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Scandinavian Journal of Gastroenterology Volume 24, 1989 - Issue sup163
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Review Article

A Review of Gastric Ulcer and Gastroduodenal Injury in Normal Volunteers Receiving Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs

F. L. Lanza Houston Institute for Clinical Research Houston, and Dept.of Medicine, Section of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA
Pages 24-31 | Published online: 08 Jul 2009

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Han Peng & Fereidoon Shahidi. (2023) Metabolic, toxicological, chemical, and commercial perspectives on esterification of dietary polyphenols: a review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-40.
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Hee Man Kim, Jae Hee Cho, Jin Yi Choi, Song Wook Chun, Yu Jin Kim, Hyeon Geun Cho, Si Young Song & Ki Jun Han. (2013) NSAID is inversely associated with asymptomatic gastric ulcer: Local health examination data from the Korean National Health Insurance Corporation. Scandinavian Journal of Gastroenterology 48:12, pages 1371-1376.
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A. HAMLET, C. LINDHOLM, O. NILSSON, L. OLBE. (1998) Aspirin-induced Gastritis, Like Helicobacter pylori-induced Gastritis, Disinhibits Acid Secretion in Humans: Relation to Cytokine Expression. Scandinavian Journal of Gastroenterology 33:4, pages 346-356.
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M. Leivonen, P. Sipponen & E. Kivilaakso. (1992) Gastric Changes in Coronary-Operated Patients with Low-Dose Aspirin. Scandinavian Journal of Gastroenterology 27:11, pages 912-916.
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Salim M. A. Bastaki, Ireneusz T. Padol, Naheed Amir & Richard H. Hunt. (2017) Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels in the anaesthetized rats in vivo. Molecular and Cellular Biochemistry 438:1-2, pages 25-34.
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Nadia Estela Díaz-Triste, Martha Patricia González-García, Juan Miguel Jiménez-Andrade, Gilberto Castañeda-Hernández & Aracely Evangelina Chávez-Piña. (2014) Pharmacological evidence for the participation of NO–cGMP–KATP pathway in the gastric protective effect of curcumin against indomethacin-induced gastric injury in the rat. European Journal of Pharmacology 730, pages 102-106.
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Hala El‐Zimaity & Robert H. Riddell. 2013. Morson and Dawson's Gastrointestinal Pathology. Morson and Dawson's Gastrointestinal Pathology 110 161 .
Asokumar Buvanendran. 2013. Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches. Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches 35 44 .
Bryan S. Williams & Asokumar Buvanendran. 2011. Essentials of Pain Medicine. Essentials of Pain Medicine 130 139 .
Bryan S. Williams & Asokumar Buvanendran. 2010. The Essence of Analgesia and Analgesics. The Essence of Analgesia and Analgesics 57 65 .
Georgia Charkoftaki, John Kytariolos & Panos Macheras. (2010) Novel milk-based oral formulations: Proof of concept. International Journal of Pharmaceutics 390:2, pages 150-159.
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Y.-H. YUAN, C. WANG, Y. YUAN & R. H. HUNT. (2009) Meta-analysis: incidence of endoscopic gastric and duodenal ulcers in placebo arms of randomized placebo-controlled NSAID trials. Alimentary Pharmacology & Therapeutics 30:3, pages 197-209.
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Bryan S. Williams & Asokumar Buvanendran. (2009) Nonopioid Adjuvants in Multimodal Therapy for Acute Perioperative Pain. Advances in Anesthesia 27:1, pages 111-142.
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Scott S. Reuben. 2009. Current Therapy in Pain. Current Therapy in Pain 59 72 .
Aliye Soylu, Can Dolapcioglu, Kemal Dolay, Aydin Ciltas, Nurgul Yasar, Mustafa Kalayci, Halil Alis & Nurten Sever. (2008) Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent. World Journal of Gastroenterology 14:43, pages 6704.
Crossref
Asokumar Buvanendran & Scott S. Reuben. 2008. Raj's Practical Management of Pain. Raj's Practical Management of Pain 671 692 .
A. Brack & M. Schäfer. 2008. Die Anästhesiologie. Die Anästhesiologie 274 296 .
Catherine Michaux, Xavier de Leval, Fabien Julémont, Jean-Michel Dogné, Bernard Pirotte & François Durant. (2006) Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method. European Journal of Medicinal Chemistry 41:12, pages 1446-1455.
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Francesco Dentali, James D Douketis, Karen Woods, Lehana Thabane, Gary Foster, Anne Holbrook & Mark Crowther. (2016) Does Celecoxib Potentiate the Anticoagulant Effect of Warfarin? A Randomized, Double-Blind, Controlled Trial. Annals of Pharmacotherapy 40:7-8, pages 1241-1247.
Crossref
Regina M. Botting. (2006) Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004). Journal of Thermal Biology 31:1-2, pages 208-219.
Crossref
Gérard Thiéfin. (2006) Toxicité gastroduodénale des médicaments anti-inflammatoires non stéroïdiens. EMC - Gastro-entérologie 1:1, pages 1-11.
Crossref
Bruce E. Stabile, Brian R. Smith & David L. Weeks. (2005) Helicobacter pylori Infection and Surgical Disease—Part II. Current Problems in Surgery 42:12, pages 804-862.
Crossref
Peter Bias, Anton Buchner, Bernhard Klesser & Stefan Laufer. (2004) The Gastrointestinal Tolerability of the LOX/COX Inhibitor, Licofelone, is Similar to Placebo and Superior to Naproxen Therapy in Healthy Volunteers: Results From a Randomized, Controlled Trial. American Journal of Gastroenterology 99:4, pages 611-618.
Crossref
Véronique Merle, Gérard Thiéfin & Pierre Czernichow. (2004) Épidémiologie des complications gastro-duodénales associées aux anti-inflammatoires non stéroïdiens. Gastroentérologie Clinique et Biologique 28, pages 27-36.
Crossref
Dominique Lamarque. (2004) Physiopathologie des lésions gastro-duodénales induites par les anti-inflammatoires non stéroïdiens. Gastroentérologie Clinique et Biologique 28, pages 18-26.
Crossref
Thomas Hedner, Ola Samulesson, Peter W??hrborg, Hans Wadenvik, Kjell-Arne Ung & Anders Ekbom. (2004) Nabumetone. Drugs 64:20, pages 2315-2343.
Crossref
Robynne Chutkan & Nabil Toubia. (2004) Effect of nonsteroidal anti-inflammatory drugs on the gastrointestinal tract: diagnosis by wireless capsule endoscopy. Gastrointestinal Endoscopy Clinics of North America 14:1, pages 67-85.
Crossref
John L. Wallace & Piero Del Soldato. (2003) The therapeutic potential of NO-NSAIDs. Fundamental and Clinical Pharmacology 17:1, pages 11-20.
Crossref
David W. Day, Jeremy R. Jass, Ashley B. Price, Neil A. Shepherd, James M. Sloan, Ian C. Talbot, Bryan F. Warren & Geraint T. Williams. 2003. Morson and Dawson's Gastrointestinal Pathology. Morson and Dawson's Gastrointestinal Pathology 141 161 .
Mihnea V. Chiorean, Richard G. Locke, Alan R. Zinsmeister, Cathy D. Schleck & Joseph L. Melton. (2002) Changing Rates of Helicobacter pylori Testing and Treatment in Patients With Peptic Ulcer Disease. American Journal of Gastroenterology 97:12, pages 3015-3022.
Crossref
Navtej S. Buttar, Kenneth K. Wang, Olga Leontovich, Jay Y. Westcott, Rodney J. Pacifico, Marlys A. Anderson, Krishnawatie K. Krishnadath, Lori S. Lutzke & Lawrence J. Burgart. (2002) Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. Gastroenterology 122:4, pages 1101-1112.
Crossref
Francisco J de Abajo & Luis A García Rodríguez. (2001) Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. BMC Clinical Pharmacology 1:1.
Crossref
Walter L. Straus & Joshua J. Ofman. (2001) GASTROINTESTINAL TOXICITY ASSOCIATED WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. Gastroenterology Clinics of North America 30:4, pages 895-920.
Crossref
John L. Wallace. (2001) Pathogenesis of NSAID-induced gastroduodenal mucosal injury. Best Practice & Research Clinical Gastroenterology 15:5, pages 691-703.
Crossref
Kathryn S. Wildy & Mary Chester M. Wasko. (2001) CURRENT CONCEPTS REGARDING PHARMACOLOGIC TREATMENT OF RHEUMATOID AND OSTEOARTHRITIS. Hand Clinics 17:2, pages 321-338.
Crossref
Lenard M. Lichtenberger. (2001) Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury?. Biochemical Pharmacology 61:6, pages 631-637.
Crossref
Loren Laine. (2001) Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. Gastroenterology 120:3, pages 594-606.
Crossref
Mitchell S. Cappell. (2000) GASTROINTESTINAL BLEEDING ASSOCIATED WITH MYOCARDIAL INFARCTION. Gastroenterology Clinics of North America 29:2, pages 423-444.
Crossref
P. Hochain, C. Capet & R. Colin. (2000) Complications digestives de l'aspirine. La Revue de Médecine Interne 21, pages S50-S59.
Crossref
John L. Wallace. (2000) How do NSAIDs cause ulcer disease?. Best Practice & Research Clinical Gastroenterology 14:1, pages 147-159.
Crossref
Aslam Godil, Lino DeGuzman, Robert C. SchillingIIIIII, Shahid A. Khan & Yang K. Chen. (2000) Recent nonsteroidal anti-inflammatory drug use increases the risk of early recurrence of bleeding in patients presenting with bleeding ulcer. Gastrointestinal Endoscopy 51:2, pages 146-151.
Crossref
J. R. Vane. 2000. Advances in Eicosanoid Research. Advances in Eicosanoid Research 1 23 .
Denis M McCarthy. (1999) Comparative toxicity of nonsteroidal anti-inflammatory drugs. The American Journal of Medicine 107:6, pages 37-46.
Crossref
Dammann, Burkhardt & Wolf. (2001) Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions. Alimentary Pharmacology & Therapeutics 13:8, pages 1109-1114.
Crossref
Rafael Moreno-Sánchez, Concepción Bravo, César Vásquez, Guadalupe Ayala, Luis H Silveira & Manuel Martı́nez-Lavı́n. (1999) Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs. Biochemical Pharmacology 57:7, pages 743-752.
Crossref
Larry W. Moreland & E. William St. Clair. (1999) THE USE OF ANALGESICS IN THE MANAGEMENT OF PAIN IN RHEUMATIC DISEASES. Rheumatic Disease Clinics of North America 25:1, pages 153-191.
Crossref
Frank L Lanza. (1998) A guideline for the treatment and prevention of NSAID-induced ulcers. American Journal of Gastroenterology 93:11, pages 2037-2046.
Crossref
S. Borel, P. Bonnabry, J. Desmeules & P. Dayer. (1998) Du nouveau sur les AINS: découverte de la COX-2 et implications pharmacologiques et cliniques. Douleur et Analgésie 11:2, pages 71-75.
Crossref
Frank Lanza, Mary Frances Rack, Thomas J Simon, Antonio Lombardi, Robert Reyes & Shailaja Suryawanshi. (1998) Effects of Alendronate on Gastric and Duodenal Mucosa. American Journal of Gastroenterology 93:5, pages 753-757.
Crossref
John R VaneDSc, FRSDSc, FRS & Regina M BottingPhDPhD. (1998) Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs. The American Journal of Medicine 104:3, pages 2S-8S.
Crossref
Montserrat Miralpeix, Mercedes Camacho, Jesús López‐Belmonte, Francesca Canalías, Jordi Beleta, José M Palacios & Luis Vila. (2009) Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization. British Journal of Pharmacology 121:2, pages 171-180.
Crossref
David S. Newcombe. 1997. Molecular and Cellular Pharmacology. Molecular and Cellular Pharmacology 687 722 .
A. Del Favero. 1997. 86 102 .
J. Huang & R. H. Hunt. 1997. Side Effects of Anti-Inflammatory Drugs IV. Side Effects of Anti-Inflammatory Drugs IV 139 152 .
Loren Laine. (1996) Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics of North America 6:3, pages 489-504.
Crossref
Walter E. Smalley & Marie R. Griffin. (1996) THE RISKS AND COSTS OF UPPER GASTROINTESTINAL DISEASE ATTRIBUTABLE TO NSAIDS. Gastroenterology Clinics of North America 25:2, pages 373-396.
Crossref
J. Huang & R. H. Hunt. (1996) A clinician’s view of strategies for preventing NSAID-induced gastrointestinal ulcers. Inflammopharmacology 4:1, pages 17-30.
Crossref
G. Engelhardt, R. Bögel, Chr. Schnitzer & R. Utzmann. (1996) Meloxican: Influence on arachidonic acid metabolism. Biochemical Pharmacology 51:1, pages 21-28.
Crossref
G. Engelhardt, R. Bögel, Chr. Schnitzler & R. Utzmann. (1996) Meloxican: Influence on arachidonic acid metabolism. Biochemical Pharmacology 51:1, pages 29-38.
Crossref
J. R. Vane & R. M. Botting. 1996. New Targets in Inflammation. New Targets in Inflammation 1 12 .
A. Revhaug. 1996. Acute Catabolic State. Acute Catabolic State 217 225 .
Loren Laine, Robin Sloane, Maurizio Ferretti & Fabio Cominelli. (1995) A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. Gastrointestinal Endoscopy 42:5, pages 428-433.
Crossref
A S Taha, R D Sturrock & R I Russell. (1995) Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: predisposition to ulceration and relation to Helicobacter pylori.. Gut 36:3, pages 334-336.
Crossref
A S Taha, S Dahill, R D Sturrock, F D Lee & R I Russell. (1994) Predicting NSAID related ulcers--assessment of clinical and pathological risk factors and importance of differences in NSAID.. Gut 35:7, pages 891-895.
Crossref
John Vane. (1994) Towards a better aspirin. Nature 367:6460, pages 215-216.
Crossref
P M Goggin, D A Collins, R P Jazrawi, P A Jackson, C M Corbishley, B E Bourke & T C Northfield. (1993) Prevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis.. Gut 34:12, pages 1677-1680.
Crossref
Craig E. Chamberlain. (1993) ACUTE HEMORRHAGIC GASTRITIS. Gastroenterology Clinics of North America 22:4, pages 843-873.
Crossref
Walter A. Klein, Benjamin Krevsky, Lee Klepper, Paul Ljubich, Tomasz J. Niewiarowski, Kenneth D. Rothstein, Marta A. Dabezies & Robert S. Fisher. (1993) Nonsteroidal antiinflammatory drugs and upper gastrointestinal hemorrhage in an urban hospital. Digestive Diseases and Sciences 38:11, pages 2049-2055.
Crossref
N. HUDSON, F. E. MURRAY, A. T. COLE, G. M. TURNBULL, S. LETTIS & C. J. HAWKEY. (2007) Ranitidine bismuth citrate and aspirin-induced gastric mucosal injury. Alimentary Pharmacology & Therapeutics 7:5, pages 515-521.
Crossref
Carlo Patrono & Giovanni Davì. (2009) Antiplatelet agents in the prevention of diabetic vascular complications. Diabetes/Metabolism Reviews 9:3, pages 177-188.
Crossref
J.A. Gow, L. Ebbeling & J.M. Gerrard. (1993) The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. Prostaglandins, Leukotrienes and Essential Fatty Acids 49:1, pages 515-520.
Crossref
William C. Krupski, David G. Weiss, Joseph H. Rapp, John D. Corson & Robert W. HobsonIIII. (1992) Adverse effects of aspirin in the treatment of asymptomatic carotid artery stenosis. Journal of Vascular Surgery 16:4, pages 588-600.
Crossref
Joyce M. Piper, Wayne A. Ray, James R. Daugherty & Marie R. Griffin. (1991) Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs. Annals of Internal Medicine 114:9, pages 735-740.
Crossref
G. Thiéfin. (1991) Épidémiologie et traitement des lésions gastroduodénales provoquées par les médicaments anti-inflammatoires non stéroïdiens. La Revue de Médecine Interne 12:3, pages 227-236.
Crossref
Marie R. Griffin, Joyce M. Piper, James R. Daugherty, Mary Snowden & Wayne A. Ray. (1991) Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons. Annals of Internal Medicine 114:4, pages 257-263.
Crossref
B. Goldlust, M. Doucette & C. Verduyn. 1991. Drugs in Inflammation. Drugs in Inflammation 27 31 .

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