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Original Article

Short-Chain Fatty Acids and the Irritable Bowel Syndrome: The Effect of Wheat Bran

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Pages 185-192 | Received 07 Aug 1986, Accepted 11 Sep 1986, Published online: 08 Jul 2009

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Tarek Mazzawi, Trygve Hausken, Johannes R. Hov, Jørgen Valeur, Dag André Sangnes, Magdy El-Salhy, Odd Helge Gilja, Jan Gunnar Hatlebakk & Gülen Arslan Lied. (2019) Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels. Scandinavian Journal of Gastroenterology 54:6, pages 690-699.
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Michael Camilleri, Houssam Halawi & Ibironke Oduyebo. (2017) Biomarkers as a diagnostic tool for irritable bowel syndrome: where are we?. Expert Review of Gastroenterology & Hepatology 11:4, pages 303-316.
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Ian B. Jeffery, Eamonn M. M. Quigley, Lena Öhman, Magnus Simrén & Paul W. O'Toole. (2012) The microbiota link to irritable bowel syndrome. Gut Microbes 3:6, pages 572-576.
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Jørgen Valeur, Mette Helvik Morken, Elisabeth Norin, Tore Midtvedt & Arnold Berstad. (2010) Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?. Clinical and Experimental Gastroenterology 3, pages 65-70.
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Jørgen Valeur, Mette Helvik Morken, Elisabeth Norin, Tore Midtvedt & Arnold Berstad. (2009) Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose. Scandinavian Journal of Gastroenterology 44:12, pages 1416-1423.
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Mette Helvik Morken, Jørgen Valeur, Elisabeth Norin, Tore Midtvedt, Gunnar Nysæter & Arnold Berstad. (2009) Antibiotic or bacterial therapy in post-giardiasis irritable bowel syndrome. Scandinavian Journal of Gastroenterology 44:11, pages 1296-1303.
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K. Lauritsen & E. Christensen. (1996) The Randomized Controlled Clinical Trial in Gastroenterology: The Danish Contributions from 1970 to 1994. Scandinavian Journal of Gastroenterology 31:sup216, pages 181-198.
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P. Brøbech Mortensen & M. Rye Clausen. (1996) Short-Chain Fatty Acids in the Human Colon: Relation to Gastrointestinal Health and Disease. Scandinavian Journal of Gastroenterology 31:sup216, pages 132-148.
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U. Siigur, K. E. Norin, G. Allgood, T. Schlagheck & T. Midtvedt. (1994) Concentrations and Correlations of Faecal Short-chain Fatty Acids and Faecal Water Content in Man. Microbial Ecology in Health and Disease 7:6, pages 287-294.
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M. I. McBurney & L. U. Thompson. (1989) Effect of Human Faecal Donor on in Vitro Fermentation Variables. Scandinavian Journal of Gastroenterology 24:3, pages 359-367.
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D. E. Nilssen, T. Høverstad, S. S. Frøland & T. Midtvedt. (1989) Short-Chain Fatty Acids and Other Intestinal Microflora-Associated Characteristics in Faeces of Patients with Severe B-Cell Immunodeficiency. Scandinavian Journal of Gastroenterology 24:1, pages 21-27.
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H. S. Rasmussen, K. Holtug & P. B. Mortensen. (1988) Degradation of Amino Acids to Short-Chain Fatty Acids in Humans: An in Vitro Study. Scandinavian Journal of Gastroenterology 23:2, pages 178-182.
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W. Scheppach, C. Fabian, M. Sachs & H. Kasper. (1988) The Effect of Starch Malabsorption on Fecal Short-Chain Fatty Acid Excretion in Man. Scandinavian Journal of Gastroenterology 23:6, pages 755-759.
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H. Sandvad Rasmussen, K. Holtug, J. R. Andersen, E. Krag & P. Brøbech Mortensen. (1987) The Influence of Ispaghula Husk and Lactulose on the In Viva and the In Vitro Production Capacity of Short-Chain Fatty Acids in Humans. Scandinavian Journal of Gastroenterology 22:4, pages 406-410.
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Ilnar F. Shaidullov, Dina M. Sorokina, Farit G. Sitdikov, Anton Hermann, Sayar R. Abdulkhakov & Guzel F. Sitdikova. (2021) Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome. BMC Gastroenterology 21:1.
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Mei Luo, Xiaojun Zhuang, Zhenyi Tian & Lishou Xiong. (2021) Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis. BMC Gastroenterology 21:1.
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Zhenyi Tian, Xiaojun Zhuang, Mei Luo, Wei Yin & Lishou Xiong. (2020) The propionic acid and butyric acid in serum but not in feces are increased in patients with diarrhea-predominant irritable bowel syndrome. BMC Gastroenterology 20:1.
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Shanalee C James, Karl Fraser, Wayne Young, Warren C McNabb & Nicole C Roy. (2020) Gut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome. The Journal of Nutrition 150:5, pages 1012-1021.
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Wen-Xue Zhang, Yu Zhang, Geng Qin, Kai-Min Li, Wei Wei, Su-Yun Li & Shu-Kun Yao. (2019) Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome. World Journal of Gastroenterology 25:43, pages 6416-6429.
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John C. Lindon, Jeremy K. Nicholson, Elaine Holmes & Ara W. Darzi. 2016. Metabolic Phenotyping in Personalized and Public Healthcare. Metabolic Phenotyping in Personalized and Public Healthcare 369 388 .
A. B. Vega, A. Perelló, L. Martos, I. García Bayo, M. García, V. Andreu, A. Abad & M. Barenys. (2015) Breath methane in functional constipation: response to treatment with Ispaghula husk. Neurogastroenterology & Motility 27:7, pages 945-953.
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Jun Han, Karen Lin, Carita Sequeira & Christoph H. Borchers. (2015) An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry. Analytica Chimica Acta 854, pages 86-94.
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J. Harland. 2015. Foods, Nutrients and Food Ingredients with Authorised EU Health Claims: Volume 2. Foods, Nutrients and Food Ingredients with Authorised EU Health Claims: Volume 2 109 127 .
Adele Costabile, Sara Santarelli, Sandrine P. Claus, Jeremy Sanderson, Barry N. Hudspith, Jonathan Brostoff, Jane L. Ward, Alison Lovegrove, Peter R. Shewry, Hannah E. Jones, Andrew M. Whitley & Glenn R. Gibson. (2014) Effect of Breadmaking Process on In Vitro Gut Microbiota Parameters in Irritable Bowel Syndrome. PLoS ONE 9:10, pages e111225.
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Emeran A. Mayer, Tor Savidge & Robert J. Shulman. (2014) Brain–Gut Microbiome Interactions and Functional Bowel Disorders. Gastroenterology 146:6, pages 1500-1512.
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L. Crouzet, E. Gaultier, C. Del'Homme, C. Cartier, E. Delmas, M. Dapoigny, J. Fioramonti & A. Bernalier‐Donadille. (2013) The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota . Neurogastroenterology & Motility 25:4.
Crossref
Ian Jeffery & Paul O'Toole. (2013) Diet-Microbiota Interactions and Their Implications for Healthy Living. Nutrients 5:1, pages 234-252.
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Hamish Philpott, Sanjay Nandurkar, John Lubel & Peter R Gibson. (2013) Alternative investigations for irritable bowel syndrome. Journal of Gastroenterology and Hepatology 28:1, pages 73-77.
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Michael Camilleri, Karen Lasch & Wen Zhou. (2012) Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American Journal of Physiology-Gastrointestinal and Liver Physiology 303:7, pages G775-G785.
Crossref
Lisa Ruepert, A Otto Quartero, Niek J de Wit, Geert J van der Heijden, Gregory Rubin & Jean WM Muris. (2011) Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews 2013:3.
Crossref
Jacoline Gerritsen, Hauke Smidt, Ger T. Rijkers & Willem M. de Vos. (2011) Intestinal microbiota in human health and disease: the impact of probiotics. Genes & Nutrition 6:3, pages 209-240.
Crossref
Kannan Ponnusamy, Jung Nam Choi, Jiyoung Kim, Sun-Young Lee & Choong Hwan Lee. (2011) Microbial community and metabolomic comparison of irritable bowel syndrome faeces. Journal of Medical Microbiology 60:6, pages 817-827.
Crossref
Uday C Ghoshal & Prabhat Ranjan. (2011) Post-infectious irritable bowel syndrome: The past, the present and the future. Journal of Gastroenterology and Hepatology 26, pages 94-101.
Crossref
. (2010) Scientific Opinion on the substantiation of health claims related to wheat bran fibre and increase in faecal bulk (ID 3066), reduction in intestinal transit time (ID 828, 839, 3067, 4699) and contribution to the maintenance or achievement of a normal body. EFSA Journal 8:10, pages 1817.
Crossref
c. tana, y. umesaki, a. imaoka, t. handa, m. kanazawa & s. fukudo. (2009) Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterology & Motility.
Crossref
Toku Takahashi, Yukiomi Nakade, Hiroyuki Fukuda, Kiyoshi Tsukamoto, Christopher Mantyh & Theodore. N. Pappas. (2008) Daily Intake of High Dietary Fiber Slows Accelerated Colonic Transit Induced by Restrain Stress in Rats. Digestive Diseases and Sciences 53:5, pages 1271-1277.
Crossref
E. Scarpellini, E.C. Lauritano, A. Lupascu, C. Petruzzellis, M.L. Novi, D. Roccarina, M. Gabrielli, M. Serricchio, G. Gasbarrini & A. Gasbarrini. (2007) Efficacy of butyrate in the treatment of diarrhoea-predominant irritable bowel syndrome. Digestive and Liver Disease Supplements 1:1, pages 19-22.
Crossref
n. b. dass, a. k. john, a. k. bassil, c. w. crumbley, w. r. shehee, f. p. maurio, g. b. t. moore, c. m. taylor & g. j. sanger. (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterology & Motility 19:1, pages 66-74.
Crossref
A Otto Quartero, Villy Meiniche-Schmidt, Jean Muris, Gregory Rubin & Niek de Wit. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
René Bijkerk, Jean Muris, André Knottnerus, Arno Hoes & Niek de Wit. (2005) Vezels zijn maar weinig effectief bij het prikkelbaredarmsyndroom: een systematische review. Huisarts en Wetenschap 48:4, pages 754-761.
Crossref
C. J. Bijkerk, J. W. M. Muris, J. A. Knottnerus, A. W. Hoes & N. J. De Wit. (2004) Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 19:3, pages 245-251.
Crossref
J. Valenzuela, J. Alvarado, H. Cohen, A. Damiao, C. Francisconi, L. Frugone, J.C. González, A. Hernández, B. Iade, M.H. Itaqui Lopes, R. Latorre, J. Prado, P. Moraes-Filho, M. Schmulson, L. Soifer, M.A. Valdovinos, E. Vesco & A. Zalar. (2004) Un consenso latinoamericano sobre el síndrome del intestino irritable. Gastroenterología y Hepatología 27:5, pages 325-343.
Crossref
Jeffrey L Jackson, Patrick G O’Malley, Glen Tomkins, Erin Balden, James Santoro & Kurt Kroenke. (2000) Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis11The opinions in this article represent those of the authors and are not to be construed, in any way, to represent those of the U.S. Army or the Department of Defense.. The American Journal of Medicine 108:1, pages 65-72.
Crossref
William R. Treem, Naheedt Ahsan, Geraldine Kastoff & Jeffrey S. Hyams. (1996) Fecal Short-Chain Fatty Acids in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: In Vitro Studies of Carbohydrate Fermentation. Journal of Pediatric Gastroenterology &amp Nutrition 23:3, pages 280-286.
Crossref
Michael I. McBurney & Lilian U. Thompson. (2016) Dietary Fiber and Total Enteral Nutrition: Fermentative Assessment of Five Fiber Supplements. Journal of Parenteral and Enteral Nutrition 15:3, pages 267-270.
Crossref
John Lindenbaum, David G. Savage, Sally P. Stabler & Robert H. Allen. (2006) Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. American Journal of Hematology 34:2, pages 99-107.
Crossref
Michael I McBurney, Darcye J Cuff & Lilian U Thompson. (1990) Rates of fermentation and short chain fatty acid and gas production of six starches by human faecal microbiota. Journal of the Science of Food and Agriculture 50:1, pages 79-88.
Crossref
Per Brøbech Mortensen, Jens Hegnhøj, Terje Rannem, Henrik Sandvad Rasmussen & Klavs Holtug. (1989) Short-chain fatty acids in bowel contents after intestinal surgery. Gastroenterology 97:5, pages 1090-1096.
Crossref
Furio Brighenti, Giulio Testolin, Enrica Canzi, Annamaria Ferrari, Thomas M.S. Wolever, Salvatore Ciappellano, Marisa Porrini & Paolo Simonetti. (1989) Influence of long-term feeding of different purified dietary fibers on the volatile fatty acid (VFA) profile, pH and fiber-degrading activity of the cecal contents in rats. Nutrition Research 9:7, pages 761-772.
Crossref
MICHAEL I. McBURNEY & LILIAN U. THOMPSON. (1989) In Vitro Fermentabilities of Purified Fiber Supplements. Journal of Food Science 54:2, pages 347-350.
Crossref
N. E. Schindlbeck. 1989. Chronische Obstipation und Stuhlinkontinenz. Chronische Obstipation und Stuhlinkontinenz 53 65 .
Per Brøbech Mortensen, Klas Holtug & Henrik Sandvad Rasmussen. (1988) Short-Chain Fatty Acid Production from Mono- and Disaccharides in a Fecal Incubation System: Implications for Colonic Fermentation of Dietary Fiber in Humans. The Journal of Nutrition 118:3, pages 321-325.
Crossref
S. A Muller-Lissner. (1988) Effect of wheat bran on weight of stool and gastrointestinal transit time: a meta analysis. BMJ 296:6622, pages 615-617.
Crossref

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