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Original Article

The Effect of Trimipramine in Patients with the Irritable Bowel Syndrome

A Double-Blind Study

, , , &
Pages 871-875 | Received 02 Jan 1982, Accepted 09 Feb 1982, Published online: 19 Feb 2010

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Read on this site (3)

Johannes Gade & Fqul Thorn. (1989) Paraghurt for Patients with Irritable Bowel Syndrome: A Controlled Clinical Investigation from General Practice. Scandinavian Journal of Primary Health Care 7:1, pages 23-26.
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Einar Krag. (1985) Irritable Bowel Syndrome: Current Concepts and Future Trends. Scandinavian Journal of Gastroenterology 20:sup109, pages 107-115.
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J. Myren, B. Løvland, S.-E. Larssen & S. Larsen. (1984) A Double-Blind Study of the Effect of Trimipramine in Patients with the Irritable Bowel Syndrome. Scandinavian Journal of Gastroenterology 19:6, pages 835-843.
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Articles from other publishers (75)

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Sun Jung Oh, Will Takakura & Ali Rezaie. (2020) Shortcomings of Trials Assessing Antidepressants in the Management of Irritable Bowel Syndrome: A Critical Review. Journal of Clinical Medicine 9:9, pages 2933.
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Christopher J Black, Yuhong Yuan, Christian P Selinger, Michael Camilleri, Eamonn M M Quigley, Paul Moayyedi & Alexander C Ford. (2020) Efficacy of soluble fibre, antispasmodic drugs, and gut–brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. The Lancet Gastroenterology & Hepatology 5:2, pages 117-131.
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Alexander C. Ford, Brian E. Lacy, Lucinda A. Harris, Eamonn M.M. Quigley & Paul Moayyedi. (2019) Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis. American Journal of Gastroenterology 114:1, pages 21-39.
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Alexander C. Ford, Paul Moayyedi, William D. Chey, Lucinda A. Harris, Brian E. Lacy, Yuri A. Saito & Eamonn M. M. Quigley. (2018) American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome. American Journal of Gastroenterology 113, pages 1-18.
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Chen Xie, Yurong Tang, Yunfeng Wang, Ting Yu, Yun Wang, Liuqin Jiang & Lin Lin. (2015) Efficacy and Safety of Antidepressants for the Treatment of Irritable Bowel Syndrome: A Meta-Analysis. PLOS ONE 10:8, pages e0127815.
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Lin Chang, Anthony Lembo & Shahnaz Sultan. (2014) American Gastroenterological Association Institute Technical Review on the Pharmacological Management of Irritable Bowel Syndrome. Gastroenterology 147:5, pages 1149-1172.e2.
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Alexander C Ford, Paul Moayyedi, Brian E Lacy, Anthony J Lembo, Yuri A Saito, Lawrence R Schiller, Edy E Soffer, Brennan M R Spiegel & Eamonn M M Quigley. (2014) American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation. American Journal of Gastroenterology 109, pages S2-S26.
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Katy E. Trinkley & Milap C. Nahata. (2014) Medication Management of Irritable Bowel Syndrome. Digestion 89:4, pages 253-267.
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Eric Shah, Sharon Kim, Kelly Chong, Anthony Lembo & Mark Pimentel. (2012) Evaluation of Harm in the Pharmacotherapy of Irritable Bowel Syndrome. The American Journal of Medicine 125:4, pages 381-393.
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Lisa Ruepert, A Otto Quartero, Niek J de Wit, Geert J van der Heijden, Gregory Rubin & Jean WM Muris. (2011) Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews 2013:3.
Crossref
K. E. Trinkley & M. C. Nahata. (2011) Treatment of irritable bowel syndrome. Journal of Clinical Pharmacy and Therapeutics 36:3, pages 275-282.
Crossref
Joong Goo KwonKyung Sik ParkJung Ho ParkJae Myung ParkCheol Hee ParkKwang Jae LeeHyo-Jin ParkJong Chul Rhee. (2011) Guidelines for the Treatment of Irritable Bowel Syndrome. The Korean Journal of Gastroenterology 57:2, pages 82.
Crossref
A. C. Ford & P. Moayyedi. (2010) Meta‐analysis: factors affecting placebo response rate in the irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 32:2, pages 144-158.
Crossref
Octavia Pickett-Blakely, Linda A. Lee & Gerald Mullin. 2010. Principles of Gender-Specific Medicine. Principles of Gender-Specific Medicine 347 356 .
Brian E. Lacy, Kirsten Weiser & Ryan De Lee. (2009) Review: The treatment of irritable bowel syndrome. Therapeutic Advances in Gastroenterology 2:4, pages 221-238.
Crossref
Heitham Abdul-Baki, Ihab I El Hajj, Lara ElZahabi, Cecilio Azar, Elie Aoun, Assaad Skoury, Hani Chaar & Ala I Sharara. (2009) A randomized controlled trial of imipramine in patients with irritable bowel syndrome. World Journal of Gastroenterology 15:29, pages 3636.
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Lawrence J. Brandt, William D. Chey, Amy E. Foxx-Orenstein, Eamonn M.M. Quigley, Lawrence R. Schiller, Philip S. Schoenfeld, Brennan M. Spiegel, Nicholas J. Talley & Paul Moayyedi. (2009) An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome. American Journal of Gastroenterology 104, pages S8-S35.
Crossref
H. VAHEDI, S. MERAT, S. MOMTAHEN, A. S. KAZZAZI, N. GHAFFARI, G. OLFATI & R. MALEKZADEH. (2008) Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 27:8, pages 678-684.
Crossref
Bénédicte Verdu, Isabelle Decosterd, Thierry Buclin, Friedrich Stiefel & Alexandre Berney. (2008) Antidepressants for the Treatment of Chronic Pain. Drugs 68:18, pages 2611-2632.
Crossref
Tom Kraft & David Kraft. (2007) Irritable bowel syndrome: symptomatic treatment versus integrative psychotherapy. Contemporary Hypnosis 24:4, pages 161-177.
Crossref
Mihaela Podovei & Braden Kuo. (2006) Irritable Bowel Syndrome: A Practical Review. Southern Medical Journal 99:11, pages 1235-1242.
Crossref
J. TACK, M. FRIED, L. A. HOUGHTON, J. SPICAK & G. FISHER. (2006) Systematic review: the efficacy of treatments for irritable bowel syndrome - a European perspective. Alimentary Pharmacology and Therapeutics 24:2, pages 183-205.
Crossref
R. HEADING, K. BARDHAN, S. HOLLERBACH, A. LANAS & G. FISHER. (2006) Systematic review: the safety and tolerability of pharmacological agents for treatment of irritable bowel syndrome - a European perspective. Alimentary Pharmacology and Therapeutics 24:2, pages 207-236.
Crossref
s. m. patel, w. b. stason, a. legedza, s. m. ock, t. j. kaptchuk, l. conboy, k. canenguez, j. k. park, e. kelly, e. jacobson, c. e. kerr & a. j. lembo. (2005) The placebo effect in irritable bowel syndrome trials: a meta-analysis1. Neurogastroenterology and Motility 17:3, pages 332-340.
Crossref
Philip Schoenfeld. (2005) Efficacy of Current Drug Therapies in Irritable Bowel Syndrome: What Works and Does Not Work. Gastroenterology Clinics of North America 34:2, pages 319-335.
Crossref
A Otto Quartero, Villy Meiniche-Schmidt, Jean Muris, Gregory Rubin & Niek de Wit. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
D. Lesbros‐Pantoflickova, P. Michetti, M. Fried, C. Beglinger & A. L. Blum. (2004) Meta‐analysis: the treatment of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 20:11-12, pages 1253-1269.
Crossref
Albena Halpert & Douglas A Drossman. 2004. Evidence‐based Gastroenterology and Hepatology. Evidence‐based Gastroenterology and Hepatology 265 283 .
Nicholas J. Talley. (2003) Evaluation of drug treatment in irritable bowel syndrome. British Journal of Clinical Pharmacology 56:4, pages 362-369.
Crossref
D BA Silk. (2003) Management of irritable bowel syndrome. European Journal of Gastroenterology & Hepatology 15:6, pages 679-696.
Crossref
T. O. C. Kilkens, A. Honig, N. Rozendaal, M. A. Van Nieuwenhoven & R.-J. M. Brummer. (2003) Serotonergic modulators in the treatment of irritable bowel syndrome - influence on psychiatric and gastrointestinal symptoms. Alimentary Pharmacology & Therapeutics 17:1, pages 43-51.
Crossref
Prakash S. Masand, Sanjay Gupta, Thomas L. Schwartz, David Kaplan, Subhdeep Virk, Ahmad Hameed & Kari Lockwood. (2002) Does a Preexisting Anxiety Disorder Predict Response to Paroxetine in Irritable Bowel Syndrome?. Psychosomatics 43:6, pages 451-455.
Crossref
M. Camilleri, R. C. Heading & W. G. Thompson. (2002) Consensus report: clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 16:8, pages 1407-1430.
Crossref
William L. Hasler. (2001) Augmented visceral perception. Current Treatment Options in Gastroenterology 4:4, pages 339-349.
Crossref
Richard Lea & Peter J. Whorwell. (2001) Diarrhea- and constipation-predominant irritable bowel syndrome. Current Treatment Options in Gastroenterology 4:4, pages 299-308.
Crossref
Michael Camilleri. (2001) Management of the irritable bowel syndrome. Gastroenterology 120:3, pages 652-668.
Crossref
William C Orr, Sigrid Elsenbruch & Michael J Harnish. (2000) Autonomic Regulation of Cardiac Function During Sleep in Patients With Irritable Bowel Syndrome. American Journal of Gastroenterology 95:10, pages 2865-2871.
Crossref
Bernard Coulie & Michael Camilleri. (2000) New therapies for functional bowel diseases. Current Gastroenterology Reports 2:5, pages 355-363.
Crossref
Jeffrey L Jackson, Patrick G O’Malley, Glen Tomkins, Erin Balden, James Santoro & Kurt Kroenke. (2000) Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis11The opinions in this article represent those of the authors and are not to be construed, in any way, to represent those of the U.S. Army or the Department of Defense.. The American Journal of Medicine 108:1, pages 65-72.
Crossref
Michael Camilleri. (1999) Therapeutic approach to the patient with irritable bowel syndrome. The American Journal of Medicine 107:5, pages 27-32.
Crossref
M. Camilleri. (1999) Review article: clinical evidence to support current therapies of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 13, pages 48-53.
Crossref
Bradley N. Gaynes & Douglas A. Drossman. (2014) The Role of the Mental Health Professional in the Assessment and Management of Irritable Bowel Syndrome. CNS Spectrums 4:4, pages 19-30.
Crossref
. (1999) Alimentary Pharmacology & Therapeutics. Alimentary Pharmacology & Therapeutics 13, pages 0-0.
Crossref
Fabrizio De Ponti & Juan-Ramon Malagelada. (1998) Functional Gut Disorders. Pharmacology & Therapeutics 80:1, pages 49-88.
Crossref
MANI RAJAGOPALAN, GEORGE KURIAN & JACOB JOHN. (2008) Symptom relief with amitriptyline in the Irritable Bowel syndrome. Journal of Gastroenterology and Hepatology 13:7, pages 738-741.
Crossref
L. A. Houghton, J. Rogers, P. J. Whorwell, F. C. Campbell, N. S. Williams & J. Goka. (2003) Zamifenacin (UK‐76, 654), a potent gut M 3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome . Alimentary Pharmacology & Therapeutics 11:3, pages 561-568.
Crossref
Amanda J. Gruber, James I. Hudson & Harrison G. PopeJrJr. (1996) THE MANAGEMENT OF TREATMENT-RESISTANT DEPRESSION IN DISORDERS ON THE INTERFACE OF PSYCHIATRY AND MEDICINE. Psychiatric Clinics of North America 19:2, pages 351-369.
Crossref
Judith Bammert Adams, Robert E. Pyke, J. Costa, Neal R. Cutler, Edward Schweizer, Charles S. Wilcox, Peter G. Wisselink, Martha Greiner, Mark W. Pierce & Atul C. Pande. (1995) A Double-Blind, Placebo-Controlled Study of a CCK-B Receptor Antagonist, CI-988, in Patients With Generalized Anxiety Disorder. Journal of Clinical Psychopharmacology 15:6, pages 428-434.
Crossref
D. A. Gorard, G. W. Libby & M. J. G. Farthing. (1995) Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome. Digestive Diseases and Sciences 40:1, pages 86-95.
Crossref
Ray E. Clouse. (1994) Antidepressants for functional gastrointestinal syndromes. Digestive Diseases and Sciences 39:11, pages 2352-2363.
Crossref
R. E. CLOUSE, P. J. LUSTMAN, R. A. GEISMAN & D. H. ALPERS. (2007) Antidepressant therapy in 138 patients with irritable bowel syndrome: a five‐year clinical experience. Alimentary Pharmacology & Therapeutics 8:4, pages 409-416.
Crossref
D. A. GORARD, G. W. LIBBY & M. J. G. FARTHING. (2007) Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 8:2, pages 159-166.
Crossref
Edward A. Walker, Mark D. Sullivan & Morton A. Stenchever. (1993) USE OF ANTIDEPRESSANTS IN THE MANAGEMENT OF WOMEN WITH CHRONIC PELVIC PAIN. Obstetrics and Gynecology Clinics of North America 20:4, pages 743-751.
Crossref
Ray E. Clouse. (1992) Psychopharmacologic approaches to therapy for chest pain of presumed esophageal origin. The American Journal of Medicine 92:5, pages S106-S113.
Crossref
Elizabeth O'Keefe & Nicholas J. Talley. (1991) The Irritable Bowel Syndrome in the Elderly. Gastroenterology Clinics of North America 20:2, pages 369-390.
Crossref
Elizabeth O’Keefe & Nicholas J. Talley. (1991) Irritable Bowel Syndrome in the Elderly. Clinics in Geriatric Medicine 7:2, pages 265-286.
Crossref
R. N. RATNAIKE. (1990) Diarrhoea in the elderly: epidemiological and aetiological factors. Journal of Gastroenterology and Hepatology 5:4, pages 449-458.
Crossref
G Bleijenberg & J F Fennis. (1989) Anamnestic and psychological features in diagnosis and prognosis of functional abdominal complaints: a prospective study.. Gut 30:8, pages 1076-1081.
Crossref
William J. Kinnier, James F. Kachur, Vicki H. Audia & Carl Kaiser. (2006) Irritable bowel syndrome: Present and prospective pharmacological intervention. Medicinal Research Reviews 9:3, pages 325-342.
Crossref
Kenneth B. Klein. (1988) Controlled treatment trials in the irritable bowel syndrome: A critique. Gastroenterology 95:1, pages 232-241.
Crossref
M. J. LAWSON, R. E. KNIGHT, K. TRAN, G. WALKER & I. C. ROBERTS‐THOMSON. (2008) Failure of enteric‐coated peppermint oil in the irritable bowel syndrome: A randomized, double‐blind crossover study. Journal of Gastroenterology and Hepatology 3:3, pages 235-238.
Crossref
Harry S. Shabsin & William E. Whitehead. 1988. Biological Barriers in Behavioral Medicine. Biological Barriers in Behavioral Medicine 193 220 .
Douglas A. Drossman. (1987) Clinical Research in the Functional Digestive Disorders. Gastroenterology 92:5, pages 1267-1269.
Crossref
David S. Greenbaum, James E. Mayle, Lawrence E. Vanegeren, John A. Jerome, Joan W. Mayor, Ruth B. Greenbaum, Robert W. Matson, Gary E. Stein, Howard A. Dean, Nancy A. Halvorsen & Lionel W. Rosen. (1987) Effects of desipramine on irritable bowel syndrome compared with atropine and placebo. Digestive Diseases and Sciences 32:3, pages 257-266.
Crossref
G. Stacher & A. L. Blum. 1987. Gastroenterologische Pathophysiologie. Gastroenterologische Pathophysiologie 47 61 .
A. T. R. Axon. (1986) Functional diarrhoea. International Journal of Colorectal Disease 1:1, pages 49-53.
Crossref
Douglas A. Drossman & Betsy C. Lowman. (1985) Irritable Bowel Syndrome: Epidemiology, Diagnosis and Treatment. Clinics in Gastroenterology 14:3, pages 559-573.
Crossref

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