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Review Article

Phospholipase A2 in Acute Pancreatitis

Pages 897-904 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Anu Mäkelä, Timo Kuusi, Pekka Nuutinen & Tom Schröder. (1999) Phospholipase A2 Activity in Body Fluids and Pancreatic Tissue in Patients with Acute Necrotising Pancreatitis. The European Journal of Surgery 165:1, pages 35-42.
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Erich Kaiser. (1999) Phospholipase A2: Its Usefulness in Laboratory Diagnostics. Critical Reviews in Clinical Laboratory Sciences 36:2, pages 65-163.
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A. Mäkelä, T. Kuusi & T. Schröder. (1997) Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scandinavian Journal of Clinical and Laboratory Investigation 57:5, pages 401-407.
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A. N. Kingsnorth. (1996) Platelet-Activating Factor. Scandinavian Journal of Gastroenterology 31:sup219, pages 28-31.
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N-E. L. Saris, B. Steinbrückner, T. Thurén, M. L. T. Lalla, H. van den Bosch, P. K. J. Kinnunen & G. E. Hoffmann. (1992) Characterization of cellular and elevated serum phospholipase A2 activities with a comparison of two methods. Scandinavian Journal of Clinical and Laboratory Investigation 52:1, pages 19-25.
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A. Mäkelä, B. Sternby, T. Kuusi, P. Puolakkainen & T. Schröder. (1990) Phospholipase A2 Activity and Concentration in Several Body Fluids in Patients with Acute Pancreatitis. Scandinavian Journal of Gastroenterology 25:9, pages 944-950.
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Articles from other publishers (50)

C. Thangam, Rozario Cyril, Ramya Sekar, R. Jayasree, Veerakumar Ramachandran, Kulanthaivel Langeswaran, A. Billy Asir & Gowtham Kumar Subbaraj. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 315 335 .
Timo J. Nevalainen. (2007) Phospholipase A2 in acute pancreatitis: review. The American Journal of Surgery 194:4, pages S28-S32.
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George W Browne. (2006) Pathophysiology of pulmonary complications of acute pancreatitis. World Journal of Gastroenterology 12:44, pages 7087.
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J M Grönroos, A J Hietaranta & T J Nevalainen. (1992) Renal tubular cell injury and serum phospholipase A2 activity in acute pancreatitis. British Journal of Surgery 79:8, pages 800-801.
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A N Kingsnorth, S W Galloway & L J Formela. (1995) Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. British Journal of Surgery 82:10, pages 1414-1420.
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L J Formela, S W Galloway & A N Kingsnorth. (1995) Inflammatory mediators in acute pancreatitis. British Journal of Surgery 82:1, pages 6-13.
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Jozef Vracko & Karl-Ludvig Wiechel. (2003) Increased Gallbladder Trypsin in Acute Cholecystitis Indicates Functional Disorder in the Sphincter of Oddi and Could Make EPT a Logical Procedure. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, pages 308-313.
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Johannes Aufenanger, Michael Samman, Michael Quintel, Klaus Fassbender, Wilma Zimmer & Thomas Bertsch. (2002) Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk. Clinical Chemistry and Laboratory Medicine 40:3.
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David A. Partrick, Ernest E. Moore, Christopher C. Silliman, Carlton C. Barnett & Frans A. Kuypers. (2001) Secretory phospholipase A2 activity correlates with postinjury multiple organ failure. Critical Care Medicine 29:5, pages 989-993.
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Krystyna Sztefko & Józefa Panek. (2001) Serum Free Fatty Acid Concentration in Patients with Acute Pancreatitis. Pancreatology 1:3, pages 230-236.
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Ronald F. Martin. 2001. Surgical Intensive Care Medicine. Surgical Intensive Care Medicine 645 658 .
Timo J. Nevalainen, Markku M. Haapamäki & Juha M. Grönroos. (2000) Roles of secretory phospholipases A2 in inflammatory diseases and trauma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1488:1-2, pages 83-90.
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Hartmut Kern, Wolfram Johnen, Jan Braun, Bettina Frey, Bernd Rüstow, Wolfgang J. Kox & Michael Schlame. (2000) Heparin Induces Release of Phospholipase A2 into the Splanchnic Circulation. Anesthesia & Analgesia 91:3, pages 528-532.
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Hartmut Kern, Wolfram Johnen, Jan Braun, Bettina Frey, Bernd Rüstow, Wolfgang J. Kox & Michael Schlame. (2000) Heparin Induces Release of Phospholipase A2 into the Splanchnic Circulation. Anesthesia & Analgesia 91:3, pages 528-532.
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Z ??ledzi??ski, M Wo??niak, A Brunelli, E Lezoche, G Scutti, E Kossowska, K Jankowski, A Stanek & E Bertoli. (2000) Experimental Pancreatitis Induced by Synthetic Prooxidant Tert-butyl Hydroperoxide. Pancreas 20:2, pages 146-151.
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Lin Yu, Robert J. Ternansky, Jackie F. Crisologo, Julia Chang, Brian L. Baker & Stephen M. Coutts. (1998) Carbonothioate Phospholipids as Substrate for a Spectrophotometric Assay of Phospholipase A2. Analytical Biochemistry 265:1, pages 35-41.
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Beat GloorHoward A. Reber. (2016) Effects of Cytokines and Other Inflammatory Mediators on Human Acute Pancreatitis. Journal of Intensive Care Medicine 13:6, pages 305-312.
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Beat Gloor & Howard A. Reber. (1998) Effects of Cytokines and Other Inflammatory Mediators on Human Acute Pancreatitis. Journal of Intensive Care Medicine 13:6, pages 305-312.
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John H. C. Ranson & Peter Shamamian. (1997) Diagnostic standards for acute pancreatitis. World Journal of Surgery 21:2, pages 136-142.
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W. Uhl, R. Vogel & M. W. Büchler. 1997. Diagnostic Procedures in Pancreatic Disease. Diagnostic Procedures in Pancreatic Disease 119 130 .
G. Uomo, G. Manes & P. G. Rabitti. 1997. Diagnostic Procedures in Pancreatic Disease. Diagnostic Procedures in Pancreatic Disease 97 107 .
Steven C. Kazmierczak. 1997. Clinical Pathology of Pancreatic Disorders. Clinical Pathology of Pancreatic Disorders 75 124 .
David Rae, Nazira Sumar, Nicolas Beechey-Newman, Mark Gudgeon & John Hermon-Taylor. (1995) Type 1-prophospholipase A2 propeptide immunoreactivity is released from activated Granulocytes. Clinical Biochemistry 28:1, pages 71-78.
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Shin-ichi Yamashita, Michio Ogawa, Kiyoshi Sakamoto, Toshihiko Abe, Hirofumi Arakawa & Jun-ichi Yamashita. (1994) Elevation of serum group II phospholipase A2 levels in patients with advanced cancer. Clinica Chimica Acta 228:2, pages 91-99.
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N. Reisfeld, D. Lichtenberg & S. Yedgar. (1994) Inhibition of LDL-Associated Phospholipase A Activity in Human Plasma by Albumin. Journal of Basic and Clinical Physiology and Pharmacology 5:2.
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Timo J. Nevalainen & Juha M. Grönroos. 1994. Esterases, Lipases, and Phospholipases. Esterases, Lipases, and Phospholipases 253 261 .
Antti J. Hietaranta, Heikki J. Aho & Timo J. Nevalainen. (1993) Pancreatic phospholipase A2 in cerulein-induced acute pancreatitis in the rat. International journal of pancreatology 14:3, pages 261-267.
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Kazuko Yamamoto, Yasuhisa Shinomura, Hiromasa Tojo, Mitsuhiro Okamoto & Sciichiro Tarui. (1993) Serum pancreatic phospholipase A2 and prophospholipase A2 in acute pancreatitis and after endoscopic retrograde pancreatography. Gastroenterologia Japonica 28:5, pages 679-686.
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Timo J. Nevalainen & Timo J. Haapanen. (1993) Distribution of pancreatic (group I) and synovial-type (group II) phospholipases A2 in human tissues. Inflammation 17:4, pages 453-464.
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P. Martikainen, K. Nyman & T.J. Nevalainen. (1993) Toxic effects of human pancreatic and snake and bee venom phospholipases A2 on MCF-7 cells in culture. Toxicon 31:7, pages 835-843.
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Pirjo T. Kortesuo, Antti J. Hietaranta, Miia Jämiä, Pirkko Hirsimäki & Timo J. Nevalainen. (1993) Rat pancreatic phospholipase A2. International journal of pancreatology 13:2, pages 111-118.
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S. Domschke, P. Malfertheiner, W. Uhl, M. Büchler & W. Domschke. (1993) Free fatty acids in serum of patients with acute necrotizing or edematous pancreatitis. International journal of pancreatology 13:2, pages 105-110.
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Akihiro Funakoshi, Yukio Yamada, Yoshikatsu Migita & Hideyuki Wakasugi. (1993) Simultaneous determinations of pancreatic phospholipase A2 and prophospholipase A2 in various pancreatic diseases. Digestive Diseases and Sciences 38:3, pages 502-506.
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Heikki J. Peuravuori, Hitoshi Funatomi & Timo J. Nevalainen. (1993) Group I and Group II Phospholipases A2 in Serum in Uraemia. Clinical Chemistry and Laboratory Medicine 31:8.
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D. Closa, J. Rosello-Catafau, A. Martrat, G. Hotter, O. Bulbena, L. Fernandez-Cruz & E. Gelpi. (1993) Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate-and cerulein-induced acute pancreatitis in rats. Digestive Diseases and Sciences 38:1, pages 33-38.
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Akiko Kanda, Mikio Tamaki, Etsuo Nakamura, Hiroshi Teraoka & Nobuo Yoshida. (1992) Characterization of recombinant human and rat pancreatic phospholipases A2 secreted from Saccharomyces cerevisiae: Difference in proteolytic processing. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1171:1, pages 1-10.
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A. Martrat, J. Roselló-Catafau, D. Closa, G. Hotter, D. Vargas, L. Fernández-Cruz & E. Gelpí. (1992) Altered systemic and tissue prostacyclin in cerulein induced acute pancreatitis in rats. Prostaglandins, Leukotrienes and Essential Fatty Acids 46:4, pages 261-264.
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C. Fabris, D. Basso, M. P. Panozzo, G. Del Favero, T. Meggiato, M. Plebani, C. Ferrara, P. Fogar, M. Zaninotto & R. Naccarato. (1992) Urinary phospholipase A2 excretion in chronic pancreatic diseases. International Journal of Pancreatology 11:3.
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Simon R. Langton & Joanne Dench. (1991) Phospholipase A2 is associated with albumin in patients with acute pancreatitis. Clinica Chimica Acta 203:2-3, pages 249-257.
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Motoji Kitagawa, Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Yuzo Sakai, Hiroshi Sobajima, Hiroshi Ishiguro, Makoto Tanikawa, Yasuyuki Nakae, Saeko Kameya & Aiji Noda. (1991) Elevation of serum phospholipase A2 in patients at an intensive care unit. International journal of pancreatology 10:3-4, pages 279-286.
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Cornelia Lipperheide, Robert Müller & Klaus Otto. (1991) The activation in vitro of porcine pancreatic prophospholipase A2 by lysosomal enzymes. Biochemical Pharmacology 41:6-7, pages 1093-1095.
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Motoji Kitagawa, Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Yuzo Sakai, Hiroshi Sobajima, Hiroshi Ishiguro & Yasuyuki Nakae. (1991) The diagnostic value of serum pancreatic phospholipase A2 (PLA2) in pancreatic diseases. Gastroenterologia Japonica 26:1, pages 62-68.
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S. Aulikki Santavuori, Pirjo T. Kortesuo, Jarkko U. Eskola & Timo J. Nevalainen. (1991) Application of a New Monoclonal Antibody for Time-resolved Fluoroimmunoassay of Human Pancreatic Phospholipase A2. Clinical Chemistry and Laboratory Medicine 29:12.
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K. Ohlsson & S. Genell. 1991. Pancreatic Disease. Pancreatic Disease 213 226 .
Octávio M.O. Filgueiras & Fred Possmayer. (1990) Purification and characterization of a phospholipase A2 associated with rabbit lung microsomes: some evidence for its mitochondrial origin. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1046:3, pages 258-266.
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P. Vadas, W. Pruzanski, E. Stefanski & B. Sternby. (1990) Compartmental heterogeneity of soluble phospholipases A. Inflammation 14:2, pages 173-183.
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Markus Büchler, Peter Malfertheiner, Hella Schädlich, Timo J. Nevalainen, Helmut Friess & Hans G. Beger. (1989) Role of phospholipase A2 in human acute pancreatitis. Gastroenterology 97:6, pages 1521-1526.
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Antti J. Hietaranta, Timo J. Nevalainen, Heikki J. Aho, Outi M. Hämäläinen & Sari H. Suortamo. (1989) Pancreatic acinar cell necrosis with intact storage of digestive enzymes in selenomethionine treated rats. Virchows Archiv B Cell Pathology Including Molecular Pathology 58:1, pages 397-403.
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M. Büchler, A. Deller, P. Malfertheiner, H. O. Kleine, H. Wiedeck, W. Uhl, M. Samtner, H. Frieß, T. Nevalainen & H. G. Beger. (1989) Serum phospholipase A2 in intensive care patients with peritonitis, multiple injury, and necrotizing pancreatitis. Klinische Wochenschrift 67:3, pages 217-221.
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M. Büchler, P. Malfertheiner, H. Schädlich, T. Nevalainen, T. Mavromatis & H. G. Beger. (1989) Prognostic value of serum phospholipase A in acute pancreatitis. Klinische Wochenschrift 67:3, pages 186-189.
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