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Scandinavian Journal of Gastroenterology Volume 26, 1991 - Issue 4
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Original Article

Availability of Mesalazine (5-Aminosalicylic Acid) from Enemas and Suppositories during Steady-State Conditions

B. A. Jacobsen Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
,
K. Abildgaard Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
,
H. H. Rasmussen Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
,
L. A. Christensen Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
,
J. Fallingborg Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
,
S. H. Hansen Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
&
S. Nørby Rasmussen Dept. of Medical Gastroenterology, Aalborg Hospital, Aalborg, and Dept. of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
 show all
Pages 374-378 | Received 20 Sep 1990, Accepted 19 Oct 1990, Published online: 08 Jul 2009

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P. G. Farup, ø. Hovde, F. A. Halvorsen, N. Raknerud & U. Brodin. (1995) Mesalazine Suppositories versus Hydrocortisone Foam in Patients with Distal Ulcerative Colitis:A Comparison of the Efficacy and Practicality of Two Topical Treatment Regimens. Scandinavian Journal of Gastroenterology 30:2, pages 164-170.
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Articles from other publishers (29)

Luc J. J. Derijks, Dennis R. Wong, Daniel W. Hommes & Adriaan A. van Bodegraven. (2018) Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Inflammatory Bowel Disease. Clinical Pharmacokinetics 57:9, pages 1075-1106.
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David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek & Sharath Hegde. (2017) Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy. Journal of Inflammation 14:1.
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E. G. Quetglas, A. Armuzzi, S. Wigge, G. Fiorino, L. Barnscheid, M. Froelich & Silvio Danese. (2015) Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment. European Journal of Clinical Pharmacology 71:7, pages 773-799.
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Tammie S. MacFie, Richard Poulsom, Alexandra Parker, Gary Warnes, Tatjana Boitsova, Anke Nijhuis, Nirosha Suraweera, Angela Poehlmann, Jaroslaw Szary, Roger Feakins, Rosemary Jeffery, Richart W. Harper, Adrian M. Jubb, James O. Lindsay & Andrew Silver. (2014) DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid. Inflammatory Bowel Diseases 20:3, pages 514-524.
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Tom B Vree, Erik Dammers, Peter S Exler & Robert A A Maes. (2000) Mono- and Biphasic Plasma Concentration-time Curves of Mesalazine from a 500 mg Suppository in Healthy Male Volunteers Controlled by the Time of Defecation before Dosing. Journal of Pharmacy and Pharmacology 52:6, pages 645-652.
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M.T. Pimpo, B. Galletti, G. Palumbo, A. Viscido, P. Gentile, R. Caprilli & G. Frieri. (2010) Mesalazine vanishing time from rectal mucosa following its topical administration. Journal of Crohn's and Colitis 4:1, pages 102-105.
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Jaime Kaufman, Tanya A. Griffiths, Michael G. Surette, Susan Ness & Kevin P. Rioux. (2009) Effects of mesalamine (5-aminosalicylic acid) on bacterial gene expression. Inflammatory Bowel Diseases 15:7, pages 985-996.
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M. P. THORPE, E. D. EHRENPREIS, K. S. PUTT & B. HANNON. (2009) A dynamic model of colonic concentrations of delayed-release 5-aminosalicylic acid (Asacol). Alimentary Pharmacology & Therapeutics 29:11, pages 1193-1201.
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E. C. CHU, J. CHAI, A. AHLUWALIA & A. S. TARNAWSKI. (2007) Mesalazine downregulates c-Myc in human colon cancer cells. A key to its chemopreventive action?. Alimentary Pharmacology & Therapeutics 25:12, pages 1443-1449.
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Pim J. Koelink & Hein W. Verspaget. (2007) 5-ASA and Colorectal Cell-Cycle Progression. Gastroenterology 132:4, pages 1635-1636.
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Christel Rousseaux, Bruno Lefebvre, Laurent Dubuquoy, Philippe Lefebvre, Olivier Romano, Johan Auwerx, Daniel Metzger, Walter Wahli, Béatrice Desvergne, Gian Carlo Naccari, Philippe Chavatte, Amaury Farce, Philippe Bulois, Antoine Cortot, Jean Frédéric Colombel & Pierre Desreumaux. (2005) Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ. The Journal of Experimental Medicine 201:8, pages 1205-1215.
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Altamash I. Qureshi & Russell D. Cohen. (2005) Mesalamine delivery systems: do they really make much difference?. Advanced Drug Delivery Reviews 57:2, pages 281-302.
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Fady Daniel, Philippe Seksik, Wulfran Cacheux, Raymond Jian & Philippe Marteau. (2004) Tolerance of 4-Aminosalicylic Acid Enemas in Patients with Inflammatory Bowel Disease and 5-Aminosalicylic–induced Acute Pancreatitis. Inflammatory Bowel Diseases 10:3, pages 258-260.
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E L BerrymanA C Zerouala, C Meschter & J Spenard. (2016) Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs. Human & Experimental Toxicology 21:3, pages 159-163.
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Tom B. Vree, Erik Dammers, Peter S. Exler, Fritz Sorgel, Stig Bondesen & Robert A. Maes. (2001) Upper and Lower Limits in the Renal Clearance of Acetylmesalazine in Humans. Clinical Drug Investigation 21:2, pages 147-156.
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Matthias Schwab & Ulrich Klotz. (2001) Pharmacokinetic Considerations in the Treatment of Inflammatory Bowel Disease. Clinical Pharmacokinetics 40:10, pages 723-751.
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J. Keller & P. Layer. 2001. Chronisch entzündliche Darmerkrankungen. Chronisch entzündliche Darmerkrankungen 123 134 .
Martine de Vos. (2000) Clinical Pharmacokinetics of Slow Release Mesalazine. Clinical Pharmacokinetics 39:2, pages 85-97.
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Tom B. Vree, Erik Dammers, Peter S. Exler, Fritz S??rgel & Robert A.A. Maes. (2000) Saturable Active Tubular Reabsorption in the Renal Clearance of Mesalazine in Human Volunteers. Clinical Drug Investigation 20:1, pages 35-42.
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John K Marshall & Jan E Irvine. (2000) Putting Rectal 5-Aminosalicylic Acid in Its Place: The Role in Distal Ulcerative Colitis. American Journal of Gastroenterology 95:7, pages 1628-1636.
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Pierre Michetti & Mark A. Peppercorn. (1999) MEDICAL THERAPY OF SPECIFIC CLINICAL PRESENTATIONS. Gastroenterology Clinics of North America 28:2, pages 353-370.
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Ulrich Klotz. (1999) Pharmakokinetische Daten für verschiedene 5-Aminosalicylsäure- und BudesonidpräparatePharmacokinetic properties of various preparations of 5-Aminosalicylic acid (5-ASA) and budesonide. Medizinische Klinik 94:S1, pages 16-22.
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P. Gionchetti, F. Rizzello, A. Venturi, M. Ferretti, C. Brignola, M. Miglioli & M. Campieri. (1998) Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis. Diseases of the Colon & Rectum 41:1, pages 93-97.
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Stig Bondesen. (1997) INTESTINAL FATE OF 5-AMINOSALICYLIC ACID: REGIONAL AND SYSTEMIC KINETIC STUDIES IN RELATION TO INFLAMMATORY BOWEL DISEASE. Pharmacology & Toxicology 81, pages 1-30.
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R. Schoonjans, M. De Vos, A.-M. Schelfhout, M. Praet & A. Elewaut. (1996) Distribution and concentrations of 5-aminosalicylic acid in rectosigmoid biopsy specimens after rectal administration. Diseases of the Colon & Rectum 39:7, pages 788-793.
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J. K. MARSHALL & E. J. IRVINE. (2007) Rectal aminosalicylate therapy for distal ulcerative colitis: a meta‐analysis. Alimentary Pharmacology & Therapeutics 9:3, pages 293-300.
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Alain Bitton & Mark A. Peppercorn. (1995) Medical Therapy of Ulcerative Proctitis and Proctosigmoiditis, Including Refractory Disease. Inflammatory Bowel Diseases 1:3, pages 207-219.
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Joan Jensen, Claus Cornett, Carl Erik Olsen, Jette Tjørnelund & Steen Honoré Hansen. (1993) Synthesis and structural elucidation of glutathione and N-aceyl-cysteine conjugates of 5-aminosalicylic acid. European Journal of Pharmaceutical Sciences 1:3, pages 143-150.
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Joan Jensen, Claus Cornett, Carl Erik Olsen, Stig Bondesen, John Christensen, Lisbet A. Christensen, Jette Tjørnelund & Steen Honoré Hansen. (1993) Identification of oxidation products of 5-aminosalicylic acid in faeces and the study of their formation invitro. Biochemical Pharmacology 45:6, pages 1201-1209.
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