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Original Article

Gastric Acid Secretion in the Totally Isolated, Vascularly Perfused Rat Stomach: A Selective Muscarinic-1 Agent Does, Whereas Gastrin Does Not, Augment Maximal Histamine-Stimulated Acid Secretion

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Pages 705-713 | Received 13 Nov 1986, Accepted 27 Feb 1987, Published online: 08 Jul 2009

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Read on this site (18)

Helge L. Waldum. (2020) Clinical consequences of controversies in gastric physiology. Scandinavian Journal of Gastroenterology 55:6, pages 752-758.
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Helge L. Waldum, Øyvind Hauso, Eiliv Brenna, Gunnar Qvigstad & Reidar Fossmark. (2016) Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?. Scandinavian Journal of Gastroenterology 51:7, pages 767-773.
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Jens F. Rehfeld. (2015) Gastrointestinal hormone research – with a Scandinavian annotation. Scandinavian Journal of Gastroenterology 50:6, pages 668-679.
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Helge L Waldum, Per M Kleveland & Reidar Fossmark. (2015) Upper gastrointestinal physiology and diseases. Scandinavian Journal of Gastroenterology 50:6, pages 649-656.
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Björn I. Gustafsson, Ingunn Bakke, Øyvind Hauso, Mark Kidd, Irvin M. Modlin, Reidar Fossmark, Eiliv Brenna & Helge L. Waldum. (2011) Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism for histamine induced secretion of hydrochloric acid. Scandinavian Journal of Gastroenterology 46:5, pages 531-537.
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Helge L. Waldum, Gunnar Qvigstad, Reidar Fossmark, Per M. Kleveland & Arne K. Sandvik. (2010) Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint. Scandinavian Journal of Gastroenterology 45:4, pages 389-394.
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Helge L. Waldum, Per M. Kleveland, Eiliv Brenna, Ingunn Bakke, Gunnar Qvigstad, Tom Chr. Martinsen, Reidar Fossmark, Bjørn I. Gustafsson & Arne K. Sandvik. (2009) Interactions between gastric acid secretagogues and the localization of the gastrin receptor. Scandinavian Journal of Gastroenterology 44:4, pages 390-393.
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Helge L. Waldum, Eiliv Brenna, Arne K. Sandvik. (1998) Maximal Gastric Acid Secretion in Man: A Concept That Needs Precision. Scandinavian Journal of Gastroenterology 33:10, pages 1009-1015.
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H. Watanabe, T. Mochizuki & K. Maeyama. (1996) Transient Increase of Blood Histamine Level Induced by Pentagastrin Continuous Monitoring by in vivo Microdialysis. Scandinavian Journal of Gastroenterology 31:12, pages 1144-1150.
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Helge L. Waldum, Arne K. Sandvik, Unni Syversen & Eiliv Brenna. (1993) The Enterochromaffin-Like (ECL) Cell Physiological and pathophysiological role. Acta Oncologica 32:2, pages 141-147.
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H. L. Waldum, M. Mignon, A. K. Sandvik & S. Bonfils. (1992) Biologic and Immunologic Gastrin Activity in Serum of Patients with Gastrinoma. Bioassay of Gastrin Activity in Serum. Scandinavian Journal of Gastroenterology 27:12, pages 1039-1044.
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H. L. Waldum, E. Brenna, A. K. Sandvik & H. Petersen. (1991) Session 5: Trophic Effect of Histamine on the Stomach. Scandinavian Journal of Gastroenterology 26:sup180, pages 137-142.
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H. L. Waldum, A. K. Sandvik, E. Brenna & B. Schulze Søgnen. (1991) Radioimmunoassay of Histamine. Scandinavian Journal of Gastroenterology 26:sup180, pages 32-39.
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E. Brenna & H. L. Waldum. (1991) Studies of Isolated Parietal and Enterochromaffin-Like Cells from the Rat. Scandinavian Journal of Gastroenterology 26:12, pages 1295-1306.
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H. L. Waldum, T. Lehy, E. Brenna, A. K. Sandvik, H. Petersen, B. Schulze Søgnen, S. Bonfils & M. J. M. Lewin. (1991) Effect of the Histamine-1 Antagonist Astemizole Alone or with Omeprazole on Rat Gastric Mucosa. Scandinavian Journal of Gastroenterology 26:1, pages 23-35.
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M. D. Basson, T. E. Adrian & I. M. Modlin. (1990) Effects of Cholecystokinin and Cholinergic Receptor Blockade on Guinea Pig Pepsinogen Secretion. Scandinavian Journal of Gastroenterology 25:8, pages 825-833.
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Helge L. Waldum & Arne K. Sandvik. (1989) Histamine and the Stomach. Scandinavian Journal of Gastroenterology 24:2, pages 130-139.
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A. K. Sandvik, H. L. Waldum, P. M. Kleveland & B. Schulze Søgnen. (1987) Gastrin Produces an Immediate and Dose-Dependent Histamine Release Preceding Acid Secretion in the Totally Isolated, Vascularly Perfused Rat Stomach. Scandinavian Journal of Gastroenterology 22:7, pages 803-808.
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Articles from other publishers (38)

Helge Waldum & Patricia Mjønes. (2023) The central role of gastrin in gastric cancer. Frontiers in Oncology 13.
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Jens F. Rehfeld. (2021) Gastrin and the Moderate Hypergastrinemias. International Journal of Molecular Sciences 22:13, pages 6977.
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Helge Waldum. (2021) Tumor Classification Should Be Based on Biology and Not Consensus: Re-Defining Tumors Based on Biology May Accelerate Progress, An Experience of Gastric Cancer. Cancers 13:13, pages 3159.
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Helge Waldum. 2020. Hormonal Signaling in Biology and Medicine. Hormonal Signaling in Biology and Medicine 341 359 .
Helge L. Waldum, Per M. Kleveland & Øystein F. Sørdal. (2016) Helicobacter pylori and gastric acid: an intimate and reciprocal relationship . Therapeutic Advances in Gastroenterology 9:6, pages 836-844.
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Kristin M Aasarød, Masoud Ramezanzadehkoldeh, Maziar Shabestari, Mats P Mosti, Astrid K Stunes, Janne E Reseland, Vidar Beisvag, Erik Fink Eriksen, Arne K Sandvik, Reinhold G Erben, Christiane Schüler, Malcolm Boyce, Bjørn H Skallerud, Unni Syversen & Reidar Fossmark. (2016) Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice. Journal of Endocrinology 230:2, pages 251-262.
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Helge L. Waldum, Øyvind Hauso, Øystein F. Sørdal & Reidar Fossmark. (2014) Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach. Digestive Diseases and Sciences 60:6, pages 1522-1527.
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H. L. Waldum, Ø. Hauso & R. Fossmark. (2014) The regulation of gastric acid secretion - clinical perspectives. Acta Physiologica 210:2, pages 239-256.
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Frederick J. Mitchelson. (2012) The pharmacology of McN-A-343. Pharmacology & Therapeutics 135:2, pages 216-245.
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Helge L Waldum, Arne K Sandvik, Øyvind Hauso, Gunnar Qvigstad & Reidar Fossmark. (2012) Withdrawing PPI Therapy: Response to Metz et al.. American Journal of Gastroenterology 107:2, pages 325-326.
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Constantin S. Jianu, Reidar Fossmark, Unni Syversen, Øyvind Hauso & Helge L. Waldum. (2010) A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia. Tumor Biology 31:5, pages 373-380.
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Helge L. Waldum, Tom C. Martinsen, Øyvind Hauso & Gunnar Qvigstad. (2010) Oral proton-pump inhibitors and step-down therapy for nonulcer dyspepsia: is this the right approach?. Therapeutic Advances in Gastroenterology 3:2, pages 73-76.
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Tobias Rudholm, Per Mikael Hellström, Elvar Theodorsson, Colin Allan Campbell, Peter Geoffrey McLean & Erik Näslund. (2008) Bravo capsule system optimizes intragastric pH monitoring over prolonged time: Effects of ghrelin on gastric acid and hormone secretion in the rat. World Journal of Gastroenterology 14:40, pages 6180.
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Vidar Fykse, David H Coy, Helge Lyder Waldum & Arne Kristian Sandvik. (2005) Somatostatin-receptor 2 (sst 2 )-mediated effects of endogenous somatostatin on exocrine and endocrine secretion of the rat stomach . British Journal of Pharmacology 144:3, pages 416-421.
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R. Fossmark, G. Johnsen, E. Johanessen & H. L. Waldum. (2005) Rebound acid hypersecretion after long-term inhibition of gastric acid secretion. Alimentary Pharmacology and Therapeutics 21:2, pages 149-154.
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Gunnar Qvigstad & Helge Waldum. (2004) Rebound Hypersecretion after Inhibition of Gastric Acid Secretion. Basic & Clinical Pharmacology & Toxicology 94:5, pages 202-208.
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Ian M. Joseph & Denise Kirschner. (2004) A model for the study of Helicobacter pylori interaction with human gastric acid secretion. Journal of Theoretical Biology 228:1, pages 55-80.
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DHRUV SUD, IAN M. P. JOSEPH & DENISE KIRSCHNER. (2011) PREDICTING EFFICACY OF PROTON PUMP INHIBITORS IN REGULATING GASTRIC ACID SECRETION. Journal of Biological Systems 12:01, pages 1-34.
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Peter Ericsson, Per Norlén, Maria Bernsand, Per Alm, Peter Höglund & Rolf Håkanson. (2003) ECL Cell Histamine Mobilization Studied byGastric Submucosal Microdialysis in Awake Rats:Methodological Considerations. Pharmacology & Toxicology 93:2, pages 57-65.
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Ian M. P. Joseph, Yana Zavros, Juanita L. Merchant & Denise Kirschner. (2003) A model for integrative study of human gastric acid secretion. Journal of Applied Physiology 94:4, pages 1602-1618.
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Helge L. Waldum, Per M. Kleveland, Arne K. Sandvik, Eiliv Brenna, Unni Syversen, Ingunn Bakke & Karin Tømmerås. (2003) The Cellular Localization of the Cholecystokinin 2 (Gastrin) Receptor in the Stomach. Pharmacology & Toxicology 91:6, pages 359-362.
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Karin Tømmerås, Ingunn Bakke, Arne K Sandvik, Erik Larsson & Helge L Waldum. (2002) Rat parietal cells express CCK2 receptor mRNA: gene expression analysis of single cells isolated by laser-assisted microdissection. Biochemical and Biophysical Research Communications 297:2, pages 335-340.
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G.‐L. CUI, A. K. SANDVIK, B. MUNKVOLD & H. L. WALDUM. (2002) Glycine‐extended gastrin‐17 stimulates acid secretion only via CCK‐2 receptor‐induced histamine release in the totally isolated vascularly perfused rat stomach. Acta Physiologica Scandinavica 174:2, pages 125-130.
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Arne K. Sandvik, Guanglin Cui, Ingunn Bakke, Bjørn Munkvold & Helge L. Waldum. (2001) PACAP stimulates gastric acid secretion in the rat by inducing histamine release. American Journal of Physiology-Gastrointestinal and Liver Physiology 281:4, pages G997-G1003.
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QVIGSTAD, BJØRGAAS, EIDE, SANDVIK & WALDUM. (2001) Vagal stimulation augments maximal (penta) gastrin‐stimulated acid secretion in humans. Acta Physiologica Scandinavica 165:3, pages 277-281.
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Brendan J. Grabau, Yana Zavros, Kenneth J. Hardy & Arthur Shulkes. (1999) Developmental Regulation of Gastric Somatostatin Secretion in the Sheep*. Endocrinology 140:2, pages 603-608.
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A. Yu. Sklyarov, A. M. Maslyanko & T. I. Bondarchuk. (1999) Combined effects of neurotransmitters upon secretory function of the rat stomach at different functional states of the gastric mucosa. Neurophysiology 31:1, pages 56-58.
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H L Waldum, J S Arnestad, E Brenna, I Eide, U Syversen & A K Sandvik. (1996) Marked increase in gastric acid secretory capacity after omeprazole treatment.. Gut 39:5, pages 649-653.
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D. WONG & CW OGLE. (2008) The contrasting influence of chronic nicotine intake on gastrin and gastric acid secretion. Journal of Gastroenterology and Hepatology 10:5, pages 577-584.
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James W. Freston, Kurt Borch, Stephen J. Brand, Enar Carlsson, W. Creutzfeldt, Rolf Håkanson, Lars Olbe, Enrico Solcia, John H. Walsh & M. Michael Wolfe. (1995) Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. Digestive Diseases and Sciences 40:S2, pages 50S-62S.
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Masakyo Asahara, Yoshikazu Kinoshita, Hirohisa Nakata, Yumi Matsushima, Yoko Naribayashi, Akira Nakamura, Toshimitsu Matsui, Kazuo Chihara, Jun Yamamoto, Atsushi Ichikawa & Tsutomu Chiba. (1994) Gastrin receptor genes are expressed in gastric parietal and enterochromaffin-like cells ofMastomys natalensis. Digestive Diseases and Sciences 39:10, pages 2149-2156.
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H. L. WALDUM, E. BRENNA, P. M. KLEVELAND, A. K. SANDVIK & U. SYVERSEN. (2007) Review article: the use of gastric acid‐inhibitory drugs—physiological and pathophysiological considerations. Alimentary Pharmacology & Therapeutics 7:6, pages 589-596.
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E. BRENNA, H. L. WALDUM, A. K. SANDVIK, B. SCHULZE SØGNEN & A. KRISTENSEN. (2007) Effects on the rat oxyntic mucosa of the histamine 2 ‐antagonist loxtidine and the H + , K + ‐ATPase inhibitor omepvazole . Alimentary Pharmacology & Therapeutics 6:3, pages 335-349.
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H-C. Hsu, L. J. Flancbaum, E. Kasziba, G. F. Merrill & H. Fisher. (1991) Roles ofin vitro- andin vivo-administered histamine and serotonin in compound 48/80-induced gastric acid secretion in isolated, perfused rat stomach. Digestive Diseases and Sciences 36:12, pages 1708-1714.
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H L Waldum, A K Sandvik, E Brenna & H Petersen. (1991) Gastrin-histamine sequence in the regulation of gastric acid secretion.. Gut 32:6, pages 698-701.
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R. Håkanson & F. Sundler. 1991. Histamine and Histamine Antagonists. Histamine and Histamine Antagonists 325 346 .
K. Iwasa, A. K. Sandvik & H. L. Waldum. 1991. New Perspectives in Histamine Research. New Perspectives in Histamine Research 429 434 .
A. K. SANDVIK, J. KOFSTAD, J. J. HOLST & H. L. WALDUM. (2008) Ionized calcium influences gastrin stimulated histamine release and acid secretion, but not histamine stimulated acid output in the totally isolated vascularly perfused rat stomach. Acta Physiologica Scandinavica 134:3, pages 443-448.
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