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Original Article

Phospholipase C from Clostridium perfringens Stimulates Phospholipase A2-Mediated Arachidonic Acid Release in Cultured Intestinal Epithelial Cells (INT 407)

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Pages 363-371 | Received 19 Jun 1989, Accepted 26 Oct 1989, Published online: 08 Jul 2009

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Read on this site (8)

Richard W. Titball & Ajit K. Basak. (2005) The Bacterial Zinc‐Metallophospholipases C. Journal of Toxicology: Toxin Reviews 23:4, pages 509-554.
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C. Gustafson-Svärd, I. Lilja, R. Sjödahl & C. Tagesson. (1995) Cytosolic Phospholipase A2 and Cyclooxygenase-2 Mediate Release and Metabolism of Arachidonic Acid in Tumor Necrosis Factor-α-Primed Cultured Intestinal Epithelial Cells (INT 407). Scandinavian Journal of Gastroenterology 30:10, pages 1000-1007.
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R.J. Holdsworth & D. Parratt. (1994) Development of an Elisa Assay for Clostridium Perfringens Phospholipase C (Alpha Toxin). Journal of Immunoassay 15:3, pages 293-304.
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B. Kald, R. -M. Boll, C. Gustafson-Svärd, R. Sjodahl & C. Tagesson. (1994) Phospholipase C from Clostridium perfringens Stimulates Acetyltransferase-Dependent Formation of Platelet-Activating Factor in Cultured Intestinal Epithelial Cells (INT 407). Scandinavian Journal of Gastroenterology 29:3, pages 243-247.
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C. Gustafson-svärd, C. Tagesson, R.-M. Boll & B. Kald. (1993) Tumor Necrosis Factor-α Potentiates Phospholipase A2-Stimulated Release and Metabolism of Arachidonic Acid in Cultured Intestinal Epithelial Cells (INT 407). Scandinavian Journal of Gastroenterology 28:4, pages 323-330.
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C. Gustafson, M. Lindahl & C. Tagesson. (1991) Hydrogen Peroxide Stimulates Phospholipase A2-Mediated Arachidonic Acid Release in Cultured Intestinal Epithelial Cells (INT 407). Scandinavian Journal of Gastroenterology 26:3, pages 237-247.
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C. Gustafson, B. Kald, R. Sjödahl & C. Tagesson. (1991) Phospholipase C from Clostridium perfringens Stimulates Formation and Release of Platelet-Activating Factor (PAF-Acether) in Cultured Intestinal Epithelial Cells (INT 407). Scandinavian Journal of Gastroenterology 26:10, pages 1000-1006.
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C. Gustafson, R. Sjödahl & C. Tagesson. (1990) Phospholipase Activation and Arachidonic Acid Release in Intestinal Epithelial Cells from Patients with Crohn's Disease. Scandinavian Journal of Gastroenterology 25:11, pages 1151-1160.
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Articles from other publishers (29)

Lisa Badilla-Vargas, Reynaldo Pereira, José Arturo Molina-Mora, Alberto Alape-Girón & Marietta Flores-Díaz. (2023) Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils. Frontiers in Cellular and Infection Microbiology 13.
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Vinayak Singh, Rupal Rai, Bijina J. Mathew, Rashmi Chourasia, Anirudh K. Singh, Awanish Kumar & Shivendra K. Chaurasiya. (2023) Phospholipase C: underrated players in microbial infections. Frontiers in Cellular and Infection Microbiology 13.
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Vinayak Singh, Bijina J. Mathew, Rupal Rai & Shivendra K. Chaurasiya. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 217 234 .
Laura Monturiol‐Gross, Fabian Villalta‐Romero, Marietta Flores‐Díaz & Alberto Alape‐Girón. (2021) Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase. FEBS Open Bio 11:12, pages 3262-3275.
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Marco M. Manni, Juan G. Valero, Miriam Pérez-Cormenzana, Ainara Cano, Cristina Alonso & Félix M. Goñi. (2017) Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin. Chemistry and Physics of Lipids 203, pages 54-70.
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André Desrochers & David E. Anderson. (2016) Intestinal Surgery. Veterinary Clinics of North America: Food Animal Practice 32:3, pages 645-671.
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Laura Monturiol-Gross, Marietta Flores-Díaz, Maria Jose Pineda-Padilla, Ana Cristina Castro-Castro & Alberto Alape-Giron. (2014) Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation. PLoS ONE 9:1, pages e86475.
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Mohamed M. Elhanafy, Dennis D. French & Ueli Braun. (2013) Understanding jejunal hemorrhage syndrome. Journal of the American Veterinary Medical Association 243:3, pages 352-358.
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L. Monturiol-Gross, M. Flores-Diaz, C. Araya-Castillo, M.-J. Pineda-Padilla, G. C. Clark, R. W. Titball & A. Alape-Giron. (2012) Reactive Oxygen Species and the MEK/ERK Pathway Are Involved in the Toxicity of Clostridium perfringens  -Toxin, a Prototype Bacterial Phospholipase C. Journal of Infectious Diseases 206:8, pages 1218-1226.
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Richard W. Titball. (2011) More than an enzyme: the biochemical basis of bacterial disease revealed. Biochemical Journal 2011:1, pages c2-c3.
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J. Bender & A. Flieger. 2010. Handbook of Hydrocarbon and Lipid Microbiology. Handbook of Hydrocarbon and Lipid Microbiology 3241 3258 .
Irving Jacoby. 2008. Physiology and Medicine of Hyperbaric Oxygen Therapy. Physiology and Medicine of Hyperbaric Oxygen Therapy 397 418 .
Richard W. Titball & Ajit K. Basak. 2006. The Comprehensive Sourcebook of Bacterial Protein Toxins. The Comprehensive Sourcebook of Bacterial Protein Toxins 516 534 .
Richard W. Titball. (2005) Gas gangrene: an open and closed case. Microbiology 151:9, pages 2821-2828.
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S.Steve Yan & Jeffrey M Gilbert. (2004) Antimicrobial drug delivery in food animals and microbial food safety concerns: an overview of in vitro and in vivo factors potentially affecting the animal gut microflora. Advanced Drug Delivery Reviews 56:10, pages 1497-1521.
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Marietta Flores-Dı́az, Monica Thelestam, Graeme C. Clark, Richard W. Titball & Alberto Alape-Girón. (2004) Effects of Clostridium perfringens phospholipase C in mammalian cells. Anaerobe 10:2, pages 115-123.
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Julian T. Eaton, Claire E. Naylor, Angela M. Howells, David S. Moss, Richard W. Titball & Ajit K. Basak. (2002) Crystal Structure of the C.perfringens Alpha-toxin with the Active Site Closed by a Flexible Loop Region. Journal of Molecular Biology 319:2, pages 275-281.
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Takeshi Into, Yosinobu Nodasaka, Akira Hasebe, Tsugumi Okuzawa, Jun‐ichiro Nakamura, Noboru Ohata & Ken‐ichiro Shibata. (2013) Mycoplasmal Lipoproteins Induce Toll‐Like Receptor 2‐ and Caspases‐Mediated Cell Death in Lymphocytes and Monocytes. Microbiology and Immunology 46:4, pages 265-276.
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Nicola Walker, Jane Holley, Claire E Naylor, Marietta Flores-Dı́az, Alberto Alape-Girón, Graham Carter, Frank J Carr, Monica Thelestam, Martin Keyte, David S Moss, Ajit K Basak, Julie Miller & Richard W Titball. (2000) Identification of Residues in the Carboxy-Terminal Domain of Clostridium perfringens α-Toxin (Phospholipase C) Which Are Required for Its Biological Activities. Archives of Biochemistry and Biophysics 384:1, pages 24-30.
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Claire E Naylor, Marie Jepson, Dennis T Crane, Richard W Titball, Julie Miller, Ajit K Basak & Barbara Bolgiano. (1999) Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin 1 1Edited by A Klug. Journal of Molecular Biology 294:3, pages 757-770.
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Marie Jepson, Angela Howells, Helen L. Bullifent, Barbara Bolgiano, Dennis Crane, Julie Miller, Jane Holley, Pramukh Jayasekera & Richard W. Titball. (1999) Differences in the Carboxy-Terminal (Putative Phospholipid Binding) Domains of Clostridium perfringens and Clostridium bifermentans Phospholipases C Influence the Hemolytic and Lethal Properties of These Enzymes . Infection and Immunity 67:7, pages 3297-3301.
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Richard W Titball, Claire E Naylor & Ajit K Basak. (1999) The Clostridium perfringensα-toxin. Anaerobe 5:2, pages 51-64.
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Richard W. Titball. 1997. The Clostridia. The Clostridia 223 242 .
George Kolios, Duncan A.F. Robertson, Nicola J. Jordan, Adrian Minty, Daniel Caput, Pascal Ferrara & John Westwick. (2012) Interleukin‐8 production by the human colon epithelial cell line HT‐29: modulation by interleukin‐13. British Journal of Pharmacology 119:2, pages 351-359.
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K ShibataT SasakiT Watanabe. (1995) AIDS-associated mycoplasmas possess phospholipases C in the membrane. Infection and Immunity 63:10, pages 4174-4177.
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Volker Gross, Tilo Andus, Rosemarie Daig, Elisabeth Aschenbrenner, Jürgen Schölmerich & Werner Falk. (1995) Regulation of interleukin-8 production in a human colon epithelial cell line (HT-29). Gastroenterology 108:3, pages 653-661.
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R W Titball. (1993) Bacterial phospholipases C. Microbiological Reviews 57:2, pages 347-366.
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Jan Dimberg, Christina Gustafson-Svärd, Björn Weström, Christer Tagesson & Peter Söderkvist. (1992) Group I phospholipase A2 mRNA expression in rat glandular stomach and pancreas. Ontogenic development and effects of cortisone acetate. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1130:1, pages 47-51.
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Martin Diener, Cécile Eglème & Walter Rummel. (1991) Phospholipase C-induced anion secretion and its interaction with carbachol in the rat colonie mucosa. European Journal of Pharmacology 200:2-3, pages 267-276.
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