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Original Article

Gastrin Produces an Immediate and Dose-Dependent Histamine Release Preceding Acid Secretion in the Totally Isolated, Vascularly Perfused Rat Stomach

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Pages 803-808 | Received 28 Feb 1987, Accepted 25 Mar 1987, Published online: 08 Jul 2009

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Read on this site (40)

Helge L. Waldum, Øyvind Hauso, Eiliv Brenna, Gunnar Qvigstad & Reidar Fossmark. (2016) Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?. Scandinavian Journal of Gastroenterology 51:7, pages 767-773.
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Lars Aabakken. (2015) Scandinavian journal of gastroenterology – the editors-in-chief. Scandinavian Journal of Gastroenterology 50:6, pages 630-635.
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Jens F. Rehfeld. (2015) Gastrointestinal hormone research – with a Scandinavian annotation. Scandinavian Journal of Gastroenterology 50:6, pages 668-679.
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Helge L Waldum, Per M Kleveland & Reidar Fossmark. (2015) Upper gastrointestinal physiology and diseases. Scandinavian Journal of Gastroenterology 50:6, pages 649-656.
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Björn I. Gustafsson, Ingunn Bakke, Øyvind Hauso, Mark Kidd, Irvin M. Modlin, Reidar Fossmark, Eiliv Brenna & Helge L. Waldum. (2011) Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism for histamine induced secretion of hydrochloric acid. Scandinavian Journal of Gastroenterology 46:5, pages 531-537.
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Helge L. Waldum, Gunnar Qvigstad, Reidar Fossmark, Per M. Kleveland & Arne K. Sandvik. (2010) Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint. Scandinavian Journal of Gastroenterology 45:4, pages 389-394.
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Helge L. Waldum, Per M. Kleveland, Eiliv Brenna, Ingunn Bakke, Gunnar Qvigstad, Tom Chr. Martinsen, Reidar Fossmark, Bjørn I. Gustafsson & Arne K. Sandvik. (2009) Interactions between gastric acid secretagogues and the localization of the gastrin receptor. Scandinavian Journal of Gastroenterology 44:4, pages 390-393.
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Arne K Sandvik, Helge L Waldum & Eiliv Brenna. (2002) Long-term safety of proton pump inhibitors: risks of gastric neoplasia and infections. Expert Opinion on Drug Safety 1:1, pages 29-38.
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John V. Fleming & Timothy C. Wang. (2000) Amino- and Carboxy-Terminal PEST Domains Mediate Gastrin Stabilization of Rat l-Histidine Decarboxylase Isoforms. Molecular and Cellular Biology 20:13, pages 4932-4947.
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R. Marrvik, A. K. Sandvik & H. L. Waldum. (1997) Evaluation of Biologic Gastrin Activity of Compound CI-988 in the Isolated, Vascularly Perfused Rat Stomach. Scandinavian Journal of Gastroenterology 32:6, pages 519-522.
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A. K. Sandvik, E. Brenna, A. Sundan, J. J. Holst & H. L. Waldum. (1997) Bombesin Inhibits Histamine Release from the Rat Oxyntic Mucosa by a Somatostatin-dependent Mechanism. Scandinavian Journal of Gastroenterology 32:5, pages 427-432.
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R. Mårvik, A. K. Sandvik & H. L. Waldum. (1997) Gastrin Stimulates Histamine Release from the Isolated Pig Stomach. Scandinavian Journal of Gastroenterology 32:1, pages 2-5.
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H. Watanabe, T. Mochizuki & K. Maeyama. (1996) Transient Increase of Blood Histamine Level Induced by Pentagastrin Continuous Monitoring by in vivo Microdialysis. Scandinavian Journal of Gastroenterology 31:12, pages 1144-1150.
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G. Soldani, M. Garbarg, L. Intorre, S. Bertini, A. Rouleau & J.-C. Schwartz. (1996) Modulation of Pentagastrin-Induced Histamine Release by Histamine H3 Receptors in the Dog. Scandinavian Journal of Gastroenterology 31:7, pages 631-638.
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K. Andersson, E. Lindström, D. Chen, H.-J. Monstein, Å. Boketoft & R. Håkanson. (1996) Depletion of Enterochromaffin-Like Cell Histamine Increases Histidine Decarboxylase and Chromogranin: A mRNA Levels in Rat Stomach by a Gastrin-Independent Mechanism. Scandinavian Journal of Gastroenterology 31:10, pages 959-965.
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D. Chen, C.-M. Zhao, A.-G. Nylander, F. Sundler & R. Håkanson. (1995) Trophic Effects in the Acid-Producing Part of the Rat Stomach after Pyloric Stenosis. Scandinavian Journal of Gastroenterology 30:12, pages 1147-1152.
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E. Brenna, Y. Tielemans, P. M. Kleveland, A. K. Sandvik, G. Willems & H. L. Waldum. (1995) Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa. Scandinavian Journal of Gastroenterology 30:4, pages 311-314.
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B. Simon, R. Eissele, M. Czornik, B. Swarovsky & R. Arnold. (1995) Effect of Gastrin Receptor Blockade on Gastrin and Histidine Decarboxylase Gene Expression in Rats during Achlorhydria. Scandinavian Journal of Gastroenterology 30:6, pages 503-510.
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A. I. Lanas, J. W. Anderson, N. Uemura & B. I. Hirschowitz. (1994) Effects of Cholinergic, Histaminergic, and Peptidergic Stimulation on Pepsinogen Secretion by Isolated Human Peptic Cells. Scandinavian Journal of Gastroenterology 29:8, pages 678-683.
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R. Mårvik, A. H. Johnsen, J. F. Rehfeld, A. Sandvik & H. L. Waldum. (1994) Effect of Cionin on Histamine and Acid Secretion by the Perfused Rat Stomach. Scandinavian Journal of Gastroenterology 29:7, pages 591-594.
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Helge L. Waldum, Arne K. Sandvik, Unni Syversen & Eiliv Brenna. (1993) The Enterochromaffin-Like (ECL) Cell Physiological and pathophysiological role. Acta Oncologica 32:2, pages 141-147.
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B. Romell, K. Girma, R. Seensalu & G. Nilsson. (1993) Effects of Carbachol and Gastrin on 14C-Aminopyrine Accumulated in Rabbit Gastric Glands and Cells. Scandinavian Journal of Gastroenterology 28:6, pages 545-550.
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A.-G. Nylander, R. Håkanson, D. Chen, I. Lilja, J. Axelson, I. Ihse, J. F. Rehfeld & F. Sundler. (1993) Enterochromaffin-like Cells in Rat Stomach Respond to Short-Term Infusion of High Doses of Cholecystokinin But Not to Long-Term, Sustained, Moderate HyperCCKemia Caused by Continuous Cholecystokinin Infusion or Pancreaticobiliary Diversion. Scandinavian Journal of Gastroenterology 28:1, pages 73-79.
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G. Nilsson, B. Romell, K. Girma & R. Seensalu. (1993) Effects of H1-Receptor Antagonists on 14C-Aminopyrine Accumulated in Histamine-Stimulated Rabbit Gastric Glands. Scandinavian Journal of Gastroenterology 28:1, pages 41-48.
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Y. Tielemans, D. Chen, F. Sundler, R. Håkanson & G. Willems. (1992) Reversibility of the Cell Kinetic Changes Induced by Omeprazole in the Rat Oxyntic Mucosa: An Autoradiographic Study Using Tritiated Thymidine. Scandinavian Journal of Gastroenterology 27:2, pages 155-160.
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H. L. Waldum, M. Mignon, A. K. Sandvik & S. Bonfils. (1992) Biologic and Immunologic Gastrin Activity in Serum of Patients with Gastrinoma. Bioassay of Gastrin Activity in Serum. Scandinavian Journal of Gastroenterology 27:12, pages 1039-1044.
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H. L. Waldum, O. A. Haugen, C. Isaksen, R. Mecsei & A. K. Sandvik. (1991) Session 5: Enterochromaffin-Like Tumour Cells in the Diffuse but not the Intestinal Type of Gastric Carcinomas. Scandinavian Journal of Gastroenterology 26:sup180, pages 165-169.
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H. L. Waldum, E. Brenna, A. K. Sandvik & H. Petersen. (1991) Session 5: Trophic Effect of Histamine on the Stomach. Scandinavian Journal of Gastroenterology 26:sup180, pages 137-142.
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P. H. Guth. (1991) Session 4: Pentagastrin and Histamine in the Regulation of Gastric Mucosal Blood Flow. Scandinavian Journal of Gastroenterology 26:sup180, pages 118-125.
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A. K. Sandvik & H. L. Waldum. (1991) Session 4: Aspects of the Regulation of Gastric Histamine Release. Scandinavian Journal of Gastroenterology 26:sup180, pages 108-112.
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P. M. Kleveland & H. L. Waldum. (1991) Session 3: The Gastrin Receptor Assay. Scandinavian Journal of Gastroenterology 26:sup180, pages 62-69.
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H. L. Waldum, A. K. Sandvik, E. Brenna & B. Schulze Søgnen. (1991) Radioimmunoassay of Histamine. Scandinavian Journal of Gastroenterology 26:sup180, pages 32-39.
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H. Petersen. (1991) Session 1: Histamine and the Stomach: Introduction. Scandinavian Journal of Gastroenterology 26:sup180, pages 2-3.
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E. Brenna & H. L. Waldum. (1991) Studies of Isolated Parietal and Enterochromaffin-Like Cells from the Rat. Scandinavian Journal of Gastroenterology 26:12, pages 1295-1306.
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H. L. Waldum, T. Lehy, E. Brenna, A. K. Sandvik, H. Petersen, B. Schulze Søgnen, S. Bonfils & M. J. M. Lewin. (1991) Effect of the Histamine-1 Antagonist Astemizole Alone or with Omeprazole on Rat Gastric Mucosa. Scandinavian Journal of Gastroenterology 26:1, pages 23-35.
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M. D. Basson, T. E. Adrian & I. M. Modlin. (1990) Effects of Cholecystokinin and Cholinergic Receptor Blockade on Guinea Pig Pepsinogen Secretion. Scandinavian Journal of Gastroenterology 25:8, pages 825-833.
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Helge L. Waldum & Arne K. Sandvik. (1989) Histamine and the Stomach. Scandinavian Journal of Gastroenterology 24:2, pages 130-139.
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A. K. Sandvik, P. M. Kleveland & H. L. Waldum. (1988) Muscarinic M2 Stimulation Releases Histamine in the Totally Isolated, Vascularly Perfused Rat Stomach. Scandinavian Journal of Gastroenterology 23:9, pages 1049-1056.
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H. L. Waldum, Ø. Hauso & R. Fossmark. (2014) The regulation of gastric acid secretion - clinical perspectives. Acta Physiologica 210:2, pages 239-256.
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P. Ericsson, R. Håkanson, J.F. Rehfeld & P. Norlén. (2010) Gastrin release: Antrum microdialysis reveals a complex neural control. Regulatory Peptides 161:1-3, pages 22-32.
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Shinichi Kato, Eitaro Aihara, Katsuhide Yoshii & Koji Takeuchi. (2005) Dual action of prostaglandin E 2 on gastric acid secretion through different EP-receptor subtypes in the rat . American Journal of Physiology-Gastrointestinal and Liver Physiology 289:1, pages G64-G69.
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P. Norlén, P. Ericsson, M. Kitano, M. Ekelund & R. Håkanson. (2005) The vagus regulates histamine mobilization from rat stomach ECL cells by controlling their sensitivity to gastrin. The Journal of Physiology 564:3, pages 895-905.
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M Bernsand, P Ericsson, M Björkqvist, C -M Zhao, R Håkanson & P Norlén. (2003) Submucosal microinfusion of endothelin and adrenaline mobilizes ECL-cell histamine in rat stomach, and causes mucosal damage: a microdialysis study. British Journal of Pharmacology 140:4, pages 707-717.
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