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Original Article

Oxygen-Derived Free Radicals in Cerulein-Induced Acute Pancreatitis

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Pages 1245-1249 | Received 18 Apr 1988, Accepted 01 Aug 1988, Published online: 08 Jul 2009

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A. Dabrowski & A. Gabryelewicz. (1994) Nitric Oxide Contributes to Multiorgan Oxidative Stress in Acute Experimental Pancreatitis. Scandinavian Journal of Gastroenterology 29:10, pages 943-948.
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Articles from other publishers (48)

Wei Liu, Juan-Juan Du, Zeng-Hui Li, Xin-Yu Zhang & Hou-Dong Zuo. (2021) Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms. World Journal of Clinical Cases 9:34, pages 10418-10429.
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Jianping Liu, Miaomiao Wu, Run Zhang & Zhi Ping Xu. (2021) Oxygen‐derived free radicals: Production, biological importance, bioimaging, and analytical detection with responsive luminescent nanoprobes. VIEW 2:5, pages 20200139.
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Sapana Bansod, Shrilekha Chilvery, Mohd Aslam Saifi, Tridip Jyoti Das, Hui Tag & Chandraiah Godugu. (2020) Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model. Environmental Toxicology 36:4, pages 530-539.
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Hanan H. Hagar, Sarah A. Almubrik, Nada M. Attia & Sarah N. Aljasser. (2020) Mesna Alleviates Cerulein-Induced Acute Pancreatitis by Inhibiting the Inflammatory Response and Oxidative Stress in Experimental Rats. Digestive Diseases and Sciences 65:12, pages 3583-3591.
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Mami Takahashi, Michihiro Mutoh, Rikako Ishigamori, Gen Fujii & Toshio Imai. (2012) Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. Seminars in Immunopathology 35:2, pages 203-227.
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Jin Hwan Lee, Chun San An, Bok Sun Yun, Kum Suk Kang, Young Ae Lee, Sun Mi Won, Byoung Joo Gwag, Sung Ig Cho & Ki-Baik Hahm. (2012) Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis. European Journal of Pharmacology 687:1-3, pages 28-38.
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David M. BoothRajarshi MukherjeeRobert SuttonDavid N. Criddle. (2011) Calcium and Reactive Oxygen Species in Acute Pancreatitis: Friend or Foe?. Antioxidants & Redox Signaling 15:10, pages 2683-2698.
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Kyung Hee Jung, Sang‐Won Hong, Hong‐Mei Zheng, Hee‐Seung Lee, Hyunseung Lee, Don‐Haeng Lee, Sang Yoon Lee & Soon‐Sun Hong. (2010) Melatonin ameliorates cerulein‐induced pancreatitis by the modulation of nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB in rats. Journal of Pineal Research 48:3, pages 239-250.
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Baris D. Yildiz & Erhan Hamaloglu. (2010) Basic Experimental Pancreatitis Models for Beginners. Surgical Science 01:02, pages 31-39.
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Po Sing LeungYuk Cheung Chan. (2009) Role of Oxidative Stress in Pancreatic Inflammation. Antioxidants & Redox Signaling 11:1, pages 135-166.
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Yun Ju Jo, Ho Soon Choi, Dae Won Jun, Oh Young Lee, Joo Seop Kang, Il Gyu Park, Kyung Hwan Jung & Joon Soo Hahm. (2008) The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats. International Immunopharmacology 8:7, pages 959-966.
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Conor J. ShieldsConor P. DelaneyDesmond C. WinterLeonie YoungThomas F. GoreyJohn M. Fitzpatrick. (2006) Induction of Nitric Oxide Synthase is a Key Determinant of Progression to Pulmonary Injury in Experimental Pancreatitis. Surgical Infections 7:6, pages 501-511.
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Mukaddes Eşrefoğlu, Mehmet Gül, Burhan Ateş & Ismet Yilmaz. (2006) Ultrastructural clues for the protective effect of ascorbic acid and N-acetylcysteine against oxidative damage on caerulein-induced pancreatitis. Pancreatology 6:5, pages 477-485.
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I de Dios, L Ramudo, AC García‐Montero & MA Manso. (2006) Redox‐sensitive modulation of CD45 expression in pancreatic acinar cells during acute pancreatitis. The Journal of Pathology 210:2, pages 234-239.
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Mukaddes Eşrefoğlu, Mehmet Gül, Burhan Ateş, Kadir Batçıoğlu & Mukadder Ayşe Selimoğlu. (2006) Antioxidative effect of melatonin, ascorbic acid and N -acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats . World Journal of Gastroenterology 12:2, pages 259.
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Helge Kleinhans. (2006) Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World Journal of Gastroenterology 12:18, pages 2914.
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Mukaddes Esrefoglu, Mehmet Gul, Burhan Ates & Mukadder Ayse Selimoglu. (2006) Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. Journal of Pineal Research 40:1, pages 92-97.
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L J Formela, S W Galloway & A N Kingsnorth. (1995) Inflammatory mediators in acute pancreatitis. British Journal of Surgery 82:1, pages 6-13.
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Giuseppe M. Campo, Angela Avenoso, Salvatore Campo, Alida M. Ferlazzo & Alberto Calatroni. (2004) Administration of Hyaluronic Acid and Chondroitin-4-Sulfate Limits Endogenous Antioxidant Depletion and Reduces Cell Damage in Experimental Acute Pancreatitis. Pancreas 28:2, pages e45-e53.
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S Sevillano, A.M de la Mano, M.A Manso, A Orfao & I De Dios. (2003) N-acetylcysteine prevents intra-acinar oxygen free radical production in pancreatic duct obstruction-induced acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1639:3, pages 177-184.
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Roberto Ferreira Meirelles Jr.Reginaldo Ceneviva, José Liberato Ferreira CabocloMichael M. Eisenberg. (2003) Reactive oxygen species inactivation improves pancreatic capillary blood flow in caerulein-induced pancreatitis in rats. Acta Cirurgica Brasileira 18:suppl 5, pages 29-33.
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Christine C. Winterbourn, Martin J.D. Bonham, Hendrikje Buss, Fikri M. Abu-Zidan & John A. Windsor. (2003) Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis. Pancreatology 3:5, pages 375-382.
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Jens Werner, Werner Hartwig, Waldemar Uhl, Christophe Müller & Markus W. Büchler. (2003) Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis. Pancreatology 3:2, pages 115-127.
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Jolanta Jaworek, Anna Leja-Szpak, Joanna Bonior, Katarzyna Nawrot, Romana Tomaszewska, Jerzy Stachura, Ryszard Sendur, Wiesław Pawlik, Tomasz Brzozowski & Stanisław J. Konturek. (2003) Protective effect of melatonin and its precursor L -tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion . Journal of Pineal Research 34:1, pages 40-52.
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C J Shields, D C Winter, S Sookhai, L Ryan, W O Kirwan & H P Redmond. (2000) Hypertonic saline attenuates end-organ damage in an experimental model of acute pancreatitis. British Journal of Surgery 87:10, pages 1336-1340.
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Shi-Bing Su, Yoshiharu Motoo, Min-Jue Xie, Hisatsugu Mouri, Kohtaro Asayama & Norio Sawabu. (2002) Superoxide Dismutase Is Induced During Rat Pancreatic Acinar Cell Injury. Pancreas 24:2, pages 146-152.
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Chih-Hsien Chi, Shu-Chu Shiesh & Xi-Zang Lin. (2002) Total antioxidant capacity and malondialdehyde in acute abdominal pain. The American Journal of Emergency Medicine 20:2, pages 79-82.
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Conor J. Shields, Shastri Sookhai, Desmond C. Winter, Joseph F. Dowdall, Gearoid Kingston, Nollaig Parfrey, Jiang H. Wang, William O. Kirwan & H. Paul Redmond. (2001) Attenuation of Pancreatitis-Induced Pulmonary Injury by Aerosolized Hypertonic Saline. Surgical Infections 2:3, pages 215-224.
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Fumio Furukawa, Akiyoshi Nishikawa, Ken-ichiro Kasahara, Makoto Miyauchi, Hideaki Nakamura, Hwa-Young Son, Koji Uchida & Masao Hirose. (2001) Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats. Pancreas 22:4, pages 427-430.
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Peter Kruse, Mary E Anderson & Steffen Loft. (2001) Minor role of oxidative stress during intermediate phase of acute pancreatitis in rats. Free Radical Biology and Medicine 30:3, pages 309-317.
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Andrzej Dąbrowski, Stanislaw J. Konturek, Jan W. Konturek & Antoni Gabryelewicz. (1999) Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis. European Journal of Pharmacology 377:1, pages 1-11.
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J.H. Sweiry, I. Shibuya, N. Asada, K. Niwa, K. Doolabh, Y. Habara, T. Kanno & G.E. Mann. (1999) Acute oxidative stress modulates secretion and repetitive Ca2+ spiking in rat exocrine pancreas. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1454:1, pages 19-30.
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George H. Sakorafas, Gregory G. Tsiotos, Thomas C. Bower & Michael G. Sarr. (1998) Ischemic necrotizing pancreatitis. International journal of pancreatology 24:2, pages 117-121.
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Teoman Coskun, Serhasan Bozoklu, Ahmet Özenç & Arif Özdemir. (1998) Effect of hydrogen peroxide on permeability of the main pancreatic duct and morphology of the pancreas. The American Journal of Surgery 176:1, pages 53-58.
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Zhan-Liang Lu. (1998) Traditional Chinese medicine "Qing Yi Tang" alleviates oxygen free radical injury in acute necrotizing pancreatits. World Journal of Gastroenterology 4:4, pages 357.
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MH Schoenberg, D Birk & HG Beger. (1995) Oxidative stress in acute and chronic pancreatitis. The American Journal of Clinical Nutrition 62:6, pages 1306S-1314S.
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Zbigniew Śledziński, Michal Woźniak, J⊹drzej Antosiewicz, Emanuele Lezoche, Massimo Familiari, Enrico Bertoli, Lucedio Greci, Alessandro Brunelli, Nino Mazera & Zdzisław Wajda. (1995) Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis. International journal of pancreatology 18:2, pages 153-160.
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Jædrzej Antosiewicz, Jerzy Popinigis, Hiroshi Ishiguro, Tetsuo Hayakawa & Takashi Wakabayashi. (1995) Cerulein-induced acute pancreatitis diminished vitamin E concentration in plasma and increased in the pancreas. International journal of pancreatology 17:3, pages 231-236.
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Andrzej Dabrowski, Antoni Gabryelewicz & Lech Chyczewski. (1995) The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress. International journal of pancreatology 17:2, pages 173-180.
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Giorgio Emanuelli, Giuseppe Montrucchio, Luca Dughera, Ezio Gaia, Enrico Lupia, Edda Battaglia, Antonella De Martino, Paolo De Giuli, Luciano Gubetta & Giovanni Camussi. (1994) Role of platelet activating factor in acute pancreatitis induced by lipopolysaccharides in rabbits. European Journal of Pharmacology 261:3, pages 265-272.
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M. H. Schoenberg, M. Büchler, M. Younes, R. Kirchmayr, U. B. Brückner & H. G. Beger. (1994) Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis. Digestive Diseases and Sciences 39:5, pages 1034-1040.
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D. Closa, O. Bulbena, J. Rosello-Catafau, L. Fernandez-Cruz & E. Gelpi. (1993) Effect of prostaglandins and superoxide dismutase administration on oxygen free radical production in experimental acute pancreatitis. Inflammation 17:5, pages 563-571.
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Andrzej Dabrowski & Antoni Gabryelewicz. (1992) Oxidative stress. International journal of pancreatology 12:3, pages 193-199.
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KAZUYO FUJIMURA, YOSHITSUGU KUBOTA, MAMI OGURA, TAKASHI YAMAGUCHI, TAKESHI BINNAKA, KAZUHIRO TANI, SHIN‐ICHI KITAGAWA, TAKAKO MIZUNO & KYOICHI INOUE. (2008) Role of endogenous platelet‐activating factor in caerulein‐induced acute pancreatitis in rats: Protective effects of a PAF‐antagonist. Journal of Gastroenterology and Hepatology 7:2, pages 199-202.
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M.H. Schoenberg, M. Büchler & H.G. Beger. (1992) The role of oxygen radicals in experimental acute pancreatitis. Free Radical Biology and Medicine 12:6, pages 515-522.
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M. L. Steer, P. L. Rutledge, R. E. Powers, M. Saluja & A. K. Saluja. (1991) The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: Effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. Klinische Wochenschrift 69:21-23, pages 1012-1017.
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Andrzej Da̧browski, Antoni Gabryelewicz & Marek Chwiećko. (1991) Products of lipid peroxidation and changes in sulfhydryl compounds in pancreatic tissue of rats with caerulein-induced acute pancreatitis. Biochemical Medicine and Metabolic Biology 46:1, pages 10-16.
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Andrzej Dabrowski, Antoni Gabryelewicz & Lech Chyczewski. (1991) The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals. International journal of pancreatology 8:1, pages 1-11.
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