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Review Article

Role of Epidermal Growth Factor in Gastroprotection and Ulcer Healing

Pages 129-133 | Published online: 08 Jul 2009

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A. Palomino, F. Hernández-Bernal, W. Haedo, S. Franco, J. A. Más, J. A. Fernández, G. Soto, A. Alonso, T. González, P. López-Saura. (2000) A Multicenter, Randomized, Double-Blind Clinical Trial Examining the Effect of Oral Human Recombinant Epidermal Growth Factor on the Healing of Duodenal Ulcers. Scandinavian Journal of Gastroenterology 35:10, pages 1016-1022.
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Articles from other publishers (34)

Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien & Tomasz Brzozowski. (2017) Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions. Journal of Gastroenterology 53:5, pages 618-630.
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G Yetkin, N Çelebi, Ç Özer, B Gönül & C Özoğul. (2004) The healing effect of TGF-α on gastric ulcer induced by acetylsalicylic acid in rats. International Journal of Pharmaceutics 277:1-2, pages 163-172.
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Yoji Matsumoto, Kohki Kanamoto, Keishi Kawakubo, Hitoshi Aomi, Takayuki Matsumoto, Setsuro Ibayashi & Masatoshi Fujishima. (2001) Gastroprotective and vasodilatory effects of epidermal growth factor: the role of sensory afferent neurons. American Journal of Physiology-Gastrointestinal and Liver Physiology 280:5, pages G897-G903.
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Hisamasa Kodaira, Kazuhiko Ishihara, Kyoko Hotta, Masatoyo Kagoshima, Hideyo Shimada & Kunio Ishii. (1999) Rat Gastric Mucous Gel Layer Contains Sialomucin Not Produced by the Stomach. Japanese Journal of Pharmacology 81:1, pages 86-93.
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JOHN M SAYLES, VICTOR D'ADDIO, JIAN-YING WANG & BARBARA L BASS. (1998) Epidermal growth factor-stimulated rabbit oesophageal mucosal growth: Role of polyamines. Journal of Gastroenterology and Hepatology 13:S3, pages S149-S155.
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JOHN SAYLES, VICTOR D’ADDIO, JIAN-YING WANG & BARBARA BASS. (1998) Epidermal growth factor-stimulated rabbit oesophageal mucosal growth: Role of polyamines. Journal of Gastroenterology and Hepatology 13:11-s4, pages S149-S155.
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Shoou-Lih Wang, Jian Feng & Chi Ying Wu-Wang. (1997) Time-dependent alteration of epidermal growth factor receptor in rat stomach by ethanol feeding. Toxicology Letters 90:2-3, pages 115-123.
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Damien A. F. Lynch, Nicholas P. Mapstone, Fraser Lewis, Judith Pentith, Anthony T. R. Axon, Michael F. Dixon & Phillip Quirke. (2007) Serum and Gastric Luminal Epidermal Growth Factor in Helicobacter Pylori—Associated Gastritis and Peptic Ulcer Disease. Helicobacter 1:4, pages 219-226.
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S.-L. Wang, C.Y. Wu-Wang, J. Feng, N. Espina & A.J. Garro. (1996) Chronic ethanol feeding alters the structure and function of the epidermal growth factor receptor in rat stomach. Alcohol 13:5, pages 461-466.
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J. Piotrowski, J. Majka, S. Sano, P. Nowak, V.L.N. Murty, A. Slomiany & B.L. Slomiany. (1995) Enhancement in gastric mucosal EGF and PDGF receptor expression with ulcer healing by sulglycotide. General Pharmacology: The Vascular System 26:4, pages 749-753.
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Karnam R. Purushotham, Tivadar Zelles, Josef Blazsek, Paoli Wang, George A. Paul, Micah Kerr & Michael G. Humphreys-Beher. (1995) Effect of EGF on rat parotid gland secretory function. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 110:1, pages 7-14.
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Frank Procaccino, Max Reinshagen, Peter Hoffmann, Jörg M. Zeeh, Jayaraman Lakshmanan, James A. McRoberts, Avanish Patel, Samuel French & Viktor E. Eysselein. (1994) Protective effect of epidermal growth factor in an experimental model of colitis in rats. Gastroenterology 107:1, pages 12-17.
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B.L. Slomiany, J. Piotrowski, A. Czajkowski, F. Yotsumoto, J. Majka & A. Slomiany. (1994) Gastric mucosal laminin receptor expression with ulcer healing by ebrotidine. General Pharmacology: The Vascular System 25:3, pages 451-455.
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S.-L. Wang, C.Y. Wu-Wang, A. Slomiany & B.L. Slomiany. (1994) Effect of acute ethanol treatment on epidermal growth factor receptor in the rat stomach. Alcohol 11:1, pages 11-15.
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T. Brzozowski, S. J. Konturek, J. Majka, A. Dembinski & D. Drozdowicz. (1993) Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats. Digestive Diseases and Sciences 38:2, pages 276-283.
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J. Liu, Z. Fekete, A. Slomiany & B.L. Slomiany. (1993) Activation of gastric mucosal calcium channels by epidermal growth factor. International Journal of Biochemistry 25:1, pages 29-35.
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Barbara Orsini, Antonio Calabrò, Stefano Milani, Cecilia Grappone, Hermann Herbst & Calogero Surrenti. (1993) Localization of epidermal growth factor/transforming growth factor-α receptor in the human gastric mucosa. Virchows Archiv A Pathological Anatomy and Histopathology 423:1, pages 57-63.
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J. Liu, A. Slomiany & B.L. Slomiany. (1992) Effect of sucralfate on gastric mucosal calcium channels activity. General Pharmacology: The Vascular System 23:6, pages 1129-1133.
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B.L. Slomiany, Z. Fekete, J. Liu, V.L.N. Murty & A. Slomiany. (1992) Activation of dihydropyridine-sensitive parotid salivary gland calcium channels by epidermal growth factor. Archives of Oral Biology 37:11, pages 863-868.
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B.L. Slomiany, J. Liu, P. Yao & A. Slomiany. (1992) GM1-ganglioside regulation of EGF-induced gastric mucosal calcium channel activation. General Pharmacology: The Vascular System 23:5, pages 799-803.
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B.L. Slomiany, J. Liu, J.P. Keogh, J. Piotrowski & A. Slomiany. (1992) Enhancement of gastric mucosal epidermal growth factor and platelet-derived growth factor receptor expression by sucralfate. General Pharmacology: The Vascular System 23:4, pages 715-718.
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Jolanta Jaworek, Stanislaw J. Konturek, Wladystaw Bielanski, Jan Bilskiy & Mariusz Hladij. (1992) Release and binding of epidermal growth factor in the pancreas of rats. International journal of pancreatology 11:1.
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S.K. Saxena, J.S. Thompson, S.S. Joshi & J.G. Sharp. (1992) Association of radiolabeled urogastrone binding with regenerating intestinal mucosa and epidermal growth factor/ urogastrone producing organs in rat. Life Sciences 51:5, pages 381-387.
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Stanislaw J. Konturek, Toman Brzozowski, Danuta Drozdowicz, J. Garlicki, J. Majka & J. Pytko-Polonczyk. (1991) Role of acid milieu in the gastroprotective and ulcer-healing activity of sucralfate. The American Journal of Medicine 91:2, pages S20-S29.
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S.J. Konturek, T. Brzozowski, P.K. Konturek, J. Majka & A. Dembiński. (1991) Role of salivary glands and epidermal growth factor (EGF) in gastric secretion and mucosal integrity in rats exposed to stress. Regulatory Peptides 32:2, pages 203-215.
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