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Scandinavian Journal of Gastroenterology Volume 26, 1991 - Issue 7
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Original Article

Final Report on a Placebo-Controlled, Double-Blind, Randomized, Multicentre Trial of Cyclosporin Treatment in Active Chronic Crohn's Disease

J. Brynskov Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
L. Freund Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
S. Nørby Rasmussen Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
K. Lauritsen Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
O. Schaffalitzky De Muckadell Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
C. N. Williams Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
A. S. Macdonald Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
R. Tanton Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
F. Molina Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
M. C. Campanini Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
P. Bianchi Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
T. Ranzi Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
F. Quarto Di Palo Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
A. Malchow-Møller Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
O. Østergaard Thomsen Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
U. Tage-jensen Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
V. Binder Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
&
P. Riis Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Internal Medicine and Gastroenterology S, Odense University Hospital, Odense; Dept. of Internal Medicine and Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Division of Gastroenterology, Dept. of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Surgery, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada; Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
 show all
Pages 689-695 | Received 30 Nov 1990, Accepted 25 Feb 1991, Published online: 08 Jul 2009

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Dorothy KL Chow & Rupert WL Leong. (2007) The use of tacrolimus in the treatment of inflammatory bowel disease. Expert Opinion on Drug Safety 6:5, pages 479-485.
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F. Baert, S. Vermeire, M. Noman, G. Van Assche, G. D’ Haens & P. Rutgeerts. (2004) MANAGEMENT OF ULCERATIVE COLITIS AND CROHN’S DISEASE. Acta Clinica Belgica 59:5, pages 304-314.
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R Mark Beattie & A Ronald F Bremner. (2002) Therapy of Crohn’s disease in childhood. Expert Opinion on Pharmacotherapy 3:7, pages 809-825.
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Philip M Ginsburg, Themistocles Dassopoulos & Eli D Ehrenpreis. (2001) Thalidomide treatment for refractory Crohn's disease: a review of the history, pharmacological mechanisms and clinical literature. Annals of Medicine 33:8, pages 516-525.
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J. Brynskov & S. Nørby Rasmussen. (1996) Clinical Pharmacology in Gastroenterology: Development of New Forms of Treatment of Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 31:sup216, pages 175-180.
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J. Brynskov. (1993) Cyclosporin for Inflammatory Bowel Disease: Mechanisms and Possible Actions. Scandinavian Journal of Gastroenterology 28:10, pages 849-857.
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J. Brynskov, L. Freund, M. C. Campanini & J. P. Kampmann. (1992) Cyclosporin Pharmacokinetics after Intravenous and Oral Administration in Patients with Crohn's Disease. Scandinavian Journal of Gastroenterology 27:11, pages 961-967.
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J. Brynskov, O. H. Nielsen, I. Ahnfelt-Rønne & K. Bendtzen. (1992) Cytokines in Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 27:11, pages 897-906.
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