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Original Article

Omeprazole: Pharmacokinetics and Metabolism in Man

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Pages 33-40 | Published online: 08 Jul 2009

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J.-H. Tu, D.-L. Hu, L.-L. Dai, Y. Sun, L. Fan, M. Zhang, Z.-R. Tan, Y. Chen, Z. Li & H.-H. Zhou. (2010) Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes. Xenobiotica 40:6, pages 393-399.
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Nan He, Song-Lin Huang, Rong-Hua Zhu, Zhi-Rong Tan, Jie Liu, Bing Zhu & Hong-Hao Zhou. (2003) Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent. Xenobiotica 33:2, pages 211-221.
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M. Sagar, R. Seensalu, G. Tybring, M.-L. Dahl, L. Bertilsson. (1998) CYP2C19 Genotype and Phenotype Determined with Omeprazole in Patients with Acid-Related Disorders with and without Helicobacter pylori Infection. Scandinavian Journal of Gastroenterology 33:10, pages 1034-1038.
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Jessica C. Wise, Kristopher J. Hughes, Scott Edwards, Glenn A. Jacobson, Christian K. Narkowicz & Sharanne L. Raidal. (2020) Pharmacokinetic and pharmacodynamic effects of 2 registered omeprazole preparations and varying dose rates in horses. Journal of Veterinary Internal Medicine 35:1, pages 620-631.
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Won Kyung Kim, Hun Hwi Cho, Gi Won Lee, Yong Woon Jeong, Jin Su Kim, Alessio Bucciarelli, Jeong Eun Song & Gilson Khang. (2019) Alleviated Side Effects and Improved Efficiency of Omeprazole Using Oral Thin Film: In Vitro Evaluation. Macromolecular Research 28:5, pages 417-424.
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Hien Van Nguyen, Namhyun Baek & Beom-Jin Lee. (2017) Enhanced gastric stability of esomeprazole by molecular interaction and modulation of microenvironmental pH with alkalizers in solid dispersion. International Journal of Pharmaceutics 523:1, pages 189-202.
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Jin-Liang Zhang, Min Liu, Qing Yang, Shi-Yong Lin, Hong-Bo Shan, Hui-Yun Wang & Guo-Liang Xu. (2017) Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer. World Journal of Gastroenterology 23:14, pages 2575.
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Ahmed Al Subaie, Elham Emami, Iskandar Tamimi, Marco Laurenti, Hazem Eimar, Mohamed-Nur Abdallah & Faleh Tamimi. (2016) Systemic administration of omeprazole interferes with bone healing and implant osseointegration: an in vivo study on rat tibiae. Journal of Clinical Periodontology 43:2, pages 193-203.
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Stephânia Katurchi Mendes Mélo, Tito Alves Santiago, Thaisa de Lima Duarte, José Mário Girão Abreu & Hélio Cordeiro Manso Filho. (2014) A Proton-Pump Inhibitor Modifies the Concentration of Digestion Biomarkers in Healthy Horses. Journal of Equine Veterinary Science 34:11-12, pages 1318-1323.
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Sadayuki Hashioka, Andis Klegeris & Patrick L. Mcgeer. (2011) Proton pump inhibitors reduce interferon‐γ‐induced neurotoxicity and STAT3 phosphorylation of human astrocytes. Glia 59:5, pages 833-840.
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Laurian Vlase, Maria Neag, Adina Popa, Dana Muntean & Sorin E. Leucuta. (2010) Pharmacokinetic interaction between fluoxetine and omeprazole in healthy male volunteers: a prospective pilot study. Current Therapeutic Research 71:6, pages 360-368.
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Sadayuki Hashioka, Andis Klegeris & Patrick L. McGeer. (2009) Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity. Experimental Neurology 217:1, pages 177-183.
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Hideki WATANABE, Yoshiaki TAKEUCHI & Michio IMAWARI. (2006) Mosapride Citrate Beneficially Affects Pharmacokinetic Parameters of Omeprazole. The Showa University Journal of Medical Sciences 18:1, pages 43-49.
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Héctor M. Gonzalez, Elba M.T. Romero, A.L. Aaron Peregrina, Teresa de J.C. Chávez, Estanislao Escobar‐Islas, Lozano K. Felipe & Carlos Hoyo‐Vadillo. (2013) CYP2C19‐ and CYP3A4‐Dependent Omeprazole Metabolism in West Mexicans. The Journal of Clinical Pharmacology 43:11, pages 1211-1215.
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