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Original Article

High Incidence of Extrahepatic Carcinomas in Idiopathic Hemochromatosis

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Pages 733-736 | Received 10 Feb 1980, Accepted 27 Feb 1980, Published online: 23 Feb 2010

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Shinya Toyokuni. (2002) Iron and carcinogenesis: from Fenton reaction to target genes. Redox Report 7:4, pages 189-197.
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Marco T. Núñez, Victoria Tapia, Shinya Toyokuni & Shigeru Okada. (2001) Iron-induced oxidative damage in colon carcinoma (caco-2) cells. Free Radical Research 34:1, pages 57-68.
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J. Kaczynski, G. Hansson, G. Norkrans & S. Wallerstedt. (1991) Lack of Correlation Between Hepatitis B Virus Infection and the Increasing Incidence of Primary Liver Cancer in Sweden. Acta Oncologica 30:7, pages 811-813.
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Gordon D. McLaren, W. Angus Muir, Robert W. Kellermeyer & Allan Jacobs. (1983) Iron Overload Disorders: Natural History, Pathogenesis, Diagnosis, and Therapy. CRC Critical Reviews in Clinical Laboratory Sciences 19:3, pages 205-266.
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Articles from other publishers (34)

Chang-Kyu Oh & Yuseok Moon. (2019) Dietary and Sentinel Factors Leading to Hemochromatosis. Nutrients 11:5, pages 1047.
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Nathan Jones, Joseph Ashmore, Sang Lee, John Richie, Philip Lazarus & Joshua Muscat. (2015) Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers 7:4, pages 2386-2396.
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Henryk DancygierClaus Niederau. 2010. Clinical Hepatology. Clinical Hepatology 1045 1070 .
Charronne F. Davis & M. Tevfik Dorak. 2010. Environmental Factors, Genes, and the Development of Human Cancers. Environmental Factors, Genes, and the Development of Human Cancers 445 475 .
Shinya Toyokuni. (2009) Role of iron in carcinogenesis: Cancer as a ferrotoxic disease. Cancer Science 100:1, pages 9-16.
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A. Kalt, A. Wagner, S. Zeuzem, W. Tilgen & J. Reichrath. (2005) Generalisierte Hyperpigmentierung und Acanthosis nigricans maligna bei einem Patienten mit hereditärer Hämochromatose und MagenkarzinomGeneralized hyperpigmentation and malignant acanthosis nigricans in a patient with hereditary hemochromatosis and gastric cancer. Der Hautarzt 56:6, pages 581-585.
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James C Barton, Luigi F Bertoli & Ronald T Acton. (2004) HFE C282Y and H63D in adults with malignancies in a community medical oncology practice. BMC Cancer 4:1.
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Kris V. Kowdley. (2004) Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 127:5, pages S79-S86.
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Maria Elmberg, Rolf Hultcrantz, Anders Ekbom, Lena Brandt, Sigvard Olsson, Rolf Olsson, Stefan Lindgren, Lars Lööf, Per Stål, Sven Wallerstedt, Sven Almer, Hanna Sandberg-Gertzén & Johan Askling. (2003) Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology 125:6, pages 1733-1741.
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Shinya Toyokuni. 2003. Redox-Genome Interactions in Health and Disease. Redox-Genome Interactions in Health and Disease.
N. J. Shaheen, L. M. Silverman, T. Keku, L. B. Lawrence, E. M. Rohlfs, C. F. Martin, J. Galanko & R. S. Sandler. (2003) Association Between Hemochromatosis (HFE) Gene Mutation Carrier Status and the Risk of Colon Cancer. JNCI Journal of the National Cancer Institute 95:2, pages 154-159.
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Graeme A Macdonald, Jabsar Tarish, Vicki Jl Whitehall, Sally J M, George D MellickRon L Buttenshaw, Anthony G JohnsonJoanne Young & Barbara A Leggett. (2001) No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation. Journal of Gastroenterology and Hepatology 14:12, pages 1188-1191.
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Marcelo Hermes-Lima, Eva Nagy, Prem Ponka & Herbert M Schulman. (1998) The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against OH-mediated strand breaks. Free Radical Biology and Medicine 25:8, pages 875-880.
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Shigeru Okada. (1998) Iron and carcinogenesis in laboratory animals and humans: A mechanistic consideration and a review of literature. International Journal of Clinical Oncology 3:4, pages 191-203.
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Gürsel Soybir, Ferda Köksoy, Hülya Koyuncu, Orhan Yalçin, Hakki Köse & Cemalettin Topuzlu. (1998) Chemoprevention of DMBA-induced mammary gland carcinogenesis – preventive effects of free oxygen radical scavengers. Breast Cancer Research and Treatment 50:2, pages 193-199.
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Mieko Kimura & Tomio Hirohata. 1997. Food Factors for Cancer Prevention. Food Factors for Cancer Prevention 389 395 .
David L. Witte, William H. Crosby, Corwin Q. Edwards, Virgil F. Fairbanks & Frank A. Mitros. (1996) Hereditary hemochromatosis. Clinica Chimica Acta 245:2, pages 139-200.
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Shinya Toyokuni. (1996) Iron-induced carcinogenesis: The role of redox regulation. Free Radical Biology and Medicine 20:4, pages 553-566.
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Ann W. Hsing, Joseph K. McLaughlin, Jorgcn H. Olsen, Lenc Mellemkjar, Sholom Wacholder & Joseph F. FraumeniJr.Jr.. (2006) Cancer risk following primary hemochromatosis: A population‐based cohort study in Denmark. International Journal of Cancer 60:2, pages 160-162.
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C. Niederau, W. Stremmel & G.W.W. Strohmeyer. (1994) 7 Clinical spectrum and management of haemochromatosis. Baillière's Clinical Haematology 7:4, pages 881-901.
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Claus Niederau, Georg Strohmeyer & Wolfgang Stremmel. 1994. Progress in Iron Research. Progress in Iron Research 293 302 .
Shinya Toyokuni & Jose-Luis Sagripanti. (1993) Induction of oxidative single- and double-strand breaks in DNA by ferric citrate. Free Radical Biology and Medicine 15:2, pages 117-123.
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Hie-Won L. Hann, Mark W. Stahlhut, Raphael Rubin & Willis C. Maddrey. (1992) Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice. Cancer 70:8, pages 2051-2056.
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Eugene D. Weinberg. (1992) Roles of iron in neoplasia. Biological Trace Element Research 34:2, pages 123-140.
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Silvia Fargion, Clara Mandelli, Alberto Piperno, Bruno Cesana, Anna L. Fracanzani, Mirella Fraquelli, Paolo A. Bianchi, Gemino Fiorelli & Dario Conte. (1992) Surival and prognostic factors in 212 Italian patients with genetic hemochromatosis. Hepatology 15:4, pages 655-659.
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Christopher F. Bryan, Stephen H. Leech, Prem Kumar, Richard Gaumer, Brian Bozelka & Jane Morgan. (1991) The Immune System in Hereditary Hemochromatosis: A Quantitative and Functional Assessment of the Cellular Arm. The American Journal of the Medical Sciences 301:1, pages 55-61.
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Norman D. Grace. 1989. Current Perspectives in Hepatology. Current Perspectives in Hepatology 287 297 .
Georg Strohmeyer, Claus Niederau & Wolfgang Stremmel. (1988) Survival and Causes of Death in Hemochromatosis.. Annals of the New York Academy of Sciences 526:1 Hemochromatos, pages 245-257.
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M.F. Good, L.W. Powell & J.W. Halliday. (1988) Iron status and cellular immune competence. Blood Reviews 2:1, pages 43-49.
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Robin A. Bradbear, June W. Halliday, Mark L. Bassett, W. Graham Cooksley & Lawrie W. Powell. 1987. Neoplasms of the Liver. Neoplasms of the Liver 189 197 .
C. Niederau, W. Stremmel & G. Strohmeyer. 1987. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics 117 148 .
Lawrie W. Powell. (1986) Hemochromatosis: Precirrhotic therapy restores normal life expectancy. Hepatology 6:6, pages 1423-1425.
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Claus Niederau, Rudolf Fischer, Amnon Sonnenberg, Wolfgang Stremmel, Hans J. Trampisch & Georg Strohmeyer. (1985) Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis. New England Journal of Medicine 313:20, pages 1256-1262.
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Raymond J. ShambergerRaymond J. Shamberger. 1984. Nutrition and Cancer. Nutrition and Cancer 195 262 .

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