Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 20, 1985 - Issue sup114
Submit an article Journal homepage
53
Views
82
CrossRef citations to date
0
Altmetric
Original Article

The Human Gastrointestinal Secretory Immune System in Health and Disease

P. Brandtzaeg Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
,
K. Valnes Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
,
H. Scott Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
,
T. O. Rognum Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
,
K. Bjerke Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
&
K. Baklien Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
Pages 17-38 | Published online: 08 Jul 2009

Citations (82)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

P. B. Ernst, Y. Jin, V. E. Reyes & S. E. Crowe. (1994) The Role of the Local Immune Response in the Pathogenesis of Peptic Ulcer Formation. Scandinavian Journal of Gastroenterology 29:sup205, pages 22-28.
Read now
C. Fiocchi. (1990) Immune Events Associated with Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 25:sup172, pages 4-12.
Read now
William R. Brown & Thomas M. Kloppel. (1989) The role of the liver in Translocation of IgA into the Gastrointestinal Tract. Immunological Investigations 18:1-4, pages 269-285.
Read now
Claudio Fiocchi. (1989) Lymphokines and the Intestinal immune response. Role in Inflammatory Bowel Disease. Immunological Investigations 18:1-4, pages 91-102.
Read now
K. Valnes, P. Brandtzaeg, R. Stave & K. Elgjo. (1988) Local Immune Defence in Relation to Gastritis in Billroth-II-Resected Stomachs. Scandinavian Journal of Gastroenterology 23:10, pages 1217-1224.
Read now
P. Brandtzaeg. (1985) Research in Gastrointestinal Immunology State of the Art. Scandinavian Journal of Gastroenterology 20:sup114, pages 137-156.
Read now

Articles from other publishers (76)

Hakimeh Sharafi, Venos Derakhshan, Mojgan Paknejad, Leila Alidoust, Azadeh Tohidi, Majid Pornour, Hamidreza Hajfarajollah, Hossein Shahbani Zahiri & Kambiz Akbari Noghabi. (2014) Lactobacillus crustorum KH: Novel Prospective Probiotic Strain Isolated from Iranian Traditional Dairy Products. Applied Biochemistry and Biotechnology 175:4, pages 2178-2194.
Crossref
Matthieu Perreau, Selena Vigano, Florence Bellanger, Céline Pellaton, Guillaume Buss, Denis Comte, Thierry Roger, Christine Lacabaratz, Pierre-Alexandre Bart, Yves Levy & Giuseppe Pantaleo. (2014) Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. Journal of Experimental Medicine 211:10, pages 2033-2045.
Crossref
Yaron Niv & Marko Banić. (2014) Gastric Barrier Function and Toxic Damage. Digestive Diseases 32:3, pages 235-242.
Crossref
Shradha Agarwal & Lloyd Mayer. 2013. Food Allergy. Food Allergy 1 15 .
Peter Greaves. 2012. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 325 431 .
S. T. Guseinova, N. G. Omarova & T. S. Guseinov. (2011) Cell Characteristics of the Lymphoid Nodules in the Peripheral Organs of Immunogenesis. Bulletin of Experimental Biology and Medicine 152:2, pages 262-265.
Crossref
Miriam Zago, Maria Emanuela Fornasari, Domenico Carminati, Patricia Burns, Viviana Suàrez, Gabriel Vinderola, Jorge Reinheimer & Giorgio Giraffa. (2011) Characterization and probiotic potential of Lactobacillus plantarum strains isolated from cheeses. Food Microbiology 28:5, pages 1033-1040.
Crossref
E.A. McLaughlin & R.J. Aitken. (2011) Is there a role for immunocontraception?. Molecular and Cellular Endocrinology 335:1, pages 78-88.
Crossref
S. Marsilio, S. Kleinschmidt, J. Harder, I. Nolte & M. Hewicker-Trautwein. (2011) Numbers and Distribution of Immune Cells in the Tunica Mucosa of the Small and Large Intestine of Full-Thickness Biopsies from Healthy Pet Cats. Anatomia, Histologia, Embryologia 40:1, pages 61-67.
Crossref
Anitra D Thomas & William Parker. (2010) Cultivation of epithelial-associated microbiota by the immune system. Future Microbiology 5:10, pages 1483-1492.
Crossref
Ralf Ignatius & Thomas Schneider. 2010. Topley & Wilson's Microbiology and Microbial Infections. Topley & Wilson's Microbiology and Microbial Infections.
L Prigent-Delecourt, B Coffin, J F Colombel, J P Dehennin, J P Vaerman & J C Rambaud. (1995) Secretion of immunoglobulins and plasma proteins from the colonic mucosa: an in vivo study in man . Clinical and Experimental Immunology 99:2, pages 221-225.
Crossref
D E NILSSEN, R SÖDERSTRÖM, P BRANDTZAEG, K KETT, L HELGELAND, G KARLSSON, T SÖDERSTRÖM & L Å HANSON. (1991) Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies. Clinical and Experimental Immunology 83:1, pages 17-24.
Crossref
P MARTEAU, J F COLOMBEL, J NEMETH, J P VAERMAN, J C DIVE & J C RAMBAUD. (1990) Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA . Clinical and Experimental Immunology 80:2, pages 196-201.
Crossref
Sven Kleinschmidt, Felix Meneses, Ingo Nolte & Marion Hewicker-Trautwein. (2008) Distribution of mast cell subtypes and immune cell populations in canine intestines: Evidence for age-related decline in T cells and macrophages and increase of IgA-positive plasma cells. Research in Veterinary Science 84:1, pages 41-48.
Crossref
D. K. Slizhikova, M. V. Zinovyeva, D. V. Kuzmin, E. V. Snezhkov, M. I. Shakhparonov, R. I. Dmitriev, N. V. Antipova, L. L. Zavalova & E. D. Sverdlov. (2007) Decreased expression of the human immunoglobulin J-chain gene in squamous cell cancer and adenocarcinoma of the lungs. Molecular Biology 41:4, pages 594-600.
Crossref
Peter Greaves. 2007. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 334 456 .
A. M WESTENDORF, D. BRUDER, W. HANSEN & J. BUER. (2006) Intestinal Epithelial Antigen Induces CD4+ T Cells with Regulatory Phenotype in a Transgenic Autoimmune Mouse Model. Annals of the New York Academy of Sciences 1072:1, pages 401-406.
Crossref
Charles O. Elson & Casey T. Weaver. 2005. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 67 99 .
Mary Lou Everett, Daniel Palestrant, Sara E Miller, R.Randal Bollinger & William Parker. (2004) Immune exclusion and immune inclusion: a new model of host-bacterial interactions in the gut. Clinical and Applied Immunology Reviews 4:5, pages 321-332.
Crossref
Charles O. Elson & Casey T. Weaver. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 67 99 .
Matthieu Allez, Jens Brimnes, Iris Dotan & Lloyd Mayer. (2002) Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 123:5, pages 1516-1526.
Crossref
Pamela A. Kozlowski, Rebecca M. Lynch, Rosalyn R. Patterson, Susan Cu-Uvin, Timothy P. Flanigan & Marian R. Neutra. (2000) Modified Wick Method Using Weck-Cel Sponges for Collection of Human Rectal Secretions and Analysis of Mucosal HIV Antibody. JAIDS Journal of Acquired Immune Deficiency Syndromes 24:4, pages 297-309.
Crossref
Pamela A. Kozlowski, Rebecca M. Lynch, Rosalyn R. Patterson, Susan Cu-Uvin, Timothy P. Flanigan & Marian R. Neutra. (2000) Modified Wick Method Using Weck-Cel Sponges for Collection of Human Rectal Secretions and Analysis of Mucosal HIV Antibody. Journal of Acquired Immune Deficiency Syndromes 24:4, pages 297-309.
Crossref
Peter Greaves. 2000. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 312 431 .
Jason Moy, Donald J Lee, Carroll M Harmon, Robert A Drongowski & Arnold G Coran. (1999) Confirmation of Translocated Gastrointestinal Bacteria in a Neonatal Model. Journal of Surgical Research 87:1, pages 85-89.
Crossref
Gerard Corthier & Pierre Renault. 1999. Biotherapeutic Agents and Infectious Diseases. Biotherapeutic Agents and Infectious Diseases 269 304 .
Harold Marcotte & Marc C. Lavoie. (1998) Oral Microbial Ecology and the Role of Salivary Immunoglobulin A. Microbiology and Molecular Biology Reviews 62:1, pages 71-109.
Crossref
Klaus Lauer. (1997) Diet and multiple sclerosis. Neurology 49:2_suppl_2.
Crossref
C. O. Elson. 1997. Mechanisms in the Pathogenesis of Enteric Diseases. Mechanisms in the Pathogenesis of Enteric Diseases 373 385 .
I. Mayoral, L. Peǹa, F. Rodriguez-Franco, A. Sainz, M. A. Tesouro & E. Ynaraja. (1996) Immunohistological Study of IgA, IgG and IgM in Endoscopic Biopsies of Dogs with Plasmacytic-Lymphocytic Colitis. Journal of Veterinary Medicine, Series B 43:1-10, pages 613-620.
Crossref
Maria T. Abreu-Martin & Stephan R. Targan. 1996. Essentials of Mucosal Immunology. Essentials of Mucosal Immunology 227 245 .
B. D. Forrest. 1996. Cholera and the Ecology of Vibrio cholerae. Cholera and the Ecology of Vibrio cholerae 95 124 .
Robert M. Genta. 1996. Enteric Infections and Immunity. Enteric Infections and Immunity 239 256 .
T Caballero, F Nogueras, M T Medina, M D Caracuel, C de Sola, F J Martinez-Salmeron, M Rodrigo & R Garcia del Moral. (1995) Intraepithelial and lamina propria leucocyte subsets in inflammatory bowel disease: an immunohistochemical study of colon and rectal biopsy specimens.. Journal of Clinical Pathology 48:8, pages 743-748.
Crossref
Masahiko Urao, Jason Moy, Joan Van Camp, Robert Drongowski, Maher Altabba & Arnold G Coran. (1995) Determinant of bacterial translocation in the newborn: Small bowel versus large bowel colonization. Journal of Pediatric Surgery 30:6, pages 831-836.
Crossref
Joyce A. NettletonJoyce A. Nettleton. 1995. Omega-3 Fatty Acids and Health. Omega-3 Fatty Acids and Health 187 248 .
Steven J. Harper, James H. Pringle, Anthony C.B. Wicks, Jane Hattersley, Lorna Layward, Alice Allen, Angela Gillies, Ian Lauder & John Feehally. (1994) Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. Kidney International 45:3, pages 836-844.
Crossref
Hiroshi Kiyono & Jerry R. McGhee. 1994. Handbook of Mucosal Immunology. Handbook of Mucosal Immunology 263 274 .
M. Zeitz. 1994. Ökosystem Darm VI. Ökosystem Darm VI 117 124 .
Masahiko Amano, Jerry R. McGhee, Martin J. McCutcheon, Kan-ichi Fujii & Hiroshi Kiyono. (1993) Application of the ILISPOT-IDIP system for the enumeration of different sizes of IgA spot forming cells in the murine small and large intestine. Journal of Immunological Methods 164:1, pages 79-90.
Crossref
James J. Pestka. 1993. 1 66 .
D.J. Smith, K. Joshipura, R. Kent & M.A. Taubman. (2016) Effect of Age on Immunoglobulin Content and Volume of Human Labial Gland Saliva. Journal of Dental Research 71:12, pages 1891-1894.
Crossref
H. J. F. Hodgson. (1992) Immunological aspects of inflammatory bowel diseases of the human gut. Agents and Actions 36:3-4, pages C27-C31.
Crossref
Kenneth W. Beagley & Charles O. Elson. (1992) CELLS AND CYTOKINES IN MUCOSAL IMMUNITY AND INFLAMMATION. Gastroenterology Clinics of North America 21:2, pages 347-366.
Crossref
H. J. F. Hodgson. (1992) Immunological aspects of inflammatory bowel diseases of the human gut. Agents and Actions 36:S1, pages C27-C31.
Crossref
Bengt Lav�, Folke Knutson, Lars Knutson, Olof Sj�berg & Roger H�llgren. (1992) Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease. Digestive Diseases and Sciences 37:1, pages 53-59.
Crossref
D.J. Smith, M.A. Taubman & P. Ali-Salaam. (2016) Immunoglobulin Isotypes in Human Minor Gland Saliva. Journal of Dental Research 70:3, pages 167-170.
Crossref
W D Foulkes, C Sewry, J Calam & H J Hodgson. (1991) Rhabdomyolysis after intramuscular iron-dextran in malabsorption.. Annals of the Rheumatic Diseases 50:3, pages 184-186.
Crossref
S Kárpáti, S Kárpáti, Th Krieg, M Meurer, W Stolz, O Braun-Falco & A Burgin-Wolff. (1990) Binding to human jejunum of serum IgA antibody from children with coeliac disease. The Lancet 336:8727, pages 1335-1338.
Crossref
Kjell Kett, Helge Scott, Olav Fausa & Per Brandtzaeg. (1990) Secretory immunity in celiac disease: Cellular expression of immunoglobulin a subclass and joining chain. Gastroenterology 99:2, pages 386-392.
Crossref
Jacques Schmitz, Franck Arnaud-Battandier & Nadine Cerf-Bensussan. 1990. Malnutrition in Chronic Diet-Associated Infantile Diarrhea. Malnutrition in Chronic Diet-Associated Infantile Diarrhea 151 159 .
K Kett & P Brandtzaeg. 1990. Advances in Mucosal Immunology. Advances in Mucosal Immunology 753 754 .
P. Brandtzaeg, T.S. Halstensen, K. Kett, P. Krajči, D. Kvale, T.O. Rognum, H. Scott & L.M. Sollid. (1989) Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes. Gastroenterology 97:6, pages 1562-1584.
Crossref
A E WoldU I DahlgrenL A HansonI Mattsby-BaltzerT Midvetdt. (1989) Difference between bacterial and food antigens in mucosal immunogenicity. Infection and Immunity 57:9, pages 2666-2673.
Crossref
L. K. Trejdosiewicz, S. Badr-El-Din, Christine J. Smart, G. Malizia, D. Jane Oakes, R. V. Heatley & M. S. Losowsky. (1989) Colonic mucosal T lymphocytes in ulcerative colitis: Expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Digestive Diseases and Sciences 34:9, pages 1449-1456.
Crossref
K. Ishikawa, Y. Satoh, Y. Oomori, M. Yamano, M. Matsuda & K. Ono. (1989) Influence of conventionalization on cecal wall structure of germ-free Wistar rats: quantitative light and qualitative electron microscopic observations. Anatomy and Embryology 180:2, pages 191-198.
Crossref
William R. Brown & Thomas M. Kloppel. (1989) The liver and IgA: Immunological, cell biological and clinical implications. Hepatology 9:5, pages 763-784.
Crossref
S. SENDA, E. CHENG & H. KAWANISHI. (1989) IgG in Murine Intestinal Secretions Aging Effect and Possible Physiological Role. Scandinavian Journal of Immunology 29:1, pages 41-47.
Crossref
Sarolta Kárpáti, Istvän Kósnai, Éva Török & Judit B. Kovács. (1988) Immunoglobulin A Deposition in Jejunal Mucosa of Children with Dermatitis Herpetiformis. Journal of Investigative Dermatology 91:4, pages 336-339.
Crossref
S Badr-el-Din, L K Trejdosiewicz, R V Heatley & M S Losowsky. (1988) Local immunity in ulcerative colitis: evidence for defective secretory IgA production.. Gut 29:8, pages 1070-1075.
Crossref
Wilhelm Kaulfersch, Claudio Fiocchi & Thomas A. Waldmann. (1988) Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease. Gastroenterology 95:2, pages 364-370.
Crossref
K. Kett, P. Brandtzaeg & O. Fausa. (1988) J-chain expression is more prominent in immunoglobulin A2 than in immunoglobulin A1 colonic immunocytes and is decreased in both subclasses associated with inflammatory bowel disease. Gastroenterology 94:6, pages 1419-1425.
Crossref
K GrimwoodJ C LundB S CoulsonI L HudsonR F BishopG L Barnes. (1988) Comparison of serum and mucosal antibody responses following severe acute rotavirus gastroenteritis in young children. Journal of Clinical Microbiology 26:4, pages 732-738.
Crossref
K. Kett & P. Brandtzaeg. 1988. Histophysiology of the Immune System. Histophysiology of the Immune System 725 728 .
H. Scott, L. M. Sollid, P. Brandtzaeg & E. Thorsby. 1988. Histophysiology of the Immune System. Histophysiology of the Immune System 689 693 .
H. SCOTT, L. M. SOLLID, O. FAUSA, P. BRANDTZAEG & E. THORSBY. (2006) Expression of Major Histocompatibility Complex Class II Subregion Products by Jejunal Epithelium in Patients with Coeliac Disease. Scandinavian Journal of Immunology 26:5, pages 563-571.
Crossref
K. Kett, T.O. Rognum & P. Brandtzaeg. (1987) Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon. Gastroenterology 93:5, pages 919-924.
Crossref
Daniel J. Smith, Martin A. Taubman & William F. King. (1987) Immunological features of minor salivary gland saliva. Journal of Clinical Immunology 7:6, pages 449-455.
Crossref
S K F Chong & J A Walker-Smith. (2018) Immunology of small bowel disease. Journal of the Royal Society of Medicine 80:10, pages 656-659.
Crossref
E. K. Lund & M. W. Smith. (1987) Effect of graft versus host reaction on cell cycle time in neonatal mouse jejunum. Cell Proliferation 20:4, pages 369-378.
Crossref
R. Pabst. (1987) The anatomical basis for the immune function of the gut. Anatomy and Embryology 176:2, pages 135-144.
Crossref
C. J. Smart, J. E. Crabtree, R. V. Heatley, L. K. Trejdosiewicz & M. S. Losowsky. 1987. Recent Advances in Mucosal Immunology. Recent Advances in Mucosal Immunology 475 481 .
P. Brandtzaeg, K. Kett & T. O. Rognum. 1987. Recent Advances in Mucosal Immunology. Recent Advances in Mucosal Immunology 321 333 .
K. Bjerke & P. Brandtzaeg. 1987. Recent Advances in Mucosal Immunology. Recent Advances in Mucosal Immunology 313 319 .
R. Moqbel. (1986) Helminth-induced intestinal inflammation. Transactions of the Royal Society of Tropical Medicine and Hygiene 80:5, pages 719-727.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.