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Review Article

Review: Abnormal Intestinal Permeability in Crohn's Disease: A Possible Pathogenic Factor

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Pages 321-328 | Published online: 08 Jul 2009

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Read on this site (8)

S. J. Baker, E. Jacob, G. H. Bowden. (2000) Crohn Disease Arthropathy: Antigens in Synovial Fluid Share Epitopes with Strains of Two Species of Viridans Streptococci. Scandinavian Journal of Gastroenterology 35:3, pages 287-292.
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L. Halme, J. Edgren, U. Turpeinen, K. Von Smitten & U. H. Stenman. (1997) Urinary Excretion of Iohexol as a Marker of Disease Activity in Patients with Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 32:2, pages 148-152.
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E. Lindberg, J. D. Söderholm, G. Olaison, C. Tysk & G. Järnerot. (1995) Intestinal Permeability to Polyethylene Glycols in Monozygotic Twins with Crohn's Disease. Scandinavian Journal of Gastroenterology 30:8, pages 780-783.
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Leena Halme, J. Edgren, K. von Smitten & H. Linden. (1993) Increased Urinary Excretion of Iohexol after Enteral Administration in Patients with Ileal Crohn's Disease. Acta Radiologica 34:3, pages 237-241.
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J. Kjeldsen & O. B. Schaffalitzky De Muckadell. (1993) Assessment of Disease Severity and Activity in Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 28:1, pages 1-9.
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R. Andersen, F. Lærum, D. Bay, K. Aas, T. S. Halstensen & A. Stordahl. (1992) Experimental Colonic Inflammation and Ulceration: Permeation of a Water-Soluble Contrast Medium as a Measure of ‘Disease’ Activity. Scandinavian Journal of Gastroenterology 27:9, pages 757-763.
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Daniel Hollander. (1992) The Intestinal Permeability Barrier: A Hypothesis as to Its Regulation and Involvement in Crohn's Disease. Scandinavian Journal of Gastroenterology 27:9, pages 721-726.
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Lars Aabakken. (1991) NSAIDs and the Gastrointestinal Tract—Case Closed?. Scandinavian Journal of Gastroenterology 26:8, pages 801-805.
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Articles from other publishers (36)

Daniel Hollander. (2022) DDS Perspective: Crohn’s Disease and Increased Intestinal Permeability—Initial Demonstration and Birth Pains. Digestive Diseases and Sciences 67:9, pages 4337-4338.
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Alba Miranda-Ribera, Maria Ennamorati, Gloria Serena, Murat Cetinbas, Jinggang Lan, Ruslan I. Sadreyev, Nitya Jain, Alessio Fasano & Maria Fiorentino. (2019) Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune Profiles. Frontiers in Immunology 10.
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Warren M. Miner-Williams & Paul J. Moughan. (2016) Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel. Nutrition Research Reviews 29:1, pages 40-59.
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Warren M. Miner-Williams, Bruce R. Stevens & Paul J. Moughan. (2015) Are intact peptides absorbed from the healthy gut in the adult human?. Nutrition Research Reviews 27:2, pages 308-329.
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Ervice Pouokam, Sandra Bader, Brigitta Brück, Bärbel Schmidt & Martin Diener. (2012) ATP-sensitive K+ channels in rat colonic epithelium. Pflügers Archiv - European Journal of Physiology 465:6, pages 865-877.
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Francesco Russo, Michele Linsalata, Caterina Clemente, Marisa Chiloiro, Antonella Orlando, Emanuele Marconi, Guglielmina Chimienti & Giuseppe Riezzo. (2012) Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers. Nutrition Research 32:12, pages 940-946.
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R.M. Smith, K.H. Erlwanger & G.G. Rogers. (2012) The effect of a single dose of tumor necrosis factor alpha inhibitor on gut permeability in rats during exposure to a heat stress. Journal of Thermal Biology 37:2, pages 151-158.
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Mimi Pham, Steven T. Leach, Daniel A. Lemberg & Andrew S. Day. (2010) Subclinical Intestinal Inflammation in Siblings of Children with Crohn’s Disease. Digestive Diseases and Sciences 55:12, pages 3502-3507.
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Stephen M. Collins & Kenneth Croitoru. 2010. Inflammatory Bowel Disease. Inflammatory Bowel Disease 182 194 .
Yousheng Li, Zeping Yu, Fangnan Liu, Li Tan, Bo Wu & Jieshou Li. (2018) Oral Glutamine Ameliorates Chemotherapy-induced Changes of Intestinal Permeability and Does not Interfere with the Antitumor Effect of Chemotherapy in Patients with Breast Cancer: A Prospective Randomized Trial. Tumori Journal 92:5, pages 396-401.
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L E M Willemsen, J P Hoetjes, S J H Van Deventer & E A F Van Tol. (2005) Abrogation of IFN-γ mediated epithelial barrier disruption by serine protease inhibition. Clinical and Experimental Immunology 142:2, pages 275-284.
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Heather L. Cameron & Mary H. Perdue. (2005) Stress Impairs Murine Intestinal Barrier Function: Improvement by Glucagon-Like Peptide-2. Journal of Pharmacology and Experimental Therapeutics 314:1, pages 214-220.
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Stephen M. Collins & Kenneth Croitoru. 2005. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 223 234 .
Steven J. Brown, Ashley M. Miller, Peter J. Cowan, John Slavin, William R. Connell, Gregory T. Moore, Sally Bell, P. Ross Elliott, Paul V. Desmond & Anthony J. F. d’Apice. (2004) Altered Immune System Glycosylation Causes Colitis in α1,2-Fucosyltransferase Transgenic Mice. Inflammatory Bowel Diseases 10:5, pages 546-556.
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M Secondulfo, D Iafusco, R Carratù, L deMagistris, A Sapone, M Generoso, A Mezzogiorno, F.C Sasso, M Cartenı̀, R De Rosa, F Prisco & V Esposito. (2004) Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Digestive and Liver Disease 36:1, pages 35-45.
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Stephen M. Collins & Kenneth Croitoru. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 223 234 .
M. Secondulfo, L. de Magistris, R. Fiandra, L. Caserta, M. Belletta, M.T. Tartaglione, G. Riegler, F. Biagi, G.R. Corazza & R. Carratù. (2001) Intestinal permeability in Crohn's disease patients and their first degree relatives. Digestive and Liver Disease 33:8, pages 680-685.
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N.P. Breslin, C. Nash, R.J. Hilsden, N.B. Hershfield, L.M. Price, J.B. Meddings & L.R. Sutherland. (2001) Intestinal permeability is increased in a proportion of spouses of patients with Crohn's disease. The American Journal of Gastroenterology 96:10, pages 2934-2938.
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G. ARSLAN, T. ATASEVER, M. CINDORUK & İ. S. YILDIRIM. (2001) 51CrEDTA colonic permeability and therapy response in patients with ulcerative colitis. Nuclear Medicine Communications 22:9, pages 997-1001.
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Karen L. Johnston, Olivier P. Ballèvre & Roger M. Batt. (2001) Use of an orally administered combined sugar solution to evaluate intestinal absorption and permeability in cats. American Journal of Veterinary Research 62:1, pages 111-118.
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S. Pascual, J. Martínez & M. Pérez-Mateo. (2001) La barrera intestinal: trastornos funcionales en enfermedades digestivas y extradigestivas. Gastroenterología y Hepatología 24:5, pages 256-267.
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S Pathmakanthan & C J Hawkey. (2000) A lay doctor’s guide to the inflammatory process in the gastrointestinal tract. Postgraduate Medical Journal 76:900, pages 611-617.
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Johan D. Söderholm, Kajsa Holmgren Peterson, Gunnar Olaison, Lennart E. Franzén, Björn Weström, Karl-Eric Magnusson & Rune Sjödahl. (1999) Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?. Gastroenterology 117:1, pages 65-72.
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Romano Carratù, Mario Secondulfo, Laura de Magistris, Dario Iafusco, Anna Urio, Maria Grazia Carbone, Gabriele Pontoni, Marilena Cartenì & Francesco Prisco. (1999) Altered Intestinal Permeability to Mannitol in Diabetes Mellitus Type I. Journal of Pediatric Gastroenterology & Nutrition 28:3, pages 264-269.
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Kazunori Miki, David J. Moore, Ross N. Butler, Emma Southcott, Richard T.L. Couper & Geoffrey P. Davidson. (1998) The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease. The Journal of Pediatrics 133:6, pages 750-754.
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Per Brandtzaeg, Guttorm Haraldsen & Jarle Rugtveit. (1997) Immunopathology of human inflammatory bowel disease. Springer Seminars in Immunopathology 18:4, pages 555-589.
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John D. Johnston, Christopher J. Harvey, Ian S. Menzies & David F. Treacher. (1996) Gastrointestinal permeability and absorptive capacity in sepsis. Critical Care Medicine 24:7, pages 1144-1149.
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H. S. Brand, A. Bosma, R. J. Van Ketel, P. Speelman & R. A. F. M. Chamuleau. (1994) Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities. Digestive Diseases and Sciences 39:6, pages 1210-1215.
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Mark Hudson, Christopher Piasecki, Andrew J. Wakefield, Elizabeth A. Sankey, Amar P. Dhillon, Martin Osborne, Rosalind Sim & Roy E. Pounder. (1994) A vascular hypersensitivity model of acute multifocal gastrointestinal infarction. Digestive Diseases and Sciences 39:3, pages 534-539.
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P Munkholm, E Langholz, D Hollander, K Thornberg, M Orholm, K D Katz & V Binder. (1994) Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives.. Gut 35:1, pages 68-72.
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Daniel Hollander. (1993) Permeability in Crohn's disease: Altered barrier functions in healthy relatives?. Gastroenterology 104:6, pages 1848-1851.
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E. Zuccato, C. Bertolo, L. Colombo & E. Mussini. (1992) Indomethacin-induced enteropathy: Effect of the drug regimen on intestinal permeability in rats. Agents and Actions 36:3-4, pages C18-C21.
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E. Zuccato, C. Bertolo, L. Colombo & E. Mussini. (1992) Indomethacin-induced enteropathy: Effect of the drug regimen on intestinal permeability in rats. Agents and Actions 36:S1, pages C18-C21.
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P. Brandtzaeg, T. S. Halstensen, L. Helgeland & K. Kett. 1992. Immunology of Gastrointestinal Disease. Immunology of Gastrointestinal Disease 19 39 .
Joseph B. Kirsner. (1991) Inflammatory bowel disease part I: Nature and pathogenesis. Disease-a-Month 37:10, pages 610-666.
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Steven R. Weiner, Jan Clarke, Nansi A. Taggart & Peter D. Utsinger. (1991) Rheumatic manifestations of inflammatory bowel disease. Seminars in Arthritis and Rheumatism 20:6, pages 353-366.
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