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Original Article

Effect of Z-103 on Compound 48/80-Induced Gastric Lesions in Rats

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Pages 202-205 | Published online: 08 Jul 2009

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Xue Gao, Mohammed A Al-Baadani, Minjie Wu, Ningyang Tong, Xinkun Shen, Xi Ding & Jinsong Liu. (2022) Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane. International Journal of Nanomedicine 17, pages 17-29.
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Theng Choon Ooi, Kok Meng Chan & Razinah Sharif. (2017) Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine: A Potential Cancer Chemopreventive Agent?. Nutrition and Cancer 69:2, pages 201-210.
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Tatsuya Ohkawara, Hiroshi Takeda, Kanji Kato, Kencho Miyashita, Mototsugu Kato, Toshihiko Iwanaga & Masahiro Asaka. (2005) Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice. Scandinavian Journal of Gastroenterology 40:11, pages 1321-1327.
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S. Furuta, S. Toyama & H. Sano. (1994) Absorption mechanism of polaprezinc (zinc L-carnosine complex) by an everted sac method. Xenobiotica 24:11, pages 1085-1094.
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A. Rodríguez-Caballero, D. Torres-Lagares, M. Robles-García, J. Pachón-Ibáñez, D. González-Padilla & J.L. Gutiérrez-Pérez. (2012) Cancer treatment-induced oral mucositis: a critical review. International Journal of Oral and Maxillofacial Surgery 41:2, pages 225-238.
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Joshua K Ko & Catherine C Leung. (2010) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. Journal of Gastroenterology and Hepatology 25:12, pages 1861-1869.
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Takeaki Nagamine, Kastuyuki Nakajima, Hisashi Takada, Yoshitaka Sekine & Kazuhiro Suzuki. (2009) Induction of type 1 interferon receptor by zinc in U937 cells. Cytokine 46:3, pages 346-350.
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Tadashi Nishida, Shuzo Ohata, Chiaki Kusumoto, Shinsuke Mochida, Junya Nakada, Yoshimi Inagaki, Yoshiji Ohta & Tatsuya Matsura. (2009) Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70. Journal of Clinical Biochemistry and Nutrition 46:1, pages 43-51.
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Junzo Kamei, Masahiro Ohsawa, Shigeo Miyata & Shun-ichi Tanaka. (2008) Preventive effect of l-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice. European Journal of Pharmacology 600:1-3, pages 83-86.
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Kenji Nakayama, Mitsuru Kubota, Yoshinobu Katoh, Yukiharu Sawada, Akiko Saito, Kazuhiko Nishimura, Eiji Katsura, Naoshi Ichihara, Tomohiro Suzuki, Hirokazu Kouguchi, Masahide Tamura, Hiroshi Honma, Setsuo Kanzaki, Hitoshi Itami, Akihiko Ohtake, Kunihiko Kobayashi, Tadashi Ariga, Kenji Fujieda, Norikazu Shimizu & Tsugutoshi Aoki. (2008) Early and presymptomatic detection of Wilson’s disease at the mandatory 3-year-old medical health care examination in Hokkaido Prefecture with the use of a novel automated urinary ceruloplasmin assay. Molecular Genetics and Metabolism 94:3, pages 363-367.
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Gavino Faa, Valeria M. Nurchi, Alberto Ravarino, Daniela Fanni, Sonia Nemolato, Clara Gerosa, Peter Van Eyken & Karel Geboes. (2008) Zinc in gastrointestinal and liver disease. Coordination Chemistry Reviews 252:10-11, pages 1257-1269.
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Mutsumi MATSUU-MATSUYAMA, Kazuko SHICHIJO, Kumio OKAICHI, Toshiyuki NAKAYAMA, Masahiro NAKASHIMA, Takashi UEMURA, Daisuke NIINO & Ichiro SEKINE. (2008) Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells. Journal of Radiation Research 49:4, pages 341-347.
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Masaru Odashima, Michiro Otaka, Mario Jin, Isao Wada, Youhei Horikawa, Tamotsu Matsuhashi, Reina Ohba, Natsumi Hatakeyama, Jinko Oyake & Sumio Watanabe. (2006) Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-κB activation. Life Sciences 79:24, pages 2245-2250.
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Tatsuya Ohkawara. (2006) Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: Relevant to cytoprotective heat shock proteins. World Journal of Gastroenterology 12:38, pages 6178.
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Hiraishi, Sasai, Oinuma, Shimada, Sugaya & Terano. (1999) Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro . Alimentary Pharmacology & Therapeutics 13:2, pages 261-269.
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TETSUYA YASUHIRO, AKIRA KONAKA, SHINICHI KATO & KOJI TAKEUCHI. (2008) Gastric mucosal damage induced by compound 48/80: Roles of serotonin and nitric oxide. Journal of Gastroenterology and Hepatology 13:11, pages 1099-1106.
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T Yasuhiro, A Konaka, H Ukawa, S Kato & K Takeuchi. (1997) Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound in rats. Journal of Physiology-Paris 91:3-5, pages 131-138.
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Toshikazu Yoshikawa, Yuji Naito, Toru Tanigawa, Tomoyuki Yoneta & Motoharu Kondo. (1991) The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-l-histidinato zinc. Biochimica et Biophysica Acta (BBA) - General Subjects 1115:1, pages 15-22.
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Mikio ITO, Takao TANAKA & Yoshio SUZUKI. (1990) Effect of N-(3-Aminopropionyl)-L-Histidinato Zinc (Z-103) on Healing and Hydrocortisone-lnduced Relapse of Acetic Acid Ulcers in Rats with Limited Food-Intake-Time. Japanese Journal of Pharmacology 52:4, pages 513-521.
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