinavian Journal of Gastroenterology 31:sup216, pages 181-198.
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D. Andersen & P. Wara. (1996) Bleeding Ulcer. Scandinavian Journal of Gastroenterology 31:sup216, pages 20-26.
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R. J. Adamek, M. Freitag, W. Opferkuch, G. H. Rühl & M. Wegener. (1994) Intravenous Omeprazole/Amoxicillin and Omeprazole Pretreatment in Helicobacter pylori-Positive Acute Peptic Ulcer Bleeding: A Pilot Study. Scandinavian Journal of Gastroenterology 29:10, pages 880-883.
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C. O'morain, A. Tobin & J. Coghlan. (1988) The Management of Duodenal Ulcer Relapse. Scandinavian Journal of Gastroenterology 23:sup153, pages 89-98.
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J. J. Misiewicz. (1988) Effects of Pirenzepine, Prostaglandin Analogues, and Omeprazole on Gastric Function. Scandinavian Journal of Gastroenterology 23:sup153, pages 2-14.
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M. J. S. Langman. (1987) Drug Treatment of Haematemesis and Melaena. Scandinavian Journal of Gastroenterology 22:sup137, pages 67-70.
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U. Haglund. (1987) Role of Histamine H2 Receptor Antagonists in Non-Operative Management of Gastroduodenal Ulcer Haemorrhage. Scandinavian Journal of Gastroenterology 22:sup137, pages 39-42.
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W. Londong. (1986) Present Status and Future Perspectives of Muscarinic Receptor Antagonists. Scandinavian Journal of Gastroenterology 21:sup125, pages 55-60.
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J. J. Gonvers, S. Realini, A. Bretholz, M. Voirol, J. Arnold, R. Birchler, J. B. Ollyo, J. Guyot & Y. Capitaine. (1986) Gastric Ulcer: A Double-Blind Comparison of 100 Mg Pirenzepine plus Antacid Versus 800 Mg Cimetidine plus Antacid. Scandinavian Journal of Gastroenterology 21:7, pages 806-808.
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A. Falk, N. Darle, U. Haglund & A. Törnqvist. (1985) Histamine2-Receptor Antagonists in Gastroduodenal Ulcer Haemorrhage. Scandinavian Journal of Gastroenterology 20:sup110, pages 95-100.
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G. G. Birnie, E. M. M. Quigley, G. Allan, B. M. Goudie, F. Kennedy, K. E. L. McColl, C. MacKay, G. D. Murray, W. Murray, R. Pickard, B. Sugden & G. Watkinson. (1984) A Double-Blind Randomized Trial of Cimetidine in Acute Upper Gastrointestinal Bleeding. Scandinavian Journal of Gastroenterology 19:7, pages 885-888.
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M.Michael Wolfe & George Sachs. (2000) Acid suppression: Optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology 118:2, pages S9-S31.
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Robert M Dettmer, Thomas H Riley, Floyd Byfield & Peter H R Green. (1999) The Use of Intravenous H2-Receptor Antagonists in A Tertiary Care Hospital. American Journal of Gastroenterology 94:12, pages 3473-3477.
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HIROKO NEBIKI, TETSUO ARAKAWA, KAZUHIDE HIGUCHI & KENZO KOBAYASHI. (1997) Quality of ulcer healing influences the relapse of gastric ulcers in humans. Journal of Gastroenterology and Hepatology 12:2, pages 109-114.
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W. L. PETERSON. (2008) The role of acid in upper gastrointestinal haemorrhage due to ulcer and stress-related mucosal damage. Alimentary Pharmacology & Therapeutics 9, pages 43-46.
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Charles S. LieberLawrence Feinman, Mark A. Korsten & Charles S. Lieber. 1992. Medical and Nutritional Complications of Alcoholism. Medical and Nutritional Complications of Alcoholism 307 340 .
G. Bianchi Porro, M. Lazzaroni, G. Mazzacca, G. Piai, P.R. Dal Monte, E. Colombo, A. Ferrara, A. Prada, A. Battocchia, R. Venturelli, V. Benvestito, L. Cipolletta, G. Iaquinto, G.M. Claar, L. Santoro, R. Cremonini & G. Bensi. (2016) Combined Ranitidine and Pirenzepine in the Treatment of Duodenal Ulcer: A Multicentre Double-Blind Study Using Endoscopy. Journal of International Medical Research 18:5, pages 341-350.
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Walter L. Peterson. (1990) Bleeding Peptic Ulcer. Gastroenterology Clinics of North America 19:1, pages 155-170.
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Ralph I. Horwitz. (1987) Complexity and contradiction in clinical trial research. The American Journal of Medicine 82:3, pages 498-510.
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Rory Collins & Michael Langman. (1985) Treatment with Histamine H 2 Antagonists in Acute Upper Gastrointestinal Hemorrhage . New England Journal of Medicine 313:11, pages 660-666.
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L Ivarsson, N Darle & O Lundgren. (1984) Effect of cimetidine on augmented gastric blood flow in duodenal ulcer patients.. Gut 25:10, pages 1093-1099.
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D. L. Carr-Locke, D. Taverner & A. C. Wicks. (1984) Cimetidine therapy does not prevent rebleeding from peptic ulceration.. Postgraduate Medical Journal 60:704, pages 400-403.
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Gary Zuckerman, Richard Welch, Adrian Douglas, Rebecca Troxell, Sidney Cohen, Stanley Lorber, Clifford Melnyk, Charles Bliss, Philip Christiansen & Fred Kern. (1984) Controlled trial of medical therapy for active upper gastrointestinal bleeding and prevention of rebleeding. The American Journal of Medicine 76:3, pages 361-366.
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David Barer, Alan Ogilvie, David Henry, Michael Dronfield, David Coggon, Shelagh French, Susan Ellis, Michael Atkinson & Michael Langman. (1983) Cimetidine and Tranexamic Acid in the Treatment of Acute Upper-Gastrointestinal-Tract Bleeding. New England Journal of Medicine 308:26, pages 1571-1575.
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H. Peerenboom, E. Keck, H. K. Kley, H. L. Krüskemper, G. Strohmeyer, J. Happ, M. Philipp, U. Cordes, M. Schäfer, S. Störkel, K. Hahn, J. Beyer, E. Jungmann, P.-H Althoff, W. Magnet, F. Schulz, K. H. Usadel, K. Schöffling, H. L. Fehm, S. H. Pal, J. Homoki, W. Maier, C. Herfarth, E. F. Pfeiffer, R. Grün, A. Scheuer, K. Ehlenz, W. D. Heine, M. Grün, E. Schifferdecker, F. A. Horster, D. Keltz, W. Raschke, H.-G. Hoff, R. Windeck, D. Reinwein, A. Wirth, P. Björntorp, H. Schatz, E. Mäser, J. Teuber, O. Schröder, S. Grebe, K. Federlin, O. A. Müller, B. Leisner, U. Löhrs, C. R. Pickardt, P. C. Scriba, K. Helmke, U. Loos, R. Grau, F. Keck, L. Duntas, H. Dirks, G. Hintze, H. Schicha, D. Emrich, G. Mayer, H. C. Blossey, J. Köbberling, R. Bressel, C. Rosak, H. M. Brecht, G. Benker, W. D. Zäh, L. Tharandt, M. Wicklmayr, G. Dietze, B. Günther, R. Geiger, H. Brunnbauer, G. Heberer, H. Mehnert, H. H. Bartsch, W. D. Hetzei, C. H. Unckel, K. Mann, R. Gilch, P. Haidl, T. Hellmann, H. J. Karl, W. Londong, V. Londong, R. Mühlbauer, A. König, H. Etzrodt, W. Beischer, V. Maier, J. Rosenthal, H.-C. Scholz, H. Liebau, R.-D. Hesch, U. Schweigart, P. Bottermann, R. Ermler, P. Burmeister, H. Neumann, H. Fabricius, R. Engelhardt, B. Allolio, W. Winkelmann, H. Brosch, F. X. Hipp & B. Schröder. 1981. Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin 563 640 .
C. G. Meredith, M. C. Kennedy, D. N. Wade, M. V. Sweeten, D. J. Byrnes, D. J. Frommer & W. B. Hennessy. (2008) Cimetidine and Acute Upper Gastrointestinal Bleeding: A Double‐blind Controlled Trial. Australian and New Zealand Journal of Medicine 10:6, pages 611-614.
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