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Original Article

Effect of Metronidazole and Sulfasalazine on the Normal Human Faecal Flora

Pages 587-592 | Received 17 Jun 1980, Accepted 25 Sep 1980, Published online: 22 Feb 2010

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S. Maraki, A.N. Margioris, E. Orfanoudaki, Y. Tselentis, E. Koumantakis, D.P. Kontoyiannis, M. Rovithi & G. Samonis. (2003) Effects of Doxycycline, Metronidazole and their Combination on Candida species Colonization of the Human Oropharynx, Intestinal Lumen and Vagina. Journal of Chemotherapy 15:4, pages 369-373.
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M. Katoulp, A. S. Erhardt-Bennet, I. Kühn, B. Kollberg & R. Möllby. (1992) Metabolic Capacity and Pathogenic Properties of the Intestinal Coliforms in Patients with Ulcerative Colitis. Microbial Ecology in Health and Disease 5:5, pages 245-255.
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H. Sandberg Gertzen, J. Kjellander, B. Sundberg-Gillar & G. Jarrnerot. (1985) In Vitro Effects of Sulphasalazine, Azodisal Sodium, and Their Metabolites on Clostridium difficile and Some Other Faecal Bacteria. Scandinavian Journal of Gastroenterology 20:5, pages 607-612.
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Articles from other publishers (31)

Volodymyr Chernyavskiy, Mariia Postemska & Dmytro Reshotko. (2022) Microbiome and Leaky Gut Syndrome as Extra-articular Factors for Rheumatoid Arthritis. Family medicine. European practices:4, pages 35-42.
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Ting Zhao, Yuanyuan Wei, Youyang Zhu, Zhaohu Xie, Qingshan Hai, Zhaofu Li & Dongdong Qin. (2022) Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities. Frontiers in Immunology 13.
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Mario M. Zaiss, Hsin-Jung Joyce Wu, Daniele Mauro, Georg Schett & Francesco Ciccia. (2021) The gut–joint axis in rheumatoid arthritis. Nature Reviews Rheumatology 17:4, pages 224-237.
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Frederikke Schønfeldt Troelsen & Susan Jick. (2019) Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case–Control Study in the UK Clinical Practice Research Datalink. Inflammatory Bowel Diseases.
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Irène Mangin, Flore Dossou-Yovo, Christophe Lévêque, Marie-Vincent Dessoy, Olivier Sawoo, Antonia Suau & Philippe Pochart. (2018) Oral administration of viable Bifidobacterium pseudolongum strain Patronus modified colonic microbiota and increased mucus layer thickness in rat. FEMS Microbiology Ecology 94:11.
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Kenneth F. Blount, Cynthia Megyola, Mark Plummer, David Osterman, Tim O'Connell, Paul Aristoff, Cheryl Quinn, R. Alan Chrusciel, Toni J. Poel, Heinrich J. Schostarez, Catherine A. Stewart, Daniel P. Walker, Peter G. M. Wuts & Ronald R. Breaker. (2015) Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora. Antimicrobial Agents and Chemotherapy 59:9, pages 5736-5746.
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Jerod L. Nagel & David M. Aronoff. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 350 357.e2 .
Ryan Ungaro, Charles N Bernstein, Richard Gearry, Anders Hviid, Kaija-Leena Kolho, Matthew P Kronman, Souradet Shaw, Herbert Van Kruiningen, Jean-Frédéric Colombel & Ashish Atreja. (2014) Antibiotics Associated With Increased Risk of New-Onset Crohn’s Disease But Not Ulcerative Colitis: A Meta-Analysis. American Journal of Gastroenterology 109:11, pages 1728-1738.
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Dorothy F. Newton, Sandra Macfarlane & George T. Macfarlane. (2013) Effects of Antibiotics on Bacterial Species Composition and Metabolic Activities in Chemostats Containing Defined Populations of Human Gut Microorganisms. Antimicrobial Agents and Chemotherapy 57:5, pages 2016-2025.
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David J.A. Jenkins, Cyril W.C. Kendall, Maryam Hamidi, Edward Vidgen, Dorothea Faulkner, Tina Parker, Nalini Irani, Thomas M.S. Wolever, Ignatius Fong, Peter Kopplin, Philip W. Connelly, Andrew Onderdonk & A. Venket Rao. (2005) Effect of antibiotics as cholesterol-lowering agents. Metabolism 54:1, pages 103-112.
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Gjalt W. WELLING, Alida C. M. WILDEBOER-VELOO, Nicole W. M. LEMMERS, Runlan TIAN, Qiang GAO, Gerwin C. RAANGS, Rudi H. J. TONK, Gijsbert J. JANSEN, John E. DEGENER & Hermie J. M. HARMSEN. (2002) FluorescentIn Situ Hybridization (FISH) as a Tool in Intestinal Bacteriology. Bioscience and Microflora 20:4, pages 115-120.
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Itzhak Brook. (2001) The Effects of Amoxicillin Therapy on Skin Flora in Infants. Pediatric Dermatology 17:5, pages 360-363.
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Jyrki Tillonen, Satu Väkeväinen, Ville Salaspuro, Yong Zhang, Merja Rautio, Hannele Jousimies‐Somer, Kai Lindros & Mikko Salaspuro. (2006) Metronidazole Increases Intracolonic but Not Peripheral Blood Acetaldehyde in Chronic Ethanol‐Treated Rats. Alcoholism: Clinical and Experimental Research 24:4, pages 570-575.
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Jyrki Tillonen, Satu V??kev??inen, Ville Salaspuro, Yong Zhang, Merja Rautio, Hannele Jousimies-Somer, Kai Lindros & Mikko Salaspuro. (2000) Metronidazole Increases Intracolonic but Not Peripheral Blood Acetaldehyde in Chronic Ethanol-Treated Rats. Alcoholism: Clinical and Experimental Research 24:4, pages 570-575.
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H. J. Freeman. (1993) Sulphasalazine-induced forms of colitis. InflammoPharmacology 2:3, pages 301-305.
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J Ejderhamn, J J Rafter & B Strandvik. (1991) Faecal bile acid excretion in children with inflammatory bowel disease.. Gut 32:11, pages 1346-1351.
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Stevan W. Djuric, Timothy S. Gaginella, Donald J. Fretland & Peter H. Jones. 1989. 167 175 .
Paul J. Honig, Bruce Gribetz, James J. Leyden, Kenneth J. McGinley & Lizabeth A. Burke. (1988) Amoxicillin and diaper dermatitis. Journal of the American Academy of Dermatology 19:2, pages 275-279.
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Robert S. Pinals. (1988) Sulfasalazine in the rheumatic disease. Seminars in Arthritis and Rheumatism 17:4, pages 246-259.
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B. M. Peskar, K. W. Dreyling, B. May, K. Schaarschmidt & H. Goebell. (1987) Possible mode of action of 5-aminosalicylic acid. Digestive Diseases and Sciences 32:S12, pages S51-S56.
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J. R. S. Hoult. 1987. Side-Effects of Anti-Inflammatory Drugs. Side-Effects of Anti-Inflammatory Drugs 223 234 .
F. Schulze & P. Kielstein. (1987) Zum Einfluß des Metronidazols auf die Gastrointestinalflora von Läuferschweinen. Food / Nahrung 31:5-6, pages 481-484.
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Robert S. Pinals, Stanley B. Kaplan, Jeffrey G. Lawson & Bonnie Hepburn. (2005) A double‐blind, placebo‐controlled trial. Arthritis & Rheumatism 29:12, pages 1427-1434.
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N. S. Ambrose, R. N. Allan, M. R. B. Keighley, D. W. Burdon, Denise Youngs, P. Barnes & J. E. Lennard-Jones. (1985) Antibiotic therapy for treatment in relapse of intestinal Crohn's disease. Diseases of the Colon & Rectum 28:2, pages 81-85.
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J. P. van de Merwe. (1984) The human faecal flora and Crohn’s disease. Antonie van Leeuwenhoek 50:5-6, pages 691-700.
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Josep M. Piqué, Miquel Pallarés, Eulalia Cusó, Josep Vilar-Bonet & Miquel A. Gassull. (1984) Methane production and colon cancer. Gastroenterology 87:3, pages 601-605.
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Donald H. Burr & Hiroshi Sugiyama. (1983) Metronidazole-induced susceptibility of adult mice to intestinalClostridium botulinum colonization. Current Microbiology 9:5, pages 275-278.
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C Greenfield, J R Aguilar Ramirez, R E Pounder, T Williams, M Danvers, S R Marper & P Noone. (1983) Clostridium difficile and inflammatory bowel disease.. Gut 24:8, pages 713-717.
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J. G. H. Ruseler-Van Embden & H. C. Both-Patoir. (1983) Effect of selective media on recovery of obligately anaerobic gram-negative rods from human faeces. Antonie van Leeuwenhoek 49:4-5, pages 411-416.
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SYDNEY M. FINEGOLD, GLENN E. MATHISEN & W. LANCE GEORGE. 1983. Human Intestinal Microflora in Health and Disease. Human Intestinal Microflora in Health and Disease 355 446 .
J. G. H. Ruseler-van Embden & H. C. Both-Patoir. (1983) Anaerobic gram-negative faecal flora in patients with Crohn's Disease and healthy subjects. Antonie van Leeuwenhoek 49:2, pages 125-132.
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