422
Views
48
CrossRef citations to date
0
Altmetric
Original Article

Mechanism of Action of Omeprazole

Pages 11-16 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Esmail Vessally, Aazam Monfared, Zahra Eskandari, Morteza Abdoli & Akram Hosseinian. (2021) A new strategy for the synthesis of 2-mercaptobenzazole derivatives by green chemistry metrics. Phosphorus, Sulfur, and Silicon and the Related Elements 196:1, pages 1-5.
Read now
Lateef Ahmad, Zafar Iqbal, Shabnam Nazir, Yasar Shah, Abad Khan, MuhammadI. Khan, Fazli Nasir & Abbas Khan. (2011) OPTIMIZATION AND VALIDATION OF HPLC-UV METHOD FOR SIMULTANEOUS DETERMINATION OF OMEPRAZOLE AND ITS METABOLITES IN HUMAN PLASMA: EFFECTS OF VARIOUS EXPERIMENTAL CONDITIONS AND PARAMETERS. Journal of Liquid Chromatography & Related Technologies 34:15, pages 1488-1501.
Read now
D. K. Manifold, R. E. K. Marshall, A. Anggiansah, W. J. Owen. (2000) Effect of Omeprazole on Antral Duodenogastric Reflux in Barrett Oesophagus. Scandinavian Journal of Gastroenterology 35:8, pages 796-801.
Read now
. (1992) Patent Evaluation: Novel Imidazol[2,1-b]thiazole Derivatives as Anti-ulcer Agents. Current Opinion on Therapeutic Patents 2:5, pages 628-629.
Read now
G. Brunner & W. Creutzfeldt. (1989) Omeprazole in the Long-term Management of Patients with Acid-related Diseases Resistant to Ranitidine. Scandinavian Journal of Gastroenterology 24:sup166, pages 101-105.
Read now

Articles from other publishers (43)

Yuqing Wu, Zhiguang Duan, Linlin Qu, Yi Zhang, Chenhui Zhu & Daidi Fan. (2023) Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway. Food & Function 14:11, pages 5167-5181.
Crossref
Kamal Krishna Rajbongshi, Binoyargha Dam & Bhisma Kumar Patel. 2022. N-Heterocycles. N-Heterocycles 1 49 .
Francis Ackah Armah, Isaac Tabiri Henneh, John Alake, Wisdom Ahlidja, Benjamin Amoani, Eric Gyamerah Ofori, Baffour Asante-Kyei, Gbadamosi Ismail Temitayo & Christian Kweku Adokoh. (2021) Allanblackia floribunda Seed Extract Attenuates the Ethanol-Induced Gastric Ulcer in Rats via the Inhibition of TNF-α and INF-γ Levels and Modulation in the Expression of Ki67 Protein. BioMed Research International 2021, pages 1-10.
Crossref
Gaetano F. Bellia, Guzman Gil-Ramirez, Mark G. Baron, Ruth Croxton & Jose Gonzalez-Rodriguez. (2020) Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis. Vibrational Spectroscopy 106, pages 102996.
Crossref
Valerio Cirillo, Michael J. Van Oosten, Miriam Izzo & Albino Maggio. (2019) Omeprazole treatment elicits contrasting responses to salt stress in two basil genotypes. Annals of Applied Biology 174:3, pages 329-338.
Crossref
Johan Gabrielsson, Lambertus A. Peletier & Stephan Hjorth. (2018) Lost in translation: What's in an EC? Innovative PK/PD reasoning in the drug development context. European Journal of Pharmacology 835, pages 154-161.
Crossref
Michael J. Van Oosten, Silvia Silletti, Gianpiero Guida, Valerio Cirillo, Emilio Di Stasio, Petronia Carillo, Pasqualina Woodrow, Albino Maggio & Giampaolo Raimondi. (2017) A Benzimidazole Proton Pump Inhibitor Increases Growth and Tolerance to Salt Stress in Tomato. Frontiers in Plant Science 8.
Crossref
Maria Koukoula, Yannis Dotsikas, Elina Molou, Kleopatra H. Schulpis, Georgia Thodi, Maria Chatzidaki, Olga Triantafylli & Yannis L. Loukas. (2017) Study of the effect of CYP2C19 polymorphisms on omeprazole pharmacokinetics by utilizing validated LC–MS/MS and Real Time-PCR methods. Journal of Chromatography B 1047, pages 173-179.
Crossref
K. Birkmann, H.K. Junge, E. Maischberger, M. Wehrli Eser & C.C. Schwarzwald. (2014) Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses. Journal of Veterinary Internal Medicine 28:3, pages 925-933.
Crossref
Takashi Nonaka, Takaomi Kessoku, Yuji Ogawa, Kento Imajyo, Shogo Yanagisawa, Tadahiko Shiba, Takashi Sakaguchi, Kazuhiro Atsukawa, Hisao Takahashi, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Yasunobu Abe, Eiji Gotoh, Shin Maeda, Atsushi Nakajima & Masahiko Inamori. (2011) Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System). Journal of Neurogastroenterology and Motility 17:3, pages 287-293.
Crossref
L. Scaringi, P. Cornacchione, E. Ayroldi, L. Corazzi, E. Capodicasa, R. Rossi & P. Marconi. (2016) Omeprazole Induces Apoptosis in Jurkat Cells. International Journal of Immunopathology and Pharmacology 17:3, pages 331-342.
Crossref
M. Frazzoni, E. De Micheli, A. Grisendi & V. Savarino. (2002) Hiatal hernia is the key factor determining the lansoprazole dosage required for effective intra-oesophageal acid suppression. Alimentary Pharmacology & Therapeutics 16:5, pages 881-886.
Crossref
F. M. ANDREWS, R. L. SIFFERMAN, W. BERNARD, F. E. HUGHES, J. E. HOLSTE, C. P. DAURIO, R. ALVA & J. L. COX. (2010) Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine Veterinary Journal 31:S29, pages 81-86.
Crossref
M. Sullivan & D.A. Yool. (1998) Gastric disease in the dog and cat. The Veterinary Journal 156:2, pages 91-106.
Crossref
Luigi Benini, Greta Castellani, Enrico Bardelli, Carlo Sembenini, Maria Teresa Brentegani, Silvio Caliari & Italo Vantini. (1996) Omeprazole causes delay in gastric emptying of digestible meals. Digestive Diseases and Sciences 41:3, pages 469-474.
Crossref
Francesco Di Mario, Giuseppe Battaglia, Michele De Boni, Emanuela De Bona, Gioacchino Leandro, Giorgio Chiozzini, Michele Pasini, Giovanni Andrea Grasso, Marina Ferrana, Alfredo Saggioro & Marcello Pasquino. (1996) Omeprazole in the maintenance treatment of duodenal ulcer: results after 6 months of 20 mg daily, 20 mg every other day, or 40 mg on weekends. Current Therapeutic Research 57:1, pages 33-41.
Crossref
F‐Y CHANG, C‐Y CHIANG, T‐N TAM, W‐W NG & S‐D LEE. (2008) Comparison of lansoprazole and omeprazole in the short‐term management of duodenal ulcers in Taiwan. Journal of Gastroenterology and Hepatology 10:5, pages 595-601.
Crossref
Susumu Okabe, Kenichi Shimosako & Hiroyuki Harada. (1995) Antisecretory Effect of Leminoprazole on Histamine-Stimulated Gastric Acid Secretion in Dogs: Potent Local Effect. Japanese Journal of Pharmacology 69:2, pages 91-100.
Crossref
Francesco Di Mario, Giuseppe Battaglia, Stefano Andrea Grassi, Sergio Vigneri, Anna Scialabba, Rosanna Termini, Paola Dotto, Bastianello Germanà, Marina Feriana, Fabio Vianello & Giuseppe Del Favero. (1994) Different doses of omeprazole in the maintenance treatment of patients with peptic ulcers resistant to H2-blockers. Current Therapeutic Research 55:11, pages 1363-1371.
Crossref
Gregory Champion, Joel E Richter, Michael F Vaezi, Swarnjit Singh & Ronald Alexander. (1994) Duodenogastroesophageal reflux: Relationship to pH and importance in Barrett's esophagus. Gastroenterology 107:3, pages 747-754.
Crossref
K. Sivakumar & M.C. Dalakas. (1994) Autoimmune syndrome induced by omeprazole. The Lancet 344:8922, pages 619-620.
Crossref
S. PAN, C. H. LIAO, G. S. LIEN & S. H. CHEN. (2008) Histological maturity of healed duodenal ulcer and ulcer recurrence after treatment with omeprazole or cimetidine. Journal of Gastroenterology and Hepatology 9:S1.
Crossref
Mark G. Papich. (1993) Antiulcer Therapy. Veterinary Clinics of North America: Small Animal Practice 23:3, pages 497-512.
Crossref
G. BRUNNER, R. ARNOLD, U. HENNIG & W. FUCHS. (2007) An open trial of long-term therapy with lansoprazole in patients with peptic ulceration resistant to extended high-dose ranitidine treatment. Alimentary Pharmacology & Therapeutics 7, pages 51-55.
Crossref
J.C. Drieman, H.H.W. Thijssen & H.A.J. Struyker‐Boudier. (2012) Renal selective N‐acetyl‐ l ‐γ‐glutamyl prodrugs: studies on the selectivity of some model prodrugs . British Journal of Pharmacology 108:1, pages 204-208.
Crossref
Lars Werkö. (2009) Problems with Toxicity Studies in the Assessment of New Drugs. International Journal of Technology Assessment in Health Care 9:2, pages 189-201.
Crossref
C‐Y. WANG, T‐H. WANG, K‐H. LAI, C‐P. SIAUW, P‐C. CHEN, K‐C. YANG, Y‐T. TSAI & J‐L. SUNG. (2008) Double‐blind comparison of omeprazole 20 mg om and ranitidine 300 mg NOCTE in duodenal ulcer: A Taiwan multi‐centre study. Journal of Gastroenterology and Hepatology 7:6, pages 572-576.
Crossref
Martin J. Collen & Richard M. Strong. (1992) Comparison of omeprazole and ranitidine in treatment of refractory gastroesophageal reflux disease in patients with gastric acid hypersecretion. Digestive Diseases and Sciences 37:6, pages 897-903.
Crossref
M.-A. Wallander, P. Lundborg & K. Sv�rdsudd. (1992) Adverse event monitoring in clinical trials of felodipine and omeprazole. European Journal of Clinical Pharmacology 42:5, pages 517-522.
Crossref
Carl L. Berg & M. Michael Wolfe. (1991) Zollinger-Ellison Syndrome. Medical Clinics of North America 75:4, pages 903-921.
Crossref
S. Holt & C. W. Howden. (1991) Omeprazole. Digestive Diseases and Sciences 36:4, pages 385-393.
Crossref
Thomas A. Lampkin, Daniele Ouellet, Lawrence J. Hak & George E. Dukes. (2016) Omeprazole: A Novel Antisecretory Agent for the Treatment of Acid-Peptic Disorders. DICP 24:4, pages 393-402.
Crossref
Martin J. Collen, James H. Lewis & Stanley B. Benjamin. (1990) Gastric acid hypersecretion in refractory gastroesophageal reflux disease. Gastroenterology 98:3, pages 654-661.
Crossref
R. ARNOLD. (2008) Therapeutic strategies in the management of endocrine GEP tumours. European Journal of Clinical Investigation 20:1, pages 82-90.
Crossref
R. HÅKANSON & F. SUNDLER. (2008) Proposed mechanism of induction of gastric carcinoids: the gastrin hypothesis. European Journal of Clinical Investigation 20:1, pages 65-71.
Crossref
Paul N. Maton, Jerry D. Gardner & Robert T. Jensen. (1989) Recent Advances in the Management of Gastric Acid Hypersecretion in Patients with Zollinger-Ellison Syndrome. Gastroenterology Clinics of North America 18:4, pages 847-863.
Crossref
G. Sachs, J. Kaunitz, J. Mendlein & B. Wallmark. 2011. Comprehensive Physiology. Comprehensive Physiology 229 253 .
Iain G. Beattie & Timothy J. A. Blake. (1989) The structural identification of drug metabolites using thermospray liquid chromatography/mass spectrometry. Biological Mass Spectrometry 18:10, pages 872-877.
Crossref
Timothy J. A. Blake & Iain G. Beattie. (1989) Rapid structural analysis of thein vitro andin vivo metabolism of SK&F 95448 by the combined use of thermospray liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry. Biological Mass Spectrometry 18:8, pages 637-644.
Crossref
Rolf Håkanson, Jan Axelson, Rolf Ekman & Frank Sundler. (1988) Hypergastrinaemia evoked by omeprazole stimulates growth of gastric mucosa but not of pancreas or intestines in hamster, guinea pig and chicken. Regulatory Peptides 23:1, pages 105-115.
Crossref
YUKIO FUJINO, KEIKO MITSUNAGA & IKUO YASUMASU. (2008) Inhibitory Effect of Omeprazole, a Specific Inhibitor of H + , K + ‐ATPase, on Spicule Formation in Sea Urchin Embryos and in Cultured Micromere‐Derived Cells. . Development, Growth & Differentiation 29:6, pages 591-597.
Crossref
M. Hell & K.‐Fr. Sewing. (2012) Effect of omeprazole on eicosanoid formation in and release from guinea‐pig gastric mucosal cells. British Journal of Pharmacology 91:1, pages 69-75.
Crossref
Susumu OKABE, Yasushi AKIMOTO, Hiroki MIYAKE & Junko IMADA. (1987) Effects of NC-1300 and Its Degradation Products on Gastric Secretion and HOEthanol-lnduced Gastric Lesions in Rats. Japanese Journal of Pharmacology 44:1, pages 7-14.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.