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Original Article

Final Report on a Placebo-Controlled, Double-Blind, Randomized, Multicentre Trial of Cyclosporin Treatment in Active Chronic Crohn's Disease

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Pages 689-695 | Received 30 Nov 1990, Accepted 25 Feb 1991, Published online: 08 Jul 2009

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Dorothy KL Chow & Rupert WL Leong. (2007) The use of tacrolimus in the treatment of inflammatory bowel disease. Expert Opinion on Drug Safety 6:5, pages 479-485.
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F. Baert, S. Vermeire, M. Noman, G. Van Assche, G. D’ Haens & P. Rutgeerts. (2004) MANAGEMENT OF ULCERATIVE COLITIS AND CROHN’S DISEASE. Acta Clinica Belgica 59:5, pages 304-314.
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R Mark Beattie & A Ronald F Bremner. (2002) Therapy of Crohn’s disease in childhood. Expert Opinion on Pharmacotherapy 3:7, pages 809-825.
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Philip M Ginsburg, Themistocles Dassopoulos & Eli D Ehrenpreis. (2001) Thalidomide treatment for refractory Crohn's disease: a review of the history, pharmacological mechanisms and clinical literature. Annals of Medicine 33:8, pages 516-525.
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Peter L. Moses, Brad R. Moore, Nicholas Ferrentino, Steven P. Bensen & James A. Vecchio. (1998) Inflammatory bowel disease. Postgraduate Medicine 103:5, pages 77-102.
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K. Lauritsen & E. Christensen. (1996) The Randomized Controlled Clinical Trial in Gastroenterology: The Danish Contributions from 1970 to 1994. Scandinavian Journal of Gastroenterology 31:sup216, pages 181-198.
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J. Brynskov. (1993) Cyclosporin for Inflammatory Bowel Disease: Mechanisms and Possible Actions. Scandinavian Journal of Gastroenterology 28:10, pages 849-857.
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J. Brynskov, L. Freund, M. C. Campanini & J. P. Kampmann. (1992) Cyclosporin Pharmacokinetics after Intravenous and Oral Administration in Patients with Crohn's Disease. Scandinavian Journal of Gastroenterology 27:11, pages 961-967.
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J. Brynskov, O. H. Nielsen, I. Ahnfelt-Rønne & K. Bendtzen. (1992) Cytokines in Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 27:11, pages 897-906.
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Articles from other publishers (57)

Stefanie Steiner, Carolin Daniel, Anika Fischer, Imke Atreya, Simon Hirschmann, Maximilian Waldner, Helmut Neumann, Markus Neurath, Raja Atreya & Benno Weigmann. (2014) Cyclosporine A Regulates Pro-Inflammatory Cytokine Production in Ulcerative Colitis. Archivum Immunologiae et Therapiae Experimentalis 63:1, pages 53-63.
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Joseph B. Kirsner. 2011. Inflammatory Bowel Disease. Inflammatory Bowel Disease 1 16 .
Brani VidakovicBrani Vidakovic. 2011. Statistics for Bioengineering Sciences. Statistics for Bioengineering Sciences 229 277 .
Michael B. Sternthal, Seamus J. Murphy, James George, Asher Kornbluth, Simon Lichtiger & Daniel H. Present. (2008) Adverse Events Associated With the Use of Cyclosporine in Patients With Inflammatory Bowel Disease. The American Journal of Gastroenterology 103:4, pages 937-943.
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C. A. SIEGEL & B. E. SANDS. (2005) Review article: practical management of inflammatory bowel disease patients taking immunomodulators. Alimentary Pharmacology and Therapeutics 22:1, pages 1-16.
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John WD McDonald, Brian G Feagan, Derek P Jewell, Jorn Brynskov, Eduard F Stange & John K MacDonald. (2005) Cyclosporine for induction of remission in Crohn's disease. Cochrane Database of Systematic Reviews.
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Conor G Loftus, Laurence J Egan & William J Sandborn. (2004) Cyclosporine, tacrolimus, and mycophenolate mofetil in the treatment of inflammatory bowel disease. Gastroenterology Clinics of North America 33:2, pages 141-169.
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Chinyu Su, Gary R. Lichtenstein, Karen Krok, Colleen M. Brensinger & James D. Lewis. (2004) A meta-analysis of the placebo rates of remission and response in clinical trials of active crohn’s disease. Gastroenterology 126:5, pages 1257-1269.
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Brinderjit Kaila, David Grant, Norman Pettigrew, Howard Greenberg & Charles N Bernstein. (2004) Crohn's Disease Recurrence in a Small Bowel Transplant. American Journal of Gastroenterology 99:1, pages 158-162.
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Stephen B. Hanauer & Themistocles Dassopoulos. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 659 680 .
Parvaneh Rafiee, Christopher P. Johnson, Mona S. Li, Hitoshi Ogawa, Jan Heidemann, Pamela J. Fisher, Thomas H. Lamirand, Mary F. Otterson, Keith T. Wilson & David G. Binion. (2002) Cyclosporine A Enhances Leukocyte Binding by Human Intestinal Microvascular Endothelial Cells through Inhibition of p38 MAPK and iNOS. Journal of Biological Chemistry 277:38, pages 35605-35615.
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K Fellermann, K.R Herrlinger, T Witthoeft, N Homann, D Ludwig & E.F Stange. (2001) Tacrolimus: a new immunosuppressant for steroid refractory inflammatory bowel disease. Transplantation Proceedings 33:3, pages 2247-2248.
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Crossref
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L. Abreu García, J.P. Rincón Fuentes & M.I. Vera Mendoza. (2000) Tratamiento médico de la enfermedad de crohn. Medicine - Programa de Formación Médica Continuada Acreditado 8:6, pages 279-283.
Crossref
A. H. Steinhart. 2000. Trends in Inflammatory Bowel Disease Therapy 1999. Trends in Inflammatory Bowel Disease Therapy 1999 128 136 .
Bruce Yacyshyn, Walter Maksymowych & Mary Beth Bowen-Yacyshyn. (1999) Differences in P-glycoprotein-170 expression and activity between Crohn’s disease and ulcerative colitis. Human Immunology 60:8, pages 677-687.
Crossref
Pierre Michetti & Mark A. Peppercorn. (1999) MEDICAL THERAPY OF SPECIFIC CLINICAL PRESENTATIONS. Gastroenterology Clinics of North America 28:2, pages 353-370.
Crossref
Robert B. Stein & Stephen B. Hanauer. (1999) MEDICAL THERAPY FOR INFLAMMATORY BOWEL DISEASE. Gastroenterology Clinics of North America 28:2, pages 297-321.
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Alexandra Lavy. (1999) Long-Term Cyclosporine for Resistant Crohn's Disease. Journal of Clinical Gastroenterology 28:3, pages 254-255.
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Maureen O'Reilly Brown. (1999) INFLAMMATORY BOWEL DISEASE. Primary Care: Clinics in Office Practice 26:1, pages 141-170.
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Gunnar Järnerot, Hanna Sandberg-Gertzén & Curt Tysk. (1998) 4 Medical therapy of active Crohn's disease. Baillière's Clinical Gastroenterology 12:1, pages 73-92.
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Robert T. Przemioslo & Paul J. Ciclitira. (1996) Cytokines and gastrointestinal disease mechanisms. Baillière's Clinical Gastroenterology 10:1, pages 17-32.
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E. ELTON & S. B. HANAUER. (2007) Review article: The medical management of Crohn's disease. Alimentary Pharmacology & Therapeutics 10:1, pages 1-22.
Crossref
Jeffrey S. Hyams. (1996) CROHN'S DISEASE IN CHILDREN. Pediatric Clinics of North America 43:1, pages 255-277.
Crossref
Guido AdlerGuido Adler. 1996. Morbus Crohn - Colitis ulcerosa. Morbus Crohn - Colitis ulcerosa 215 241 .
Alain Bitton & Mark A. Peppercorn. (1995) MEDICAL MANAGEMENT OF SPECIFIC CLINICAL PRESENTATIONS. Gastroenterology Clinics of North America 24:3, pages 541-558.
Crossref
Stephen B. Hanauer & Michael I. Schulman. (1995) NEW THERAPEUTIC APPROACHES. Gastroenterology Clinics of North America 24:3, pages 523-540.
Crossref
William J. Sandborn. (1995) Cyclosporine therapy for inflammatory bowel disease: Definitive answers and remaining questions. Gastroenterology 109:3, pages 1001-1003.
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Simone S. Flückiger, Christoph Schmidt, Ansgar Meyer, Zoltan Kallay, Atholl Johnston & Klaus Kutz. (2013) Pharmacokinetics of Orally Administered Cyclosporine in Patients with Crohn's Disease. The Journal of Clinical Pharmacology 35:7, pages 681-687.
Crossref
William J. Sandborn. (1995) A Critical Review of Cyclosporine Therapy in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 1:1, pages 48-63.
Crossref
S Nicholls, P Domizio, C B Williams, A Dawnay, C P Braegger, T T MacDonald & J A Walker-Smith. (1994) Cyclosporin as initial treatment for Crohn's disease.. Archives of Disease in Childhood 71:3, pages 243-247.
Crossref
Peter R. Gibson. (2012) Inflammatory Bowel Disease. Clinical Immunotherapeutics 2:2, pages 134-160.
Crossref
R. Balfour Sartor. (1994) Cyclosporine Therapy for Inflammatory Bowel Disease. New England Journal of Medicine 330:26, pages 1897-1898.
Crossref
Douglas S. Levine. 1994. 171 234 .
J Bellanger, J Cosnes, JP Gendre, L Beaugerie, M Malafosse & Y Le Quintrec. (1994) Traitement de la maladie de Crohn de l'adulte. La Revue de Médecine Interne 15:10, pages 676-689.
Crossref
A. B. R. Thomson. 1994. Inflammatory Bowel Disease. Inflammatory Bowel Disease 385 423 .
MARK E. STARK & WILLIAM J. TREMAINE. (1993) Maintenance of Symptomatic Remission in Patients With Crohn's Disease. Mayo Clinic Proceedings 68:12, pages 1183-1190.
Crossref
M. CARPANI KASKI & H. J. F. HODGSON. (2007) Rolling review: inflammatory bowel diseas. Alimentary Pharmacology & Therapeutics 7:5, pages 567-579.
Crossref
Scott A. Strong & Victor W. Fazio. (1993) Crohn's Disease of the Colon, Rectum, and Anus. Surgical Clinics of North America 73:5, pages 933-963.
Crossref
R. A. KOZAREK. (2007) Review article: immunosuppressive therapy for inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 7:2, pages 117-123.
Crossref
Guido AdlerGuido Adler. 1993. Morbus Crohn Colitis ulcerosa. Morbus Crohn Colitis ulcerosa 184 210 .
WILLIAM J. SANDBORN & WILLIAM J. TREMAINE. (1992) Cyclosporine Treatment of Inflammatory Bowel Disease. Mayo Clinic Proceedings 67:10, pages 981-990.
Crossref
E. LANGHOLZ, J. BRYNSKOV, K. BENDTZEN, M. VILIEN & V. BINDER. (2007) Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. Alimentary Pharmacology & Therapeutics 6:4, pages 495-502.
Crossref
David L. Geier & Philip B. MinerJrJr. (1992) New therapeutic agents in the treatment of inflammatory bowel disease. The American Journal of Medicine 93:2, pages 199-208.
Crossref
J. W. Harting. (1992) New developments in the pharmacotherapy of inflammatory bowel disease. Pharmaceutisch Weekblad Scientific Edition 14:4, pages 275-286.
Crossref

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