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Scandinavian Journal of Gastroenterology Volume 24, 1989 - Issue sup164
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Original Article

Effect of Prostaglandin on Indomethacin-Induced Increased Intestinal Permeability in Man

I. Bjarnason Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
,
P. Smethurst Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
,
P. Clark Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
,
I. Menzies Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
,
J. Levi Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
&
T. Peters Section of Gastroenterology and Division of Clinical Cell Biology and Computing and Statistics, MRC Clinical Research Centre, Harrow, Middlesex, UK;; Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital, London, UK
Pages 97-103 | Published online: 08 Jul 2009

Citations (33)

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Read on this site (5)

I. Bjarnason, K. Takeuchi, A. Bjarnason, S. N. Adler & K. Teahon. (2004) The G.U.T. of gut. Scandinavian Journal of Gastroenterology 39:9, pages 807-815.
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P. Suenaert, V. Bulteel, E. Den Hond, B. Geypens, F. Monsuur, A. Luypaerts, Y. Ghoos & P. Rutgeerts. (2003) In vivo Influence of Nicotine on Human Basal and NSAID-induced Gut Barrier Function. Scandinavian Journal of Gastroenterology 38:4, pages 399-408.
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S. Somasundaram, H. Hayllar, S. Rafi, J. M. Wrigglesworth, A. J. S. Macpherson & I. Bjarnason. (1995) Review: The Biochemical Basis of Non-Steroidal Anti-Inflammatory Drug-Induced Damage to the Gastrointestinal Tract: A Review and a Hypothesis. Scandinavian Journal of Gastroenterology 30:4, pages 289-299.
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I. Bjarnason, P. Smethurst, A. J. Levi, I. S. Menzies & T. J. Peters. (1991) The Effect of Polyacrylic Acid Polymers on Small-Intestinal Function and Permeability Changes Caused by Indomethacin. Scandinavian Journal of Gastroenterology 26:7, pages 685-688.
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I. Bjarnason & A. Macpherson. (1989) The Changing Gastrointestinal Side Effect Profile of Non-Steroidal Anti-Inflammatory Drugs: A New Approach for the Prevention of a New Problem. Scandinavian Journal of Gastroenterology 24:sup163, pages 56-64.
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Articles from other publishers (28)

K.D. Rainsford & Ingvar Bjarnason. 2015. Ibuprofen. Ibuprofen 363 429 .
Massimo Montalto, Antonella Gallo, Antonio Gasbarrini & Raffaele Landolfi. (2012) NSAID enteropathy: could probiotics prevent it?. Journal of Gastroenterology 48:6, pages 689-697.
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Hiroshi Imaoka, Shunji Ishihara, Hideaki Kazumori, Yasunori Kadowaki, Md. Monowar Aziz, Farzana Binte Rahman, Takayuki Ose, Hiroyuki Fukuhara, Shin Takasawa & Yoshikazu Kinoshita. (2010) Exacerbation of indomethacin-induced small intestinal injuries in Reg I -knockout mice . American Journal of Physiology-Gastrointestinal and Liver Physiology 299:2, pages G311-G319.
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K D Rainsford, P I Stetsko, S P Sirko & S Debski. (2003) Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. Journal of Pharmacy and Pharmacology 55:5, pages 661-668.
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Majella E Lane & Mi-Jeong Kim. (2006) Assessment and prevention of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. Journal of Pharmacy and Pharmacology 58:10, pages 1295-1304.
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Ingvar Bjarnason & Ken Takeuchi. (2009) Intestinal permeability in the pathogenesis of NSAID-induced enteropathy. Journal of Gastroenterology 44:S19, pages 23-29.
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Paul J Fortun & Christopher J Hawkey. (2007) Nonsteroidal antiinflammatory drugs and the small intestine. Current Opinion in Internal Medicine 6:3, pages 253-260.
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Molly Jacob, Russel Foster, Gudmundur Sigthorsson, Robert Simpson & Ingvar Bjarnason. (2006) Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81:4, pages 291-298.
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L. LAINE, R. SMITH, K. MIN, C. CHEN & R. W. DUBOIS. (2006) Systematic review: the lower gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs. Alimentary Pharmacology and Therapeutics 24:5, pages 751-767.
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C. J. Hawkey. (2006) NSAIDs, Coxibs, and the Intestine. Journal of Cardiovascular Pharmacology 47:Supplement 1, pages S72-S75.
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N. G. Venneman, M. Petruzzelli, J. E. Dijk, A. Verheem, L. M. A. Akkermans, A. B. A. Kroese & K. J. Erpecum. (2006) Indomethacin disrupts the protective effect of phosphatidylcholine against bile salt-induced ileal mucosa injury. European Journal of Clinical Investigation 36:2, pages 105-112.
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Thomas Y. Ma & James M. Anderson. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 1559 1594 .
O. A. Hatoum, D. G. Binion & D. D. Gutterman. (2005) Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. European Journal of Clinical Investigation 35:10, pages 599-609.
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Paul James Fortun & Christopher John Hawkey. (2005) Nonsteroidal antiinflammatory drugs and the small intestine. Current Opinion in Gastroenterology 21:2, pages 169-175.
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I. Bjarnason, F. Bissoli, A. Conforti, L. Maiden, N. Moore, U. Moretti, K.D. Rainsford, K. Takeuchi & G.P. Velo. 2005. Nimesulide — Actions and Uses. Nimesulide — Actions and Uses 315 415 .
Simon Smale & Ingvar Bjarnason. (2003) Determining small bowel integrity following drug treatment. British Journal of Clinical Pharmacology 56:3, pages 284-291.
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David N. Perkins & Paul K. Keith. (2002) Food– and exercise-induced anaphylaxis: importance of history in diagnosis. Annals of Allergy, Asthma & Immunology 89:1, pages 15-23.
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Zuzana Červinková, Dagmar Radvaková & Pavel Kohout. (2002) Liver Response to Indomethacin-Induced Intestinal Injury. Acta Medica (Hradec Kralove, Czech Republic) 45:1, pages 13-18.
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Babak Mohajer & Thomas Y Ma. (2000) Eicosanoids and the small intestine. Prostaglandins & Other Lipid Mediators 61:3-4, pages 125-143.
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E. DEN HOND, PEETERS, HIELE, BULTEEL, GHOOS & RUTGEERTS. (1999) Effect of glutamine on the intestinal permeability changes induced by indomethacin in humans. Alimentary Pharmacology & Therapeutics 13:5, pages 679-685.
Crossref
Melissa L. Davis-Whitenack, Bernice O. Adeleye, Lester L. Rolf & Barbara J. Stoecker. (1996) Biliary excretion of 51chromium in bile-duct cannulated rats. Nutrition Research 16:6, pages 1009-1015.
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Ingvar Bjarnason & Timothy J. Peters. (1996) Influence of anti-rheumatic drugs on gut permeability and on the gut associated lymphoid tissue. Baillière's Clinical Rheumatology 10:1, pages 165-176.
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Ingvar Bjarnason, Andrew Macpherson & Daniel Hollander. (1995) Intestinal permeability: An overview. Gastroenterology 108:5, pages 1566-1581.
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MICHAEL W. YOCUM & DAVID A. KHAN. (1994) Assessment of Patients Who Have Experienced Anaphylaxis: A 3-Year Survey. Mayo Clinic Proceedings 69:1, pages 16-23.
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I. Bjarnason, A. Macpherson & I. S. Menzies. 1994. Inflammatory Bowel Disease. Inflammatory Bowel Disease 53 70 .
Derek M. McKay & Mary H. Perdue. (1993) Intestinal epithelial function: The case for immunophysiological regulation. Digestive Diseases and Sciences 38:9, pages 1735-1745.
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Gareth R. Davies, Martin E. Wilkie & David S. Rampton. (1993) Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability. Digestive Diseases and Sciences 38:3, pages 417-425.
Crossref
Mary H. Perdue & Derek M. Mckay. 1993. Immunopharmacology of the Gastrointestinal System. Immunopharmacology of the Gastrointestinal System 15 39 .

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