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Original Article

The Preparation of Bioactive 125I-Gastrin, Using Iodo-gen as Oxidizing Agent, and the Use of This Tracer in Receptor Studies

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Pages 569-576 | Received 16 Apr 1984, Accepted 14 Sep 1984, Published online: 08 Jul 2009

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Read on this site (24)

Hólmfríður Helgadóttir, Sigrún H. Lund, Sveinbjörn Gizurarson, Helge Waldum & Einar S. Björnsson. (2021) Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and females. Scandinavian Journal of Gastroenterology 56:2, pages 128-136.
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Liv Sagatun, Reidar Fossmark, Constantin S. Jianu, Gunnar Qvigstad, Ivar S. Nordrum, Patricia Mjønes & Helge L. Waldum. (2016) Follow-up of patients with ECL cell-derived tumours. Scandinavian Journal of Gastroenterology 51:11, pages 1398-1405.
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Kristin Matre Aasarød, Mats Peder Mosti, Astrid Kamilla Stunes, Janne Elin Reseland, Trude Basso, Unni Syversen & Reidar Fossmark. (2016) Impaired skeletal health in patients with chronic atrophic gastritis. Scandinavian Journal of Gastroenterology 51:7, pages 774-781.
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Liv Sagatun, Constantin S Jianu, Reidar Fossmark, Ronald Mårvik, Ivar S Nordrum & Helge L Waldum. (2014) The gastric mucosa 25 years after proximal gastric vagotomy. Scandinavian Journal of Gastroenterology 49:10, pages 1173-1180.
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Constantin S. Jianu, Reidar Fossmark, Unni Syversen, Øyvind Hauso, Vidar Fykse & Helge L. Waldum. (2011) Five-year follow-up of patients treated for 1 year with octreotide long-acting release for enterochromaffin-like cell carcinoids. Scandinavian Journal of Gastroenterology 46:4, pages 456-463.
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Karin E. Bakkelund, Helge L. Waldum, Ivar Skjåk Nordrum, Øyvind Hauso & Reidar Fossmark. (2010) Long-term gastric changes in achlorhydric H+/K+-ATPase beta subunit deficient mice. Scandinavian Journal of Gastroenterology 45:9, pages 1042-1047.
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Karin Bakkelund, Reidar Fossmark, Ivar S. Nordrum & Helge L. Waldum. (2009) Effect of antrectomy in hypergastrinaemic female Japanese cotton rats. Scandinavian Journal of Gastroenterology 44:1, pages 32-39.
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Reidar Fossmark, Constantin S Jianu, Tom C. Martinsen, Gunnar Qvigstad, Unni Syversen & Helge L. Waldum. (2008) Serum gastrin and chromogranin A levels in patients with fundic gland polyps caused by long-term proton-pump inhibition. Scandinavian Journal of Gastroenterology 43:1, pages 20-24.
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Vidar Fykse, Arne Kristian Sandvik & Helge Lyder Waldum. (2005) One-year follow-up study of patients with enterochromaffin-like cell carcinoids after treatment with octreotide long-acting release. Scandinavian Journal of Gastroenterology 40:11, pages 1269-1274.
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A. K. Sandvik, E. Brenna, A. Sundan, J. J. Holst & H. L. Waldum. (1997) Bombesin Inhibits Histamine Release from the Rat Oxyntic Mucosa by a Somatostatin-dependent Mechanism. Scandinavian Journal of Gastroenterology 32:5, pages 427-432.
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E. Brenna, Y. Tielemans, P. M. Kleveland, A. K. Sandvik, G. Willems & H. L. Waldum. (1995) Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa. Scandinavian Journal of Gastroenterology 30:4, pages 311-314.
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Unni Syversen, Michel Mignon, Serge Bonfils, Anne Kristensen & Helge L Waldum. (1993) Chromogranin a and Pancreastatin-Like Immunoreactivity in Serum of Gastrinoma Patients. Acta Oncologica 32:2, pages 161-165.
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H. L. Waldum, M. Mignon, A. K. Sandvik & S. Bonfils. (1992) Biologic and Immunologic Gastrin Activity in Serum of Patients with Gastrinoma. Bioassay of Gastrin Activity in Serum. Scandinavian Journal of Gastroenterology 27:12, pages 1039-1044.
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P. M. Kleveland & H. L. Waldum. (1991) Session 3: The Gastrin Receptor Assay. Scandinavian Journal of Gastroenterology 26:sup180, pages 62-69.
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E. Brenna, R. Håkanson, F. Sundler, A. K. Sandvik & H. L. Waldum. (1991) The Effect of Omeprazole-Induced Hypergastrinemia on the Oxyntic Mucosa of Mastomys. Scandinavian Journal of Gastroenterology 26:6, pages 667-672.
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H. L. Waldum, T. Lehy, E. Brenna, A. K. Sandvik, H. Petersen, B. Schulze Søgnen, S. Bonfils & M. J. M. Lewin. (1991) Effect of the Histamine-1 Antagonist Astemizole Alone or with Omeprazole on Rat Gastric Mucosa. Scandinavian Journal of Gastroenterology 26:1, pages 23-35.
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T. Johannessen, U. Fjøsne, P. M. Kleveland, T. Halvorsen, P. Kristensen, I. Løge, P. E. Hafstad, P. Sandbakken & H. Petersen. (1988) Cimetidine Responders in Non-Ulcer Dyspepsia. Scandinavian Journal of Gastroenterology 23:3, pages 327-336.
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H. Ong, S. Meloche, A. De Léan & P. Larose. (1987) Purification of Radioiodinated Peptides with PRP-1 Polystyrene Cartridges and HPLC: Application to Atrial Natriuretic Factor and Vasopressin. Journal of Liquid Chromatography 10:14, pages 3085-3100.
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P. M. Kleveland & H. L. Waldum. (1986) Binding and Degradation of 125I-Gastrin by Plasma Membranes from Homogenized Rat Gastric Mucosa. Scandinavian Journal of Gastroenterology 21:5, pages 547-555.
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Helge L. Waldum & Per M. Kleveland. (1986) Gastrointestinal Regulatory Peptides: Radioimmunoassay and Biological Activity. Scandinavian Journal of Gastroenterology 21:9, pages 1025-1028.
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P. M. Kleveland, H. L. Waldum, K. S. Bjerve & H. E. Fjøsne. (1986) Bioassay of Gastrin, Using the Totally Isolated, Vascularly Perfused Rat Stomach: A Biomodel Sensitive to Gastrin in Physiological Concentrations. Scandinavian Journal of Gastroenterology 21:8, pages 945-950.
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Articles from other publishers (49)

Kristin M. Aasarød, Mats P. Mosti, Malin T. Finstad, Astrid K. Stunes, Reidar Fossmark & Unni Syversen. (2021) Do patients with gastroesophageal reflux disease exhibit compromised bone quality prior to proton pump inhibitor therapy?. Bone Reports 14, pages 101095.
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Kristin Matre Aasarød, Helge Lyder Waldum, Astrid Kamilla Stunes, Arne Kristian Sandvik, Arnar Flatberg, Patricia Mjønes, Unni Syversen, Ingunn Bakke & Reidar Fossmark. (2020) Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice. International Journal of Molecular Sciences 21:3, pages 927.
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Helge Waldum. 2020. Hormonal Signaling in Biology and Medicine. Hormonal Signaling in Biology and Medicine 341 359 .
Helge L. Waldum & Reidar Fossmark. 2020. Encyclopedia of Gastroenterology. Encyclopedia of Gastroenterology 265 272 .
E. Grong, C. Nord, I. B. Arbo, M. Eriksson, B. E. Kulseng, U. Ahlgren & R. Mårvik. (2017) The effect of hypergastrinemia following sleeve gastrectomy and pantoprazole on type 2 diabetes mellitus and beta-cell mass in Goto-Kakizaki rats. Journal of Endocrinological Investigation 41:6, pages 691-701.
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Pål Vange, Torunn Bruland, Berit Doseth, Reidar Fossmark, Mirta M. L. Sousa, Vidar Beisvag, Øystein Sørdal, Gunnar Qvigstad, Helge L. Waldum, Arne K. Sandvik & Ingunn Bakke. (2017) The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival. PLOS ONE 12:9, pages e0184514.
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Liv Sagatun, Patricia Mjønes, Constantin S. Jianu, Malcolm Boyce, Hege L. Waldum & Reidar Fossmark. (2016) The gastrin receptor antagonist netazepide (YF476) in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours: review of long-term treatment. European Journal of Gastroenterology & Hepatology 28:11, pages 1345-1352.
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Kristin M. Aasarød, Astrid K. Stunes, Mats P. Mosti, Masoud Ramezanzadehkoldeh, Bjørn I. Viggaklev, Janne E. Reseland, Bjørn H. Skallerud, Reidar Fossmark & Unni Syversen. (2016) Effects of the Histamine 1 Receptor Antagonist Cetirizine on the Osteoporotic Phenotype in H + /K + ATPase Beta Subunit KO Mice . Journal of Cellular Biochemistry 117:9, pages 2089-2096.
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Kristin M Aasarød, Masoud Ramezanzadehkoldeh, Maziar Shabestari, Mats P Mosti, Astrid K Stunes, Janne E Reseland, Vidar Beisvag, Erik Fink Eriksen, Arne K Sandvik, Reinhold G Erben, Christiane Schüler, Malcolm Boyce, Bjørn H Skallerud, Unni Syversen & Reidar Fossmark. (2016) Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice. Journal of Endocrinology 230:2, pages 251-262.
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Eivind Grong, Hallvard Græslie, Bjørn Munkvold, Ingerid Brænne Arbo, Bård Erik Kulseng, Helge L. Waldum & Ronald Mårvik. (2015) Gastrin Secretion After Bariatric Surgery—Response to a Protein-Rich Mixed Meal Following Roux-En-Y Gastric Bypass and Sleeve Gastrectomy: a Pilot Study in Normoglycemic Women. Obesity Surgery 26:7, pages 1448-1456.
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Reidar Fossmark, Shalini Rao, Patricia Mjønes, Bjørn Munkvold, Arnar Flatberg, Andrea Varro, Liv Thommesen & Kristin G. Nørsett. (2016) PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa. Peptides 79, pages 83-94.
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Eivind Grong, Bård Kulseng, Ingerid Brænne Arbo, Christoffer Nord, Maria Eriksson, Ulf Ahlgren & Ronald Mårvik. (2015) Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography. Surgical Endoscopy 30:2, pages 532-542.
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Reidar Fossmark, Liv Sagatun, Ivar S. Nordrum, Arne K. Sandvik & Helge L Waldum. (2015) Hypergastrinemia is associated with adenocarcinomas in the gastric corpus and shorter patient survival. APMIS 123:6, pages 509-514.
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Eivind Grong, Ingerid Brænne Arbo, Ole Kristian Forstrønen Thu, Esther Kuhry, Bård Kulseng & Ronald Mårvik. (2014) The effect of duodenojejunostomy and sleeve gastrectomy on type 2 diabetes mellitus and gastrin secretion in Goto-Kakizaki rats. Surgical Endoscopy 29:3, pages 723-733.
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Øystein Sørdal, Helge Waldum, Ivar S. Nordrum, Malcolm Boyce, Kåre Bergh, Bjørn Munkvold & Gunnar Qvigstad. (2013) The Gastrin Receptor Antagonist Netazepide (YF476) Prevents Oxyntic Mucosal Inflammation Induced by Helicobacter Pylori Infection in Mongolian Gerbils . Helicobacter 18:6, pages 397-405.
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Reidar Fossmark, Øystein F. Sørdal, Karin E. Bakkelund, Ivar Skjåk Nordrum & Helge Waldum. (2013) The effects of unilateral truncal vagotomy on gastric carcinogenesis in hypergastrinemic Japanese female cotton rats. Regulatory Peptides 184, pages 62-67.
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R. Fossmark, Ø. Sørdal, C. S. Jianu, G. Qvigstad, I. S. Nordrum, M. Boyce & H. L. Waldum. (2012) Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A. Alimentary Pharmacology & Therapeutics 36:11-12, pages 1067-1075.
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Sten Even Erlandsen, Gunnar Qvigstad, Reidar Fossmark, Ingunn Bakke, Duan Chen & Arne K. Sandvik. (2012) Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomach. Regulatory Peptides 177:1-3, pages 53-59.
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Christina Sæten FjeldboIngunn BakkeSten Even ErlandsenJannicke HolmsethAstrid LægreidArne K. Sandvik, Liv ThommesenTorunn Bruland. (2012) Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 302:1, pages G21-G33.
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Reidar Fossmark, Astrid K. Stunes, Christiane Petzold, Helge L. Waldum, Marina Rubert, Aina-Mari Lian, Janne E. Reseland & Unni Syversen. (2012) Decreased bone mineral density and reduced bone quality in H+/K+ATPase beta-subunit deficient mice. Journal of Cellular Biochemistry 113:1, pages 141-147.
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Constantin S. Jianu, Reidar Fossmark, Unni Syversen, Øyvind Hauso & Helge L. Waldum. (2010) A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia. Tumor Biology 31:5, pages 373-380.
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G. Qvigstad, Ø. Kolbjørnsen, E. Skancke & H.L. Waldum. (2008) Gastric Neuroendocrine Carcinoma Associated with Atrophic Gastritis in the Norwegian Lundehund. Journal of Comparative Pathology 139:4, pages 194-201.
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Kristin G. Nørsett, Astrid Lægreid, Waclaw Kusnierczyk, Mette Langaas, Sonja Ylving, Reidar Fossmark, Simen Myhre, Sture Falkmer, Helge L. Waldum & Arne K. Sandvik. (2008) Changes in gene expression of gastric mucosa during therapeutic acid inhibition. European Journal of Gastroenterology & Hepatology 20:7, pages 613-623.
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Andreas Tartaglia, Guida M. Portela-Gomes, Kjell Öberg, Paolo Vezzadini, Maria P. Foschini & Mats Stridsberg. (2006) Chromogranin A in gastric neuroendocrine tumours: an immunohistochemical and biochemical study with region-specific antibodies. Virchows Archiv 448:4, pages 399-406.
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Tom C. Martinsen, Ingunn Bakke, Duan Chen, Arne K. Sandvik, Kolbjørn Zahlsen, Trond Aamo & Helge L. Waldum. (2005) Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-α. American Journal of Physiology-Gastrointestinal and Liver Physiology 289:6, pages G1052-G1060.
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Michael Mahler, Wiebke Heidtmann, Stefan Niewiesk, Achim Gruber, Reidar Fossmark, Winfried Beil, Hans Hedrich & Siegfried Wagner. (2005) Experimental Helicobacter pylori Infection Induces Antral-Predominant, Chronic Active Gastritis in Hispid Cotton Rats (Sigmodon hispidus). Helicobacter 10:4, pages 332-344.
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Kristin G. Nørsett, Astrid Lægreid, Mette Langaas, Sara Wörlund, Reidar Fossmark, Helge L. Waldum & Arne K. Sandvik. (2005) Molecular characterization of rat gastric mucosal response to potent acid inhibition. Physiological Genomics 22:1, pages 24-32.
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REIDAR FOSSMARK, CHUN-MEI ZHAO, TOM C. MARTINSEN, SHIRO KAWASE, DUAN CHEN & HELGE L. WALDUM. (2005) Dedifferentiation of enterochromaffin-like cells in gastric cancer of hypergastrinemic cotton rats. APMIS 113:6, pages 436-449.
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E Hofsli, L Thommesen, F Yadetie, M Langaas, W Kusnierczyk, U Falkmer, A K Sandvik & A Laegreid. (2005) Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells. British Journal of Cancer 92:8, pages 1506-1516.
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Vidar Fykse, David H Coy, Helge Lyder Waldum & Arne Kristian Sandvik. (2005) Somatostatin-receptor 2 (sst 2 )-mediated effects of endogenous somatostatin on exocrine and endocrine secretion of the rat stomach . British Journal of Pharmacology 144:3, pages 416-421.
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R. Fossmark, G. Johnsen, E. Johanessen & H. L. Waldum. (2005) Rebound acid hypersecretion after long-term inhibition of gastric acid secretion. Alimentary Pharmacology and Therapeutics 21:2, pages 149-154.
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Kristin G Nørsett, Astrid Lægreid, Herman Midelfart, Fekadu Yadetie, Sten Even Erlandsen, Sture Falkmer, Jon E Grønbech, Helge L Waldum, Jan Komorowski & Arne K Sandvik. (2004) Gene expression based classification of gastric carcinoma. Cancer Letters 210:2, pages 227-237.
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Reidar Fossmark, Tom C. Martinsen, Karin E. Bakkelund, Shiro Kawase & Helge L. Waldum. (2004) ECL-Cell Derived Gastric Cancer in Male Cotton Rats Dosed with the H2-Blocker Loxtidine. Cancer Research 64:10, pages 3687-3693.
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Ingunn Bakke, Tommy A Hammer, Arne K Sandvik & Helge L Waldum. (2002) PPARα stimulates the rat gastrin-producing cell. Molecular and Cellular Endocrinology 195:1-2, pages 89-97.
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G.‐L. CUI, A. K. SANDVIK, B. MUNKVOLD & H. L. WALDUM. (2002) Glycine‐extended gastrin‐17 stimulates acid secretion only via CCK‐2 receptor‐induced histamine release in the totally isolated vascularly perfused rat stomach. Acta Physiologica Scandinavica 174:2, pages 125-130.
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Bakke, Qvigstad, Brenna, Sandvik & Waldum. (2001) Gastrin has a specific proliferative effect on the rat enterochromaffin‐like cell, but not on the parietal cell: A study by elutriation centrifugation. Acta Physiologica Scandinavica 169:1, pages 29-37.
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Gunnar Qvigstad, Sture Falkmer, BjøRn Westre & Helge L. Waldum. (1999) Clinical and histopathological tumour progression in ECL cell carcinoids (“ECLomas”). APMIS 107:7-12, pages 1085-1092.
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QVIGSTAD, BJØRGAAS, EIDE, SANDVIK & WALDUM. (2001) Vagal stimulation augments maximal (penta) gastrin‐stimulated acid secretion in humans. Acta Physiologica Scandinavica 165:3, pages 277-281.
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Arne K Sandvik & Graham J Dockray. (1999) Biological activity of carboxy-terminal gastrin analogs. European Journal of Pharmacology 364:2-3, pages 199-203.
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Helge L. Waldum, Steinar Aase, Igor Kvetnoi, Eiliv Brenna, Arne K. Sandvik, Unni Syversen, Gjermund Johnsen, Lars Vatten & Julia M. Polak. (1998) Neuroendocrine differentiation in human gastric carcinoma. Cancer 83:3, pages 435-444.
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Arne K Sandvik, Ronald Mårvik, Rod Dimaline & Helge L Waldum. (2009) Carbachol stimulation of gastric acid secretion and its effects on the parietal cell. British Journal of Pharmacology 124:1, pages 69-74.
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R. MÅRVIK, A. K. SANDVIK & H. L. WALDUM. (2008) Bioassay of gastrin using the isolated vascularly perfused rat stomach. A new, simplified and sensitive method. Acta Physiologica Scandinavica 155:3, pages 323-327.
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E Brenna, H G Swarts, C H Klaassen, J J de Pont & H L Waldum. (1994) Evaluation of the trophic effect of longterm treatment with the histamine H2 receptor antagonist loxtidine on rat oxyntic mucosa by differential counting of dispersed cells.. Gut 35:11, pages 1547-1550.
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J.C. GALLEYRAND, A.C. LIMA‐LEITE, J.C. LALLEMENT, M.F. LIGNON, N. BERNAD, P. FULCRAND & J. MARTINEZ. (2009) Synthesis and characterization of a new labeled gastrin ligand, 125 I‐BH‐[Leu 15 ]‐gastrin‐(5‐17), on binding to canine fundic mucosal cells and Jurkat cells . International Journal of Peptide and Protein Research 44:4, pages 348-356.
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Eiliv Brenna, Kolbjörn Zahlsen, Ronald Mårvik, Turid Nilsen, Odd G. Nilsen & Helge L. Waldum. (1993) Effect of nicotine on the enterochromaffin like cells of the oxyntic mucosa of the rat. Life Sciences 53:1, pages 21-29.
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E. BRENNA, H. L. WALDUM, A. K. SANDVIK, B. SCHULZE SØGNEN & A. KRISTENSEN. (2007) Effects on the rat oxyntic mucosa of the histamine 2 ‐antagonist loxtidine and the H + , K + ‐ATPase inhibitor omepvazole . Alimentary Pharmacology & Therapeutics 6:3, pages 335-349.
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Eirik Helseth, Are Dalen, Geirmund Unsgaard, Randi Vik & Are Helseth. (1989) Overexpression of the epidermal growth factor receptor gene in a human carcinoma cell line, derived from a brain metastasis. Journal of Neuro-Oncology 7:1, pages 81-88.
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A. K. SANDVIK, J. KOFSTAD, J. J. HOLST & H. L. WALDUM. (2008) Ionized calcium influences gastrin stimulated histamine release and acid secretion, but not histamine stimulated acid output in the totally isolated vascularly perfused rat stomach. Acta Physiologica Scandinavica 134:3, pages 443-448.
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Eirik Helseth, Geirmund Unsgaard, Are Dalen & Randi Vik. (1988) The effects of type beta transforming growth factor on proliferation and epidermal growth factor receptor expression in a human glioblastoma cell line. Journal of Neuro-Oncology 6:3, pages 269-276.
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